Science. Aging. Life.
Executive Director, XPRIZE Healthspan + adjunct faculty at Wake Forest University School of Medicine. Scientist, Mom, Outdoor Enthusiast.
LET'S GO! Mark your calendars! 🗓️
@XPRIZE
is launching the largest competition in history and you’re invited to the livestream event on Nov. 29 at 10:30am ET / 7:30am PT. Be a part of the momentous launch and register for the event here:
I am blown away! This is such an incredible honor, and it speaks volumes about my mentors and the incredible people I have the great fortune to work with. THANK YOU
@AFARorg
! Together we can change how we study and treat aging
AFAR is proud to announce our 2022 Vincent Cristofalo Rising Star Award in Aging Research recipient, Jamie N. Justice, PhD. The award encourages young scientists to investigate important problems in the biology of aging.
@wakeforestmed
@j_n_justice
To be clear: this is XPRIZE Healthspan, not age reversal prize. But, it is a huge opportunity for the science and I sincerely hope you collaborate with us and join the competition! to learn more!
@xprize
This is great! Biomarker people take note & please sign up!
I am a consortium member and this biomarker challenge is partnered with
@xprize
#xprizehealthspan
. Accelerating aging research together!
1/6 🏅 Registration for our Biomarkers of Aging Challenge is live! Our Challenge was developed to crowdsource and stimulate participation to best predict chronological age, survival/mortality and multi-morbidity incidence, using our open-source ML tooling Biolearn and datasets.
I am speaking (IN PERSON!) at AGE - American Aging Association Changing the Way We Age: 50 Years of Research in the Biology of Aging. Checkout the details:
If you missed me in Riyadh, you can catch me in person at BAAM and meetings in the Bay Area next week!
Let’s talk aging, science, and
@xprize
$101M Healthspan prize!
Please register by Dec 1
Honored to speak at the NIA Nathan Shock Award lecture, and share the virtual podium with my friend and colleague, Nir Barzilai! Catch it live and online on Nov 10! - 32nd Annual Nathan W. Shock Award Lecture
🌍WORLD VIEW: Jamie Justice introduces the XPRIZE Healthspan, a 7-year global competition to develop gerotherapeutics, and invites the community to shape the 1st phase of the competition
@j_n_justice
@xprize
@hevolution_f
@SOLVEFSHD
What an honor to be interviewed along with a few of my science friends and heroes. Three cheers to my fellow scientists and to all who are aging well!
Want to live to be 100? Here’s what experts recommend.
Dog Aging Project is central to meaningful insights into biological aging and therapeutics - not only for our 4 legged companions but humans as well. Please, please support! This is too important to lose momentum.
Help save the Dog Aging Project.
Despite being one of the most influential, productive and impactful NIH supported projects over the past 5 years, the National Institute on Aging has inexplicably chosen to withdraw support for the Dog Aging Project. For now, I’m won't get into
Great chat about science, aging, and our Global Collaborative Competition:
@xprize
Healthspan! Phil
@LongevityTech
was a generous and insightful host. Thank you!
PS - go to to learn more about the prize!
Could
@xprize
deliver the ‘holy grail’ for longevity science?
Dr
@j_n_justice
on how the $101m competition can deliver a lasting legacy to the longevity field – and it’s not about the prize money.
#healthspan
#longevity
#aging
A profound loss. Judy illuminated our field; a revolutionary scientist and person. We only collaborated in last couple of years, and I am grateful for every moment - no matter how brief. My deepest sympathies to her family, friends, and mentees.
I'm deeply saddened to share that we have lost a remarkable friend, a wonderful mentor and esteemed colleague, Judith Campisi. Judith's impact on those around her was profound and lasting. Her legacy will continue to inspire us all. Rest in peace, Judy. You will be greatly missed
Want to learn more about how breakthrough innovations will extend healthy aging for everyone? Join me for an XSpaces on Dec. 13 at 12pm ET / 9am PT to learn more about
@XPRIZE
’s
#XPRIZEHealthspan
global competition.
Joined by
@CambrianBio
@BuckInstitute
Have more questions about the
#XPRIZEHealthspan
competition? XPRIZE Healthspan Executive Director
@J_N_Justice
and the prize team will be hosting a Discord AMA ("Ask Me Anything"). Get your Qs answered and join us tomorrow, Dec. 14 at 1pm ET / 10am PT at
Really enjoyed sitting with PPP podcast this morning! Please listen in as we discuss aging, science, and
#XPRIZEhealthspan
and
@xprize
To get the details or join the journey:
Great news! New podcast episode with the great
@statto
just released! I hope you enjoy as much as I enjoyed talking aging science and
#xprizehealthspan
!
There’s a new $101 MILLION prize to reverse aging!
I spoke to
@PeterDiamandis
and
@j_n_justice
about
@XPRIZE
Healthspan.
Why a prize, not $101m of grants? Is it too easy or too hard? And how can we get more billionaires interested? Watch to find out:
Great piece by
@AubreyNPR
- thrilled to be even a small piece of what will hopefully be Allison Aubrey’s deep-dive on the science of aging and longevity.
#xprizehealthspan
@xprize
Super excited to speak at HLTH. Europe in Amsterdam this summer! I'm slated to speak on June 19 - will post more when agendas are final.
Discount code below for those interested in meeting in person and learning more about
#xprizehealthspan
!
@xprize
🇸🇦Live from
#Riyadh
at the inaugural Global Healthspan Summit, Hevolution's CEO Dr. Khan and
@XPRIZE
CEO Dr. Peter Diamandis announce the largest XPRIZE in history - a $101 million XPRIZE Healthspan - with Hevolution Foundation as the largest sponsor for the prize, contributing
@KarlPfleger
@PeterDiamandis
Milestone 1: $10M to 40 teams ($250K each) based on qualifying submission that includes supporting R&D stage evidence - materials due Dec 2024, awarding Q1 2025
Interesting thread and simulation by one of my favorites ,
@DrMorganLevine
. Model is necessarily oversimplified, but a great starting point for future discussions .
@aubreydegrey
@statto
Here are some results from the simulation. As mentioned, I am going to try to make this available so people can use it themselves. It is imperfect and can continue being improved. All comments are welcome.
Can’t wait to see you all next week in the Bay Area - great collection of meetings &people.
If you want to talk science, aging, and , and you missed our launch at the Global Healthspan Summit, please find me at the Buck!
Don’t miss Longevity Week! Dec 4 – 8. We’re proud to be hosting/participating in events focusing on biomarkers of aging, the longevity ecosystem and longevity clinics. And don’t forget BAAM
@Stanford
! Great speakers
@agingbiomarkers
@LongevityGL
Interesting results: higher prevalence of immunosuppression in >25k persons surveyed regarding medical conditions or medication use. Prevalence ~2x vs 2013, and unsurprisingly higher in older adults. Immune health is a key to healthy aging.
#xprizehealthspan
team will be at
#ICFSR
in Albuquerque this March! You should definitely attend the meeting. We’d love to see you at the public Healthspan Town Hall event!
@xprize
#frailty
We're kicking off our Biomarkers of Aging Challenge on March 1st with
@mfoundation
's
@DaneGobel
and
@j_n_justice
from
@xprize
#XPRIZEHealthspan
in our first ever X Spaces to discuss how our Challenge will support the development and validation of next-gen biomarkers of aging for
@agingdoc1
Love this study! - I’m a bit biased as a former co-I on SOMMA, but 1st findings from this unmatched resource are just being released. There is SO MUCH DATA! Anyone interested in aging muscle, adipose, energetics, and mobility disability should check it out!
If you’ve not followed developments in dog aging - this is really big news, for furry companions and their humans. Incredible work by
@loyalfordogs
and the
@DogAgingProject
are changing the game for how people think about and treat aging. Love this!
@PeterDiamandis
@xprize
To be clear, this is NOT the “age reversal” prize - it is XPRIZE Healthspan. We are talking about improving function and extending the period of healthy life per the goal of our sponsors, endpoints committee, and advisors.
Super cool stuff from my former grad student colleague
@mpascoe
Incredible to see how far he’s come since we left CU Boulder and I can’t wait to get this book. Looks great!
@agingbiomarkers
@xprize
Looking forward to this event; biomarkers are critical for clinical trials - especially for aging and geroscience given the time-scales, heterogeneity / variability, and need for mechanistic insight. These are conversations and consensus so needed in the field.
@statto
@PeterDiamandis
@xprize
A lovely time on your show, Andrew! Truly impressed and grateful for the opportunity to talk science, life, and healthy aging! Cheers!
@jpsenescence
Good thought and one our advisory board is still grappling with. Exercise intervention may hit one of the functional domains, but not likely to hit all three on its own.
@agingup
Thank you Steve for the mentorship and continued support. (and for being generous with your time when pestered you about the talk - THANK YOU!). Would not get this award without you and the team at
@wakeforestmed
@WakeGeriatrics
@PepperOAIC
@jpsenescence
If an exercise + drug/bio/device intervention is used we discussed whether the appropriate design might be 2x2 factorial where exercise alone is control and additive is primary hypothesis. We did not write these into the preliminary guidelines as public is comment needed.
@KarlPfleger
@PeterDiamandis
@xprize
Important: this prize endpoint is not disease-based by design. Quite different than my previous work on TAME. We specifically pursued a non-disease awarding metric, and measures capable of bi-directional change - improvement or decline over time or with intervention.
@DrMorganLevine
A fellow long distance runner / scientist / mom: the parallels are undeniable. Rigor, commitment, and chunking huge challenges into left foot - right foot- repeat. And seconds off goal?!? Amazing! That is a win for a long race - Congrats!
@KarlPfleger
@PeterDiamandis
@xprize
A thoughtful, informed response! Karl landed at exactly the heart of the matter - it is rate of aging, but in this case indexing an improvement in function that offsets rate of decline. It is not quite reversal per se, but not quite prevention. metrics+semantics+marketing
Congratulations to
@ZachSClayton
and the rest of the authors!
Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence - Mahoney - Aging Cell - Wiley Online Library
@MattYousefzadeh
I just made banana bread to avoid throwing out 3 questionable bananas - then decided I could no longer live without spotless kitchen cabinets, walls, fridge, baseboards. Def Procrasti-cleaning to avoid the manuscript reviews this afternoon.
@GriffinBrumley
@mkaeberlein
guess, but prob multifactorial: 1) NIH study section conservative + tough to approve /retain large scale projects like DAP from general funds; 2) NIA pay lines are shit and now >16% cut for general fund in 2024 interim budget. Need to diversify $$ for ambitious proj like DAP
@macauleylab
A brutal cut but still better than paylines for tips of us toiling on aging research projects “below the neck” - we’ve been decapitated by NIA funding for years. One of the big reasons I left academia.
@LaurieGreen36
@statto
@PeterDiamandis
@xprize
shows work needs to be done to educate the public about the progress from academic and commercial. Many trials of in field or complete: senotherapeutics, Joan Mannick’s rapamycin + analogues trials,
@CambrianBio
early trials, and BG-105 in trials by
@bioagelabs
to name a few.
@KarlPfleger
@PeterDiamandis
Milestone 2: $10M to 10 teams ($1M each) for proof of concept / feasibility study of 30-60 days - prospective data submission using protocols needed for Finals assessment. Data submission & awarding in 2026.
@AFARorg
@wakeforestmed
WOW! This is such an incredible honor. THANK YOU
@AFARorg
for the opportunity and the support you provide us as we work together to change aging!
@BuckInstitute
@JProteomeRes
Well earned Christina! One of my favorite *gets-shit-done* people recognized for getting-shit-done in a spectacular way (and being awesome!). 👏
@mkaeberlein
High praise from someone I respect so much, and who’s work made this moment possible - thank you!
@mkaeberlein
looking forward to taking on this global challenge with you -to make this a win for the field and healthy aging!
@DrMorganLevine
@PeterDiamandis
Agreed, Morgan - and that part was completely unscripted -
@EricVerdin
dropped the line of the night! So glad you are an advisor to the prize; this will be a great adventure
@nnhooten
@NirBarzilaiMD
Thank you! And thank you so much for attending the virtual talk yesterday! Your support means so much. And would be great to connect regarding how your work at NIA on EVs could help advance to biomarkers for clinical trials in older adults.
@GriffinBrumley
@mkaeberlein
Feel their pain acutely. Lived through that on major projects that could not lift on NIH funds (s.g. TAME). One of the factors that took me to
@xprize
- aging is too important to wait for our federal govt alone to $$ ambitious projects.
@DrGlorioso
assumptions overlook potency. Rotenone is a far more potent complex 1 inhibitor than either met or rapa. + one great thing about met is that it kinda sucks as a drug. It is only weakly mitohormetic; at therapeutic doses exists in micromolar circulating concentrations.
@agingbiomarkers
Fantastic! So excited for this to. The biomarkers consortium are contributing in a substantial way to the thoughts and directions for biomarker testing in the prize. So happy for this partnership & scientific collaboration! Cheers!
@MattYousefzadeh
Thanks, Matt! It was great to see you as always, and happy to share info about
#XPRIZEHealthspan
- such a great group @ Columbia pushing geroscience and aging forward
@Madam_Mito
@statto
@PeterDiamandis
@xprize
There is no need to be offensive. To goal is to raise investment and awareness for aging research and create a testing pipeline. We would love Levin’s team to compete; I have addressed direct inquiries that suggest they will.
@erganeshsharma
@xprize
Thank you! It has been an incredible experience so far and we are just getting started! So happy to start this Global “Coopera-tition”
@DrGlorioso
3/2 (sorry, I could keep going). In sum: conflating rotenone studies to suggest any mito complex 1 inhib may have neuro consequences is a bit overkill. But definitely more studies of both rapa and met are needed.
@middleeast
@xprize
To be clear: this is not “anti-aging” - the focus is on improving function and health in a way this is audacious yet achievable and to the benefit of our society. As there are so many positives of an aging society, I would never call this “anti-aging” but pro healthy aging.
@anterhetoric
@statto
@PeterDiamandis
@xprize
Yes. Scalability / accessibility are not awarding criteria per se but judged considerations that includes safety, tolerability, and supportive biomarkers within a rubric used for advancement in prize.
@kapahi_pankaj
Thanks, PK!! Looking forward to seeing you next week at the Buck! And can’t wait to working with you on this prize - hoping to see you on a team
@WFCTSI
My work - literally - would not be possible without the support by
@WFCTSI
. THANK YOU for making research happen through the CRU, cores, biostatistics /study design support, etc. I am so grateful for our CTSI and
@AtriumHealthWFB
commitment to science and junior faculty!