Thank you, @LongevityTech !

@LeoBez7 Let’s keep it simple, friend! No professors here, only a few guys searching there was in the galaxy ;) kidding. I’m very impressed with what I learned about tardigrades and am not yet able to grasp it fully.

@LeoBez7 You can get a bunch of questions without obvious answers immediately - all very interesting. You may see how my “tardigrades series” here on X match the narrative in my last preprint. Questions to keep in mind + I’ll find a good tardigrade biologist to offload them eventually

@LeoBez7 My first thought was that ROS-theory of aging does not want to die :) the next thought was that proteins involved in chromatin organization should be well studied for clues involving their role in DNA protection and gene expression regulation leading to noise and aging

@afedintsev @LidskyPeter @epsilonklm @schw90 Reading with pleasure :)

Surprisingly for what I’d call level-2 drugs (those that can bring the average to maximum lifespan without intercepting functional decline) - the path is very clear plus there are model animals with huge market potential in their own. For better drugs we still do not know how to test them

More cynical response would be that to prove that something doubles human lifespan it may take a few more than five years :) still, we should not underestimate the impact and possibilities here and lough at the guys - there's a learning curve but they are coming with good tools, resources, and determination

@Dizer_YM @GeroMaxim @jpsenescence @ydeigin We tend to massively overestimate the rate but underestimate impact of future tech. Change 5 to 10-20 and you are probably good

Known longevity drugs (aka geroprotectors) may look like or be marketed as elixirs of youth, but their true nature, at least in their current form, appears to be different. Rather than directly reversing aging, these drugs primarily target the so-called hallmarks of aging, acting as modulators of stress responses that arise with age. Aging can be understood as having both irreversible and reversible components. The slow accumulation of molecular damage is entropic and irreversible, while the dynamic, reversible component arises from stress responses—both to everyday environmental factors (which usually average out) and to aging itself. These stress responses manifest as hallmarks of aging, including chronic inflammation, immune senescence, and metabolic imbalances. As is typical in complex systems approaching a breaking point, these components become highly correlated and are collectively captured by biological clocks, such as GrimAge or PhenoAge. Stress, however, doesn’t arise only from aging. Microgravity experienced during space travel induces physiological changes that, intriguingly, mimic those of aging. The body responds to microgravity as if it were under stress, leading to muscle loss, immune suppression, and shifts in blood composition. Notably, this coupling to biological aging is not given but rather depends on body mass—worms, for instance, live longer in space than on Earth. The connection between stress and aging is supported by multiple examples. Aging biomarkers such as the CD4:CD8 T-cell ratio and the senescence marker p16 are correlated both with stress and aging. P16, a well-known marker of cellular senescence, is elevated in mice exposed to social stress. Similarly, chronic social stress in humans increases cancer risk, likely through its effects on immune function and inflammation. Immune senescence—a hallmark of aging—further weakens the body’s ability to detect and destroy cancer cells. If social stress accelerates cancer risk via aging-like pathways, then, due to correlated character of hallmarks of aging, the physiological stresses of microgravity may pose a similar threat to astronauts. Evidence supports the idea that addressing aging or stress-induced immune dysfunction can improve health and longevity. Immunotherapy drugs, which enhance the immune system’s ability to detect and eliminate cancer cells, have been shown to reduce frailty and increase lifespan in mice. Longevity drugs, by alleviating stress responses and bolstering immune resilience, could help mitigate the adverse effects of microgravity. These drugs won’t address space radiation’s impact on mutation rates (which is, of course, the acerbated entropic aging). They could, however, counteract the immune senescence that exacerbates cancer risk and other health challenges in space. In their current form, longevity drugs are not true "anti-aging" therapies, but they may serve a broader purpose than initially envisioned. By modulating stress responses, they could become essential tools for managing health in extreme environments, including space – a critical task for long-term missions to Mars and beyond. As usual, I am kindly requesting your likes and repost - this is a good way to show me that I need to post more.

got accidentally cited in by @joekloc in @nytimes as "scientists at one biotechnology firm have argued that, unencumbered by disease, the body could potentially make it all the way to age 150." The lesser discussed issue is that by focusing on the irradication of diseases rather than on intercepting aging people will live up to 120-150 but in increasingly terrible functional state. To me this explains why many people a wary of longevity biotechnology - the relation manifesting in a spectrum of disbelief and indifference.

Bay Area vibes

@durand_guillau there's a hidden agenda why I post about the guys - If I have time, I will post how is that all related to longevity medicine and health in space

@MaxDiffusionRL @jangruber467 I’m not a pessimist (otherwise I would not be doing what I’m doing). Trying to define the best of what’s realistically possible and then focus to achieve - as the saying goes, a pessimist is a well informed realist ;)

Hi! 1) there’s already a better graph (we’ve got more species). The correlation is obscured because different species are different not only in temperature. 2) we’ve got a far better graph from our own experiment in one species (look after a following work) and hence decided to publish

@schw90 @jangruber467 Aging drift increase fluctuations due to progressive loss of resilience. The probability of death and chronic disease is (roughly) exponential in eff. temperature^-1. Reducing the temperature increases lifespan.