age1
@age1vc
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Backing contrarian founders building breakthrough longevity companies to increase healthy human lifespan.
San Francisco, CA
Joined September 2023
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We found that a drug approved and indicated for aging would conservatively have a peak global market size ~$150-$200 billion annually.
A company that owned only this drug would be more valuable than the top 2 big pharma companies (J&J and Pfizer) in terms of revenue…combined.
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We launched... again! Thanks to all who came to our event at JPM 2024 - our GP
@AlexJColville
and team tip our hats off to you 😀
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20 years ago, scientists figured out how to make mice live 150% longer by altering one singular gene. What have we learned since this groundbreaking discovery?
In our debut video,
@alexkesin
seeks to find out.
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Confirmed:
@loyalfordogs
just got a shoutout at the Emmys! Before our very eyes, we're starting to see public acceptance of aging drugs.
@celinehalioua
is truly a phenom. We are proud and thrilled of what she and Loyal are accomplishing every day.
CAN SOMEONE TELL ME IF WE ACTUALLY JUST GOT A SHOUT OUT AT THE EMMYS??????
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As we ring in the new year, the age1 team has put together a New Year’s Company Wish List of ideas we’d love to see future founders work on.
We want exceptional founders to work on achieving healthy lifespan extension in the next decade.
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The economics of delivering such value to human health at scale are unprecedented:
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An aging drug is a drug that has been rigorously shown to increase healthy lifespan in people, with emphasis on the ability of such an intervention to extend quality of life. It could allow older adults to enjoy a higher quality of life, for longer.
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Keep your eyes and ears peeled! We're releasing our first video this Friday at 10 am PST.
Written and produced by
@alexkesin
.
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We're proud to share our ambitious plan to get an aging drug on pharmacy shelves within a decade.
Introducing the Longevity Funnel Framework (LFF), spearheaded by our very own
@maggie_1i
.
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Happy Lunar New Year! To celebrate, we’re giving away some books that we love
Like + repost for a chance to be one of 5 lucky people to win a brand new book, endorsed by the age1 team!
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More on the exciting implications of this study from
@faunabio
via a
@NASA
grant!
Unraveling how mammals resist disease could lead to new aging interventions and enable long-term space travel
Congratulations to
@DocMarkerB
and
@Ryan
Sprenger for being awarded a
@NASA
Innovative Advanced Concepts (NIAC) grant to test the potential of hibernation to protect astronauts from the damaging effects of space travel!
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Richard Miller is a renowned figure in our field.
We're delighted to soon share a new series focused on the latest developments in longevity biotech. We'll kick off with a special feature on the Interventions Testing Program, including insights from Dr. Miller himself.
In today's episode (Ep.
#281
) of The Drive, I speak with Rich Miller, M.D., Ph.D, the Director of the Center for Aging Research at the University of Michigan. We delve into potential life-extending interventions in mice and more.
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Every disease resembling accelerated aging is linked to a mutation in genome maintenance - and yet there are only a handful of companies tackling this.
@alantomusiak
argues why genome instability is fundamental to aging, and why we must do more to address it.
What drives aging?
Entropy? Information loss? A software flaw? Mutations? Epigenetic drift?
Choose any - but it all comes down to maintaining the genome. And yet there are so few people working on this central pillar.
A post on why you should:
(1/7)
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Kind thanks to everyone who came to our impromptu dinner chat last night - good vibes all around!
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While women live longer on average, they experience a sharp decline in quality of life and health at menopause.
Why have we accepted this as an inevitable truth ?
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Ground squirrels can lower their body temperatures to hibernate for weeks, before rewarming with their incredible ability to regulate metabolic activity.
They are 1 of the 65 hibernators (out of 450+ mammal species!) that
@faunabio
leverages for their Convergence AI platform.
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It's with heavy hearts that we learn the news of Dr. Judy Campisi's passing.
She was a pioneer in understanding cellular senescence and the linkage between aging and cancer.
Very upsetting news for the longevity field. Dr. Judy Campisi, professor
@BuckInstitute
and co-founder of our portfolio company
@UnityBiotech
, has passed away.
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Thanks to all who came for chai and chatting yesterday evening at our tea room social - we had a great time hosting you!
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Our giveaway is heating up...
Like + RT by 10pm PST tonight and you can be one of the lucky few to win a beautiful hardcover book, endorsed by yours (...ours?) truly :)
Happy Lunar New Year! To celebrate, we’re giving away some books that we love
Like + repost for a chance to be one of 5 lucky people to win a brand new book, endorsed by the age1 team!
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Hmm, "age1" would probably make a great name for a fund investing in longevity biotech.
Wait a minute...
What venture firms do you think have the best names? Other than Trust Fund, obvi...
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We are firm believers in founder-driven visions — brainstorm with us:
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We'll always remember her as a trailblazing scientist and a mentor who inspired so many.
Her dedication to exploring aging and disease has left an enduring mark through the countless lives she touched throughout her career. Rest in peace, Judy.
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@alexsaraki
@AlexJColville
@alantomusiak
@AntoineEmileM
@MaxUnfried
@kia_winslow
@RobinMansukhani
@armandcognetta
@JoanneZPeng
@gelenbe
@mattkrisiloff
@alexkesin
A special thanks to Mitzi,
@AlexJColville
's amazing pup. She stole the show!!
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If you want to live longer - keep in mind that diet and exercise are still the best ways to do so.
We can do better.
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@AlexJColville
@LauraDeming
@alantomusiak
@_LilyClayton
@alexkesin
@maggie_1i
More pictures from Tuesday night:
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A warm thank you to our speakers as well:
@kevinhartz
,
@celinehalioua
, and Cynthia Kenyon – we appreciate you!
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Announcing our Lunar New Year's giveaway winners!
Congratulations to:
@anandcpatelmdms
@heyitsbasu
@BenSiranosian
@sunshowerguy
@thoughtsbyze
Our giveaway is heating up...
Like + RT by 10pm PST tonight and you can be one of the lucky few to win a beautiful hardcover book, endorsed by yours (...ours?) truly :)
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Congrats to
@celinehalioua
+
@loyalfordogs
team on this historic milestone, truly an inflection point for longevity biotech!
1 - Loyal has earned what we believe is the FDA’s first-ever formal acceptance that a drug can be developed + approved for lifespan extension
2 - We have 'technical section complete' AKA the 'does it work' data for LOY-001 - our large dog lifespan extension drug - is done
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If you've been selected, please DM
@alexkesin
and/or
@KKajderowicz
for your choice of book + shipping details. We're excited to send them out to you!
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Hmm, "age1" would probably make a great name for a fund investing in longevity biotech.
Wait a minute...
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Fauna is the first to identify novel targets by integrating data with human patients and animals that naturally resist disease.
Congrats to
@ashleyz413
@LindaBGoodman
and Katie +
@faunabio
team for $494 mil strategic collaboration with
@EliLillyandCo
!
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Menopause is devastating – its onset is correlated with a dramatic increase in risk of multiple age related diseases, like osteoporosis, cancer, and diabetes.
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In our latest post,
@_Carol_Mag
comprehensively covers the landscape of how to delay and treat menopause - a much needed primer for an overlooked condition that affects half the human population.
Why has menopause become a normal part of every woman's life, when it causes unnecessary suffering?
Why is reproductive aging research still significantly underfunded when half of the population experiences menopause?
I believe this *needs* to change, so I wrote a piece about
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We are thrilled to announce this groundbreaking partnership in the field of obesity with our new partner Eli Lilly and Company!
#drugdiscovery
#genomics
#femalefounders
#obesity
#ai
#biotech
#lifesciences
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This profile of Judy from Science magazine, written 20 years ago, is worth sharing.
Predating her co-founding Unity Biotechnology by 5 years and her National Academy of Sciences induction by 14 years – it presciently predicts her future career successes.
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Many kudos to
@alantomusiak
for finding the wonderful venue and masterminding this event; a true vibe curating renaissance man.
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