Omar Saleem, MD
@healthspan_md
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Preventive and precision health focused practicing physician passionate about medicine going exponential. IM/Obesity board certified. Founder MDLux Health; BTC
Joined July 2023
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Pinned Tweet
We are slowly seeing many parts coming together to form the exponential medical age.
Might not seem so clear right now, once its evident, it will be everywhere.
This movement is powered by 0-1 thinkers such as
@bryan_johnson
,
@PeterAttiaMD
,
@PeterDiamandis
. Pushed forward by
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@iam_preethi
South Asians have 4x the risk of coronary disease vs the general population
Preventing this starts early, ideally in 20s-30s. Omega-3s, Vit D (also usually lower in south asians) and regular exercise (pref zone 2 and HIIT). Diet also plays a big role. Start early, be proactive
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@paulg
Their recent paper on Bridge RNAs (programmable recombination) as a tool for genome design is phenomenal. Its a big development in areas where CRISPR (nucleic acid guided system) has been struggling.
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@nntaleb
@RyanKenaley
Well said, few in medicine or population health understand this distinction
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'Get the incentive right' -Charlie Munger
Why we need
#DeSci
and platforms like
@ResearchHub
that align incentives for physician-scientists to flourish.
The current model only takes from them with giving nothing back.
The Emerging Physician-Scientist Crisis in America
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New paper peer-reviwed by authors and published on
@ResearchHub
on the links of viral infections to Alzheimer's disease
The new medium for scientific research is coming alive
Title: ‘From Viral Infections To Alzheimer's Disease: Unveiling The Mechanistic Links Through Systems Bioinformatics’
Reviewers:
@brendanKball
@kevolutn
@faizjab
Rating: ⭐⭐⭐
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@Nilzkool
Check out
@ResearchHub
. Its a free market concept for academic research and ideas
Example: Posted a bounty question on the current landscape of genomics in preventative health. Got better answers than any AI or journal could give, from ppl in the weeds
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@amasad
Just getting started.
“Nebraska study finds billions of nanoplastics released when microwaving containers”
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@altcap
@theallinpod
Most common first sign of caridac disease is sudden death
Thank you for being vocal about this, saves lives.
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@MananShahmd
@hubermanlab
Couldn’t agree more. Even with a primary care, genetics are hard to overcome if you’re short and stocky vs tall and lean. You want the best person for the job working with your body
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@DrNadolsky
What’s interesting is everyone celebrates the science of Neuralink for sticking an electrode in you, yet when science makes a medication that helps reduce weight and CVD risk by magnitudes and transform lives, it should be taken off the market.
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@nikillinit
'Agentic' nature of the scribes is where most power is at. As a physician I can do notes in seconds already. Taking what a physician speaks to the patient about and converting it to action items, then compounding on that further into somewhat of a flywheel
Some Examples I
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@rikrenard
Seems like most here missed the key differentiatin factor in the postings
Its VERY hard to get a long term employee for Home visits
Having done home visits, hospital and clinic and would prefer the latter over home visits any day. Commute, weather etc is rough. Hence the Bonus
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@nntaleb
@ChouaIsaac
That sounds amazing, only in Queens! Not sure if this was in Steinway, but there's a great Egyptian seafood place called Abuqir, they are from Alexandria. Right next-door is one of the best Knafeh I've had.
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LLMs such as those DocsGPT by
@Doximity
will help small physician practices improve margins and finally compete with the biggest healthcare systems and bring back the personalized magic of primary care.
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@SportsSurgeryNY
Happening in IM as well. And its leading to new attendings who can barely handle sick patients or busy days/nights.
Most dont realize those overnight calls are not about the hours but about the skill of managing stress and situational triaging.
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@amasad
I work at 4 different hospitals from East Bay down to South Bay/SJ and it’s become so rampant. Not a day goes by without seeing multiple cases, so sad. ‘Rainbow Fentanyl’ is more potent and easier to get regular meds
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Browsing will never be the same
@arcinternet
Arc has been my default browser for the last year, now its my default assistant
PS: The product launch video is so dope
@joshm
@MKBHD
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@Paddy_Barrett
In my experience GLP-1s have been enablers and motivators for patients to take command of their health. It’s a positive reinforcement to exercise and make other lifestyle changes.
Something that usually gets lost in the conversation about them
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@speed_daemon_
@iam_preethi
Strength training is as vital. Usually have my patients incorporate both as HIIT/Z2 cardio are critical in mitochondrial health and improve cardiorespiratory fitness while strength training builds muscle mass which helps improve fat distribution and prevents sarcopenia
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Let’s do this! We’re just get started
@stedmanhalliday
The program included:
• 2 Longevity Blood Panels from
@getinstalab
• 2 DEXA scans from
@BodySpec
• Multiple
@ShapeScale
body scans
• Live sleep, nutrition, and exercise tracking via
@cronometer
+
@WHOOP
+
@ouraring
• Coaching from me,
@stedmanhalliday
, and
@healthspan_md
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Ramadan is around the corner. If you’re going to be fasting, recommend checking out this great guide by
@AbudBakri
. Randomly found it but has great stuff and detailed information. Especially for those who work their regular timings.
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@yugacohler
@coinbase
How healthcare data should be done as well tbh. Coinbase embedded wallets transacting both the patient's data and pay for the visit. How it should be. Opens so many use cases in the backdrop of AI.
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@tszzl
Medicine will be very different in the next 5-10 years. Change happening at the grassroots level as patients demand higher quality and more efficient care at their fingertips
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@balajis
Next stage of medicine will be built on the foundation of personalization especially with genomics
Just as decentralized open-source AI is vital, one can argue decentralized genomics is more so.
Insurance claims, outcomes, employment, targeted therapy will all be tied to it
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Many hospitals and physicians unable to prescribe meds right now around the country due to a cyberattack. Yet no media coverage...
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@AbudBakri
Would also advise caution in dosage as I’ve had patients come in with SVTs after drinking Yerba mate
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For healthspan research to grow, a new decentralized paradigm of scientific publishing is vital.
@ResearchHub
is building the infrastructure to accelerate how we understand, value and distribute knowledge.
Can a decentralized movement create a new scientific publishing system?
@BanklessHQ
podcast with
@brian_armstrong
&
@joycesticks
out now:
🆘 How broken incentives corrode modern scholarly research
🧪 The mission of science
🥼 Why
#DeSci
can help
🏗️ Building
@ResearchHub
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@chefjeffsf
Would love to collaborate as a physician if you guys are looking to integrate labs etc as well. I'm in South Bay!
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@MananShahmd
@txsportsdoc
Pretty much, we've been at standstill on all reimbursements and claims for a week now.
Claims are the biggest unspoken casualty from this, prescriptions can be diverted to another pharmacy, claims cant.
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@brownedbanana
@SmalllIvy
@TPP_MD
Bottleneck only really exists at the residency level. Medical schools have a financial incentive (uncapped federal student loans) to continue to expand as fast as possible which is what we've seen in the last decade. Residency spots are Congress controlled.
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@nntaleb
@waseemhnyc
@ChouaIsaac
Ofcourse! I did my residency training in NYC so these spots were my haven. Great city to train in. Practice in the Bay Area now
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Empowering patients to understand their health is the most vital role a physician can have.
So energizing to see this movement growing, its important physicians embrace it rather than dismiss it
@chefjeffsf
@gptbrooke
@laurentannh
@bryan_johnson
Had an awesome time running free 3D body scans for our attendees. Here’s
@gptbrooke
trying her first
@ShapeScale
scan!
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Grew up on the backs of Nietzche and Dostoyevsky so this was a magical talk
Here’s a speech I gave about Nietzsche and Dostoevsky at last year’s inaugural Novitate Conference in Washington, DC. Novitate was created by
@lukeburgis
to explore and celebrate the work and life of Rene Girard.
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@MohammedAlo
I had a carnivore, zero-carb keto pt failed stress test at 43yo last month. Personally, agnostic to diets, feel its whatever works for each person, but interesting to see this.
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@kyritzb
@buildcities
Smh just saw the Fabric. Let me know if the campaign is still accepting! We need more of your work in medicine
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@DrDeepMD
That’s beautiful! Hope both of them are in good health and enjoy! Nothing like time with family
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@farcaster_xyz
bounties organically paying out $40k to solve a puzzle...based
The largest bounty ever posted on Bountycaster is a 10 ETH (almost $40k!!) online mystery puzzle
Super cool to see that people have been teaming up from all over the world to solve it. Have fun and potentially earn a major prize pool 🔥
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As a Rajput, enemies and the haters kindle the flame within
Cognitive decline doesn't start when you forget the names of people you know; it starts when you forget the names of your enemies.
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@Jori_health
@DrSynbio
Staking genetic and personalized data for a share of revenue is likely the best business model for genetic data.
The current structure of genetic data doesnt work, why 23andMe and others struggle to build a thriving business around it
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@ankurnagpal
Vitamin deficiency and low protein are big culprits. Even for South Asians in the US. Did a deep dive on B12 and a few others.
Also South Asian specific healthspan plans are scarce. We’re building that!
Nearly 50%-75% (yes, atleast half) of the South Asian population globally suffers from Vitamin B12 deficiency having massive implications on not just on adult health (including sexual and cardiac health) but also kids, leading to issues such as neuro-developmental delay. Its
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@stedmanhalliday
@sharkoff
@chefjeffsf
@thomasschulzz
Definitely should! Landscape is already changing to favor preventative care, we're just in the beginning stages
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@JamesStoverAnth
@altcap
@theallinpod
<40: check labs inc Lp(a), apoB on top of lipids and A1c.
Exercise is by far most critical as it has asymmetric benefit. Both cardio and weights/resistance to build muscle.
Diet/Supplements can help. +Fam hx, we do CGM for 10 days to see what foods can cause insulin resistance
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Onchain from the ground up is the way to go. The recent cyberattack is proof enough, but even before that it was always needed. Add to that AI making medical data more and more valuable yet liquidity patients have no access to
There comes a point in every industry when the existing state of the art is so old, so outdated, and so stagnated that simple band aids do not patch the problem.
What is needed is to burn the house down. And then walk through those smoldering ashes and begin rebuilding a better
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5/ Different machine learning models are used for this purpose. These include CATBoost, XGBoost, Random Forest, Logistic Regression, and Support Vector Machines. Each has its unique approach, similar to various techniques for learning to ride a bike.
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@elonmusk
Both coasts currently are having a storm, barely any sunlight. How can solar solve that? Batteries cant power factories.
Nuclear is the logical answer.
Would recommend listening to
@packyM
's fantastic podcast 'Age of Miracles' on nuclear energy
That's a wrap on Age of Miracles S1!
Over 9 episodes, we've gone deep on fission & fusion.
On Ep 10, we cover what it looks like if we get it right by sharing our favorite answers to the Q:
What will the world look like when we have abundant energy?
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Most people don’t understand how much a healthspan trajectory change moving down a weight category is.
Due to obesity stigma…
Many patients who take GLP-1 medicines like Ozempic etc. don’t feel comfortable even telling others they are on the medicine.
There is NO shame in using these medicines to help with your weight (if clinically indicated).
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Should be retained as a utility which patients can then 'sell' to companies as a source of revenue. Similar to how solar is used to sell to the grid.
Okay, so if full genome sequencing prices drop to <$100/genome, can someone give an argument AGAINST sequencing (voluntarily) the entire populace, and structuring it as a public utility? Something like you can access and share your own with diagnosticians?
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Mistakes by LLMs in any industry = wrong order, delayed/wrong package
Mistakes by LLM in medial care = a life is lost
It seems many are quick to forget this advocating for no oversight or dismissing physicians from the equation
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@JacobJaber
Most powerful was how wrote about listening to Charlie even in light of giving up lessons of Ben Graham when it came to consolidating Berkshire.
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@max_blessen
@JacobJaber
I think its more stuff that will require too much time to understand i.e. accounting, taxes, medicine. Let someone handle that.
And spend that time to focus on learning things that you can eventually, with adequate time understand and learn to grow
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@morgancheatham
Would be clutch in the hospital. Most of the battle is morphology with derm since so many systemic issues cause it. Usually don’t even need a dermatologist to treat it, just a good medication. I use visual Dx during rounds, it’s solid, but slow and not always consensus
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@StuartBlitz
@alexisohanian
You'd like it! Its in Brooklyn, his kids make it and they have the magic touch as well
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@morgancheatham
@akiffpremjee
Have a friend here at Stanford working on combining this with LLMs in computational biology and drug discovery. It’s nifty
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Decided to start posting my blog posts on X directly for ease of access. Lets start with an overview of South Asian health! Will try to focus on specific aspects that impact South Asian health in the coming weeks. Let me know if there are any topics you would like to be covered!
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Pretty cool
Could Generative AI Revolutionize Single-Cell Biology? Discover the Potential of scGPT in Unraveling Cellular Mysteries.
Here is a peer review of the paper.
Link:
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@kyritzb
@Jori_health
Congratulations, this looks amazing! Much needed, especially in oncology where so much trial data is monetized
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Twitter feed changing from medical AI to crypto. Bull market is here
To all those who kept believing and building through the bear 🫡
Medicine needs the blockchain just as much, if not more, than AI
If you don’t understand this then likely ngmi
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@DrDeepMD
@jackmurphylive
@tjparker
It echoes the early 2000s with opioids and how pharma pushed that narrative of "Pain is the 5th vital sign and should be 0"
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Many sleepless nights thinking about how to best serve my patients. That time spent with them is the best part of the day
Every doctor wishes they had more time to spend with patients.
There is constant pressure to serve more patients with limited time and resources.
We think about you after hours.
We worry about how you’re doing.
We want the very best for you, even if it doesn’t feel that way.
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@morgancheatham
@NEJM_AI
@NatureMedicine
@zakkohane
Solid read. To me this is the most understated aspect:
"Clarify that, similarly, the technology companies must move toward accepting some responsibility for outcomes when patients use the AI directly, just as with any other direct-to consumer health tool or resource"
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@WillManidis
Curious how HealthTech companies handle liability and adverse outcomes from decisions made by LLMs. They’ve historically never been exposed to it.
In telemedicine, there is someone holding the liability for mistakes, no matter how it’s prescribed
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@agingdoc1
Had seen some data on role of intermittent fasting in NAFLD in small trials with hopeful results. Any large scale trials working on this?
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@kyritzb
@Jori_health
Very much, and as AI guided treatments become the norm, that data will become all the more valuable
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@amasad
He's celebrated as a Black swan while having all the traits of a white swan. Bought some Argentina ETFs early last year, this is as predictable as it gets.
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Use cases such as these are more impactful on patient lives and experience than many other ‘revolutionize medicine AI’ thrown around.
Surgical consents/intakes are tedious for pts yet contain vital information and help pts fully understand the procedures they are about to have.
🚨📜 New paper from our team:
We show that GPT-4 can not only simplify generic surgical consents 📝, but also generate highly readable & accurate procedure-specific consents from scratch 💡 - a key step towards truly informed consent! ✅
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The amount of ED and hospital visits that happen after shoveling snow validate this
Every single smartwatch on earth should have “snow shoveling” as a workout type and I don’t know a soul that would disagree
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@KDimitratos
Biggest winner from all this is Delta. They’re nearly all Airbus outside of a few lingering old 757,767
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@yugacohler
It also seems heavily generational. Younger generations growing up digital-native invest so much into crafting their digital persona that they will start to value it as an asset, and crypto gives that asset utility as you mention.
AI amplifies this need
Most dont see it yet
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@DrSynbio
Yup, slowly getting the flywheel going and dropping costs lower. Great time to be alive!
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@JacobJaber
Also more than customer, that premium is more to get rid of any US based middleman/importer or drop-shipper. They're paying to bring the factory to the consumer.
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Patients don’t realize how much flexibility and personalized care an independent doc is able to bring into a practice. While employed docs are constrained by the system and it’s mandated templates
Independent docs have been pushed out. Biggest losers from this will be patients
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'And I started asking, "What are the important problems of your field?" And after a week or so, "What important problems are you working on?" And after some more time I came in one day and said, "If what you are doing is not important, and if you don't think it is going to lead
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@StuartBlitz
The flight day experience of the United app has no competition vs the rest of the aviation world
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@cyrilzakka
Yup have it set up on my desktop in the clinic. Also got a friend (who knows actual coding) to have it learn to my voice. Literally the biggest cost has been finding a great mic 😂.
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If you're a fan of cold morning workouts (like myself) then something to think about. Great info by
@stedmanhalliday
!
Health PSA on this one: I don't make a regular habit of outdoor exercise before ~8 am in SF for immunity reasons.
A 5ºC drop in internal nasal temperature decreases efficacy of one of the upper respiratory system's primary infection barriers by >40%.
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@coffeehustler
@JacobJaber
Yup couldn’t agree more. Human interaction is always the gold standard. Nothing beats a great conversation over coffee 🤝
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