Shahaf Peleg 🌅
@DocLarus
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Tenured PI at FBN. Co-founder of Luminova Biotech. Working on Light and energy replacement. Into anti-aging. Amateur ♟ LoL = L of Light
Deutschland
Joined June 2013
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We have recently traveled with our 4 months old baby to Iceland. Here are some essential tips for parents who wish to do the same:
1. Don’t do it.
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Following 7 years of revision, he was the only lab member left to celebrate the publication
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My lab’s first pre-print! We present the “Killifish” for a mammalian model:-) We describe a mouse model that was generated by 45 years (!!) of breeding. These are the biggest mice in the world - say hello to Titan mice... More work to follow...
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🔥🔥🔥 new preprint! This is the most important scientific work that I will ever contribute to.
Enabling a metazoan to harness the energy of light and directly translate it to chemical energy (Energy replacement) extends life span. More work to come!
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I am happy to share that our manuscript has finally seen the Light (!!) of day in
@NatureAging
:)
@impetusgrants
The concept of external Energy Replacement to treat aging is still new and I am eager to see what the future brings!
#aging
#mitochiondria
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Got my first ever grant as a PI in Germany:-) 2021 started well
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And synthetic biology said, „let there be light“, and there was light
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Nicely showing we didnt really treat aging - we just made it possible for greater % of our population reach old age.
Reaching 150 years? Being young like when 80? We are not even close.
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🔥🔥🔥Our latest contribution to science. 50 years of ongoing selection generated (probably) the largest mouse lab - well over 140 grams. If you would like to know more about these Titan mice (or other selected mice), contact me:)
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We have too much free time during the corona...so we ended up with this super long review
#aging
#epigenetics
#lifespan
Enjoy:)
How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span
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The problem with anti aging - people are looking for simple things - diet, drugs, sleep, red light.
None of them will really work. Not radical enough.
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Inside a western blot
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Does anyone else here have P. Jimenez, Ph.D. as their best email junk friend?:)
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🔥🔥🔥
I am very happy to share that our lab got a second Impetus Grant! Credit goes to my student
@BenetotheG
for preparing the application with me. In this grant, we will focus anti-aging interventions in giant Rock mice.
Thank you
#impetusgrants
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Super duper month:
2 new PhD students
1 Impetus grant
2 Papers accepted
1 pre-print
1 company
Amazing ARDD conference
Makes me almost feel like I am succesful:) Haha
But soon comes the interview for my son's 5th grade private scool (on zoom!). I am nervous:)
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Scientists should not be promoting their ideas too hard. If the idea is good, based on solid reproducible data, then the idea would promote itself. But when a scientist promotes shakey data, it directs the field in wrong directions and halt progress for an astonishing long time.
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Every dollar spent on aging research is a blessing! But we repeat our mistakes - we must not invest the money in only few so called promising ideas. Not invest only in few 'high profile selected' few labs. If we put all our eggs in one basket, we will end up disappointed.
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Still looking for PhD candidates on metabolism and epigenetic in my lab....:)
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Super cool analysis of our 50 years (!!) selected mice! Here you can find some insights on the whole genome sequencing of these mice!
Genomic characterization of world’s longest selection experiment in mouse reveals the complexity of polygenic traits
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Here is some of our (
@vt_tiwary
@galow
and Andrew Wojtovich) thoughts about mtON as a partial energy replacement in aging.
Our Luminova Biotech is going to follow up on this exciting technology!
Funded by
@impetusgrants
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Acetyl-coa lovers:
Acetyl-CoA and Metabolite Fluxes Regulate White Adipose Tissue Expansion
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We should fight aging, fight climate change, go to Mars, use all our knowledge to move forward.
Instead, I notice we shift towards 12th century religious extremists and nationalism.
Where did we go wrong? We are going back to dark ages here!
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Our lab first major contribution to science. We tried to answer a long lasting mystery in the field of aging and characterised the survival of DRY ICE in room temperature. By applying semi rigorous techniques with N=1 box, attached please find the data for future FEDEX shipment:)
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I’m happy to share that I’m starting a new position as Co-Founder at Luminova Biotech!
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To the twitter community: Please help me share this PhD position advertisement in my lab in Germany.
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@PeppeGanga
You are welcome to write to corresponding author and inquire what did the first author contribute....:) On the other hand, he has the time, and keen about marine life...anyway...
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An electrogenetic interface to program mammalian gene expression by direct current
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Distinct longevity mechanisms across and within species and their association with aging
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@davidasinclair
If it won't stop till 70%, wouldn't it be indeed wise to just have the elderly stay home, but the young acting more normal? Are we just prolonging the inventible?
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For all you acetyl-CoA and aging lovers:
Acetyl-CoA Metabolism and Histone Acetylation in the
Regulation of Aging and Lifespan
#aging
#acetylation
#acetylcoa
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Me trying to look for witty GIFs like
@OdedRechavi
over the weekend instead of working on manuscript/grans/important stuff...
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Magical month;
2 accepted papers
1 preprint
1 grant accepted
last month of non-tenured
formation of Luminova Biotec
talk at foresight institute
....and also magical ARDD meeting.
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Does anyone has the phone number of Elon Musk? I wanna call him to ask if he’d be interested to finance my lab for the next 5 years.
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You can try ignoring it, however if you really wish to see human live pass 120, you must invest in new lines of thoughts.
Investing in diet/exercise/drugs that activate or inhibit a single "in-program" pathway, will not only not achieve your goal but also inhibit promising ideas
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I am thrilled to share that our lab and our collaborator got an Impetus grant!! 🔥🔥This project is super crazy and I would like to thank the Impetus organization for the rapid process and willingness to fund such crazy project. I hope we see more of such amazing funding schemes
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@Melikson24
יפה מאוד!
טוב שלא אמר שהוא אוהד ארגנטינה והיית צריך להיפרד מהחולצה של מסי…
תמשיך לשמח אנשים מאור!
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Preprint alert 🔥 🔥 🔥
Great work by
@BenetotheG
and colleagues!
Funded by
@impetusgrants
from the very first round - thank you!
Longevity interventions in Titan mice attenuate frailty and senescence accumulation
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Every research on tackling aging is a blessing.
But, we should divide our efforts and funding:
1) Diet intervention - mild potential
2)Interventions to impact healthy/median life span (Rapamycin, metformin)
3)Radical interventions for max human life span - need much more funding.
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Thoughts?
Loss of Epigenetic Information as a Cause of Mammalian Aging
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Why no one showed a lifelong OKSM reprogramming in a mouse yet? Why starting only in old mice or some DNA damage mouse model? I know it has been shown in flies. Isn’t it straight forward?
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I think my soul got scratched.
But once the war is over and Hamas is gone we need to face the hard truth.
Many children are dead from both sides. Unimaginable number. There are no Israeli or Palestinian children. Children are children.
We must find a long term solution.
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If we seriously wish to radically increase life span...live beyond 120 - we must start funding and supporting radical ideas. I really believe it is the only way forward.
Likewise, I also believe that only a computer aging engine (like in chess) can integrate data well enough.
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Our company...we begin, and lets see where the Journey takes us
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Happy 7th birthday Aiden!
Since the day you were born, life has been in a bit of a turmoil....but one thing is constantly certain....that I will always, unconditionally love you till the rest of my days....and that my main goal would be to seek the path to ensure your happiness!
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@jonykipnis
I dislike this advice
You should behave like yourself. A postdoc should be a good fit to the lab and vice versa. All this extra politeness is extra 'artificial' -gives a false impression . I rather the person behaves as normal as possible to know what I get than fake politeness.
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Spearheaded by
@mitobrandon
! Check his summary!
Thanks
@impetusgrants
for believing in our crazy project and funding it! I hope we can get more funding to continue this exciting concept!
And....I hope more labs can show this is reproducible!
So damn happy!
I am happy to share that our manuscript has finally seen the Light (!!) of day in
@NatureAging
:)
@impetusgrants
The concept of external Energy Replacement to treat aging is still new and I am eager to see what the future brings!
#aging
#mitochiondria
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The best (yet small) chance we have to increase human life span in our life time is to give money for crazy ideas and let crazy people do such research. The way we work now is pretty in the box, mainstreamed by big scientists and the need to publish a story rather than go wild.
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Hiring postdocs and PhD students metabolism and epigenetic in Brain aging
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“We could stay a thousand years. No one would find us,” she tells Jon, as the dragons watch them embrace.
My pics do not do justice for Iceland‘s beauty.
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If you are interested in PhD in metabolism - epigenetic axis in stress and longevity, contact me (DFG funded)
#metabolism
#epigenetic
#aging
#phdstudent
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I have a new PhD position in my lab on metabolism and epigenetic in aging of giant mice. Please share if you know someone who is potentially interested.
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@yangranat
100%
But as far as I know - no current heavily researched idea will increased our lifespan more than 5-10.
We have almost no out of the box idea.
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Some time off after super stressful week with 16373 things to do …but one eve at a restaurant resets my Epigenetic clock.
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The major obstacle to develop anti aging treatment, at least in my mind, is not lack of ideas or understanding aging (though we know very little).
It’s the human factor that really hinders us - politics, self interest, misinformation- all to boost a profile of certain individuals
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Paper accepted:)
Now waiting for the fate of another one...and preparing another
Busy times.
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