Joanne Peng
@JoanneZPeng
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aging research, molecular tool dev, neuroai | @mit @princeton @thielfellowship | 🇨🇦
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Pinned Tweet
very excited to announce ’s latest philanthropic project, co-led by
@naturecomputes
,
@AToliasLab
, Tirin Moore, and Barun Dutta at
@Stanford
enigma is collecting the largest single-neuron dataset, to build a foundation model of the brain
the team, with
New project:
Engineers, ML researchers, mech interp community: Reach out if you're interested in getting involved
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at Irish border control:
“an O1 visa? what’s your extraordinary ability? you know, our Cillian Murphy has an O1”
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hosting a small gathering to watch In Silico, the documentary about the 10-year, $1B failed quest to simulate a brain! ego, conflict, scientific feasibility all come into question.
this sunday, 8PM, SF
dm for invite :)
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in 2007, DARPA put out 23 mathematical challenges which are about as undefined as they can get including finding a "mathematical theory of the brain" and the "fundamental laws of biology" (the 100 year question)
so many biology problems!
(h/t
@_julesh_
)
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thinking about the fact that most of my friends who drop out to become operators still want to continue learning math/physics, but it becomes exponentially harder to justify doing so in comparison to faster feedback loops in their other work.
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there's an entire wikipedia page dedicated to chinese nobles who died taking elixirs of immortality over 2000 years
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working on longevity research is possibly a good cure for people who are indecisive about what to work on in their lives and don't feel strongly about something:
if you live forever…you *could* work on anything and everything
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the most informed consent a case study on the “right to try” could have, the ethics are the least interesting part of this
kudos to her oncologists who backed her
An expert virologist prepares lab grade virus preps (measles and VSV) & self treats her recurrent breast cancer. What happened next? Apart from an ethical minefield! The reviewers comments & rebuttals are also published and make for an interesting read...
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Isaac Asimov on New Ideas — curious for comments on “to be creative in public is particularly bad”, which is against the wave of building in public, building with the garage door up, etc.
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The new trailer for the Oppenheimer movie directed by Christopher Nolan came out and it's incredible, but I implore people to watch this documentary before they go see it in theaters
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My second tweet ever was about
@joininteract
, and it’s been an annual tradition since then! It is still beautiful to me how many talented, ambitious, and humble individuals I’ve met through Interact. ❤️
Applications are now open for the 2022 Interact Fellowship!
Learn more and apply here by February 15th: .
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funnily enough, drugs for sleeping *more* are pre-Ozempic-like breakthrough as well. most sleep aids are not safe for long term usage, aren’t recommended for the elderly, come with noticeable side effects, or just don’t work (except melatonin). mostly lifestyle interventions
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jfk, obama, the median presidential age, trump, and biden
sponsored by the national institute of aging
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Currently on a delayed flight to SFO, pilot says:
“Turns out our 15 minute delay is actually 15 airline minutes — an airline minute is a quantum phenomenon because no one knows how long they actually are”
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if you're in boston (and especially if you're an undergrad in the area) come meet the fantastic
@thedojohouse
cohort!
co-supported by
@time_initiative
, emergent ventures,
@pillar_vc
@NucleateDojo
,
@1517fund
and :)
Hosting a biotech mixer in Boston with
@pillar_vc
!
Looking forward to bringing the community together — Thurs, Aug 8 @ 6:00PM
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Learning "by the numbers" is something many of my friends have gravitated towards. Sometimes I wonder how useful it really is, but it does allow for quick sanity checks if done well, and is very fun!
Compiling a small list (please send your favorites!):
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a huge deal for the aging field -- is our first real aging drug also the weight loss drug of the century?
A big deal.
This positions the GLP-1 drugs not just as weight loss medicines, but as treatments that prevent heart disease. We will need to see the full data and read outs from other trials, but this changes the discussion.
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If anyone would like to work through Feynman's Lectures on Physics w/ me, please DM! Focus would be on understanding and re-explaining concepts weekly, and working through the problem sets. <3 no previous physics experience necessary
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“Learning how to think" really means learning how to exercise some control over how and what you think. It means being conscious and aware enough to choose what you pay attention to and to choose how you construct meaning from experience.
- David Foster Wallace
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Reha is one of the most driven & insightful people I've ever worked with -- and she's now supporting founders!
(also, princeton biotech mafia is growing -- please reach out if you're ex-princeton and work in biotech/pharma/academic bio to join our groupchat)
Thrilled to announce that I joined the investment team at
@_DimensionCap
! Excited to support founders at the intersection of biology and tech!
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individual taste comes from excessive consumption
1/ mathematical intuition requires doing lots of math
2/ personal style comes from trying on a lot of clothes
3/ writer's voice comes from writing all the time
no guarantees on a "good" taste but then it comes down to refinement
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My yearly Interact tweet — two years in, still one of the best communities I've ever been a part of. So many stories of meeting incredible, value-aligned people only to realize that they are/were an Interact Fellow.
If you have any questions, feel free to reach out! :)
There are only two weeks left to apply to the Interact Fellowship. If you are 18-23 years old and care deeply about the transformative role of technology, apply now!
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hi folks! has anyone received an RFE for an O1 before and dealt with it successfully / have any advice or ways to help?
Thanks :) can’t believe how stressful these processes are in the US
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Reading a paper about the brain in numbers and still can’t believe that until ten years ago, we thought glial cells outnumbered neurons 10:1 (actual value is 1:1!)
So much of science is updating “common knowledge” from novel or more accurate tooling / methods
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Very excited to see
@cradle_health
launch!
Introducing
@cradle_health
, co-founded with
@huntercoledavis
. We're building reversible cryo technologies. Think the hibernation pods you see in space movies for long-term travel - we want to build that.
We’ve raised $48M, built a world-class team of scientists and engineers,
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new blogpost on the extracellular matrix in the brain from
@JoshDoesNeuro
& how the cell-specific focus misses part of the story.
tldr; environment matters. we started looking into this area because of a paper from segel et al. that showed isolated aged oligodendrocyte precursor
Happy to share this piece I wrote up on behalf of the Amaranth Foundation regarding the importance of the extracellular matrix in brain aging (a 🧵 ):
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Laura has been heads-down working on this for the last two years and I can't think of a better event to learn what the frontiers of cryopreservation are.
Hosting a party diving into the ‘science and philosophy of reversible cryo’ w/ special guest
@AgnesCallard
on 6/3, 6:30pm in SF!
- Technical talk on reversible cryo (many learnings)
- Philosophy panel
~100 people, holding space for 15 who apply here 🌸
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The team at Renaissance has been an unstoppable force for scientific progress. They know how to move the needle efficiently on thorny projects.
Excited to follow
@tkalil2050
@KumarAGarg
’s progress!
I am excited to announce the launch of Renaissance Philanthropy, with a phenomenal team including
@KumarAGarg
. Our goal is to help foundations and philanthropists promote a 21st century renaissance, fueled by advances in science, technology and innovation.
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come meet the princeton biotech students for a lil happy hour, 4PM @ lux cap in NYC this tuesday, dm for invite :)
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they typically hire a tutor, some even start groups to get through textbooks together which usually tapers off over a couple months. there's often some bad feeling that is built up after this. I wonder if it's because of the lack of some external factor.
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I wish there was a twitter mechanism that was just book (or textbook, essay, articles, letter, blog, inspirations, etc.) recommendations from your favourite accounts
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life is that short period of time
between two eternities -
when matter, through the mixing of chemicals
is electrically induced to unite
and become willfully active.
until the electricity stops.
hence - life is matter gone willful, for a while
- Neil Jenney
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@elidourado
and I have spent the last few weeks working on this piece. It's time to try something new and diversify what it means to work on Alzheimer's research.
New short paper with
@JoanneZPeng
:
It turns out the government has plenty of budget for aging research. It’s all just misguidedly earmarked for Alzheimer’s disease.
This is something that can be fixed by persuading four committee staffers.
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does anyone know inspiring biotech companies, VCs, or spaces in NY to visit or would be down to give a presentation to a group of Princeton students in early May?
I have a really excellent crew of students who are motivated, brilliant, and the future of bio :)
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@hardmaru
This is one of the most interesting recent proposals to try to do this:
Into c.elegans and big data approaches? We (with
@eboyden3
and many others) started shopping around a proposal to basically identify all the I/O functions of all the neurons and produce massive complementary data. Any feedback appreciated.
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Extremely proud of
@RaianyRomanni
and the team at
@xprize
for launching an $101M prize for extending human healthspan!
The biggest science prize in history has been launched with a $101M purse. 🧬
The goal? To improve human aging by at least 10 years, with a focus on cognitive, immune, and muscle function.
This is huge.
Read my take on what it means for humanity with quotes by
@elonmusk
,
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@albrgr
I frequently reference Open Phil as one of the first to fund moonshot science ideas before the recent new orgs
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Keep updated on more of Laura's comics at — think xkcd + waitbutwhy but for explaining biology! :)
Tiny Machines teasers:
@joannezpeng
made this trailer. Now one of my favorite science-inspirational things to watch.
I made this crazy cartoon about how I think
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a beautiful collection of essays from jake seliger, who recently passed away, about his struggle with head and neck cancer. are there folks who can point me to resources about the argument against the "right to try" as well as the current state of virtual trials? context from his
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Congratulations on the launch
@SGRodriques
and Future House team! Excited to see what comes from the 10-year vision, and heads-up, they're hiring interns :)
Today, we are announcing Future House, a philanthropically-funded moonshot focused on building an AI Scientist.
At Future House, our 10-year mission is to build semi-autonomous AIs for scientific research, to accelerate the pace of discovery and to provide world-wide access to
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in France right now — scihub and libgen are blocked, which makes me very sad for all the budding young pirate scientists
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An incredible resource to read from the wonderful
@Ben_Reinhardt
I’m excited to release something we’ve been working on for a long time:
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I'm always amazed at the beautifully designed diagrams to explain complex concepts from academic papers — ex:
@nature
news and views section…
what if every paper published had this as a norm? do great labs have great design people on their team as well?
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this (
@longevitywiki
) is well-written and deserves many more eyes and scientists contributing!
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Beyond excited for
@patrickmineault
to join the team! Reach out to work & collaborate with us.
Life update! I’ve joined the Amaranth Foundation as a NeuroAI researcher. I'll work on an ambitious roadmap for neuroscience for AI safety 🎉 1/
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dream incubation prior to taking a short nap, like thinking about the word "tree" to dream about trees, is related to better creative insights on theme-related tasks afterwards🌲
this stuff is wild, we know so little about sleep!
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Could anyone direct me to a particularly good explanation or summary of why it has been hard to develop an Alzheimer's / other brain disease drugs?
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langchain/gpt (after thinking for a long time): please consult a molecular biologist
me, internally: yay I’m still useful
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finally watched verdens verste menneske (the worst person in the world) at
@WendiYan5
's recommendation, and it's one of the most exquisite, heartbreaking, real, romantic films I've ever seen -- easily tops before sunrise for me.
it's also cinematographically stunning:
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Are there any other books similar to Genentech's Beginnings of Biotech?
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NYC folks looking for a date night activity tonight: go see the sequel to the AlphaGo documentary tonight at 5PM!
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"I seem to have been only like a boy playing on the seashore, and diverting myself now and then in finding a smoother pebble or prettier shell than ordinary, while the great ocean of truth lay all undiscovered before me."
- Isaac Newton
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sometimes things move so fast that we get a quarterly update of what's new in science:
feels like now!
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The constant temptation to take the red eye flight despite knowing it will mess my sleep up for days…what do I do
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today I learned you can just *lose* memory for hours with no underlying conditions or other symptoms and nobody agrees why it happens? (transient global amnesia)
what fresh hell is this
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super exciting work led by
@c_hudpaz
for undergraduates in all fields who are interested in aging biology :)
apply apply apply!
I’m proud to announce the Time Initiative-accelerating talent in
#aging
biology. A future where we live healthier, longer will be shaped by next-gen innovators. My mission is to activate undergrad students’ interest in aging and accelerate their growth into leaders of the field.
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landing in SF and immediately feeling like I’m sleeping too much
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1) develop drugs for needing less sleep in your 20-30s which increases the demand to
2) develop drugs for needing more sleep in your 40s
3) profit
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Can’t imagine better people to collaborate with :)
We’re excited to open the applications for the Brains Coordinated Research Accelerator!
This part-time program’s goal is to help people with ambitious research ideas refine them and find a place to execute on them in government organizations, nonprofits, and beyond.
1/
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Laura’s twitch is wonderful, please join if you have the time! :)
I have no idea if this will work, but tomorrow at 6pm PT will try showing what it's like to do a visual thought experiment in biology.
This might completely fail, but it's really joyful if you get it right. Just messing around, nothing vetted to work.
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I've been sporadically replacing the word fibroblast with fireblast in my zoom calls
…nobody has noticed or called me out on it so far
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hear me out: expansion microscopy is the cellular equivalent of cereal’s “enlarged to show texture” feature
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Go give Kernel some love! ❤️
Feeling all sorts of feelings introducing Kernel to the world! Kernel has truly been a collective labour of love, and I'm honoured to steward this work alongside so many other wonderful people. A thread on what magazine is about & how it came to be🌿
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did this a lot growing up and developed the wonderful skill of turning a page with one hand and the unfortunate consequence of many food-stained books
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A truly beautiful community — please apply and message me if you have any questions!
There is only one week left to apply to the Interact Fellowship! If you're an 18-23 year-old technologist, apply now at ✨
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some favourite accounts through which I stumble across hidden gems:
@drmichaellevin
,
@power_studies
,
@AgnesCallard
,
@SamoBurja
,
@andy_matuschak
,
@michael_nielsen
,
@ArtirKel
,
@LiveLearnLog
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moving out of my current place tomorrow but somehow a ridiculous amount of books found me yesterday night; if anyone in cambridge wants books to add to their library, lmk :)
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I had the good fortune of spending a few months in Los Alamos with some friends in 2020, and watched it before going to New Mexico. I've never felt the historical significance of a place more than when we drove up the canyon into the town.
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"Science as a Craft Industry", Freeman Dyson, 1998
What are biotech's current craft industries and what will they be in the future?
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A wonderful opportunity for young, ambitious undergraduates in all fields to get hands-on experience in aging biology. Wish I had this when I started out in the field :)
Comes with a network of peers, mentorship, and the opportunity for funding
Create a healthier future for all of us. 🌍 Apply for the Time Initiative Fellowship and join the next wave of leaders in
#AgingBiology
. Deadline: June 30th. Watch and share with the ambitious
#undergrads
you know!
#TimeInitiative
🎥 full video:
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@michael_nielsen
you can play around with this personally for more intuition:
1) download predicted pdb from alphafold
2) open in pymol or UCSF chimeras
3) you can visualize from the beta sheet/alpha helices view to the individual amino acids as well as surface area accessibility
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can someone explain to me why one would require a SWAT team to deliver something to an MIT lab
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