Today we're announcing our first partnership of 2025! This year, we're partnering with @Convergent_FROs to publish seven deep articles about nonprofit, focused research organizations. Our first article, an inside look at @E11BIO, comes out tomorrow.

Last year, $9B of the $35B that the National Institutes of Health (NIH) granted for research was used for administrative overhead, what is known as “indirect costs.” Today, NIH lowered the maximum indirect cost rate research institutions can charge the government to 15%, above what many major foundations allow and much lower than the 60%+ that some institutions charge the government today. This change will save more than $4B a year effective immediately.

Scientific research has been held back by the very systems driving it. There’s no shortage of intelligence among our scientists, nor creativity and hard work. But there are essential technologies missing.

🚀 We are looking for Image Data Scientists to join our mission to advance connectomics towards whole brain scale for humans and other mammals (1/3) 🚀

A paper on microplastics accumulating in the brain was just published @NatureMedicine, open-access I review the background and major implications in a new Ground Truths edition (link in my profile)

I'm extremely excited to share Story Co's first Frontier Film: NEW SPACE

Excited to share 2p-prime, a novel physical pathway for multiphoton fluorescence generation that enables optical sectioning and excitation at red wavelengths with simple systems like continuous wave lasers. I founded @tripletimaging with @jdwong_campos to fully realize the potential of this tech and introduce a new paradigm for multiphoton fluorescence. We’re exciting real intermediary states, specifically driving forbidden triplet transitions, using picosecond and continuous wave lasers. Links to two pre-prints + explanation in the thread where we demonstrate 2p-prime with ps and CW lasers in dyes and living cells expressing fluorescent proteins. David thought of this idea, inspired by optical control of forbidden state transitions in atomic systems from his past life in quantum computing in the Monroe lab and as an early employee at @IonQ_Inc. In the limit, our approach could be optimized to replace all fluorescence microscopes with simple LED systems that can do rapid volumetric imaging with capabilities akin to existing 2p systems in optical sectioning, contrast, depth, and resolution. Low power, high throughput multiphoton imaging could enable moonshots like functional imaging of every synapse on a neuron or single cell resolution across an entire mouse cortex — datasets which are inaccessible now due to high powers required by ultrafast lasers. Fundamental insights may generate broad possibilities, and we’re investigating applications across multiple industries like diagnostics and 2p lithography. This is a white space in photophysics. No indicators have been designed or evolved for this process. We’re optimistic we’ll keep lowering power levels as indicators are optimized for these transitions, e.g. enhanced spin-orbit coupling.

We're excited to introduce the 2025 class of Brains Fellows! These talented scientists and technologists are working on ambitious ideas that are beyond the scope of individual academic labs, startups, or large companies. Check out their ideas🧵

We are accelerating

Science Corp. has created its own line of neurons that it's fusing with an animal's existing neurons via an implant, and we may end up with monkeys playing poker. How's your Thursday?

We welcome @clairebookworm1 to the @e11bio team! Claire is a MIT undergraduate and previously worked in Ed Boyden's lab on whole brain emulation of C. elegans. At E11, she will focus on neuroanatomy analysis and machine learning pipelines.

1/ 🧵Announcing CORHORT 6 of the Longevity Biotech Fellowship —the most hardcore community of longevity accelerationists! Join 700 members working to SOLVE aging entirely. ⌛️Deadline: Mar 14 Kickoff Retreat: Mar 31 - Apr 4 in Berkeley. 👉Apply: