José Luis Ricón Fernández de la Puente
@ArtirKel
Followers
20K
Following
53K
Media
7K
Statuses
175K
Head of Theory at @RetroBio_ , enjoyer of things, blog: https://t.co/8xDYgWAJHB
San Francisco, CA
Joined April 2007
TIL astrology is real, if you work in semiconductors
56
290
2K
@Aella_Girl If you take all other labels in the chart either they are too specific ('came in aella') or very normie ('we contacted'). Also 'fluffer' is an intrinsically funny word that has high memetic potential.
11
3
1K
Isn't it kind of weird that teeth grow twice? .No teeth (0) seems normal. Teeth once (1) seems also ok. Teeth all the time (Infinite) like in sharks also seems reasonable. Two (The default in humans) strikes me as a weird choice.
27
25
792
Our Applied AI team at @RetroBio_ + some @OpenAI homies working together for a few month have created GPT4b-micro, a sequence-based model for, among other things, protein design!.
15
52
568
Why we age in a nutshell:.1. You lose cells and some jobs go undone (like hair cells for hearing, beta cells for insulin, or even entire structures like teeth). 2. The cells that do remain do perform worse (largely epigenetic aging).3. The space between cells (the ECM) gets.
22
34
499
At dinner right now:.- can't eat pork, I'm Jewish.- can't eat chicken, because EA.- can't eat beef because Hindu.- can't eat tuna because mercury. But lamb brings us together.
31
14
468
A Thiel Fellowship, but to drop out of software and do something different.
21
34
471
So far I have found ChatGPT useful for coding, and not much more. Is this everyone's general view?.
208
10
441
"NYC girls" are insane because they appear to be one of the most legitimately dangerous sources of relationships with the potential to gigafry your brain, but they are pursued exclusively by SF guys who unironically want to "go on a date" and basically get oneshotted by them.
24
8
441
The best possible news for a US immigrant like me 🗽🦅🚀
69
4
423
Elon Musk's secret life goal: To show that markets are way more inefficient than we thought by repeatedly making tons of money doing what various industries have strong economic incentives to do but don't do (reusable rockets, 10x cheaper batteries).
9
19
409
Post Oppenheimer, someone outside the theater says "But he didn't invent anything, he just told people what to do. well I guess he picked those that did".Indeed, the central thing of management. At worst, taking credit for other people's work. At best, dreaming into existence.
5
19
407
Probability of choosing STEM, SEH (Socsci&Humanities/Education/Health) and business, by SES and gender, in the US.
24
154
340
There had been a longstanding debate in biosecurity circles whether one could synthesize smallpox from its sequence. One guy was like ayylmao and had it made (horsepox, as a proof of concept, protocol is the same for smallpox)
6
56
301
Basically everything that has ever been said in the "science is broken" conversation (with some baseline plausibility; disaregarding for now relative importances):
26
38
260
@catehall Related to this, obsession can pass for correctness. At first,a flat earther seems to know more about how the earth curvature is measured and to some people seem very knowledgeable and thus right. A normal person has no reason to go deep into such matters so they seem less smart.
6
5
259
I have around 5000 PDFs and documents that I want to LLM through, what's the best current way?.ie I want to be able to ask things like "What do we know about X?" "Show me some documents that discuss Y" etc.
69
10
255
I'm looking at google street view pics of San Francisco and it's surprising how low density the housing is. Madrid and SF have similar areas (see pic), yet Madrid has almost 4x the population.
25
33
229
Wow Sam went through the Steve jobs arc so fast. At an accelerated pace dareisay.
5
12
243
How it started (Feb 2020), how it's going (Oct 2021). Thanks @asterainstitute & @BuckInstitute for making it possible!.
24
19
240
Tired: Covid was a Chinese bioweapon.Wired: Covid was orchestrated by the GMU Econ department to a) increase preparation for future serious, Spanish flu-tier pandemics and importantly b) increase economic growth by accelerating the transition to remote.
6
13
215
For a while everyone was like "But partial reprogramming has never extended lifespan in wild type mice". Now it has (As I expected it eventually would):
6
33
212
Cool-shit futurism (space colonization, moon telescopes, tech for the sake of tech to some extent) vs cozy futurism (urban reform, renewable energy, solving climate change; focusing on specific problems and having tech as an ends) are categories I've been thinking about recently.
19
20
207
Today is my first day at @RetroBio_ !.Excited to join an amazing team working on therapies to extend healthy human life :)).
37
1
199
That's ~2% of US GDP right there!
Announcing The Stargate Project. The Stargate Project is a new company which intends to invest $500 billion over the next four years building new AI infrastructure for OpenAI in the United States. We will begin deploying $100 billion immediately. This infrastructure will secure.
8
9
206
Today I turn 30. Reply with life advice for incoming decade.
93
4
190
Has topology gone too far? .(via Mathematical Mathematics Memes)
8
69
184
No sequencing? No problem! You can shoot lasers at cells and read their transcriptomes at a single cell resolution (ht @AlexandreTrapp ).
3
22
172
@marannelson @josaaay10 My TSA shitpost was when they asked me the "Why are you coming to the US" I replied "To make science great again", he loled and let me through.
3
7
151
The covers of Cell Metabolism are amazing
1
18
175
1
0
176
There's a gigabrain post to be written that starts from the observation that there are potential Feynmans trapped in Jane Street, continues with the suggestion that finance should be taxed and finishes arguing that that's the highest leverage metascience intervention.
17
13
174
I wrote an article for a new publication, @helloflink on the road towards beating aging and what deep changes it may involve to our lives looking far into the future.
9
23
156
To the left, a room from the nicest hotel I've been to (Amangani, in Jackson Hole).To the right, what most hotels that try to be nice look like (Here, a Four Seasons). Obviously the former looks more cozymaxxed (ie correct) yet almost no hotel room (or room, in general) is like
27
4
162
Strong chad energy in this fire commander
8
9
143
"Bringing the scourge back would probably take a small scientific team with little specialized knowledge half a year and cost about $100,000.".
4
5
135
@webdevMason It's reaching levels of lol that wouldn't be believable if done for comedy reasons in a sitcom.
3
3
125
The unreasonable effectiveness of doing, then thinking; vs thinking too much before doing.
7
14
130
To my taste, @dwarkesh_sp is probably the best podcaster there is right now. Both he and @tylercowen research their guests in depth and try to ask novel questions. But Dwarkesh is more serious about intellectual exploration (at the expense of cultural aspects).
7
7
131
Form I-140 approved today!! One step closer to the green card 🚀.Took ~ 11 months for an EB2-NIW.
18
1
131
2
19
121
After a year of working with the great team at @meet_aiden , followed by another year at @twitter (keeping and growing the same team!) post-acquisition, I'm leaving tomorrow and moving to SF in early November to -checks notes- make science great again. Exciting times!.
23
2
132
Artificial wombs may sound weirdly dystopian but it's an equalizing and liberating technology which we should have.
we’re not even close to full-term artificial wombs. the tech’s *theoretical* value prop is saving premies. if you’re worried about population collapse my suggestion is to have a baby.
37
10
127
Why is search on Mac hilariously bad? You're on a folder, search something (On Finder) and then it does a full disk search that somehow it manages not to find the file. WTF.
16
1
123
Ok, cashed out of $GME this morning. Farewell to our fellow cosmonauts headed to deep space for an uncertain voyage.
5
0
122
Consider a parrot. Compare how likely you think a parrot is conscious* with how likely you think LLMs are conscious. A parrot will never be able to produce output like LaMDA. And yet the parrot is orders of magnitude more likely to be conscious. (*is a subject of experience).
10
14
117
1
3
109
business plan? sir, we have the mandate of heaven.
2
11
121
What do researchers in the aging field believe? A survey
5
26
107
@StuartJRitchie @hamandcheese The only real thing here is Stuart coming out as aphantasiac 🙃.
0
0
104
re that cancer cure, this is not the first time something like this happens. Killing multiple cancer cell lines while sparing normal cells is something that we've seen before with eg 6-thio-2'-deoxyguanosine or MR1 CAR-T. The hard thing is making it work in vivo, in solid tumors.
4
10
109
The perfect floor lamp hasn't been inven—.
2
7
108
@juliagalef "Galef CONFESSED to her dislike of standard journalistic practice, sources closer to the author said".
3
0
109
@dwarkesh_sp Yeah; Yarvin's model works best if you have lots of tiny countries or even overlapping jurisdictions, where you could walk away. which used to be more common in the past, where some of his historical flavoring comes from.
12
3
112
[Marked safe from Forbes 30 under 30].
5
2
107
I recorded a podcast on longevity, fixing science and assorted topics, it's now available:.
7
18
108
Related: I think this is why LLMs are for now overhyped. Software engineers are rightly impressed (as they use them day to day). Many others are like rightly unimpressed. But because a lot of the discourse comes from software land, it seems everyone finds them super useful (?).
9
5
106
The singularity starts when hordes of software engineers finally start their migration to where their brains are needed, the lower paying, more demanding (yet more meaningful) coal mines of hardware and biology. We have robots to teach and diseases to solve. It'll be glorious!.
8
5
108
I have become one one with Twitter!.@meet_aiden has now been acquired by Twitter, making me a capital-t Tweep.
16
3
106
@kulesatony DeepMind has teams competing with each other following different approaches to the same problem. There are leaderboards. Winning team absorbs the rest, then everyone works on the promising approach.
9
11
94
Today in "WTF I can't believe that valuation", Linktree is valued at over 1.3bn dollars. For a link to a list of links.
6
4
95
The opposite is true! Programming is joyful because feedback is solid and fast!.
programming is frustrating because when your mental model is incorrect, feedback is fast and impossible to refute. other tasks are don't feel as frustrating because incorrectness doesn't punch us in the face like in programming — but that doesn't mean we're any less wrong 🙃.
5
7
96
This restaurant is spicy in multiple ways
7
3
93
Tfw you try to get GPT3 to solve aging
4
8
95
I'm not a fan of boardgames and tried to figure out why. It seems to be some sort of uncanny valley situation where the situation is so close to something I like (having a great conversation with the people present) yet we are doing something else.
14
2
94
Get your blood tested randomly! Your doctor will not do this for you but it can be really helpful. I found out I was vitamin D deficient (and started supplementing). A while back I found out my blood iron was too high. I had assumed I got enough sun because Bay Area but wrong.
9
6
93
Tools for thought, half a century of trying to get adoption, half a century of failing. There's a need for a meta-literature on not how people decide, think, or remember, but on why they or do not adopt tools to help them do that. Retention remains a substantial issue.
6
5
93
When I see someone writing their name as 'X, PhD' I reduce my prior somewhat that what they are about to say is true. Is this generalized?.
13
3
88
Telomeres: everything you always wanted to know.
5
14
90
Reminder that if you liked Jiro dreams of sushi you must watch juan likes rice & chicken.
5
6
87
The Pyramid of Economic Insight and Virtue, now in meme form. From .
4
50
87
Confused about what FROs are? I made a handy chart for reference
4
8
84
Probably the most SF injury possible is dropping a chonky tungsten ball on my finger
8
0
85