Nature - A self-adjustive catalytic system with nickel under visible-light-driven redox reaction conditions provides a general method for carbon–(hetero)atom cross-coupling reactions and is...

Nature Synthesis - Performing enantioselective photocatalytic reactions with visible light is a challenging task that has seen substantial advances with the development of new catalysts. Although...

Melting point depression liquefies solid reactants to facilitate their photochemical coupling on the surface of water.

With the rapid development of photoredox catalysis, numerous concepts for asymmetric induction were successfully and broadly adapted from polar two-electron transformations to radical chemistry....

Postsynthetic diversification of peptides through selective modification of endogenous amino acid side chains has enabled significant advances in peptide drug discovery while expanding the biological...

β-Amidated carboxylic acids, or succinamic acid derivatives, constitute a valuable chemical scaffold with broad applications in pharmaceuticals, agrochemicals, and polymer sciences. Herein, we report...

Recent years have witnessed important progress in synthetic strategies exploiting the reactivity of carbocations via photochemical or electrochemical methods. Yet, most of the developed methods are...

Prompted by the increasing interest in strained hydrocarbons as potential drug candidates, we developed a simple and efficient photochemical protocol for (spiro)cyclopropanes from bench stable...

We report the iridium–nickel dual photocatalytic acceptorless and redox neutral dehydrogenation of aliphatic heterocycles yielding cyclic alkenes without overoxidation at room temperature. Excitation...

A metal-free photoredox three-component coupling of thiols with readily available alkynes and alkenes has been developed. The reaction mechanism was evaluated by combining ESI-HRMS, EPR spectroscop...

The combination of photoinduced hydrogen atom transfer (HAT) and cobalt catalysis gives access to a mild dehydroformylation sequence for the defunctionalization of benzyl alcohols to arenes. The...

The syntheses of two novel, organic, and chiral photocatalysts are presented. By combining donor–acceptor cyanoarene-based photocatalysts with a chiral phosphoric acid, bifunctional catalysts have...

A photo-induced Büchner-Curtius-Schlotterbeck type reaction for carbonyl homologation is described. The protocol allows the use of carbonyl compounds as safe and readily available diazo precursors...

The selective activation of sp3 carbon–hydrogen bonds in the presence of multiple C–H bonds is challenging and remains of supreme importance in chemical research. Late-stage modification of complex...

Oxytocin (OT) and vasopressin (VP) are related neuropeptides that regulate many biological processes. In humans, OT and VP act via four G protein-coupled receptors, OTR, V1aR, V1bR, and V2R (VPRs),...

Hypervalent iodine compounds have evolved from structural curiosities into useful reagents owing to their unique polar and radical reactivity. In the last decade, many reactions based on their direct...

The sugar alcohol meglumine can solubilize organic compounds in water to synthetically useful levels, allowing the formation of enforced electron donor acceptor (EDA) complexes in water. These EDA...

Graphitic carbon nitride materials have attracted significant interest in recent years and found applications in diverse light-to-energy conversions such as artificial photosynthesis, CO2 reduction,...

The development of predictable methods to increase molecular complexity is of paramount importance in modern organic chemistry, especially in the context of synthesizing multifunctionalized (het)ar...

Cross-coupling reactions play a vital role in modern organic synthesis, enabling the construction of necessary C–C or C–(het)atom bonds for synthetic transformations. Although C(sp2)–C and C(sp2)–N...

Not so radical: The amalgamation of radical chemistry with polar chemistry is used to develop a tunable multicomponent reaction which involves CO2, sodium sulfinates and styrenes to access both...

Fentanyl-based photoswitchable tethered ligands (PTLs) were developed, targeting the μ-opioid receptor (μOR). Such ligands allow for spatial, temporal and non-invasive regulation of this medically-...

Beilstein-Institut

Iron, mostly as Fe2+ or Fe3+ bound in oxides, is the second most common element in the Earth's crust after aluminium. Salts of the d-block metal are cheap and commercially available and have already...

In this study, we report the first example of a photoswitchable copper complex with catechol oxidase activity. The distance between the two copper centres is optimal for catalytic catechol oxidation...

Novel catalytic strategies for the generation of functionalized carbanionic species by carbonyl Umpolung are discussed in this Minireview. The application of metal catalysis and photocatalysis...

In recent years, several methods for the direct desaturation of aliphatic compounds have been developed, facilitated by the unique combination of photoredox and transition-metal catalysis. Hereby,...

We report the photosubstitution of one cyano group in dicyanobenzene-based photocatalysts and thermally activated delayed fluorescence (TADF) emitters. The reaction is a general degradation pathway...

The direct C−H/N−H dehydrogenative cross-coupling of NH-sulfoximines with electron-rich arenes was realized by oxidative visible-light photoredox catalysis, applying 9-mesityl-10-methylacridinium...

A broadly applicable method for the trifluoromethylthiolation of methylene C(sp3)–H, methine C(sp3)–H, α-oxygen C(sp3)–H, and formyl C(sp2)–H bonds is presented using the decatungstate anion as the...

Nature Reviews Chemistry - Endergonic photocatalysis enables the catalytic and atom-economic synthesis of products with higher free energies than reactants. This Perspective highlights current...

Adaptive Catalysts for Coupling Reactions

Prompted by the increasing interest in strained hydrocarbons as potential drug candidates, we developed a simple and efficient photochemical protocol for (spiro)cyclopropanes from bench stable...

The carboxylation of sp3-hybridized C–H bonds with CO2 is a challenging transformation. Herein, we report a visible-light-mediated carboxylation of benzylic C–H bonds with CO2 into 2-arylpropionic...

Powering up: An induction-based energy harvesting (EH) device converted rotational energy of magnetic stirrers back to electrical energy, making it accessible for electrochemical late-stage functio...

A two-step protocol allowing the C−H amination of cyclic ethers with iminoiodinanes, followed by the reduction of the resulting intermediate has been developed for the preparation of amino alcohols....

A simple yet versatile strategy for the construction of important 1-azaspirocyclic scaffolds is described. Alkynyl-tethered N-hydroxyphthalimide esters, swiftly assembled through an alkylation/depr...

We report the synthesis of 1,4-dicarbonyl compounds and substituted alkenes (Mizoroki–Heck type coupling) starting from secondary and tertiary alkyl halides and vinyl acetate or styrene derivatives...

Oxytocin (OT) and vasopressin (VP) are related neuropeptides that regulate many biological processes. In humans, OT and VP act via four G protein-coupled receptors, OTR, V1aR, V1bR, and V2R (VPRs),...