Noor Siddiqui
@noor_siddiqui_
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Helping everyone have a healthy baby @OrchidInc Prev Stanford CS, AI Lab, @thielfellowship
San Francisco, CA
Joined November 2011
Exciting news from @OrchidInc! Today, we're announcing the world's first whole genome embryo reports. This is a massive upgrade – 100x the amount of data – and a major leap in reproductive tech. And the best part, it's now available at IVF centers across the nation.
We’re excited to announce the first whole genome screening for embryos is available! . Parents can get 100x more data about their embryos’ genomes, empowering them to make an informed decision and give their baby the best chance at a healthy start.
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Pretty absurd that chatGPT has passed the United States Medical Licensing Examination (USMLE). Today, it takes 4 years of med school and 2+ years of clinical rotations to pass. It tests ambiguous scenarios & closely-related differential diagnoses.
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In the US, 14.5% of men are 6ft or taller. Among CEOs of Fortune 500 companies, 58% are 6ft or taller (4x increase) . 3.9% of men are 6’2’’ or taller, among F500 CEOs, 30% are 6’2’’ or taller (7.6x increase).
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In the US, 5% of women are blonde. Among female CEOs of Fortune 500 companies, 48% are blonde . Female senators: 35% blonde . Blonde privilege but not height privilege for women apparently. Just 2.2% of male F500 CEOs are blonde.
In the US, 14.5% of men are 6ft or taller. Among CEOs of Fortune 500 companies, 58% are 6ft or taller (4x increase) . 3.9% of men are 6’2’’ or taller, among F500 CEOs, 30% are 6’2’’ or taller (7.6x increase).
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SO INCREDIBLY PROUD to share 2 HUGE updates:. 1) The first baby was born using @OrchidInc technology — and he’s super cute 🥰 . 2) I tested my own embryos with Orchid — we got SO much information & l feel confident now 🚀 . This is the future of how babies will be born!
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The media has leaked the master plan
Secret Master Plan .1. Build literally the best embryo report on the planet.2. Get a lot of people to use the data to have (super) healthy babies .3. Make it more affordable + convenient .4. A future where an entire generation gets a better chance at a healthy life and being.
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I think short men would argue the taller men are beneficiaries of unconscious bias, and nothing about height makes someone a better leader. I think those same people wouldn’t be as willing to admit unconscious bias contributes to other groups getting overlooked for top roles :).
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Step 3 is taken by doctors who have finished 0.5 -1 yr of postgrad medical education. and astonishingly chatGPT can pass today. AI doctor might be here faster than expected . @Willyintheworld @dbsable @nealkhosla.
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Secret Master Plan .1. Build literally the best embryo report on the planet.2. Get a lot of people to use the data to have (super) healthy babies .3. Make it more affordable + convenient .4. A future where an entire generation gets a better chance at a healthy life and being.
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First gene-edited pig kidney transplanted into a living human at Mass General yesterday . Huge milestone and could help alleviate the thousands on waitlists . Same hospital that did the first kidney transplant (human to human) in 1954!.
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It’s unfortunately not well known that you DONT need to be a sociopath to be hyper successful . There’s a ton of lore / acceptance of “difficult” personalities / asshole founders being brutal to people and that being pseudo considered a precondition to outlier success . I’ve met.
✨ Finally met my hero @patrickc, founder of 💳 @Stripe. He saw I was in Los Angeles and invited me for dinner so we flew to San Francisco of course!. He has two extremely cute 🐶 fluffy dogs and a very beautiful house. I keep realizing that unlike the cultural tropes and what
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Excited to finally share what I've been working on at @OrchidInc ✨. Some context:.I grew up watching my mom lose her vision to a degenerative retinal disease.
We believe every couple that wants to conceive, should be able to do so confidently. Announcing Orchid, a first-of-its-kind, ultra high resolution genetic testing system for couples.
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Step 1 is taken after 2 yrs of med school, covers basic science, pharmacology, and pathophysiology. students study for 300+ hours on average to pass. Step 2 is taken after 4 yrs of med school + 1.5 to 2 yrs of clinical rotations, covers clinical reasoning & medical management.
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Whole genome embryo screening will be the default way to have healthy babies faster than you’d think
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We now live in a world where every baby can be “genetically blessed”. Health doesn’t have to be a random genetic lottery at birth
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BIG NEWS! Having healthy babies is possible for more families. Orchid’s whole genome embryo report is available nationwide across IVF centers in the USA 🇺🇸. @OrchidInc in print - getting international interest from (future) parents who want the highest quality data in the world
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@c100k_ as far as the researchers are aware, the answers weren’t available in the training set, so it wasn’t “memorized”/regurgitated by the model.
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Everyone knows fertility is the ability to reproduce, but everyone hasn't heard of fecundability, the potential to reproduce. The difference has to do with reproducing versus being able to reproduce. Fecundability declines with age🧵
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Did you know that women are born with an average of 1.5 million eggs? When we're at 20 weeks of gestation, we usually have around 6.5 million!. By the time we hit puberty, the number is about 400,000, and by 37 it's 25,000. By 51, usually only about 1,000 remain.
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Terrorism deaths = 21.NYT articles on terrorism = 2,903. Gun deaths = 33,636.NYT articles on gun violence = 799
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@NickPinkston seems like that to me. physicians have a lot of protocols to “memorize” but there’s judgement and multiple modalities (written clinical history, multiple lab values) on this test.
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Microplastics are getting into our bodies orally, through the air, and through skin contact. Orally: drinking water, bottled water, seafood, salt, sugar, tea bags, milk, and so on. - the intake of plastic particles in human body is 39,000–52,000 particles/person/year.
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Wired Middle East is WAY more techno optimist than its US counterpart . Bullish on Dubai and its ability to attract and adopt new tech from around the world. It starts with actually believing the future can be better . Middle East (left) vs. US (right)
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Nada Hafez (26 y/o, Egypt) is EPIC . She’s a doctor, clinical pathologist, and beat Team USA in fencing… while 7 MONTHS PREGNANT . 🔥🔥🔥
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Wow this is actually a real video from Switzerland 👀
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In the not-so-distant past, almost everybody used to know multiple children who had died young, and usually long before they reached adulthood. Nowadays, that's no longer true for much of the world and we're rapidly progressing towards a future where children dying is incredibly
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33 years old with stage 4 lung cancer . None of us know how much time we have left . Live consciously aware that you too could wake up to this news, but you won the lottery of another day healthy.
So I guess there’s no easy way to say this but… I have been diagnosed with stage 4 lung cancer. It’s very advanced, inoperable, and we can’t do radiation. I really don’t know what else to say other than I love you all and I’m gonna fight like hell.
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I’m looking for someone with hustler energy, creative, good at storytelling, persistent to a fault. DM me to work on cool stuff with me directly (paid, will lead to more people having healthy babies) . Must be fearless.
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Honored to host George Church, PhD - Professor of Genetics at Harvard Medical School & pioneer in genomics on ep2 of pod! . "I think the trend is going to be towards everybody getting IVF as the main way of having babies. I think that's a plausible future." @geochurch
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Evolution left our genes up to a genetic lottery for 4 million years, where every parent had to roll the dice. Until now. Orchid’s embryo reports give parents the ability to stack the deck in their child’s favor. The future of reproduction is here.
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@eriktorenberg such a good idea. should be reviewed / verified by people in the field and for fast moving fields should state the years in which that path would work / expected to work. this is a cool category of product “write down unwritten knowledge”.
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Don’t be gullible. Human ingenuity can solve so many problems in unexpected ways. Have more babies :).
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Orchid is hiring a stellar statistical geneticist. Health doesn't have to be a genetic lottery randomly assigned at birth. We're working on giving every couple the ability to have a healthy child.
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The amount of baseless shaming of mom’s who chose bottle feeding instead of breastfeeding is wild.
A new randomized controlled trial comparing breastmilk to formula among extremely preterm infants was published just yesterday. Short🧵. They found no effect whatsoever on neurodevelopmental outcomes at 22-26 months of age.
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Funny interview with a sensational headline. To be clear @OrchidInc does NOT select (or “enhance”) embryos! We give parents 100x the genetic data to mitigate risk for serious diseases other tests miss. Parents decide what’s right for their family with their doctor. We want people.
Noor Siddiqui founded Orchid so people could “have healthy babies.” Now she’s using the company’s gene technology on herself—and talking about it for the first time.
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2.5 kids, a picket fence, and a dog. The ideal American family, right?. Well it seems that ideal is actually fairly recent, and the ideal before the 1970s was an even larger family!
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The Top 10 Fastest Growing Economies in the World . 1. Libya 🇱🇾 (15%).2. Ethiopia 🇪🇹 (9.6%).3. Ivory Coast 🇨🇮 (7.4%).4. India 🇮🇳 .5. Bangladesh 🇧🇩 .6. Romania 🇷🇴 .7. Cambodia 🇰🇭 .8. Laos 🇱🇦 .9. Vietnam 🇻🇳 .10. Senegal 🇸🇳 (6.8%) . (As captured by yoy real GDP growth rate)
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Fertility collapse needs more attention. The world needs more babies.
Simulated population changes in 50 years(without immigration):. S. Korea: 50% fewer people.China: 30% fewer people.Europe: 25% fewer people.America: 20% fewer people. S. America: 30% more people.Africa: 4 *times* as many people.
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Higher income inequality correlates to higher rates of obesity, imprisonment, addiction, infant mortality. http://t.co/EDYeLrtHeO.
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Emerging evidence suggests falling fertility rates are partially influenced by endocrine disrupting plastics.
Seems like the majority of us are eating a lot of plastic every day, and this might be having society-level effects that we attribute to other things.
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Right now it can seem like people are polarized into radical opinions about reproduction. There were even rumors (thankfully disconfirmed) that the Republicans were planning to ban IVF if they won in November. In the real world, IVF is nonpartisan: most Americans think it's
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This is INSANELY good. It recommended a clothing steamer I researched for 30 mins+ in not even 2 minutes (!!) 🤯. I like how it asks questions to discern which specs are important or irrelevant to you (budget, which fabrics do you steam, how often do you intend to use it, do you.
I made this last weekend to experiment w/ building an app end to end on LLMs: It's like Wirecutter, but uses an LLM to recommend product choices based on reddit conversations and reviews, so you don't have to spend 20-30min reading reddit. My experience:.
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I think they ought to name this mouse's mother "Mary.". Why? Because her mom gave birth without a man. Mary is the product of a lab, the daughter of a parthenogenetic mouse🧵
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Miscarriages are incredibly common and should be discussed openly- Dr. Jeelani demystifies the topic
Sadly, between 10 and 20% of known pregnancies end in a miscarriage. @roohijeelanimd walks through the causes of miscarriages:
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“The FDA kills more people than it helps”. overheard by a top doctor at a medical conference . “I have to send patients to Holland because some of the best treatments aren’t approved here”.
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Microplastics were present in 100% of human placentas in a study of 62 placenta samples. 🤯. The most prevalent polymer in placental tissue was polyethylene (used to make plastic bags and bottles). It accounted for 54% of the total plastics. Polyvinyl chloride (PVC) and nylon.
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More and more babies are going into neonatal intensive care units (NICU) over time. Between 2008 and 2018, the proportion of births admitted went from 6.6 to 9.1%!. Why?🧵
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Excited to introduce a brand new podcast!! It's called "Conceivable with Noor". We'll explore cutting-edge tech and ideas on the cusp of breaking out . Check us out for thought-provoking conversations that challenge you and get you excited about (building) the future
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Microplastics are more pervasive than anyone feared. Detected in *every* testicle studied , dropping sperm counts. Also found in all placentas, breast milk, and even in babies
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But let's not just look at Pew. Gallup has also polled on this issue, with a special focus on the moral side of things. IVF itself is among the most morally acceptable category of things Gallup polled on. But look further down and you'll see an apparent contradiction.
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This is Yerramatti Mangayamma and her two twin daughters. That's right—daughters, not grandkids. She gave birth to these little girls when she was 73, making her the oldest person to give birth. In the future, her story might not be all that unusual🧵
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I fully appreciate there are many smart, driven men who want to achieve great things, which often means long hours of learning and executing on difficult things—stress and time alone—but stress and time alone is not actually compatible with meeting the right girl and fatherhood.
I fully appreciate there are many smart, driven women who want to achieve great things, which often means long hours of learning and executing on difficult things—stress and time alone—but stress and time alone is not actually compatible with meeting the right guy and motherhood.
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The ability to get a whole genome embryo report is a MASSIVE upgrade over existing screening options. 99% vs. under 1% coverage of the DNA in an embryo
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the biggest threat to civilization is fertility collapse. ep3 w/ @robinhanson, on drivers: long, inflexible career paths, gender equality, disintegrated family structure - less grandparent support, higher parenting effort. & more.
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Embryo screening will be the default way to have babies sooner than you thought. More superbabies coming soon.
NEW: California will now require insurance companies to cover fertility treatments -- including IVF. We’re also expanding coverage to include LGBTQ families. While the @GOP try to strip away access, we’re expanding it. It's simple: everyone who wants to should be able to start.
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It’s unethical to stigmatize the choice to screen and gather information for the most important decision of your life.
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The world is stunning (I can’t believe this is a real place) and the future is going to be amazing 🔥. Got to hike up here to close out 2023
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Health doesn’t have to be a genetic lottery at birth. Instead of rolling the dice, with Orchid, couples today have a new ability to stack the odds in their children’s favor - toward health and against disease.
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Here's the "cool" part. Ladies who froze their eggs and underwent IVF when they were a few years older had about as much success (measured in live births) as the mothers who freshly extracted their eggs at similar ages.
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do you .- think you are invincible .- have a track record of getting shit done .- want to work super hard on one of humanity’s most fundamental areas (helping people have healthy babies). hiring a badass chief of staff, must have conquerer energy + be super kind email me.
I’m looking for someone with hustler energy, creative, good at storytelling, persistent to a fault. DM me to work on cool stuff with me directly (paid, will lead to more people having healthy babies) . Must be fearless.
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After about age 20, it becomes harder and harder to get pregnant for those who are trying. The data that shows us this is a 2.8 million person dataset assembled from samples in 62 different countries. The sample also includes men, and we can see male age matters too:
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Carrots being "good for eyesight" was actually an incredibly successful WWII propaganda campaign that helped the UK hide it's development of radar (and uncanny ability to strike down enemy targets)
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“30% of children with rare diseases do not live past the age of 10”. Treatments exist for just 5% of rare diseases.
My story today on the ongoing hunt for drugs that can cure rare diseases .
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This .gif is from an amazing new study. It shows an oocyte being extracted from an ovarian follicle and being replaced by another oocyte. This process can have an amazing effect. If you plop an old oocyte into a young follicle, it can reverse its age, making it fertile again!
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Every day someone in California is like “went on a walk” and then proceeds to post the most breathtaking landscapes god has to offer.
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Walking through my whole genome embryo reports— the most data humans have ever had before pregnancy 🧬🍼✨.
People told me it wasn't possible to make cool software videos. Let me cook
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Isn't that cool? Contrary to the popular belief that men are always able to reproduce, both male and female fertility is affected by age, and for older women, a younger man will have an easier time getting her pregnant. But the woman's age is still the more important factor:
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Yes 🔥.
IVF is good. genetic screening is good. more healthy babies is good. I am happy to die on the hill.
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Go fall in love and have babies ♥️.
We have #TechWeek, Restaurant Week, Climate Week, and now there is …. #DateWeek!! 🕊️. Super excited to collaborate with local businesses in LA and SF to put on a variety of events for singles!!. Fitness classes (Barry’s, Soulcycle, DMN8), sunset hangouts (The Penmar,
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Yale’s ED has a shortage of masks. Please message me if you have access to some my sister and her colleagues can purchase or you’re willing to donate.
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Also, we're in the news! @CNBC covered our announcement:. "Reproductive technology startup Orchid is launching the first commercially available whole genome sequencing test for embryos".
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Have healthy babies 🚀🍼.
Only about a third of the world even meets replacement rate fertility. This is the biggest problem of our time.
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Wired Middle East actually focused on the TECHNOLOGY, what’s new, how it’s different than what exists, how it will impact parents today vs. US outlet asked hypothetical back to the future questions about my mom 😂. Middle East (left) vs. US (right)
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People are often surprised I don’t drink because I’m “social”. I think the directionality flows the other way. I might have *become* more sociable because I don’t drink. It forces you to face discomfort (& let it go) rather than dampen it (& disguise it).
One thing I've realized is all the positive effects of alcohol (reduced inhibition, higher confidence, etc.) are all achievable through mental ascension and u don't really need it.
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For those still looking for love, @feross ignored me for a while… NEVER GIVE UP 😂. How it started // How it’s going
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1961 Gallup poll: only 33% of Americans in favor of moon landing.
PSA: There was *a lot* of whining about the moon mission.
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Got invited to give a guest lecture about the sci-fi stuff we’re building @OrchidInc in a scientist’s class I admire yesterday @Stanford (a place I thought I’d never get into - much less get to graduate from). Life is cool 😎 .The future is brighter than you think ☀️
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Yes. Parents decide! We’re here to help make sure they have the data to make an informed choice and benefit from decades of genetic research.
@cremieuxrecueil @OrchidInc @noor_siddiqui_ Wow what a misleading headline! Orchid is just providing data to parents, not making the decision for them. @WIRED I recommend changing the headline, the current one is inaccurate.
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My grandpa got to die peacefully because my sister is an ER doctor and helped him avoid surgeries pushed on him. Get second opinions especially for older people in your family that aren’t as equipped to research independently.
Today I want to talk about how my grandfather died. On a pretty fall morning, my grandpa fell and broke his neck.
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sf still has the highest density of capable optimists - people with the skills and imagination to build a better future.
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The world’s first whole genome embryo report is already helping people have healthy babies 🚀🍼.
The future is exciting. Embryo screening for best chance at healthy babies w/ @OrchidInc @noor_siddiqui_ + FYI best time to freeze your sperm best time was yesterday w/ @legacy @kkteily. @mjnblack & @margauxmaccoll’s latest banger is a must read:
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A heartfelt thank you to our investors @geochurch @VitalikButerin @saranormous @brian_armstrong @balajis @FEhrsam @amasad @eladgil @reshmasaujani @eriktorenberg @zoink @lucy_guo @sentientist @JedMcCaleb @juanbenet @mashadrokova and many others for supporting Orchid's vision. 🙏🏾.
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special episode on dating in tech, bravery, and masculine & feminine energy with the dazzling @stephxsher and the eloquent @Noahpinion
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Super fun to get to chat with the amazing @Liv_Boeree about embryos and babies 🍼.
It's Win-Win Wednesday! . Today's episode is on the Future of Reproduction -- a semi-personal episode as me and Igor talk about our own fertility journey with Noor Siddiqui - founder of Orchid and pioneer of full-genome embryo testing. A juicy episode as you might imagine!
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Fun to get to talk about how “don’t die” starts before pregnancy even begins. Babies don’t have to suffer from genetic diseases - it’s avoidable now, not a genetic lottery. @bryan_johnson hosted an epic event last weekend in SF, over 1k people showed up. Super smart crowd
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anyone have recs on history books? if you’ve read seeing like a state, I love how that is written, little bursts of insight on “why” the defaults are the way they are today.
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this is going to be epic. easily the best conference of the year. they are taking applications, show your wild side and see you there.
Founders Fund will be hosting the Apocalypse on October 29, 2024.
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It's possible to get pregnant *while already pregnant*. It is a rare phenomenon called "superfetation". How superfetation happens. 1. Ovulating while pregnant.Typically, pregnancy hits pause on ovulation, thanks to hormonal changes. But in superfetation, the body breaks the.
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In our first episode, @rohanseth talks about the incredible lengths he went to find a diagnosis and treatment plan for his daughter, Lydia, after she started having seizures and ended up in the NICU in her first three weeks of life .
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Rare diseases cost Americans ~$8 TRILLION dollars a year. Family’s are going bankrupt trying to get treatments to address symptoms- unable to cure the root cause . It’s time to give every family a better chance at health.
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