Nature Synthesis
@NatureSynthesis
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A synthesis-oriented chemistry & materials science journal from @SpringerNature. Tweets by the editors @ali_stoddart @PSeavill @DrARGroves & @drtwest
London, UK
Joined July 2020
Focus issue online:.Electroreduction of CO2 for C–X bond formation.Editorial: Electrosynthesis of C–X bonds from CO2.Q&A: @MartaCFigueired.Comments: B Zhang & H Wang.World View: @Jennifer_M_Dunn.Review: Kornienko & co-workers.RHs: @ali_stoddart & @PSeavill
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Our first issue is live!.📚All articles free to access 'til end of 2022.✍️A big thank you to all our authors & referees from the editors .@PSeavill @drtwest @ali_stoddart. read the Editorial ( to find out more
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Now online:. Article by @YongWu1990, @sirfrasersays & co-authors at @NUChemistry, @HKU_Chemistry. Mirror-image cyclodextrins. ($).
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Launching January 2022, Nature Synthesis will publish research, reviews and opinion articles on all aspects of synthesis, from making discrete molecules to extended materials, as well as enabling technological innovations. Learn more at
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Now online:. Article by @arseniyadis, .@FrichardChem and co-workers at @Chemistry_QMUL, @chemistryatuvic in collaboration with @LillyPad. Enantioselective synthesis of γ-butenolides through Pd-catalysed C5-selective allylation of siloxyfurans. ($).
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Now online:. Review by Daniele Leonori and co-workers @LeonoriLab . The interplay of polar effects in controlling the selectivity of radical reactions. ($).
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Now online:. Article by Kalipada Koner & Rahul Banerjee @KP_Koner @banerjee_r @iiserkol @dcsiiserkol. Porous polycyclic aromatic heterocycles via metal-free annulative π-extension. ($).
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Now online:. Article by Futo Morita, Ken Tanaka and co-workers @KenTanaka_Lab @tokyotech_en. Design and enantioselective synthesis of 3D π-extended carbohelicenes for circularly polarized luminescence. ($).
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Now online and open access:. Article by Shuming Chen, Eric Meggers and co-workers at Philipps-Universität Marburg and Oberlin College. Expedited synthesis of α-amino acids by single-step enantioselective α-amination of carboxylic acids.
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Now online and open access:. Article by @manuel_buendiam, Salvatore Filippone, Nazario Martín & co-workers @nazariolab. Enantioselective synthesis of a two-fold inherently chiral molecular nanographene.
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Now online:. Article by Zhenhua Zhang, Michael J. Tilby & Daniele Leonori @LeonoriLab . Boryl radical-mediated halogen-atom transfer enables arylation of alkyl halides with electrophilic and nucleophilic coupling partners. ($).
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Now online:. Article by Ting Guo, Jinghao Li, Zhangkai Cui, Zefan Wang & Hongjian Lu . C(sp3)–C(sp3) bond formation through nitrogen deletion of secondary amines using O-diphenylphosphinylhydroxylamine. ($).
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Now online:. Article by @maiti_iitb @Prasun8889 @anjali_sairaman and co-workers @iitbombay @BsbeIitb. Enantiodivergent synthesis of isoindolones catalysed by a Rh(III)-based artificial metalloenzyme . ($).
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OUR FIRST ARTICLE IS LIVE!.On-water synthesis of a charged 2D polymer single crystals via the irreversible Katritzky reaction.by @renhaodong @XinliangF @ZhiyongWang_TUD & co-authors @cfaed_TUD .Free to access to all for a year.
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Now online and open access:. Article by Vasyl Ripenko, Pavel K. Mykhailiuk and co-workers @MykhailiukChem @EnamineLtd . Light-enabled scalable synthesis of bicyclo[1.1.1]pentane halides and their functionalizations.
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Now online:. Article by @Tianqiong3, Omar M. Yaghi and co-workers. Catenated covalent organic frameworks constructed from polyhedra. ($).
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Now online:. Article by Xue Li, Yu Lan, Qiuling Song and co-workers . Transition-metal-free C(sp2)–C(sp3) cross-coupling of α-(pseudo)halo aliphatic ketones with boronic acids via a 1,4-metallate shift. ($).
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New online:.Article by @pchirik and co-workers @ChirikGroup @PrincetonChem . Ammonia synthesis by photocatalytic hydrogenation of a N2-derived molybdenum nitride. ($).
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Now online: . Article by Juntaro Nogami, Daisuke Hashizume, Ken Tanaka & co-workers @KenTanaka_Lab @tokyotech_en @UTokyo_News_en. Catalytic stereoselective synthesis of doubly, triply and quadruply twisted aromatic belts. ($).
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Sept issue live🎉.Nanocluster superstructures.Programmable zigzag π-extension.Synthesis of polyacenes.Stereocontrolled LRP of acrylamides.Synthesis of ionogel membranes.Single-crystal POP.Triply twisted Möbius C nanobelt.Synthesis of twisted aromatic belts.
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Featuring in our One year of Nature Synthesis collection - - and free to access for a limited time. Review by @K_Rykaczewski, @chem_em and @SchindlerLab. Reactivity of oximes for diverse methodologies and synthetic applications.
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Now online and free to read until the end of the year. Varinder Aggarwal @VarinderAggar11 and co-workers @AggarwalLab at @BristolChem provide a Review on lithiation–borylation methodology in the total synthesis of natural products.
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June issue is live!.🤖Robotic nanocrystal synthesis.⚙️HTE for polypeptide synthesis.💻Neural network informed synthesis.💡 Dual-functional Rh catalysts.🔗Bicyclopentylation.☀️Photocatalysis for H2O2.💠B-stereogenic BODIPYs.🧪Catalytic alcohol amination.
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Research Highlight now online:. Feeling the strain by @ali_stoddart. ($). Highlighting the @angew_chem article by @zhichang_liu and co-workers @Westlake_Uni.
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Now online and open access:. Article by @Eddaoudi_FMD3, @gecniv and co-workers @KAUST_News @KAUST_PSE. Face-directed assembly of tailored isoreticular MOFs using centring structure-directing agents.
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Now online:. Article by Adam Cook, Piers St. Onge & Stephen G. Newman @TheNewmanLab @uOttawaCHM @uOttawaScience . Deoxygenative Suzuki–Miyaura arylation of tertiary alcohols through silyl ethers. ($).
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Featured in our One year of Nature Synthesis collection.(Open access). Article by @ritter_lab. Copper-mediated etherification via aryl radicals generated from triplet states.
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Now online:. Article by @Zhichang_Liu and co-workers at @Westlake_Uni . Synthesis of contra-helical trefoil knots with mechanically tuneable spin-crossover properties. ($).
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Now online:. Article by Yonghao Yu, Tian Qin & co-workers. Synthesis of nimbolide and its analogues and their application as poly(ADP-ribose) polymerase-1 trapping inducers. ($).
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Now online:. Review article by Karl Anker Jørgensen and co-workers @JorgensenGroup @Chemistry_AU. Enantioselective organocatalytic cycloadditions for the synthesis of medium-sized rings. ($).
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Now online:. Article by @SimonSchreiner9, Tobias Rüffer & @KretschmerLab @TUChemnitz . A singly bonded gallanediyl with redox-active and redox-inert reactivity. ($).
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Now online:. News & Views on the Article by Zhenhua Zhang, Michael Tilby, Daniele Leonori @LeonoriLab . ($). Boryl radicals facilitate C(sp2)–C(sp3) cross-coupling reactions by Jesus Rodrigalvarez & Ruben Martin @MartinLab_ICIQ. ($).
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Now online:. Article by Li Zhang, Yuanhao Xie, Zibo Bai & Tobias Ritter @ritter_lab. Suzuki–Miyaura coupling of arylthianthrenium tetrafluoroborate salts under acidic conditions. ($).
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In this week's #NSynthPick we highlight Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition by @HuiminZhaoLab @ChemistryUIUC and Binju Wang, Xiamen University and co-workers published in @NatureCatalysis .
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Featured in our One year of Nature Synthesis collection Review article by @gilliardgroup @JacobWalley6 @L_Free_Energy. Synthesis and reactivity of low-oxidation-state alkaline earth metal complexes..
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Now online & open access:. Article by Shun Suginome, Kurumi Murota, Akira Yamamoto, Hisao Yoshida & Yoshiaki Nishibayashi. Mechanochemical nitrogen fixation catalysed by molybdenum complexes.
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Now online:. Article by Ryuhei Suzuki, Taiga Ando, Fritz Deufel, Kohsuke Ohmatsu & Takashi Ooi @OoiLab_NU. Photocatalytic carbyne reactivity of phosphorus ylides for three-component formal cycloaddition reactions. ($).
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Now online:. Article by @mibernus, @DMZ_MazDa, @jelstanic, @tnoel82 & co-workers @NoelGroupUVA . A modular flow platform for sulfur(VI) fluoride exchange ligation of small molecules, peptides and proteins. ($).
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Now online:. Review article by Burkhard König @ChemistryKoenig and Alessa Rolka @uni_regensburg . Bifunctional organic photocatalysts for enantioselective visible-light-mediated photocatalysis. ($).
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Now online:. Article by Kenta Koyamada, Kazunori Miyamoto & Masanobu Uchiyama @UTokyo_News_en @KeioGlobal @ShinshuUni. Room-temperature synthesis of m-benzyne.
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Now online: . Article by @FanWei_NUS, Toshiya M. Fukunaga, Hiroyuki Isobe, @jishan_wu & co-workers. Synthesis and chiral resolution of a triply twisted Möbius carbon nanobelt. (&).
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Now online:.Article by Scott Snyder and co-workers @SASnyderLab @UChiChemistry . The synthesis of diverse terpene architectures from phenols. ($).
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Now online: . Perspective by Kohsuke Ohmatsu & Takashi Ooi at Nagoya University. Catalytic acceptorless dehydrogenative coupling mediated by photoinduced hydrogen-atom transfer. ($).
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Now online and open access:. Article by @evamariawara, Zibo Bai, Tobias Ritter and co-workers @ritter_lab. O-, N- and C-bicyclopentylation using thianthrenium reagents.
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Now online: . Tsung-Han Chao, Xiangyu Wu, Yu Fu, Licheng Yang & @hanzyduzit at @RiceChemistry. Harnessing transaminases to construct azacyclic non-canonical amino acids. ($).
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Now online:. Article by Seiya Ouchi, Yuki Nagashima, Ken Tanaka and coworkers @KenTanaka_Lab. Design, synthesis and visible-light-induced non-radical reactions of dual-functional Rh catalysts. ($).
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Now online:. Article by @nazariolab, @nanosurflab, @nacho_urgel, @davidecijalab and co-workers @IMDEA_Nano . Generating antiaromaticity in polycyclic conjugated hydrocarbons by thermally selective skeletal rearrangements at interfaces. ($).
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Now online:. News & Views on Article by Goto, Sano, Sumida & Ohmiya @OhmiyaLab in @NatureSynthesis. Carbene- and photocatalysis redefine arene acylation by Runjiang Song, Shichao Ren and Yonggui Robin Chi at @GuizhouU. ($).
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Now online and open access:. Article by @Andrew_Sue and co-workers. Synthesis of covalent organic pillars as molecular nanotubes with precise length, diameter and chirality.
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Now online:. Article by Yamato Goto, Masaki Sano, Yuto Sumida & Hirohisa Ohmiya @OhmiyaLab . N-heterocyclic carbene- and organic photoredox-catalysed meta-selective acylation of electron-rich arenes. ($).
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A Perspective by @francesarnold @athavale_s Dave Miller @Caltech .Combining chemistry and protein engineering for new-to-nature biocatalysis.
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Now online:. Article by Xinjiang Zhang, Adam S. Foster, Shigeki Kawai, Shingo Ito & co-workers @sgitolab @NtuChemistry @NTUsg. Synthesis of azahexabenzocoronenium salts through a formal [3 + 3] cycloaddition strategy. ($).
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In this week's #NSynthPick we highlight the electrochemical C-H oxidation of amine derivatives for late stage functionalization from @SongLinLab in collaboration with the Neurock lab @UMNChemistry, @NSF_CSOE and @Genentech published in @J_A_C_S .
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Now online:. Article by Meng-Meng Zheng, Liu Cai, Jiajia Dong, Xiao-Song Xue & co-workers. Computational analysis of modular diazotransfer reactions for the development of predictive reactivity models and diazotransfer reagents. ($).
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Featured in our One year of Nature Synthesis collection. Article by @LucaDellAmicoLD and co-workers. Unveiling the impact of the light source and steric factors on [2 + 2] heterocycloaddition reactions.
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Now online:. Article by @GloriusFrank @HuanmingHuang @94peter @GloriusGroup . Catalytic multicomponent reaction involving a ketyl-type radical. ($).
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Now online:. Article by @valeriofasano, @VarinderAggar11, @AggarwalLab, @SynthAtBris and co-workers. Automated stereocontrolled assembly-line synthesis of organic molecules. ($).
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Now online and open access:. Article by Takashi Kitao, Takumi Miura, Takashi Uemura & co-workers. Synthesis of polyacene by using a metal–organic framework.
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Featured in our One year of Nature Synthesis collection Article by @Itamilab . Synthesis of a Möbius carbon nanobelt.
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Now online:. Review article by Hong Yi, Aiwen Lei & co-workers. Electrochemical oxidative C(sp3)–H cross-coupling with hydrogen evolution. ($).
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Focus on HAT for C(sp3)-H functionalization.Editorial - Hydrogen on the move.Q&As with @AlisonWendlandt + @tnoel82 .RHs on work by @MacMillan_Lab, @SevovLab @ZhangLabOSU, @ParasramLab, @KramerChemistry + Lian.Perspective by Ooi.Review by Lei + Yi.
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Now online:. News & Views on the Article by Peng-Fei Yang, Han-Tong Zhao, Xiao-Yi Chen & Wei Shu. ($). Selective cross-hydrodimerization of alkenes by Sudip Maiti & Debabrata Maiti @smaitichem @maiti_iitb @dm_lab. ($).
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Focus on Data-driven automated synthesis.Q&As w Mimi Hii @impchemistry @aicooper.Comments @procrastiprof @Robo_Perovskite.Reviews @Milad_RoboChem @EKumachevaGroup @johnmgregoire.N&V @GormleyLab.RHs on Abigail Doyle @uclachem + Connor Taylor @AlexeiLapkin.
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Our July issue is here!. 🛟 Möbius carbon nanobelts .🎯Synthesis of (+)-ribostamycin.⚙️Synthesis of β-functionalized chiral amines.🏅C–H metallation of tetrahydrofuran and application in flow.⭐️Cooperative triple catalysis for Mizoroki–Heck reactions.
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Research Highlight now online:. Spiro-buckybowl synthesis by @PSeavill. ($). Highlighting the @angew_chem article by Jialiang Xu, Xiangfeng Shao and co-workers.
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Now online and free to read for a month:. Review by @LevinChem @group_levin @SarpongGroup @chemiejisoo @balu_dherange @SojungKim20 @JustinJurczyk @UChiChemistry @UCB_Chemistry. Single-atom logic for heterocycle editing.
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Now online:. Article by Hau Sun Sam Chan, Yilin Lu & Jin-Quan Yu @YulabJin. Palladium-catalysed methylene C(sp3)–H lactamization and cycloamination enabled by chlorinated pyridine–pyridone ligands. ($).
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In this week's #NSynthPick we highlight the Mn-catalysed late-stage intermolecular allylic C-H amination by @MCWhiteGroup @ChemistryUIUC published in @J_A_C_S
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Now online and open access:. Article by @aicooper @Qiang_Zhu_LIV @JelfsChem @graeme_day @m_a_little @AICooperGroup and co-workers. Computationally guided synthesis of a hierarchical [4[2+3]+6] porous organic ‘cage of cages’.
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Light work for hydrogel synthesis .Highlight of Adv. Mater article by @BurdickLab @MauckLab .
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Now online:. Article by @YingKaiLOH, @MunzDominik, Guy Bertrand and co-workers @UCSDChemBiochem. Isolation of a pentadienyl-type radical featuring a central secondary carbon. ($).
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Now online:. Article by Kang Liang, Qinglin Zhang & Chang Guo . Enantioselective nickel-catalysed electrochemical cross-dehydrogenative amination. ($).
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New online:.Article by @sarlahlab @ChemistryUIUC @pengliu_group; @Pitt_Chemistry. Synthesis of (+)-ribostamycin by catalytic, enantioselective hydroamination of benzene. ($).
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Featuring in our One year of Nature Synthesis collection - - and free to access for a limited time. Article by @weizhangCU @YimingSZ Yingjie Zhao and co-workers. Synthesis of γ-graphyne using dynamic covalent chemistry.
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Featuring in our One year of Nature Synthesis collection - - and free to access for a limited time. Review by @K_Rykaczewski, @chem_em and @SchindlerLab. Reactivity of oximes for diverse methodologies and synthetic applications.
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An article by @GloriusFrank and co-authors @GloriusGroup @HuanmingHuang @94peter .Allylic C(sp3)―H Arylation of Olefins via Ternary Catalysis.
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In this week's #NSynthPick we highlight Enantioselective synthesis of amino acids from ammonia from Qi-Lin Zhou and co-workers @NKU1919 published in @NatureCatalysis
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Now online: . Article by @michelgravel6, @KarnjitParmar and co-workers @USaskChem . Synthesis of a highly aromatic and planar dehydro [10]annulene derivative. ($).
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Now online: . News and Views on Article by Shuming Chen, Eric Meggers & co-workers published in @NatureSynthesis . Unnatural α-amino acid synthesis by Tuan Anh Trinh & Jennifer M. Schomaker. ($).
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Now online:. Article by Zhong-Wei Zhang, Zhe Feng, Jun-An Ma & Chi Wai Cheung. Metallaphotocatalytic synthesis of anilines through tandem C–N transposition and C–H alkylation of alkylamines. ($).
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In this week's #NSynthPick we feature a new decarboxylative fluorination method developed by the @ritter_lab reported in @J_A_C_S
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Now online:. Article by Chao Liu and co-workers at the Lanzhou Institute of Chemical Physics. Alkyne synthesis through coupling of gem-diborylalkanes with carboxylic acid esters. ($).
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Now online & open access:. Article by @SourjyaMal, @Fritze_dng, K Hiesinger & M van Gemmeren @vangemmerenlab @kieluni @Kiel_Nano @dfg_public. Pd-catalysed direct β-C(sp3)–H fluorination of aliphatic carboxylic acids.
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In our February issue .🤸♂️Boronic esters show their versatility in the synthesis of natural products 🌿.📚A Review article by @VarinderAggar11 @VarinderAggar11 & co-authors.
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ICYMI: In this weeks #NSynthPick we feature the much talked about nitrogen deletion methodology developed by @LevinChem @group_levin at @UChiChemistry published in @nature highlighted by @UnsworthChem and @ajavestro
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In this week’s #NSynthPick we highlight the synthesis of conjugated metal-organic macrocycles and their self-assembly into ordered nanotubes from @thexiaolab @luscombe_OIST @UW @UWChemistry published in @J_A_C_S .
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Now online:. News & Views on the Article by P Liu, WR Gutekunst, KM Engle & co-workers @GuteGroup @pengliu_group @EngleLab . ($). Diarylation encodes precision for polyolefins by Elizabeth Elacqua @beth_elacqua. ($).
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Extra date: Join our webinar on 7 December for an introduction to the journal, including the aims and scope, guidance on submitting your work to us and the opportunity to ask your questions to Chief Editor, Ali Stoddart.
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Now online:. Article Yan Zhang, Shota Fukuma, @paradiseshang & Eiichi Nakamura . Iron-catalysed C(sp²)–H activation for aza-annulation with alkynes on extended π-conjugated systems. ($).
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In this week's #NSynthPick we highlight the transformation of aryl azides to 2-aminopyridines using blue light and oxygen by @sajancpatel and Noah Burns from @StanfordUChem @Stanford published in @J_A_C_S.
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Now online:. Article by Tianzhu Qin, Mengyang He & Weiwei Zi. Palladium-catalysed [2σ + 2π] cycloaddition reactions of bicyclo[1.1.0]butanes with aldehydes. ($).
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Now online:. Article by Zhengbo Zhu, Xuedan Wu, Zibo Li, David A. Nicewicz & co-workers @NicewiczLab . Carbon isotopic labelling of carboxylic acids enabled by organic photoredox-catalysed cyanation. ($).
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Now online:. Open access Article by Feliu Maseras, Mónica Pérez-Temprano & co-workers @Perez_Temprano @MaserasGroup @ICIQchem. Hexafluoroisopropanol-assisted selective intramolecular synthesis of heterocycles by single-electron transfer.
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Now online:. News & Views on an Article published in @angew_chem by @SzyszkoBart @alexa_sarwa @WCh_UWr and co-workers. Flexibility from fluxionality by Stephen Fielden @FieldenStephen @UoBChemistry . ($).
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Research Highlight now online: . Cation-capped chains. ($). Highlighting the @J_A_C_S Article by @ysk_isgk and co-workers from @HokkaidoUni @osaka_univ_e.
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In this week's #NSynthPick we highlight using enzymes to tame nitrogen-centred radicals for enantioselective hydroamination by @HysterLab @CornellChem @PrincetonChem and @Merck in @NatureChemistry .
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Now online and open access: . Article by @GloriusFrank @GloriusGroup , Friedrich Temps, Xiaotian Qi and co-workers. Radical thioesterification via nickel-catalysed sensitized electron transfer.
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A Review by @SchindlerLab @K_Rykaczewski and @chem_em.Reactivity of oximes for diverse methodologies and synthetic applications.
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In this week's #NSynthPick we highlight a pyridine dearomatization approach to prepare matrine-type alkaloids by @sarah_reisman @kerkovius @AnetaTurlik @houk1000 and co-workers from @CaltechCCE @uclachem published in @J_A_C_S .
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