Aubrey de Grey
@aubreydegrey
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I'm spearheading the global crusade to defeat aging. President and CSO of https://t.co/QxFW8fuCt2
Los Gatos, CA
Joined November 2009
We've posted our plan for the next in our series of uniquely audacious combination mouse lifespan studies. A few details are still unfinalised, but we'll pull the trigger as soon as funding permits. See and please support us at !.
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THE SACRIFICE PHASE IS OVER! You beautiful people - over 2000 of you, and nearly all of you new donors - have donated nearly $28M to SENS Research Foundation in the airdrop. Our work will be accelerated enormously. Thank you all - and Richard! - so much.
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I now think there is a 50% chance that we will reach longevity escape velocity by 2036. After that point (the "Methuselarity"), those who regularly receive the latest rejuvenation therapies will never suffer from age-related ill-health at any age.
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I want to thank Richard Heart; what he’s doing for us is spectacular!. We have been having a very good year with income - a big expansion of our activities is coming. Thanks to the PulseChain Airdrop, those plans are going to explode into another level entirely. 1/2.
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We’re all working tirelessly to keep up with donors and hold up our part of the process. We are probably closing in on the 20 million mark now and donations are still coming in!. Thank you so very much Richard!. 3/3.
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Our work will be greatly accelerated, resulting in huge numbers of lives saved in the future, as a direct result of Richard's supporters' wonderful generosity. It couldn't happen without his vocal and eloquent support. 2/3.
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Crypto heroes like @vitalik.eth, @RichardHeartWin & 1000s more have given 10MMs of USD to my rejuvenation work. I need your help THIS YEAR to fund more such research - and now there's a new way to do so, thanks to awesome community leader and LEV crusader @MatiAllin 1/3.
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I'm overdue for a rant. Here goes. If you don't want to get sick when you get old, but you're not allocating your time or money to hastening the medical defeat of aging, you're in one of the following categories:. 1) You think aging is a blessing in disguise.2) You're sure we.
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Anyone who can bring the airdrop to the attention of mainstream media: now is the time. Don't delay.
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A prominent Hexican, Mati Allin, livestreamed our donor event this past Saturday, online here:. If you missed the event, check it out - masses of interaction with our wonderful staff, lots of donors talking about why they support us. Thanks Mati!.
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Spot on, my friend. The pro-aging trance is the single most mind-blowing aspect of the human psyche.
Most humans take medicines to fight diseases but are horrified at the thought of a medicine to fight aging, the root cause of most diseases.
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Well said. Richard is an utter hero.
@aubreydegrey And ironically, @RichardHeartWin has been unfairly vilified for years when he’s done more to provide millions in funding to advance research in anti-aging.
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Short but sweet :-) George just gave me his talk title: "A focused plan for extreme longevity (not mere aging reversal or slowing)." Yes, George Church himself is now describing aging reversal as "mere". We're gonna get this done. .
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Deeply saddened to report that one of my foremost role models in the field, Judy Campisi, died yesterday, not even making it to 70 years old. She was the only senior gerontologist who immediately "got" the damage repair paradigm back in 2000. A monumental loss.
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@elonmusk @JuicyCreativ3 Solution: make those exceptions less rare. Leverage the counterexamples. Those who switched fields mid-career or later and then did their best work. Right? Better than letting everyone suffer immeasurably and then die? I think so.
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This should be fun. Richard is a straight-talking guy after my own heart (excuse the pun).
Livestream with @aubreydegrey founder of the 9:30am PST. Aubrey and I first met when I volunteered for SENS in 2006 in Cambridge. He's working hard to save your life. @VitalikButerin, Peter Thiel and many others have given $millions
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Here for your holiday cheer is what I expect will be the penultimate lifespan-reporting update on RMR1! Just four mice have made it to 2025 (yeah, I'm 55 hours optimistic there. ), all of them male, and once they die I will launch into the next phase of updates, which will
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LEV Foundation is live! Here's a screenshot of my Facebook post from a moment ago.
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The FDA commissioner role is not yet filled. Now is the time to lobby for @balajis - he was shortlisted in 2017 but lost out to Gottlieb. His network state work gives him huge ability to drive FOMO-based FDA modernisation. Also, another guy, whom I won't name, must be stopped.
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I'm going to try posting an RMR update directly this time, rather than as screenshots from Facebook. Let's see if people prefer it. Here's RMR1 report #13!. I mentioned last time that we were around the peak of absolute rate of death per week, and that this means there is
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This is not my/SRF's initiative, but obviously I support it. The FDA has already moved a long way in this direction but more is needed. Food and Drug Administration: AGING = Disease. It's TIME to Treat The CAUSE. - Sign the Petition! via @Change.
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Really happy to see this project become a reality and such a success. The documentary film Longevity Hackers, narrated by @_EdwardNorton_ , is finally released after almost four years of work. The film explores the latest research in the field of longevity and features scientists.
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Just home from a PHENOMENAL few days at Prospera on the (utter paradise) island of Roatan, Honduras. The team there are creating something truly world-changing, and there is already a strong focus on regenerative/longevity medicine. Be part of it!.
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@hexfridman @VitalikButerin Well found! Richard and I were actually out of contact for a few years and I didn't even know about HEX when he contacted us in 2021 to propose the airdrop which generated $27M. Separately, Vitalik has donated around $15M in total since 2017. Superheroes both.
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Behold the mice (actually this is only about 1/3 of them: 8ish/crate) that arrived at Ichor yesterday for use in our flagship study! They will now have a month to get used to their new home before the work gets going. See here for regular updates!
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Here's a 90-second video about our unprecedentedly ambitious mouse lifespan study. We desperately want to kick off the next such study as soon as possible in 2024. Please consider helping us to do so, with a donation to LEVF. Thank you so much!.
We're less than halfway through our first Robust Mouse Rejuvenation study, and the results are already very exciting. See for yourself! Our plan for the second study is also now available (. Please donate ( to help make it happen :)
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Here's RMR1 update #14!. The survival curves continue to provide tantalising but preliminary information. Particularly exciting is how long the all-control group took, measured from the start of the study, to reach the survival percentage that the all-treatment group is currently
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I invite people to read my response to Celine and Laura on Facebook:
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Right then! Please enjoy, and spread the word about, the detailed description of the first study in LEVF's flagship research program, which I'm calling "Full Throttle to Robust Mouse Rejuvenation". This is without doubt the most exciting project I've ever led. 1/2.
Details of the first study in our flagship research program, exploring the benefits of combining promising healthspan- and lifespan-extending treatments in middle-aged mice, are now available:
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For anyone who doesn't have it, Here's the link for the 5th HEX conference, hosted by @MatiAllin where I'm speaking on Wednesday at 8pm Pacific:
JUST IN: The best Hex Conference schedule in history! Thanks for your patience and support.
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@DavidFeder @senstweet @PulsechainCom I am so humbled by the support that the Hexican community is showing. It is giving me the energy to work harder than ever for the longevity mission. Thank you all, so so much.
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No aging -> far less suffering, but also far less death -> no population collapse!.
@xprize Elon said today "population collapse" will be an existential risk in about 20 years or so. It would be amazing if he gets involved in age reversal (already underway)(( ( @aubreydegrey @senstweet @elonmusk.
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Get signing everyone! This can be a genuine watershed moment in the crusade. No more can people dismiss longevists as dreamers. The scale of public support for this expert consensus must now be shown and shouted from the rooftops.
Over the course of 2023 LEV Foundation has coordinated an effort, conceived by Martin O’Dea and Dr. Aubrey de Grey, to lay to rest the lamentable opinion that aging, along with the disease and death it brings, is inevitable - and by extension, that
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Here's the August RMR1 update!. We're getting fairly near to the end of the study - but how near, we certainly can't yet say. Six of the 20 treatment groups, two male and four female, are now extinct, but the all-treatment groups of both sexes are still at 25% survival at over 35
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Check this out at 3pm Eastern today - awesome partnership between NASA and Methuselah Foundation:
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Many apologies for having skipped a monthly update - I was just too swamped with preparations for @LongevityDublin (which was a roaring success as always - if you didn't attend, you missed a real feast of education and entertainment). Back on track now though!. This update marks
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SEVEN HOURS TO GO until the end of Richard Heart's incredible PulseChain airdrop supporting SENS Research Foundation! Donate fiat, crypto or stock. Details at
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Calling all friends of longevity research! Time is running out! Our friends over at @Lifespan.io are working on something big, and they need our help ASAP. Click here:
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There it is everyone! 7y in the making, after 10y of me/Peter discussion. This is a watershed day for the crusade. What with the recent ubiquitous expert endorsement of we can truly consider 2023 a turning point.
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Mati is an absolute hero. And so is every single donor to this critical mission! Here's the wallet Mati set up for coins that LEVF can't currently accept directly): Massive thanks in advance for anything you can spare!.
Aubrey de Grey invented a whole branch of science for curing aging. 4 of his 5 most liked posts were thanking Richard Heart—including this one from this week. Aubrey’s work still needs more funding. That’s why I’ve enabled him to accept donations on PulseChain. Please share 📣.
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Proud to announce that @longevityEVF is a certified @VitalismOrg org: see We aim to bring aging under full medical control and hasten longevity escape velocity. This collab with fully like-minded orgs will strongly enhance that.
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What an utter hero Didier is. Please follow his fantastic example! Note especially that he is matching all other donations in October up to $200k. This is the kind of reward that one gets for so many years of developing donor trust and respecting donor intent.
Longevity Escape Velocity Foundation (LEVF) today welcomes two very generous donations from long-time supporter of longevity research and activism, Didier Coeurnelle. The first donation is 200,000 euros (approximately 220,000 US dollars). The second
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My first wife, Adelaide Carpenter, is a (very distinguished) geneticist. She was born in 1944 and has just been given emeritus status by the Genetics Society of America. That's no surprise - but more notably, they've given it until she reaches the age of 130. Progress!.
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My awesome friends at Humanity just made the front page of TechCrunch:
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This seems, and I haven't even read the full text yet, to be a very big deal. It may well outperform CRISPR-based approaches in certain contexts. I will be keenly monitoring followup work and I urge others to do the same.
Researchers at @UofT and @nyugrossman developed a novel #artificialintelligence technology, called ZFDesign, that can design #zincfinger proteins to target any stretch of DNA in the human genome. Learn more: #genetherapy #genetics #genomeediting
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Medical doctors should be educated in longevity medicine!.
For those registered in the next 3 days, the new Longevity Medicine course will be Free with a certificate on Udemy. We are allowed to make these 3-days campaigns only twice a month. Currently, 600+ advanced physicians are taking the course, join them! .
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I'm speaking at the CUTC event I just tweeted, but I'm so useless at social media that I couldn't work out howto say so in the retweet. .
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So let's move on from the "title spin" issue arising from Jay Olshansky's latest paper. The main thing not remotely critiqued here, nor anywhere that I've seen, is the assumption that we "clearly" need to understand aging far better in order to achieve these necessary dramatic.
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This is such fantastic news. Massive kudos to everyone involved!. (I'm so bad at this - earlier I replied rather than quote-tweeting - well, it's worth two shots :-)).
We continue our stewardship of the $ELON, generously granted to us by @VitalikButerin . As mentioned in our $ELON Plans Paper, we moved the funds to olympusmons.eth. We want to give a special thanks to our friends at @coinbase for the support in these mission-driven endeavors!.
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I'll be live tomorrow (Thursday) at 5:30pm Pacific with @MatiAllin to discuss LEV Foundation's new projects, the crypto/longevity intersection, and much more:
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ONE AND A HALF HOURS TO GO until the end of Richard Heart's incredible PulseChain airdrop supporting SENS Research Foundation! Donate fiat, crypto or stock. Details at
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I urge my colleagues to join me in deprecating the media's persistent use of weasel wordings that seduce readers into dismissing us as fanciful or misguided. Stop using "death" or "old age" to mean aging. Old age is what we want to enhance, not cure. 1/2.
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Story on rejuvenation in the Australian national media - unfortunate pandering to the pro-aging trance, but otherwise valuable:
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I'm delighted to announce the inaugural successor (so to speak) to Undoing Aging. Screenshot of my FB post attached. Happy to answer any questions!
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Here's the last few minutes of my livestream with David Wood - critical info for everyone considering an airdrop donation:
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@JamieLa35463941 @CryptoHartbeat @DavidFeder I've made a career of doing things that almost everyone considered impossible. It's not smart to bet against me - nor against the Hexicans.
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One day in and we already have over 500 signatories (plus a bunch pending email confirmation - if you've signed and not confirmed your email, please do that now!). Let's keep up the momentum. Youtubers, podcasters, all flavours of media: now is the time to get the word out.
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What a terrific video! So happy and honoured to be working with the fantastic @vita_dao team.
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Here's the archived version of my talk at the PulseChain conference and the panel following it, for anyone who missed the livestream.
Big News Revealed!.Day 2 Hour 5 with @aubreydegrey @hodpril @MatiAllin @PulseDomains_ @Tobiwan_Hexobi .🔗
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Kudos and many thanks to the lovely people at Longevity Technology who have just published a great article about the RMR study:
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For those of you without FB accounts, here's a screenshot of an update on the goings-on at SRF.
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Here's the latest RMR1 update! - sorry it's a bit delayed. The milestone we have hit this time is that all 20 groups (10 male and 10 female) have now reached their last "cull point", i.e. the point where only eight mice of the original 50 are alive and we sacrifice two of them
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There's a huge elephant-in-the-room mystery here that no one is yet mentioning, so I will. What is motivating these board members to cling on, inviting ever more intense vilification and imminent litigation, with all the attendant reputational damage to their day jobs?.
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Two days in and we're at 1000 signatories, so it's not slowing down. Let's speed it up! Incidentally, we also have a LOT of signatories not yet listed because they haven't confirmed their email addresses; people please check spam!
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Don't miss this. Diamandis and I have tried for >15 years to pull this off, and he's finally done it, in spades. Huge kudos to his team and the funders (starting with Sergey Young and Michael Antonov in the design phase). Honoured to continue as a member of a top-flight SAB.
LET'S GO! Mark your calendars! 🗓️ @XPRIZE is launching the largest competition in history and you’re invited to the livestream event on Nov. 29 at 10:30am ET / 7:30am PT. Be a part of the momentous launch and register for the event here:
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Vitalia is a thoroughly fantastic event, not least because it is happening in the special economic zone Prospera, which has wide-ranging legal autonomy and is setting up to become the global leader in rigorous medical tourism. I'm staying here for 6 more weeks. Be here!.
Hey Vitalians 💛. This week kicks off the 1st of 4 conferences at Vitalia, focusing on longevity, crypto, and AI. 🗣️ Speakers include:.• @VitalikButerin, Ethereum & Zuzalu.• @brian_armstrong, @coinbase.• @balajis, @thenetworkstate.• @bryan_johnson, Blueprint.•
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What a wonderful event it was. Thanks so much to the LEVF team, especially Martin and Beatriz, to the venue staff, to the amazing speakers and to all 300+ attendees - 30% more people than I've ever had before. Roll on Dublin 2024 - dates to be announced very soon!.
We're still buzzing with excitement at the turnout we had at #LongevitySummitDublin 2023! Thank you to everyone who participated. We hope you had as much fun as we did 🫶🙌
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I've said this so many times over the years - it's so obvious that I'm still astonished that so few other people say it. Thanks for reminding everyone.
"To say that we shouldn't cure ageing is ageism, saying that old people are unworthy of medical care." - @aubreydegrey.#HealthyAging #Ageing #Quote
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@mkaeberlein The replies here are so sad. We, the few experts in the field who interface a lot with the wider world, still seem to have utterly failed to communicate the essence of our message. I deeply believe we must converge on a demystifying form of words to define the word "aging". 1/3.
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Please see my response to the SRF board's strange decision to publicise their actions relating to my alcohol consumption:
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The announcement you've all been waiting for!.
Save the Date for Longevity Summit Dublin 2024! . Mark your calendars for JUNE 13-16, as we invite you to join us at the Dublin Royal Convention Centre.
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First of two reports from the investigator is out - see my brief statement on Facebook:
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@geochurch just made me happy :-) Someone at RAADfest asked him in Q&A how soon we will reach LEV, and he didn't dodge the question, he said probably soon enough for most people in the room. First time, to my knowledge, that anyone so credentialed has done that.
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World Economic Forum: Recognize human aging as a global risk - Sign the Petition! via @Change.
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Woah, VERY exciting paper (Nature, DOI 10.1038/s41586-024-07238-x) from regen med demigod Irv Weissman. First practical way (AFAIK) to reverse myeloid skew, which is a key aspect of immune system aging. Props to @LifespanIO for highlighting it - subscribe to their newletter!.
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RMR update #6! Sorry it's been longer than usual. Here's the customary screenshot of my Facebook post.
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As of today, we are on a roll of seven successive world's oldest living people who made it to 117, dating back to 2016. Only five other people ever have, of whom one died in 2015. The other four died last century! The WTF element continues to intensify.
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New podcast, in which I discuss in some depth the need for policy-makers and others to "anticipate the anticipation" - to plan ahead for the coming huge change in people's expectation of how long they will live, since that change will be very sudden.
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