Biomarkers of Aging Consortium
@agingbiomarkers
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Establishing reliable biomarkers of aging for longevity interventions. Promoting relevant research and updates from Consortium members & contributors.
Boston, MA
Joined April 2023
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🙌 2024 Biomarkers of Aging Conference: Updated Speaker Lineup!
We're just three weeks away from our much-anticipated 2024 Conference, and we're excited to share our updated lineup of industry and academic leaders for Day 1 and Day 2:
@omarabudayyeh
,
@austinargen
,
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📢 In case you missed it!
Our first collaborative manuscript "Biomarkers of aging for the identification and evaluation of longevity interventions", was recently published in Cell.
⚠️ The complete paper is available for free until Friday, October 20th. You can access it
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🎉 1/8 We are thrilled to unveil our inaugural publication, now available in Cell. This achievement marks a significant milestone resulting from our collaborative endeavors with prominent leaders in aging, contributing to the Biomarkers of Aging Consortium.
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1/5 🧬 Lifespan varies widely among mammals, but what defines longevity? A new study co-authored by Consortium Chair
@VadimGladyshev
explored the relationship between gene expression and lifespan across 103 mammalian species.
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🎉 The Consortium is excited to announce our inaugural 2023 Biomarkers of Aging Symposium, a full-day event focused on sharing the latest research on biomarkers of aging, discussing key issues we face moving forward, and defining Consortium priorities for 2024 & beyond.
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The Consortium is thrilled to host our inaugural 2023 Biomarkers of Aging Symposium, a full-day event focused on sharing the latest research on biomarkers of aging, discussing key issues we face moving forward, and defining Consortium priorities for 2024 & beyond, in less than a
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We're excited to join the Healthy Longevity webinar series, hosted by
@AndreaBMaier
and
@BKennedy_aging
.
Join us on November 2nd as our Executive Committee members,
@jpoganik
and
@mahdi_moqri
, will discuss with host Prof. Kennedy our mission, highlight recent and upcoming
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1/5 🐵 🕰️ Age and sex have a profound effect on cytosine methylation levels in humans and many other species. Contributor
@prof_horvath
and colleagues analyzed 2400 tissues from 37 primate species, revealing pan-primate epigenetic clocks, highly accurate for aging.
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1/6 🔋 Unraveling the links between aging and health, the SOMMA study dives into muscle mitochondrial bioenergetics in 764 older adults. Lower mitochondrial capacities are associated with higher multimorbidity, shedding light on a potential key player in the aging process.
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🙏 We are truly grateful to everyone who attended, spoke, and supported our inaugural 2023 Biomarkers of Aging Symposium. Following the Symposium, we are filled with optimism about our collective future, as well as the roadmap and programs we have developed for 2024.
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🌟 Excitement is building as we countdown to the kick-off of our inaugural 2023 Biomarkers of Aging Symposium in just under 48 hours!
🙌 A heartfelt shoutout to our incredible sponsors and partners who have been instrumental in bringing this event to life:
@mfoundation
,
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🏆 We're excited to welcome
@j_n_justice
of
@xprize
to our inaugural 2023 Biomarkers of Aging Symposium to discuss the recently launched $101M Healthspan Prize, which she leads 💪
⏳ Jamie also serves on the Consortium's Scientific Advisory Board alongside Luigi Ferrucci of the
Wow! Just wow! Grateful for the support and partnership with Hevolution. Join us! XPRIZE.or/healthspan
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We couldn’t have done it without you and the fantastic organization and Consortium Programs we have assembled and launched! 🙏🏼 ❤️
Congratulations to Methuselah co-founder
@DaneGobel
(otherwise known as
@wesheepcanfly
) on the executive committee of the
@agingbiomarkers
Consortium for presenting at the
@BuckInstitute
! 📣
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1/5 🕰️ Maximum lifespan varies across species, but what determines it? A study co-authored by Member
@VadimGladyshev
and Contributors
@prof_horvath
and Prof. Gorbunova explores the epigenetic signature of longevity across mammals. Uncover the secrets of species-specific aging.
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Tune in to the recent episode of the
@HealthyLongeviT
webinar series, titled "The Biomarkers of Aging Consortium: Characterization and Validation of Biomarkers of Aging," in which our Executive Committee members
@jpoganik
and
@mahdi_moqri
are featured as special guests with
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1/5 🕰️ The pace of aging is a puzzle in biology. Could certain biomarkers hold the key? A study led by
@prof_horvath
explores the inverse relationship between the rate of change in specific biomarkers and species' maximum lifespan.
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Enormous gratitude to our wonderful sponsors and media partners who made history with us!
🙏
@mfoundation
🙏
@VoLoFoundation
🙏 Navigage Foundation 🙏
@BuckInstitute
🙏
@hevolution_f
/
@AFARorg
🙏
@quadrascope
🙏
@foxo_tech
🙏
@OlinkProteomics
🙏
@hacking_aging
🙏
@bioagelabs
🙏
🙏 We are truly grateful to everyone who attended, spoke, and supported our inaugural 2023 Biomarkers of Aging Symposium. Following the Symposium, we are filled with optimism about our collective future, as well as the roadmap and programs we have developed for 2024.
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Only a few days leading up to our inaugural 2023 Symposium, leaders from the Consortium, including
@VadimGladyshev
,
@mahdi_moqri
, and
@DaneGobel
, presented in our collaoborative
@foresightinst
update seminar.
🛣️ Insights on our progress, key milestones, and a walk through of our
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🧬 We're excited to kick off off our upcoming 2023 Biomarkers of Aging Symposium on December 4th with
@prof_horvath
, who will deliver a Keynote delving into epigenetic biomarkers, exploring both the challenges and promising opportunities they present for longevity interventions.
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1/6 🧬 Epigenetic clocks, based on cytosine methylation, offer age prediction tools for aging research and disease risk assessment. A recent publication co-authored by
@prof_horvath
introduces the MammalMethylClock R package for advancing epigenetic clock development.
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The 2023 Biomarkers of Aging Symposium is poised to become the premier conference on aging biomarkers.
Our Early Bird Discount for General Admission is limited and ending soon, with Early Bird tickets for Academics already sold out.
Will you be joining our inaugural event?
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1/6 🧠 Linking biological age and brain health: a new study co-authored by Contributor and Symposium speaker
@Danbelsky
explores DunedinPACE, an epigenetic measure of aging, and its connection to brain structure.
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1/7 🧬 In this open access
@Aging_Cel
article co-authored by Consortium contributor
@biogerontology
, researchers show how aging and tumorigenesis share common pathways, which may translate potential promising dual-purpose targets for anti-aging and anti-cancer therapy.
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🩸🕰 In this pre-print co-authored by Consortium member Luigi Ferrucci, the Scientific Director of the
@NIHAging
, a hematology-based clock model is described as an alternative to the well-established epigenetic clocks.
The study furthermore demonstrates that a biological clock
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Extending enormous gratitude to our wonderful speakers & panelists! Thank you!
🙏
@prof_horvath
🙏
@VadimGladyshev
🙏
@SnyderShot
🙏
@AndreaBMaier
🙏
@SebastianoLab
🙏
@EricVerdin
🙏 Prof. Luigi Ferrucci of
@NIHAging
🙏
@ISBLeeHood
🙏
@mahdi_moqri
🙏
@allisondman
🙏 Prof. Vera
📊 Some highlights of our Symposium include 10 insightful short talks and 5 panels, delivered and led by key leaders — all under one roof. This unprecedented event marked the first in a series of yearly symposiums that will continue to foster collaboration and knowledge exchange.
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Just a few hours away!
🧬 We're excited to kick off off our upcoming 2023 Biomarkers of Aging Symposium on December 4th with
@prof_horvath
, who will deliver a Keynote delving into epigenetic biomarkers, exploring both the challenges and promising opportunities they present for longevity interventions.
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Big thanks to
@vita_dao
&
@MaxUnfried
for inviting our
@mahdi_moqri
and providing a platform for fellow aging scientists to discuss epigenetic clocks' relevance as biomarkers of aging. Excellent discussion! Here's the recording in case you missed it 👇
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See you in one week! Can't wait! 🩷
Don’t miss Longevity Week! Dec 4 – 8. We’re proud to be hosting/participating in events focusing on biomarkers of aging, the longevity ecosystem and longevity clinics. And don’t forget BAAM
@Stanford
! Great speakers
@agingbiomarkers
@LongevityGL
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1/4 🐭 🐳 👴 Led by
@prof_horvath
and co-authored by several Consortium members, "Universal DNA methylation age across mammalian tissues" offers new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.
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6/6 👇 Explore how muscle mitochondrial bioenergetics can shape the landscape of health in older adults in this full-text pre-print, co-authored by Symposium speakers S. Kritchevsky
@agingup
& S. Cummings of
@SutterHealth
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1/5 👴 👵 A recent manuscript co-authored by contributor
@HaggSara
and published in The Journals of Gerontology (
@geronsociety
) delves into the dynamic link between epigenetic aging clocks and frailty in aging individuals. How do these biological age markers interact over time?
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Get ready for December! We're proud to be part of the Bay Area Longevity Week, taking place December 1-6th. Events will include Foresight Vision Weekend, our inaugural Biomarkers of Aging Symposium, and Longevity Global's Summit. Get your tickets here!
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Our Symposium's afternoon session continues with our "Industry Panel" moderated by Zan Fleming of Kinexum, featuring
@biogerontology
of
@InSilicoMeds
,
@bettslacroix
of
@RetroBio_
,
@kpfortney
of
@bioagelabs
,
@fedichev
of
@hacking_aging
.
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📊 Some highlights of our Symposium include 10 insightful short talks and 5 panels, delivered and led by key leaders — all under one roof. This unprecedented event marked the first in a series of yearly symposiums that will continue to foster collaboration and knowledge exchange.
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2
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1/5 🍽️ In a recent paper co-authored by Consortium contributors
@birgits61642917
,
@Danbelsky
, and Luigi Ferrucci of
@NIHAging
, moderate calorie restriction (CR) was shown to positively affect human skeletal muscle health, as part of the CALERIE study findings.
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We’re live tweeting our 2023 Symposium in this thread👇
One of the most important conferences of our time - the Biomarkers of Aging Symposium - is happening right now in my backyard (almost literally, as I can see the Buck from my house). Live-tweeting it in this thread...
#BoAS2023
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Back in March,
@LongevityTech
sat down with
@mahdi_moqri
, who leads the Consortium’s 2023 Executive Committee, to discuss our mission, vision and roadmap for
#biomarkersofaging
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"...in many ways, we are attempting to construct a building without a foundation. One can see this by the lack of clear answers to some of the most basic questions: When does aging begin? To what extent, if any, is biological age dynamic and potentially reversible? Which
Pleased to share an opinion piece I wrote with
@VadimGladyshev
just published in
@PNASnews
. We discuss what I consider to be the most pressing (and interesting!) question in the field: what is aging?
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Thanks for attending and highlighting our event Zane! Congrats on the poster win as well!
The inaugural
@agingbiomarkers
Biomarkers of Aging Symposium
@BuckInstitute
Highlights:
- Aging from Leo Tolstoy's perspective 📚
- The pitfalls of surrogate biomarkers ❤️🩹
-
#epigeneticAging
galore (causes, failing, & more)
a 🧵
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1/4 🐬 🧬 Epigenetic approaches are increasingly used to age organisms, including nonmodel organisms such as cetaceans. Age estimation in critically endangered Māui dolphins gets an epigenetic upgrade using the Māui/Hector's epigenetic clock, co-authored by
@prov_horvath
.
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🔬 1/5 To explore the plasma proteome's relationship to age-related diseases, 1,468 Olink protein levels and their link to 23 age-related diseases & mortality with data spanning 16 years from 47,600 participants were examined. Findings were co-authored by Marioni &
@marionigroup
.
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1/6 🌾 How does early-life adversity impact biological aging? A study co-authored by Contributor and Symposium speaker
@Danbelsky
delves into the Dutch Hunger Winter Families Study, a natural experiment offering insights into the effects of in-utero famine exposure.
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As our industry grows, standards are of paramount importance. The Consortium's role is to provide the foundation and coordination layer for the development of standardized, clinically-validated tools allowing for the development of effective therapies.
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Present your work in front of the world's leading experts on aging biomarkers!
Twenty posters will be selected for presentation during our poster sessions. Accepted poster applications always receive early bird pricing ($75) as well!
Submit here 👉
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Thanks for joining us Hannah! ❤️
I had an amazing time at the Inaugural Biomarkers of Aging Symposium put on by the
@agingbiomarkers
🧪🧬
I was even able to meet many colleagues that I've collaborated with over the years and some that I've had on the podcast which made it that much more special🥳
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1/4 🧠 Psychological resilience shows an intriguing link to epigenetic aging in a study of over 4000 individuals from the Health and Retirement Study. Co-authored by
@HaggSara
, higher psychological resilience was associated with slower epigenetic aging, especially in women.
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💊 ⏩ 🎯 High-throughput systems that can perform unbiased drug screening and directly measure
#lifespan
and
#healthspan
metrics, including aging biomarkers, can support the advancement of longevity intervention discovery.
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Thanks for joining us Austin! ❤️
It was an honor to present our work on proteomic aging at the first Biomarkers of Aging Symposium. Still in disbelief that I walked away with a prize for one of the best posters. Thanks
@agingbiomarkers
and
@BuckInstitute
for hosting such an inspiring event!
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Latest publications in
@geronsociety
by Consortium members suggest mortality-trained
#biomarkers
may provide novel phenotype reflecting biological age and strengthen the current clinical geriatric health and well-being assessment.
#biomarkersofaging
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New paper by Consortium member
@biogerontology
and colleagues on Precious1GPT, a multimodal transformer-based transfer learning for
#aging
clock development and feature importance analysis for aging and age-related disease target discovery.
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1/4 🕰️ DNA methylation-based clocks may offer robust age verification in centenarians. Developed from 🩸 💦 samples of individuals 40+ yo to super-centenarians 110+ yo by Contributor
@prof_horvath
and team, these clocks bolster credibility in exceptional longevity claims.
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1/6 Research from Consortium member J. Han and colleagues have identified high ribosome levels as a potential hallmark of slowed aging at the single-cell level.
@ScienceMagazine
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1/4 ⏳ A study co-authored by Consortium contributor Steven Cummings of
@SutterHealth
and Symposium panelist
@NKLeBRASSEUR
delves into the world of senescence-associated secretory phenotype and its potential as biomarkers of aging. What was discovered about mortality prediction?
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1/5 ⌛️ Epigenetic clocks help measure aging and predict disease incidence and mortality. But how does the microbiome, exercise, and epigenetic aging intertwine? A recent study co-authored by
@prof_horvath
sought to uncover their relationship.
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Planning to attend the upcoming
@LongevityGL
Summit on December 5-6th at
@BuckInstitute
?
Then make sure to catch the talk by our Executive Committee member,
@jpoganik
to learn more about our Consortium's work and 2024 roadmap. Exciting developments are taking shape!
For
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1/5 ♋ Can frailty scores predict cancer incidence? Results from two large population-based studies (UK Biobank & SALT participants aged 38-73) by Contributor
@HaggSara
& team explored the relationships between frailty index and phenotype scores with cancer incidence.
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@NirBarzilaiMD
@Danbelsky
@drbrianchen
@cohenaginglab
@fedichev
@NIHAging
@kpfortney
@FurmanLab
@VadimGladyshev
@gladyshev_lab
@HaggSara
@prof_horvath
@j_n_justice
@AndreaBMaier
@MannickJoan
@SebastianoLab
@birgits61642917
@SnyderShot
@EricVerdin
@biogerontology
@bioagelabs
@BuckInstitute
@hacking_aging
@hevolution_f
@mfoundation
@vita_dao
@VoLoFoundation
@allisondman
@nfiorenza
@DaneGobel
@chiara_herzog
@mahdi_moqri
@jpoganik
@LudgerGoeminne
@alantomusiak
@KejunYing
👇 If you would like to learn more about the Symposium, our speakers and panel participants, how to submit a poster to present, and purchase tickets (we have a few early-bird tickets left - deadline September 30th!) visit our Symposium's website below!
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Stay in the loop with the most current Consortium updates, significant milestones, upcoming events, and the latest news delivered right to your inbox.
Sign up to receive our monthly newsletter:
P.S. We'll be launching our October 2023 newsletter
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@mahdi_moqri
@chiara_herzog
@jpoganik
@j_n_justice
@Danbelsky
@amoskalev
@cohenaginglab
@IvanBautmans
@MannickJoan
@biogerontology
@NirBarzilaiMD
@mkaeberlein
@BKennedy_aging
@prof_horvath
@EricVerdin
@AndreaBMaier
@SnyderShot
@SebastianoLab
@VadimGladyshev
@gladyshev_lab
@NIHAging
📖 8/8 Check out our publication, "Biomarkers of aging for the identification and evaluation of longevity interventions" here 👇
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1/6 💪 Aging is marked by chronic inflammation, affecting muscle health. In a study co-authored by L. Ferrucci of
@NIHAging
, the InCHIANTI cohort reveals leukocyte ratios like NL-ratio and ML-ratio correlate with muscle area, quality, & strength. Could they be aging biomarkers?
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1/5 🕒 A recent study published in
@Aging_Cell
, co-authored by
@VadimGladyshev
(
@gladyshev_lab
), compared human and mouse embryogenesis, leading to the development of the "intersection clock" used to investigate age dynamics during early development.
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💊 1/7 Geroscience envisions influencing aging mechanisms to prevent multiple diseases. A successful clinical trial focused on a molecule'(s) broad effect could fundamentally revolutionize the field. However, geroscience CTs are faced by several key challenges.
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Looking forward to this one!
📣Join our Twitter Space on August 7 at 6pm CET to explore the latest developments in Epigenetic clocks🧬⏰
Engage with experts like:
•
@mahdi_moqri
(
@gladyshev_lab
,
@davidasinclair
's lab,
@agingbiomarkers
)
•
@kristenmcgreevy
(
@prof_horvath
's lab)
•
@Meyer_DH
(
@CECAD_
)
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We are excited to collaborate with these brilliant folks from the Gladyshev Lab. Thank you for all your support and hard work! ❤️
1/🧵We are excited to announce today’s publication of our collaborative work with
@agingbiomarkers
in
@CellCellPress
, led by lab members
@mahdi_moqri
,
@jpoganik
, and
@VadimGladyshev
!
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Thanks for coming Nir! ❤️
Great to meet so many colleagues, friends and collaborators at
@BuckInstitute
Longevity week
Such great progress in this field of research!
@AndreaBMaier
@prof_horvath
@agingbiomarkers
@MaxUnfried
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Interested in presenting your work in front of the leading experts on biomarkers of aging? Be quick, deadline to submit is only a few days away!
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1/5 🐭 Heterochronic parabiosis is known for its functional rejuvenation effects across several mouse tissues, however its impact on biological age and long-term health is unknown. Contributors
@prof_horvath
,
@gladyshev_lab
, and team sought to shed some light.
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🌉 We're thrilled to be a part of this wonderful line-up of events taking place in less than 2 months in the Bay Area!
Will you be joining us? Learn more and sign up below!
🧪 Our 2023 Biomarkers of Aging Symposium
🌈
@foresightinst
's Vision Weekend
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🩷💙💛
As the
@LongevityGL
Summit comes to a close, we hear about exciting new initiatives.
1) Aging biomarker development, open-source tools, & a prediction challenge by
@agingbiomarkers
.
2) Utilizing blockchain to allow individuals to fund research with IPT tokens by
@vita_dao
.
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1/6 🧬 Investigating Bloom Syndrome's (BSyn) impact on aging: co-authored by Contributor
@prof_horvath
, this study reveals that patients with BSyn exhibit accelerated epigenetic aging in multiple tissues compared to carriers, shedding light on potential biomarkers of aging.
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1/4 💊 Multivariate genetics, transcriptomics, and drug-target nuances converge in this Prof. Marioni (
@MarioniGroup
) &
@Prof_Horvath
co-authored study, paving the way for drug repurposing and/or potential novel drug R&D to support healthy aging.
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1/5 🧠 Aging is a risk factor for the development of neurological diseases. Biomarkers of aging may offer insights into future diagnosis and clinical signs, explaining disease risk among same-age individuals.
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Chronic
#inflammation
emerges as a pivotal factor underlying frailty development. Metabolic
#biomarkers
hold key insights into
#frailty
, an age-related decline.
A comprehensive analysis of 168
#metabolomics
biomarkers and 32 clinical biomarkers by
@HaggSara
's lab (including
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🎉 And exciting news! Preparations for our 2024 Biomarkers of Aging Symposium are underway. To be the first to learn about our upcoming events, follow us here on X and subscribe to our monthly newsletter at . We look forward to seeing many of you in 2024!
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The Symposium's Afternoon Session starts with our Biomarker Validation panel, led by
@drbrianchen
, with
@lasky_su
, Douglas Kiel of
@harvardmed
, and Prof. Slagboom of
@UniLeiden
. Join us for pivotal discussions and key insights on aging biomarker validation.
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🙏 ✨ 6/8 Many thanks to all of our contributors including
@mahdi_moqri
,
@chiara_herzog
,
@jpoganik
,
@j_n_justice
,
@Danbelsky
,
@amoskalev
,
@cohenaginglab
,
@IvanBautmans
,
@MannickJoan
,
@biogerontology
,
@NirBarzilaiMD
,
@mkaeberlein
,
@BKennedy_aging
,
@prof_horvath
, as well as...
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@biogerontology
@InSilicoMeds
@bettslacroix
@RetroBio_
@kpfortney
@bioagelabs
@fedichev
@hacking_aging
@FurmanLab
@NirBarzilaiMD
leads the TAME (Targeting/Taming Aging with Metformin) multi-central study to prove the concept that multi-morbidities of aging can be delayed in humans and to change the FDA indications to allow for next generation interventions.
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1/7 ♋ Cancer is often studied using younger animal models, but understanding how it develops in an aged system is crucial. In this study, the
@gladyshev_lab
reveal how B-cell lymphoma arises as a consequence of natural aging, shedding light on age-related malignancies.
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1/4 🧠 Co-authored by Consortium contributor
@Danbelsky
, findings suggest that single timepoint measures of multi-organ decline such as DunedinPACE, a novel epigenetic (aging) biomarker, could be useful for gauging nervous system health.
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1/6 Current research in aging is revealing that what we often see as
#aging
drivers may actually be adaptations. Key features include cellular senescence, epigenetic aging, and stem cell changes, however...
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2/5 Using data from the Swedish Adoption/Twin Study of Aging, contributor
@HaggSara
and team tested the hypothesis that a biological age greater than one’s chronological age affects the risk of future neurological diagnosis and the development of clinical symptoms.
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1/4 🏃♂️ Cardiovascular health is vital, especially as we age. A study in older adults, co-authored by Contributors Stephen B Kritchevsky and Steven Cummings explored peak oxygen consumption (VO2peak) and its role in aging, with preliminary results published in
@medrxivpreprint
.
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Thank you and the VitaDAO crew for your support, Max! We are excited for the future we are building, together as a stronger and more aligned community 💛
Fantastic what the
@agingbiomarkers
has been working on:
First Conference ✅
Open source Aging Clocks through BioLearn ✅
Biomarker Challenge with prize pool ✅
Thank you for initiating this
@mahdi_moqri
@jpoganik
@DaneGobel
and the rest of their team.
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@NirBarzilaiMD
@Danbelsky
@drbrianchen
@cohenaginglab
@fedichev
@NIHAging
@kpfortney
@FurmanLab
@VadimGladyshev
@gladyshev_lab
🙏 Prof. Vera Gorbunova,
@HaggSara
, Dr. Albert Higgins-Chen,
@prof_horvath
, Dr. Lee Hood,
@j_n_justice
, Dr. Douglas P. Kiel, Dr. Stephen B Kritchevsky, Dr. Nathan LeBrasseur,
@AndreaBMaier
,
@MannickJoan
,
@SebastianoLab
,
@birgits61642917
,
@SnyderShot
,
@EricVerdin
&
@biogerontology
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2/6 🏋️ In the intricate dance of cellular energetics, the study uncovers specific associations. Lower oxidative phosphorylation in muscle linked to a greater burden of diseases, including diabetes and depressive symptoms. Are mitochondria the overlooked architects of aging?
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1/6 📊 Prof. Slagboom of
@UniLeiden
& co-authors investigated the sex-specific effects of the Growing Old TOgether (GOTO) study, a 13-week lifestyle intervention on the transcriptomes of postprandial blood, subcutaneous adipose tissue and muscle tissue in healthy older adults.
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4/6 📊 The study's findings extend beyond a general burden of diseases. Lower muscle mitochondrial capacities show varying associations, emphasizing the complexity of aging. Unraveling these intricacies opens new avenues for targeted interventions.
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1/4 🍩 New insights co-authored by Contributor
@SnyderShot
offer insights into the lipidome's diversity and dynamics in human physiology and disease, and provides us with more understanding of lipids' roles in aging and health-to-disease transitions.
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1/6 🧬 How do individuals, organs, tissues, and cells age differently throughout their lifespan? Epigenetic clocks attempt to measure differential aging between individuals, but they often overlook within-person heterogeneity by summarizing aging as a single measure.
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Some of the leading pioneers in the biology of aging space make up our 2023 Biomarkers of Aging Scientific Committee.
Learn more about them below!
#biomarkersofaging
👇
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@NirBarzilaiMD
@Danbelsky
@drbrianchen
@cohenaginglab
@fedichev
@NIHAging
@kpfortney
@FurmanLab
@VadimGladyshev
@gladyshev_lab
@HaggSara
@prof_horvath
@j_n_justice
@AndreaBMaier
@MannickJoan
@SebastianoLab
@birgits61642917
@SnyderShot
@EricVerdin
@biogerontology
@bioagelabs
@BuckInstitute
@hacking_aging
@hevolution_f
@mfoundation
@vita_dao
@VoLoFoundation
🙏 as well as our members of our Symposium's Organizing Committee
@allisondman
,
@nfiorenza
,
@danegobel
,
@chiara_herzog
,
@mahdi_moqri
,
@jpoganik
and wonderful team of volunteers
@LudgerGoeminne
,
@alantomusiak
, and
@KejunYing
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Chronic stress's cellular manifestations have remained incomplete, however new findings by Consortium members
@prof_horvath
,
@DrMorganLevine
and colleagues highlight hypermetabolism as a core feature of allostatic load.
Study link:
#Hypermetabolism
in
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@tomchapin
@agingdoc1
@BuckInstitute
Correct! Our event is part of the Bay Area Longevity Week, which is a day before The Longevity Summit. You can learn more about all the events and sign up, here:
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1/3 🧬 Latest research co-authored by Consortium contributor
@AlbertHC28
suggests a common epigenetic replication signature shared between aging and cancer, modelled through DNA methylation in immortalized human cells in vitro and tested on clinical tissues.
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Big thanks to our friends at Lifespan for highlighting our efforts and providing an overview of our first collaborative manuscript!
New aging biomarkers paper from a star-studded cast!
@gladyshev_lab
@amoskalev
@MannickJoan
@biogerontology
@davidasinclair
@NirBarzilaiMD
@mkaeberlein
@BKennedy_aging
@HealthyLongeviT
@prof_horvath
@EricVerdin
@AndreaBMaier
@mahdi_moqri
@agingbiomarkers
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1/3 🧠 In a study co-authored by L. Ferrucci of
@NIHAging
, 14 protein-based health indicators were linked to Alzheimer's and neurodegeneration markers in cognitively normal adults, suggesting subclinical health affects Alzheimer's biomarkers.
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1/6 Partial
#reprogramming
of cells may hold the key to delaying the onset of many diseases associated with aging. Recent research by
@gladyshev_lab
and colleagues explored how partial reprogramming might work.
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@MarioniGroup
analyzed DNA methylation at +700k CpG sites using blood samples from volunteers to find associations between
#methylation
and various health outcomes. Their findings suggest that blood DNA methylation can act as a marker for several common disease states.
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@VadimGladyshev
4/5 🧪 Intriguingly, genes related to methionine restriction, a strategy tied to lifespan control, were expressed and under strong selection in long-lived mammals. This suggests a shared mechanism utilized by natural selection and interventions for lifespan regulation.
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