Carol
@_Carol_Mag
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Working to extend healthy human life | @age1VC | Incoming PhD student at @stanfordmed | from 🇧🇷
San Francisco, CA
Joined June 2014
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Why has menopause become a normal part of every woman's life, when it causes unnecessary suffering?
Why is reproductive aging research still significantly underfunded when half of the population experiences menopause?
I believe this *needs* to change, so I wrote a piece about
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4th additional option: we delay menopause entirely to extend fertility *and* longevity
3rd option: women freeze their eggs and/or embryos while they are young and don’t have to pause on their ambitions until it’s convenient for them
Older fathers also contribute damaging genetic mutations as they age, freeze sperm too!
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I wrote a post about artificial wombs! First time putting myself out there in a post, so show some love 💛 and check it out! It might not be perfect but I had fun writing it :)
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Felix Donghwi Son - Quantification of Cellular Organelle Size
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@ArtirKel
I find it rlly helpful for school!! A professor might skip steps of logic because it’s second nature to them, but GPT4 does an amazing job at spelling out difficult concepts (in my opinion)
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The fact that whenever I say I’m interested in aging biology to a college friend studying bio, they reply “oh yeah, telomeres, right?” drives me insane
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🎓 Plan after graduation: build now, age later
Also, axolotls rule the world!
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If I go to Stanford for grad school, does that mean I need to learn to ride a bike ?????
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Super excited to be joining the On Deck Longevity Biotech Fellowship! I had a great time at the kickoff today and can’t wait to connect with other fellows who are revolutionizing longevity biotech 🧬🧪
#ODBL2
Thanks
@beondeck
@realNathanCheng
@adanguyenx
@michellebkwok
!
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My life in academia —> work in a windowless TC room
My life outside of academia:
Does anyone relate? 😂😅
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I compiled useful resources, such as labs working in this field and interventions that extend fertility in rodents, which can be found here.
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So incredibly happy to be part of the first group of
@vita_dao
fellows! Thanks
@vincentweisser
for the amazing opportunity. If you haven’t heard of the VitaDao Fellowship and are interested in pursuing a project in longevity, totally check them out
3 days later, we already got so many great applications that we already have our first batch of
@vita_dao
fellows funded! 🧑🔬
Apply on for our next April round!
And reach out if you want to donate crypto to fund longevity micro grants!
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SF culture is so empowering. It truly does make you feel like you can do anything you set your mind to.
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It is *so* special to have friends who share your passions.
The
@time_initiative
retreat this weekend was just a reminder that the future is bright, and we get to build it.
Thank you
@c_hudpaz
for making this happen.
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So honored to receive the
@GoldwaterSC
and thankful to all the mentors that helped me along the way!
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Instead of intro coffee chats, can I start inviting people for ping pong at the
@age1vc
office? "Would love to play some ping pong together next week if you have time"
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If you’re a woman and you'd like to be a mother, you are also most likely familiar with the biological clock ticking in the background of your decisions. From dating decisions to major career options, this ticking is subtle but present.
But, menopause is also about *quality of
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So honored to be a Time fellow!
Can’t wait to learn tons from this group, and huge thanks to
@c_hudpaz
for creating this initiative.
🚀 Introducing our 2023 Time Fellows! These trailblazers are gearing up to redefine the future of aging research. Exciting times ahead as they embark on this transformative journey! Check out the faces behind the brilliance. 🌟
#TimeInitiative
#aging
#agingbiology
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I’m truly the most content about my life when I’m in an airplane.
I started flying alone when I came to the US to study English and I think I associate flights and airports with this broad idea of “going after your dreams”
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Amazing Longevity Social yesterday!!! I always come out of these events feeling more optimistic and excited about the future. Awesome to see such a bright group of people all passionate about aging 🤩
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Longevity Social coming up – Tue, July 18th. Join us at 6:00 pm in San Francisco for an evening of drinks, food, and longevity discussions. Limited spots!
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From loss of physical independence to declining cognitive skills, the things that form our identity are slowly taken away with age. At
@age1vc
, we refuse to settle for a future where this is the reality.
I couldn't have asked for a better team to work on such a challenging but
It���s crazy how things come full circle….
When I first met
@AlexJColville
I told him I was frustrated with the lack of longevity community.
So, he encouraged me to build it.
build now, age later
@age1vc
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Nerding out about science in a group is truly one of my favorite things to do. When I was in the Church Lab, my favorite part of the day was discussing/listening to aging discussions during lunch!
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So excited to contribute to reproductive longevity research!
Please join us in welcoming Carol Vieira de Magalhaes to the Duncan Lab✨ Carol will be working with
@FarnersRiera
to study ovarian fibrosis as part of her undergraduate studies at Northwestern University!
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Our second summer Longevity Social in SF is coming up on Aug 17th! Featuring a fireside chat with
@AlexJColville
and
@MartinBJensen
🧬🕒 join us for an evening of food, drinks, and longevity discussions:
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Longevity social yesterday was such a blast! Thanks
@loyalfordogs
for letting us use your space, and
@jenngarrison
for shedding light on reproductive aging and inspiring the audience.
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“This is the decade in which we get drugs directly for longevity into the clinic” and
@age1vc
will be a catalyst
Excited to launch a new fund today:
I wrote here about my takeaways from the past decade + predictions for the next:
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Can someone help me understand IP NFTs ?
Isn’t an NFT essentially the entry on the blockchain that gives people the ownership of the digital file (the token) not the "real life" thing the token represents?
so how can DAOs own “real life” IP through an NFT ?
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It’s so hard to know how to approach the biology of aging. Such a complex issue, which is also the beauty of it!!!
@maggie_1i
wrote an an incredible framework on how to think about this field.
How do we move from lab to clinic for an aging intervention in *this* decade?
I’ve spent a lot of time thinking about this question and created a framework dubbed the longevity funnel framework (LFF) to answer it:
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Would anyone be interested in doing a small/casual/close-knit repro aging JClub with me (could be over zoom)?
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@DnaDeviants
Longevity Jclub this Thursday in SF!
Come discuss senescent cells & hair growth while drinking hot chocolate 😋🍫
RSVP link:
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Our applicants are disproportionately guys, where are the girls in stem?
If you know anyone tag them or dm me!
Applications for our BioDojo House for June to August 2022 are now open! Deadline is April 1st ⏰
For more information, check out our notion page:
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Why saving the genome might be the best way to tackle aging!
*Also* there's interesting evidence that DNA damage repair genes are linked to a later onset of menopause 🤔
What drives aging?
Entropy? Information loss? A software flaw? Mutations? Epigenetic drift?
Choose any - but it all comes down to maintaining the genome. And yet there are so few people working on this central pillar.
A post on why you should:
(1/7)
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@chloewchia
I agree! What’s interesting tho is that the most successful chains are moving toward the “grab and go” model. Starbucks is opening a bunch of new locations without the sitting area :(
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It's my last year of undergrad and I've been thinking a lot about what I *actually* learned in college. This resonated with me:
"Education is what remains after one has forgotten what one has learned in school." —Albert Einstein
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@paulinapaiz02
@girlbossintech
@singareddynm
Much cheaper than college though, and prob often more effective because you get 1-1 attention
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Boston Longevity Week off to an amazing start 🚀🧬
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Always excited to chat about this topic! Who is working/interested in this field, and I should meet?
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I've always loved biology. Recently, there's been a click and I'm obsessed with physics. Still haven't seen the beauty in chemistry though :( What chemistry principles/aspects amaze you?
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My entire family in Brazil 🤣😅
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There is so much that interests me within biology that it’s so hard to just pick one area, but it’s also important to focus. Eternal dilemma…
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Time is money 💵
What would be the revenue of an aging drug?
The economics of delivering such value to human health at scale are unprecedented:
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Want to join a co-living community in Boston with next-generation builders & young emerging scientists in biotech over the summer?
Join our waitlist, and we’ll reach out with application forms over the next few weeks!
Summer will be starting soon, and Boston is full of life.
If you're 18-23 come to spend a summer with us at our first co-living house🏠
Join our waitlist, and we will reach out with application forms soon!
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@willdepue
The closest I can think to what you’re describing is Homo Deus and Sapiens by Yuval Noah Harari. I really liked them (especially homo Deus) when I read it years ago. I’d check out a summary online and see if it sounds like what you’re looking for :)
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And biology keeps amazing me every day
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I’m so happy I always learn so much from these journal clubs 🤩
Thanks so much for tuning in today for
@DnaDeviants
#SynBio
JClub! We had an awesome time discussing programmable RNA sensors w/ 2 first authors from the Stanford (
@EerikKaseniit
) & MIT (
@idmjky
) papers!
We're incredibly excited to see you what you do next with this technology!
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It’s so interesting that estradiol and testosterone are so similar in structure but have such different physiological effects
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What are papers that look at aging through a systems bio approach ?
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Getting messages from ppl wanting to chat abt repro longevity makes my day 😊
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Incoming maximum lifespan extension by up to 35% in mice
For these reasons and more, this paper is very exciting - and opens a world of exploration! Congratulations to Linda and team.
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How does DeSci play out with IP rights? Like if
@lab_dao
,
@vita_dao
,
@Molecule_dao
, or
@PsyDAO_
is funding a specific research study, does it become not patentable?
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A few months ago we had the idea to create a biotech hacker house, today we have incredible emerging scientists and entrepreneurs living together and learning from one another!
We are so proud of the
@NucleateDojo
team.
Congrats
@subaita_rahman
and
@_Carol_Mag
on the Dojo House!
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Just had a chat with
@Sana_Rfzz
@SyntheticRabbit
and
@yasmeenbrain
about genetic engineering, fractal theory, FDA regulations, ethics of eating octopus, and so much more. I can’t wait for
@thedojohouse
this summer and all the great mind-boggling conversations we’ll have!
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Huge!!!! Where are the proposals in reproductive aging 👀
Today marks a historic moment as we launch the
#SprintForWomensHealth
! 🚀 This initiative is a bold move towards achieving gender equity in health care research and ensuring women's issues are represented. (1/2)
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I’m deep in a rabbit hole to understand time. What is time from a physics perspective? Does anyone know of good essays/books/talks on the topic ?
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Axolotls are so cool!
Did you know that axolotls have the largest genome ever sequenced with 32 billion base pairs? For comparison, the human genome is about 3 billion base pairs.
Photo credit: Christian Selden, Reed College
@SeldenChristian
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Building a startup is like playing 3d chess with advanced calculus in it somehow. There's 10000 axes and factors you have to consider and optimize for.
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As another
@DnaDeviants
initiative, we are starting a *DNADeviants JClub snack* series, where every week I'll be posting a thread on a longevity paper.
🧬Here's the first one 👇
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Highlight of my winter break: listening to Lorde and reading papers. I'm living the good life.
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Source? Was there ever a study with a large number of people that looked at regrets of people who are dying? I wonder what the exact method of questioning was
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Prevention of cancer - most drugs that extend lifespan in mice prob do that by preventing cancer
What would revolutionize cancer field?
Does it really come down to more sensitive and early diagnostics or am I naive in this thinking
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Come talk oocytes with us this Sunday! Here’s some readings to get thinking on the topic 🔥
Join us this
#SynBioSunday
(5/7/23) for
@DnaDeviants
Journal club!
Discussion around oocyte generation will be led by
@_Carol_Mag
& myself!
Paper:
Twitch:
Slack:
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Missing
@thedojohouse
Paul Graham on why ambitious people need to be around other ambitious people:
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I love this
@KKajderowicz
Congratulations to 2023
#PDSoros
Fellow
@KKajderowicz
! Kat, the child of immigrants from Poland, is a cellular & molecular neuroscience PhD student at
@MIT
and the founder of
@DnaDeviants
. 🇺🇸🧬🗽
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Every day I fall in love with the community of people in SF, but every day I get more disappointed with the city (which makes me so sad)
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Get a job that you feel energized after calls that end at midnight🌃✨
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So many interesting conversations and amazing people! I had a great time.
Thank you to
@tylercowen
and Emergent Ventures for your support and an amazing weekend! And always so great to see
@MichaelTrinh18
@_Carol_Mag
@SeyoneC
— hope to see y'all again soon!
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This is such an amazing overview of really great resources that already exist. Thanks
@kulesatony
and the
@pillar_vc
team for putting this together!
1/ At
@pillar_vc
, we’re open-sourcing all the knowledge and knowhow of building biotech companies.
Today we’re launching the Founder-led Biotech Ecosystem – a curated, open-source set of community-built resources. And we want your contribution!
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Just finished the last lecture in my undergrad bio of aging class. Final conclusion we got to: let’s all age like Tom Cruise. Amen 🙏🏼 😂
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This is gonna be an amazing summer!
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This looks really cool
Imagine seeing a disease's impact on every cell in the body. Now, you can!
We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. MouseMapper showed obesity-induced changes in facial nerves & body-wide inflammation 👉🏼🧵
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OVERALL: Rapamycin seems to have a positive impact on reproductive aging (especially at 8w), possibly through decreasing the number of growing follicles. This might happen through the inhibition of proliferation and growth of cells, which might be necessary for folliculogenesis.
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Spending hours going through tens of new reagents to find how long they’re stable in solution after they’re reconstituted. This should definitely be automated.
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Using
@alantomusiak
’s wise words: JCs for critical analysis are so yesterday, JCs for bonding and brainstorming are *in* 😎😂
Recently piloted a ~ new type of longevity journal club ~ on the topic of chemical reprogramming with an emphasis on brainstorming next steps, next experiments, next essential findings. It was beautiful! A change of pace from many journal clubs, which...
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So happy to have learned so much from
@FarnersRiera
and contributed to this project 🤩🧫
A new Duncan Lab publication by
@FarnersRiera
is now available in
@GeroScienceAGE
!
This important work on ovarian function was supported by
@GCRLE1
@NorthwesternMed
@NM_ObGyn
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I can’t wait!
VERY excited for this week's
@DnaDeviants
Journal Club!
Join us this Wednesday @ 6 PM ET on TWITCH! [link TBD].
We'll be discussing a recent ~synthetic embryos~ preprint from
@GianlucaAmadei1
+ team with special guest
@_Carol_Mag
, an awesome researcher
@geochurch
lab!
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I want to see more great biotechnology companies in the world, faster.
Join me at the Founder-Led Biotech Summit hosted by
@pillar_vc
this week to contribute to the movement.
#founderledbio
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I legit think ovarian biology is so beautiful 🥹 sometimes you find passions where you’d never imagine
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I truly think we all underestimate the role random luck plays in outcomes in our lives
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Axolotls rule the world
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TLDR:
-longevity is noisy, but snake oil cure-all medicines have always existed->what's special now is that we can modulate aging
-The FDA exists for a good reason. I'm all for living a healthy lifestyle but we need clinical trials + regulations to have a significant impact
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You don’t want to miss this out. This will be an incredible evening 🤩
Hyped to be hosting a special kind of longevity social/networking event in San Francisco on the evening of Thursday the 26th!
One of the things that struck me when I entered the longevity field was that...
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*amazing* opportunity for ambitious undergrads who want to have a big impact! No need to come from a bio background. Apply, apply, apply. Let’s make this the longevity decade.
Create a healthier future for all of us. 🌍 Apply for the Time Initiative Fellowship and join the next wave of leaders in
#AgingBiology
. Deadline: June 30th. Watch and share with the ambitious
#undergrads
you know!
#TimeInitiative
🎥 full video:
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Amazing advice for undergrads out there
If you feel like you’re too young and inexperienced to make a difference in biotech, you need to study
@JoshuaBCohen1
&
@justin_klee
. Yesterday they achieved a historic FDA approval for their drug for ALS…which they came up with in UNDERGRAD
@BrownUniversity
!! Here’s how:
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Sorry, but I still think it's weird when people intro you without asking first when it's been over a year since you've last talked
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Would anyone be willing to give me feedback on grad school apps ?
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Maybe I’m overthinking but whenever I read stuff online now I feel like I can notice parts that were written by chatgpt based on the words that were used. Like, would anyone actually say “this summit brings together trailblazers in biotechnology” ?
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