Nature Aging
@NatureAging
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Nature Aging is a thematic Nature journal that serves the broad aging research community. Follows & RT ≠ endorsements.
New York
Joined March 2020
🗞️Our January issue is out!🎉 To start off 2025, we have pieces on immune surveillance in senescent cells, geriatric care, brain aging biomarkers, societal aging and intrinsic capacity, geroprotective or senolytic agents, and much more. Read it all here 👇
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We're excited to launch @NatureAging today! The content of our first issue, "Aging in Unity", reflects the diversity of all communities working on aging: biologists, clinicians, social scientists, civil society and industry. Free to access for all here:
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NEW: In vivo partial #reprogramming by OSKM expression is effective in delaying natural #aging-related molecular and physiological phenotypes @KristenBrowder @genentech @salkinstitute
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🗞 Our February issue is out! Read about #Alzheimer disease, #sensecence, #mitochondrial rejuvenation, #GDF11 in depression and memory, #progeria, and much more. 🎨 Cover image from Sciepro/Science Photo Library/Getty and designed by Lauren Heslop.
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🗞Focus Issue! We bring together Reviews, Perspectives & Comments on the most recent advances in changing landscape of #dementia research. 🎨 Cover designed by Valentina Galata.
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NEW: Single-cell transcriptomic profiling of human blood from new-born, healthy young and old, and frail adults unveils frailty-specific immune cell characteristics with genetic signatures and regulatory molecules that underlie aging
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Online now! New study reveals that many previously reported changes in gene expression in #aging #hematopoietic stem cells (HSCs) may be linked to extraction stress rather than to aging @Lund_stem @StemcellBryder @AnnaKonturek
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Ahead of the launch of Nature Aging in January 2021, the editors have curated a collection of recent Nature Research articles on Aging, longevity and age-related diseases reflecting the increasing diversity of the field that we aim to support and feature
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🗞️Our September issue is out! Read about #mitophagy and #urolithinA, how #lysosome tubulation mediates starvation-induced longevity, #platelet factors in #cognition and much more. 🎨 Image courtesy of Ake Lu and Steve Horvath.
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Online now! A new study uses proteomics data from over 50 000 adults without dementia in the UK biobank to predict the future risk of dementia, and highlights the importance of GFAP (.
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We hope that you’ll find a few treats in our December issue – formal presentation of the ITOA, reference centiles for #IC, LTC & healthy #aging in China, TANGO trial, #reprogramming, #senolytics for #COVID19, atherogenesis, mitophagy, refeeding, and more
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NEW: #SARS-CoV-2 infection induces paracrine #senescence in adjacent uninfected cells leading to an inflammatory response that persists after SARS-CoV-2 becomes undetectable. @Biken_RIMD_en
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Online now! ✨Proteomic profiling of #CSF across disease stages identifies dysregulated proteins in #Alzheimer that reflect the multifactorial nature of disease progression + #Biomarker panels with high diagnostic accuracies
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REVIEW: Molecular damage in aging - from theoretical models to experimental approaches, and how to test interventions that reduce molecular damage burden in aging
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NEW: NFkB controls aging, inflammation and senescence. Cai and Han identify a family of lncRNAs that are increasingly expressed during aging and demonstrate that one of these aging-associated lncRNAs regulates NFkB activity in turn. Take a look:
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Online now! ✨New study shows that #senolytic #CARTcell treatment improves metabolic function & fitness in old mice. A single administration is sufficient and can have long-term preventive effects @corina_amor_MD @amor_lab @LoweLabMSKCC @MSKCancerCenter
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Online now! Universal DNA methylation age across species. Study identifies and characterizes evolutionarily conserved cytosine #methylation states related to #age across mammals and establishes pan-mammalian #epigenetic clocks @akelu38 @prof_horvath
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🗞️Our March issue is out!🎉Read about prophylactic, senescence-targeting CAR T cells, how tissue aging predisposes to melanoma, adrenal and intestinal aging in primates, predicting Alzheimer’s disease from health records, and much more. 🎨cover by Amy Cao
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Formal description and discussion of the Information Theory of Aging (ITOA) by @davidsinclair Lu and Tian in the last issue of the year -
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Please RT. Nature Aging is recruiting! If you are passionate about the science of aging and age-related diseases, and have an unquenchable thirst to learn about new discoveries, apply to join our editorial team in New York, London, or Berlin.
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Linda Partridge’s lab @MPIAGE finds conserved amino acid protein Sestrin is the key mediator of dietary restriction benefits in vivo in flies. It acts by regulating gut stem cell activity resulting in improved gut health and longevity via the TOR pathway.
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🗞️Our November issue is out! Read about #spermidine in reproductive aging, methylation and heterochromatin in #HSC aging, #neovascularization, and much more. 🎨 Image courtesy of Ernesto Llamas, cover design by Lauren Heslop.
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NEW: Metabolomic analysis of muscles from young individuals and older adults shows that aging is associated with lower levels of NAD+. NAD+ levels were also correlated with physical activity and muscle function @rhhoutkooper
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COMMENT: Alex Zhavoronkov @biogerontology, Kai-Fu Lee @kaifulee and Evelyne Bischof discuss the challenges and opportunities of applying AI to aging research, and the emergence of the field of longevity medicine. Read it here:
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Online now! Sen and colleagues show that during human cellular senescence and mouse tissue aging, chromatin alterations promote the initiation of transcription from non-canonical sites and lead to deterioration of cellular health. @berger_lab @senergystic
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REVIEW: In the new @NatureAging, Valter Longo and team @USCLeonardDavis discuss the molecular mechanisms by which intermittent and periodic fasting regulates longevity, and its therapeutic applications. Read it here:
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🎉@NatureAging is a new entry in today’s JCR 2023 journal rankings and metrics release. There are many quantitative and qualitative ways to judge the quality of a journal but today we’re proud to be ranking #1 in Geriatrics & Gerontology with a first IF over 16 and a JCI of 3 🎉.
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NEW: #Epigenetic clocks are crucial biomarkers of #aging but their use has been limited to bulk samples. @AlexandreTrapp and @gladyshev_lab now unveil a statistical framework that enables epigenetic age profiling at #singlecell resolution @VadimGladyshev.
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NEW: Transient expression of #OSKM pluripotency factors can mitigate the effects of #aging on tissue health. Neumann et al. show that expression of MYC alone rejuvenates aged oligodendrocyte progenitor cells and enhances #regeneration of the aged CNS
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NEW: Extracellular vesicles from young mouse serum rejuvenate aged skeletal muscle in a Klotho-dependent manner - @PittTweet @McGowanRM @UPMC_PMR .#aging #skeletalmuscle #regeneration #extracellularvesicles -
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REVIEW: Lamming & Mannick extensively review #rapamycin regimens and survival in mice, & discuss recent clinical trials testing if #mTOR inhibitors can safely prevent, delay or treat multiple diseases of aging #geroscience #rapalog
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Online now! Proteomic profiling of the CSF, Tijms et al., find five molecular #Alzheimer’s disease subtypes: neuronal hyperplasticity, immune activation, RNA metabolism, choroid plexus or blood-brain barrier function. Subtypes may need tailored cures.
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NEW: A study exploits infers age-associated transcription factor activity changes in single cells and reveals cell-and-tissue-type independent transcriptional changes controlling processes implicated in age-related diseases.
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Our December issue is live! Read about conferences in 2022, #longevity-ready cities, #senolytic vaccination, #COVID-19 and mental health, #telomeres and #AD, muscle #regeneration, a new approach to estimate #epigenetic age in single cells and more
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🗞️Our April issue is out!🎉 Read about HSC aging, partial reprogramming in the mammalian brain, the STEP trial, ovarian aging and much more
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Online now! @XuZhang_Mayo @NKLeBRASSEUR and @PassosLab characterize #cellularsenescence in skeletal muscle of old mice using single-cell RNA sequencing, and show that D+Q improves grip strength. #myotwitter ✨
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🗞️Our June issue is out!🎉Read about senescence in kidney repair, estrogen & beige adipogenesis, how the germline regulates aging and regeneration in killifish, stochasticity in epigenetic clocks and much more. 🎨cover by Maayan Harel
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New work from @VirusesImmunity and colleagues showing that monocytes from older people produce less type I interferon, which correlates with reduced expression of innate anti-viral signaling molecules with age
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REVIEW: Synthesis of recent research on #autophagy in health, #aging and disease and discussion of how drugs that modulate the process of autophagy could be used to suppress age-associated diseases @TheFangGroupUiO @NoAge100 @IHAatUCL
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WORLD VIEW: @WHO Director-General, @DrTedros, introduces the @UNDecadeAgeing Platform and discusses how it can be used to promote knowledge exchange on #HealthyAgeing and make the world a better place to grow older #AddingLifeToYears.
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Please RT. Nature Aging is recruiting! If you are passionate about the science of aging and age-related diseases, and have an unquenchable thirst to learn about new discoveries, apply to join our editorial team in New York, London, or Berlin.
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Online now! ✨Kedlian, Wang, Liu et al present the Muscle Aging Cell Atlas @teichlab @kedlian @KSaebParsy @bayraktar_lab @humancellatlas @sangerinstitute
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NEW: 20 year longitudinal cohort study identifies mid-life adults with signs of faster biological aging (brain aging, cognitive decline, diminished sensory-motor function) and harbour negative views about aging @max12elliott @NeurogenDuke @DukePsychNeuro
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Reproductive Aging Focus: This Perspective by Rebecca Robker and colleagues highlights the absence of clinically proven therapeutics to mitigate reproductive aging, summarizes emerging strategies, and points to future directions (.
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In this issue! Xie et al. identify activation of the innate immune cGAS-STING pathway in human Alzheimer’s disease (AD) brain and 5xFAD mouse model. Suppressing cGAS-STING pathway activation is shown to alleviate AD-associated pathogenesis in mice.
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Online now! Suda, Moriyama, Razali and colleagues find that plasma membrane damage induces senescence in yeast and human fibroblasts in a manner that is distinct from DNA damage-dependent senescence. @OIST_KonoLab @OISTedu.
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🗞️Our October issue is out!🎉 Read about weekend warriors, the interplay between aging and cancer, NAD+ and much more🎨image credit: Adehoidar / iStock / Getty Images Plus
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Online now! Xiaorui Chen, Yang Luo, Qing Zhu, Jingzi Zhang, Huan Huang et al. show that small extracellular vesicles derived from young plasma rejuvenate whole-body physiology in aged mice. (.
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REVIEW: Strategies for targeting senescent cells in human disease - Summary of current research on cellular #senescence and discussion of drugs targeting senescent cells to treat age-related multi-morbidities. @MingXuUCHC @uconnhealth @UconnAging -
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🗞️Our May issue is out!🎉Read about the aging lipidome, how to promote vaccine uptake in older adults, male reproductive aging, CSF- and neuroimaging-based tools in Alzheimer’s and much more
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Online now! Hao et al. show that TXNRD1 drives the senescence associated secretory phenotype through the cGAS-STING pathway, independently of its enzymatic activity, during senescence.
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Online now!✨RESEARCH: Yeh et al profile the effects of dietary protein or isoleucine restriction in aged male and female mice @LammingLab @UWMadison @UWSMPH
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Online now! Yang et al., show an age-related increase in the microbial-derived metabolite phenylacetylglutamine that drives host cellular senescence by inducing DNA damage and mitochondrial dysfunction via the adrenoreceptor-AMPK signalling.
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Online now!✨RESEARCH: Wen et al characterize the genetic architecture of the biological age gap of different organs, using machine learning and multimodal UK Biobank data @JunhaoWen #Multiorgan #AI #ML #BAG
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Like many of you, we are missing those informal scientific interactions at conferences or during lab visits, be it around a poster, or a cup of coffee. How about making this happen remotely?.
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Our January issue is live! Read about Nature Aging’s first year, healthy working life expectancy, genetics of human aging, heterochromatin in senescent cells, naked mole rats and more
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Online now! Llamas et al., identify SPP, a protein of the chloroplast #proteostasis machinery, that prevents pathological aggregation of polyQ in #plants; and is effective in human cell and nematode models to prevent protein aggregation and neuronal loss.
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Online now!✨RESEARCH: Ming, Yang, Huang et al design a chimeric matchmaker peptide which promotes immune-mediated senescent cell clearance in liver fibrosis, lung injury, cancer, and natural aging @ZJU_China
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Online now! Wu & Tang et al. use single-cell and spatial transcriptomics in reproductively young, middle-aged, and older human ovarian tissue to elucidate ovarian aging. They describe spatiotemporal changes and highlight the regulatory role of FOXP1.
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REVIEW: Rockwood et al. write about the degree of #frailty as a translational measure of health in #aging - from comprehensive geriatric assessment and individual care plans to #geroscience and back @KrocDoc @SusanEHowlett @DalhousieU
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NEW: Transcriptomic profiling of primary monocytes and microglia from #Parkinson’s patients by @towfiqueRaj lab reveals common and distinct pathways and genes altered in these myeloid cells @Elisa_Navarro_ @EvanUdine @SinaiBrain @SinaiGenetics #MyND
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Online now! A new study provides a computational solution to improve the reliability of epigenetic clocks for application in longitudinal studies and intervention trials @DrMorganLevine @YaleMed ✨
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Online now! Pan et al., demonstrate that hearing loss promotes cognitive decline in APP/PS1 mouse model of Alzheimer’s disease via inhibition of the GDF1 signalling pathway; unveiling GDF1 as a therapeutic target for Alzheimer’s disease.
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Online now!✨RESEARCH: Katsuumi, Shimizu, Suda et al report that SGLT2 inhibition enhances immune-mediated senescent cell clearance, and improves mouse healthspan and lifespan @t_minamino
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🗞️Our August issue is out!🎉Read about very long-lived T cells, healthy aging in Latin America, optimally vaccinating older adults, CHIP, a clinical aging clock and much more. 🎨cover by Lauren Heslop
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NEW: Senescent cells produce inflammatory cytokines (SASP) that affect aging, disease & cancer. Zhang et al. report epigenomic remodeling by KDM4 controls the SASP of stromal cells in the tumor microenvironment & promotes prostate cancer. Read it here:
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Online now! Ferrari-Souza et al., show APOEε4 allele potentiates the deleterious effects of Aβ on the longitudinal accumulation of tau tangles in neocortical brain regions, via tau phosphorylation, that coincides with brain atrophy and clinical decline.
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NEW: Targeting aging rather than individual diseases could offer economic gains worth trillions @ProfAndrewScott @NuCampEconomics @DavidASinclair.
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Make sure to check our Editorial on aging and cancer with a call for papers at their intersection - please RT @AshaniTW @sastewartlab @marc_dema @mcollado_CHUS @LoweLabMSKCC @AdamsBioAging @MLaBarge_uno @jdegregori1 @SandraMcAllist4 @lab_gomes
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Online now! UKB proteomics and brain imaging data analysis identifies circulating proteins associated with brain aging with undulating age-related changes in the plasma proteome with peaks occurring at 57, 70, and 78 years of age
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Online now! Shi, Liu, Gao et al., present a strategy to monitor and selectively eliminate senescent cells in mice during aging through controllable photodynamic therapy, which inhibited the age-related functional decline.
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More than 100 centenarians help to reveal a biomarker for long life
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🗞️ Our February issue is out! 🎉 Read about necroptosis and HSC aging, the effects of neuronal autophagy on lifespan, causality and scalability of epigenetic clocks, senescence, plasma dementia markers and so much more.
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NEW: Boehme et al. show microbiota transplant rejuvenates the aging hippocampal immune system, metabolome & transcriptome, & rescues selective cognitive deficits. @jfcryan @boehmemarcus @ktguzz @Thomazsan.@gerrymoloney @pharmabiotic @JPI_HDHL @UCCResearch.
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Multi-omics and enhanced DNA profiling of young & old classical human monocytes reveals continuous regions of age-associated DNA hyper/ hypomethylation (up & down DMRs) and their associations with changes in gene expression in healthy aging @maxim_artyomov.
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📎REVIEW: Hansson and colleagues provide an update on the most promising blood-based biomarkers relevant to Alzheimer’s disease; discussing their path to implementation in clinical practice and trials.
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Online now! The loss of HAPLN1 in aged skin fibroblasts drives melanoma progression by increasing ICAM1 and angiogenesis. Blocking ICAM1 reduces tumor size. @ashaniTW @glo_rious @Yash_Chhabra (.
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Online now! Systemic administration of #longevity factor Klotho enhances cognition in aged non-human primates @Denadubal @UCSF @Yale
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Our August issue is live! Read about #senescence and #atherosclerosis, gut #microbiome and brain #rejuvenation, #autophagy in health and disease, the degrees of #frailty, perceived #COVID-19 risk in older adults and more -
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Reproductive Aging Focus: In this Perspective Guang-Hui Liu and colleagues summarize clinical biomarkers for reproductive aging, discuss age-linked molecular changes that could serve as future biomarkers, and highlight challenges (.
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We’ve remotely attended a few talks at @AgingSciTalks. Lots of good science and good spirit. So kudos to the contributors and organizers! @William_Mair @LammingLab #scienceinconfinement
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🗞️Our July issue is out! Read about #macrophages in #inflammaging, #senescence in #adrenalcancer, the #aging neurogenic niche, #microglia in human #AD and much more. 🎨 Image courtesy of Kaitlin Basham and Kate Warde.
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Online now! ✨RESEARCH: Li et al reveal the role of epigenetic dysregulation in driving age-dependent dysfunction of neural stem and progenitor cells @CYPeterHuang #StemCellAging #BrainAging
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NEW: The hypothalamus controls systemic aging. This study show that aging is preceded by entropic speeding of GnRH pulses in mice. Lowering GnRH pulse frequency by castration or optogenetically slows aging and promotes longevity.
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NEW: Burden of protein-truncating variants identified by population-scale #exome sequencing impacts how long we live. Study reports 4 #lifespan genes with roles in cancer and clonal hematopoiesis @jimmyzliu @heikorunz @biogen @uk_biobank
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Online now!✨RESEARCH: harnessing age-related changes to the spatial organization of chromatin and epigenetic marks, ‘ImAge’ establishes an imaging-based biomarker of aging
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N&V: Bérénice Benayoun @BBParis1984 highlights a recent Resource published in @NatureAging from the @maxin_artomov lab that provides detailed multi-omics information about how human monocytes change during aging. Read it here:
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Online now! Seegren et al demonstrate that the mitochondrial calcium uptake complex as a key molecular apparatus that links age-related changes in mitochondrial physiology to systemic macrophage-mediated age-associated inflammation.
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Online now! Salvadó et al., develop and validate a CSF-based staging model for sporadic #Alzheimer, which accurately reflects biomarker and clinical changes, enhancing diagnostic and prognostic assessments of participants for clinical setting and trials.
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Online now! REVIEW📎Parkhitko et al review combinatorial approaches targeting underlying mechanisms of aging across species, and describe frameworks to analyze these interactions and their translational potential
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Reproductive Aging Focus: This review by Francesca Duncan and colleagues surveys the process of female reproductive aging based on research with physiologic aging mice, and describes the mechanisms that underlie these phenotypes (.
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Online now! Anerillas et al., provide a strategy to eliminate senescent cells based on their secretory needs. Inhibiting YAP-TEAD triggers ER stress that eliminates senescent cells from several tissues, improving age-related fibrosis. @CarlosAnerillas
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🗞Our December issue is out! Read about ovarian aging, the SenNet consortium, spermidine, digital technology for older adults, microglia in AD, enterocytes' sex and rapamycin, and more 🎨cover by Nazif Alic and Lauren Heslop
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In the launch issue of @NatureAging, the @LammingLab @uw_medicine reveal that there are sex-specific differences in whether or not protein restricted diets lacking branched chain amino acids promote healthspan and longevity in mice. Read it here:
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Our September issue is live! Read about accelerated aging in cancer, older adult involvement in research, COVID-19 and aging, genetics of human longevity, OPC rejuvenation, myeloid cell profiling in PD, chromatin plasticity and osteogenesis, and more
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Online now! Yang et al. show that inhibition of early-acting autophagy genes in neurons extend C. elegans lifespan, improve proteostasis, and increase #exopher formation via the autonomous WD40 domain-related function of ATG-16.2. @kumsta @thehansenlab
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Online now! This study reveals how infections that increase long-term dementia risk can contribute to longitudinal brain volume loss and regulate immunological proteins in plasma, and which of these proteins may drive infection-specific neurodegeneration.
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Online now! Adam, Song et al., present a multi-omics analysis of the human midbrain showing age-induced changes in genes associated with glial function, with further alterations of oligodendrocytes in Parkinson’s disease.
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Our July issue is live! Read about aging well among Indigenous Australians, a controversial FDA decision to approve a new #AD drug, the economic value of targeting aging, a new inflammatory aging clock and more -
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