Impetus
@impetusgrants
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"Huge if true" aging science. Over $34M of research funded. Next round, questions, donations and other details -
San Francisco
Joined February 2022
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Pinned Tweet
live now
@impetusgrants
applications are now open (1-31st of August)
If you are a scientist but you never worked on aging.
If you are a Ph.D. student with good ideas.
If you are a postdoc deciding on the direction of your future lab.
Come join the good pursuit. We
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Our applications are now out! Apply at
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Round 2 of Impetus Grants is happening in May! Same blinded reviews, same fast responses, same short applications - now with new topics and bounty funding format:
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We are happy to finally publicly announce our results from round 2 and our new exciting collaboration with the Hevolution Foundation. Read more about projects on our website ($4M in funding!):
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Congratulations to
@RonghaoZhou
@jengreitz
@Thomas_Rando
who will be conducting large-scale CRISPR perturbation screens in vivo, in naturally aged mice, to identify genes that can reverse molecular signatures of aging.
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Next funded project: lab of Vera Gorbunova at
@UofR
will explore mechanisms responsible for longevity of the longest-lived mammal, the bowhead whale & search for strategies to activate these mechanisms in vivo in mice and in human cells.
They are hiring a postdocs for this work!
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How do we get the next generation of the most brilliant scientists to work on aging? Science follows the incentives (= funding)
@LNuzhna
/ Riyadh, Saudi Arabia
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Many studies have described benefits of partial reprogramming but little is known about its potential genetic consequences.
@martakova
will use novel lineage tracing strategies to probe the contribution of partially reprogrammed cells in vivo. They are hiring a postdoc!
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4 more days to apply for the current round of funding
- Applications are short enough that you can write them in a day!
- Any level of scientific training and background
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"Cells are more than their constituent molecules, owing to the emergent behaviors arising from molecular complexity. We will address how these emergent properties of cells are disturbed during ageing and whether we can harness them for rejuvenation" -
@Sciezgin
&
@FedericoPietr12
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Currently, there are no therapies capable of durable hematopoietic stem cells rejuvenation in vivo.
@JD_Buenrostro
@patrick_griffN
are developing a new strategy in HSCs to improve potency of novel transcription factors and associated rejuvenation!
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A 50-PAGER AND A 2-PAGER CONTAIN THE SAME AMOUNT OF ESSENTIAL INFORMATION BUT BOTH REVIEWERS AND RESEARCHERS HATE LONG PROPOSALS SO ACTUALLY ALL GRANTS SHOULD BE 2-PAGE LONG
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Can a worm with a typical 15-day lifespan survive for a year? By combining multiple interventions, each known to extend lifespan individually, how much can we prolong life? Excited for
@JavierApfeld
to find out the plasticity of C.elegans lifespan.
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Grad students & postdocs are the engines of science. More grants should be available to them.
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Can we shield the epigenome from age-related changes, much like how SIRT6 defends the genome? Using a CRISPRi screening approach,
@XiaoTianPhD
seeks to identify genes involved in maintaining epigenome stability. His new lab
@sbpdiscovery
is recruiting for various roles!
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Up next!
@jgooten
&
@omarabudayyeh
will be using the tools developed in their lab to target specific cell states in partial reprogramming & answer all the hard questions the field has been avoiding around reprogramming and associated rejuvenation. Congrats!
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First round 3 project from
@berkeleyMCB
Gametogenesis resets lifespan and gametogenesis-specific rejuvenation (GSR) factors can be expressed to extend lifespan in model organisms.
@tinalynnsing
is identifying new GSR factors that can be used to combat age-related damage. Congrats!
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Progress on understanding female reproductive aging has been impeded by significant lack of animal models that share reproductive features with humans. Dr Kochersberger from
@BuckInstitute
plans to assess Pallas’s long-tongued bat as a model for mammalian menopause!
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Human clinical use of current senescence biomarkers is limited by invasiveness.
@saralahue
@GeriSciDoc
are creating a blood-based biomarker for quantifying senescence in adipose tissue, testing its performance against senescent cell burden and existing SASP profiles!
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The round is extended for 2 more weeks, until 15th of September. Apply at
And check out our guide for writing applications
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If you are in Cambridge / Boston, come join our launch party and lightning talks on aging from
@kpfortney
@AlexJColville
@KKajderowicz
at the end of the week!
Sunday, July 30, 18:00 at Arts at the Armory
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One of the things we funded through the first round was the upcoming Systems Aging Conference . Why conference and not research? One might find it surprising but there was a great consensus among our reviewers that it should happen...
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Another big rapamycin news today: the study we funded to test whether we can slow ovarian aging using rapamycin (VIBRANT) is now recruiting women 35-42. Check whether you qualify to join:
(ht to incredible Zev Williams and Yousin Suh making it possible!)
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From the moment of conception, our germline cells have already aged for two or three decades, implying that the embryo must undergo initial rejuvenation.
@BarcenaClea
(
@uniovi_info
) is investigating embryonic rejuvenation to develop strategies for lifespan extension!
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Giant tortoises live 100+ years with few signs of aging and offer a unique chance to study anti-aging adaptations.
@heatherfsmith
,
@spotdvm
aim to identify anti-aging adaptations of long-lived tortoises that support their resistance to senescence.
@ScarletImaging
@MidwesternUniv
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Small nucleoli are observed in long-lived mutants of C. elegans, rapamycin-treated flies, calorie-restricted flies, mice, and humans...
@AntebiLab
&
@F_Melerowicz
will test whether their morphology is a suitable predictor to discover lifespan-extending drugs!
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Cells in the heart have evolved a special ribosome to enhance proteostasis and survive heightened proteotoxic stress. Can we reactivate it in brain and other tissues to impact lifespan?
@wu_xuebing
is finding out! Congrats
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Previously, we funded a risky idea - light-controllable rejuvenation of mitochondrial membrane potential that showed lifespan extension in worms.
@DocLarus
@musabumair98
are now translating this work into mammals
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We will also hold a pre-launch event near San Francisco the night before applications go live. Come join us for food, drinks, and lightning talks about aging!
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Hibernators live longer than closely related non-hibernators, yet the mechanisms underlying this effect remain unknown.
@hrvatin_sinisa
lab aims to characterize the effects of hibernation on hamster lifespan and markers of aging! 🐹
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We just made it easier to support the program!If you are interested in making a contribution, however large or small, check this out:
We aim to have the largest impact on aging per $ spent, so, for transparency, we are also publishing our fin.statements
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If you are doing work on reproduction / reproductive aging, check out this new fast-grants opportunity started by
@sarakemppainen
@fiftyyears
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Decline in proteostasis and lysosomal function during aging leads to improper protein degradation and accumulation of toxic proteins.
@TheVilchezLab
@MarkusWehrmann_
are using directed evolution to engineer protein variants that can effectively reduce aggregates during aging.
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Dunham lab
@dunhamlab
is exploring tolerance to long term freezing as a possible new paradigm for yeast aging. Using experimental evolution, they are generating strains with exceptional cryoresistance, to sequence their genomes and discover how they've accomplished this feat.
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We continue to support studies that uncouple epigenetic age from cell differentiation status and gestational age. Check out the new preprint from a collaboration between
@gladyshev_lab
& Horvath & Peshkin labs, led by Bohan Zhang &
@Andrei_Tarkhov
and funded through Impetus ⬇️
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A reminder that we are open for 2 more weeks, until the 31st of August.
Apply at
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There are many ways to measure DNA damage, yet no responsive biomarkers!
@vakil_takhaveev
@ProfessorShana
@Toxicology_ETH
@ETH_en
are using novel DNA-damage-sequencing methods in mouse models to discover mechanistic biomarkers implicated in aging. They are hiring a PhD student!
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Proteins tend to misfold and aggregate in aging. While there are known cellular mechanisms driving protein turnover,
@fried_lab
& Savas lab identified their potential vulnerability. They propose a study to test what happens to structures of proteins in aging brain at scale!
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We got close to 600 applications in the past days of the round (total more than 1050!) so we are most definitely still deciding
@impetusgrants
@UofR
Awesome stuff!
Are all the grants decided for or are evaluations still going on?
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Leveraging Geneformer, a foundational deep learning model for biology,
@TheodorisLab
,
@m_alexanian
will determine targets that reverse age-related fibrosis. They will then validate the efficacy of these targets in in vivo to establish new avenues for anti-fibrotic therapies!
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Join a fresh study funded through Impetus!
Incredible work by
@mkaeberlein
on rapamycin safety. More in this thread:
I’m pleased to announce the official launch of the UW Rapamycin Study funded by the Impetus Grants program. Website is live and the we are actively recruiting participants:
Please RT!
@Blagosklonny
@MartinBJensen
@RapaNews
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The thymus starts to shrink after puberty, continuing and worsening throughout life.
@BiotechByron
will investigate adenoviral encoded endogenous analytes to restore thymic function in models of aging, thereby restoring immune functionality.
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>>
@SynBioGaoLab
&
@RogelioHdezL
are combining state-of-the-art synbio tools with cell therapies to target specific subsets of cells implicated in inflammaging. This approach could both probe cell's causal roles and eventually be developed into senolytics. Congrats!
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@impetusgrants
-funded paper is out at
@NatureBiotech
- circuits targeting signatures of transcriptome
@SynBioGaoLab
huge congrats
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Team of
@a1eksei_m
@PaolaAmato
@Db4qL3qnJDhKtY5
aim to elucidate the epigenetic mechanisms in the oocyte cytoplasm that govern natural, sequential reprogramming of aged somatic cells to the embryonic state. Apply to join their project as post-doc:
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Recent reports highlighted a woman with Alzheimer's-linked gene variant, who avoided cognitive impairment for three decades due to protective mutations.
@RyanDhindsa
will study the genetics of those outliving expectations despite underlying aging risk factors!
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Next work we funded is by
@GMorabito96
at
@Unipisa
: "I always considered evolution the greatest experimental biologist to ever exist. For aging, it has already figured out robust proteins for longer survival in some species. Can we use them to slow down aging in humans?"
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Another Impetus-funded rapamycin trial to receive IND approval from FDA! Congratulations to Dr Jonathan An & team . You can sign up and potentially participate in the RAPID trial yourself:
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From SASP to GDF11 and TIMP2,circulating plasma proteins play big role in both aging and rejuvenation. However, we don't yet have ways to profile targets of these factors and how they get altered in aging.
@JoshTycko
@MEGNeuro
are developing tools to profile these changes in vivo
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👀
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To overcome shortage of healthy brain donors,
@Jinte
@Eriknutma
(
@BPRC_eu
) will establish a biobank of brain samples and fluids from aging non-human primates. They will also create a multimodal brain atlas of aging macaques and identify age-related alterations in plasma and CSF!
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Congratulations to
@SDMeriney
(
@NeuroatPitt
@PittNeurosci
) pioneering development and use of a novel small molecule candidate for controlling synaptic plasticity and chemical transmitter release in aging!
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Macrophages exhibit impaired cell clearance with age, yet it is not known how this happens, or whether it can be therapeutically reversed.
@RoarkeKamber
from
@UCSF
will investigate the mechanisms of decreased macrophage function using systematic in vivo CRISPR-based screening.
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yes
the fact that the majority of scientists would change their research focus if they didn't have to apply for grants is the single most concerning reality of the current scientific funding system
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If you missed highlights we were posting here - all Impetus-funded projects and papers will now be on our main page
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Molecules, cells and organs are embedded within networks whose components depend on each other to function. To understand mechanistic interactions within these networks,
@nstroustrup1
is developing methods for analysis that can be applied to both model organism and clinical data.
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Hevolution to provide up to $25 Million in total grants in the remainder of 2023 and up to $115 Million, total, over five years for pre-clinical aging biology and geroscience research.
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The field has seen an ongoing debate on the safety of rapamycin use in healthy adults. An important study published today, on safety of low-dose rapamycin, funded by Impetus.
Congratulations!
@mkaeberlein
@IsmanAnar
@SZalzala
@DrBradleyRosen1
@Blagosklonny
@KaeberleinTammi
Full text of our paper "Evaluation of off-label rapamycin use to promote healthspan in 333 adults" published in
@GeroScienceAGE
Grateful to
@impetusgrants
for funding this project.
@KaeberleinTammi
@IsmanAnar
@SZalzala
@DrBradleyRosen1
@Blagosklonny
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Also the first publication funded through Impetus! Huge congrats on this work
@akaya_lab
@mkaeberlein
@mendenhall_lab
New Open🔓Access Paper📖
Evidence that conserved
#essentialgenes
are enriched for
#prolongevity
factors by Naci Oz et al.
@VCU
@UW
@harvardmed
#Aging
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Today (midnight PST) is the last day to submit your application for the second round. We got enough submissions for most directions but will keep the call open for the "Compiling Open Problems" bounty for another week.
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- Supporting secret societies since 2021
Secrets of longevity from the conference where it is not possible to take pictures and tweet as most data is unpublished.
@gladyshev_lab
@DrMorganLevine
@ScheibyeKnudsen
@barabasi
@eboyden3
@bioagelabs
@impetusgrants
@vita_dao
@AgingJrnl
@illumina
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While Schmidtea mediterranea is a well-established model for regeneration, its lifespan remains ambiguously documented, with many contradicting numbers. Team of
@the_technocrat
@openzyme
@splat_space
will build & distribute a monitoring device to reproducibly measure its lifespan
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time to work on really hard things -
1/ 📢 Personal announcement!
Excited to announce The Longevity Biotech Fellowship: a non-profit to help people maximize their impact in longevity
Want to get oriented, connected, and working on aging? LBF kicks off our first cohort in Jan 2023.
👉
🧵
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If you are in London, stop by Crick Institute for talks by
@LNuzhna
@vincentweisser
@VitalikButerin
@protocollabs
and many others (January 15-16 2023)
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Reminder that we are having our launch hangout tonight, 6 pm, with lightning talks from
@LNuzhna
@kpfortney
@AlexJColville
@KKajderowicz
!
Details:
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Announcing our special issue with
@GeroScienceAGE
!
📢NEW Call-for-Papers 📢- Impetus Grants
The call is providing a platform for the dissemination of results from Impetus funded projects.
Submissions open from June 2022 till September 2024.
@LNuzhna
@mkaeberlein
@MartinBJensen
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@KristerKauppi
@NirBarzilaiMD
- ,
@mkaeberlein
- rapamycin for female reproductive lifespan, Zev Williams
@Columbia
- rapamycin for age-related periodontal disease, Jonathan An
- everolimus study,
@maml_UWMadison
+ multi-omic analysis of 2 of these studies, led by Yousin Suh
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GRC Systems Aging is one of the first efforts to unite disconnected research directions. And it is at the core of the Impetus philosophy too - many new insights can happen at the intersections of mechanistic studies.
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Impetus is up on gitcoin again. We are open to crypto donations from the public!
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Join
@FounderLedBio
chat tomorrow (November 4, 3-4 pm ET) with
@LNuzhna
on how Impetus developed & where it is headed, as well as a discussion of new organizational models from
@AGamick
and
@aloktayi
To register:
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Besides, it will be one of the few platforms to bring non-aging scientists to think about aging!
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@martakova
and huge congrats on launching a new aging lab! Excited to be one of the first people to fund you :)
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@KristerKauppi
@NirBarzilaiMD
We funded ~4 big rapamycin trials for aging in the past year! Give it some time ;)
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For a while, the geroscience field has been fragmented into studies of mechanisms. While critical, there was little effort done on the side of integrating those mechanisms together, to create a bigger, "systems", picture of what aging is.
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@KristerKauppi
@NirBarzilaiMD
@mkaeberlein
@Columbia
@maml_UWMadison
(To be clear - many more incredible doctors and researchers are involved in all of these, can't fit everyone in one tweet)
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@cz_binance
We have been funding risky aging science across the globe since 2021, with almost no overhead & $34m allocated. Many of the projects are already published in top journals after being rejected by other funding institutions
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This is a very exciting & challenging opportunity. Definitely one of the most critical projects in the aging space in the next few years!
We have a post-doctoral position available in epigenomics & ageing – exploring the functional impact of the DNA methylome in ageing/ageing-related disease. Funded by
@impetusgrants
@QMULWHRI
@qmulepigenetics
#epigenomics
#ageing
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Consider applying!
Tune in for the live announcement of The Longevity Prize with
@vita_dao
, and the
@mfoundation
at 9 am PT on our Youtube channel to discover upcoming Longevity Prizes and meet the judges: .
More about the Prize: .
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We are excited to share Geneformer, our foundation model pretrained on 30 million single cell transcriptomes to enable predictions in network biology.
Manuscript:
Model:
Pretraining corpus:
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@blaisemariner
@americanaging
@GeroScienceAGE
@AgingHighlights
@labmccormick
Good luck with your defense! Glad we could support you
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For all the scientists and researchers we worked with - please consider applying to this free 1-week crash course from our friends at Pillar!
Join our free virtual 1-week crash course on tactics for building startups in biotech. Application is <1 min! Open to all.
We've had hundreds of people join us, and many have launched or joined really exciting companies.
👉
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@vita_dao
@MartinBJensen
@LNuzhna
The round isn't open right now but will be open later this year ;)
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Presenting Impetus model at Protocol Labs event next week
On Mar 3rd & 4th at 8am PT,
@juanbenet
,
@AdamMarblestone
,
@notscottmoore
,
@mala
, & other thought leaders will discuss novel experiments & future directions for funding these collective commons at the 2-day, virtual event, Funding the Commons.
Sign up 👉
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@tinalynnsing
& Ünal lab are also hiring a full-time technician for the project. Reach out to:
First round 3 project from
@berkeleyMCB
Gametogenesis resets lifespan and gametogenesis-specific rejuvenation (GSR) factors can be expressed to extend lifespan in model organisms.
@tinalynnsing
is identifying new GSR factors that can be used to combat age-related damage. Congrats!
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Impetus Retweeted
Our ADAR-based RNA sensors just came online! It allows you to express protein payloads in live cells in direct response to the presence of specific RNA transcripts. Also
@EerikKaseniit
, welcome to twitter.
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Impetus Retweeted
In the future, medicines will be programmable 🧬
An exciting day for RADAR technology:
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