Photoexcited nickel catalysis enabled silyl-radical-mediated activation of carbamoyl chlorides. This process provides an operationally simple and widely applicable amidation reaction of a plethora...

The first photo-induced Rh-catalyzed ortho-alkynylation is developed under ambient conditions without the requirement of exogenous oxidant, photosensitizer or engineered substrate/catalyst. The...

The utilization of weak coordination in promoting site-selective C(sp3)–H functionalization is of immense importance. Herein, we report a Pd-catalyzed distal γ-C(sp3)–H arylation that harnesses the...

Transition-metal-catalyzed C–H activation has developed a contemporary approach to the omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted to take the help of...

Over the years, silver salts have become an integral part of palladium-catalyzed C–H functionalization. Although most of the research works highlight the role of Ag(I) complexes solely as an oxidant,...

The significance of chelation-assisted C–H functionalization stands upon the superior site-selectivity, easy synthesis, and diverse product utility. In this work, we design a meta-directing scaffold...

Nature Communications - Transition-metal-catalyzed C–H arylations are an effective tool for the construction of biaryl motifs in an efficient and selective manner. Here the authors provide an...

In industries and academic laboratories, several late transition metal-catalyzed prerequisite reactions are widely performed during single and multistep synthesis. However, besides the desired...

C−H thioarylation of hydrocarbon building blocks is a highly desirable synthetic transformation because of its prevalence in various pharmaceuticals and organic functional materials. However, to date...

Harnessing the magic methyl trick

C–H deuteration has been intricately developed to satisfy the urgent need for site-selectively deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope effects of...

Among numerous solvents available for chemical transformations, 1,1,1,3,3,3-hexafluoro-2-propanol (popularly known as HFIP) has attracted enough attention of the scientific community in recent years....

A well-defined, bench-stable nickel catalyst is presented here, that can facilitate double alkylation of a methyl ketone to realize a wide variety of cycloalkanes. The performance of the catalyst...

The selective functionalization of C–H bonds is an extremely important topic in present-day organic synthesis, as it utilizes the most abundant portion of a molecule as a tool for synthetic manipul...

Nature Communications - Dehydrogenation chemistry can be used to generate units of unsaturation that can later be functionalized, as well as create aromaticity, which fundamentally alters the...

Carbon dioxide (CO2) has emerged as an exciting, cost-effective, abundant, and ready-to-use C1 source in synthetic organic chemistry. However, the thermodynamic stability and kinetic inertness of CO2...

Transition metal catalyzed C(sp3)–H functionalization is a rapidly growing field. Despite severe challenges, distal C–H functionalizations of aliphatic molecules by overriding proximal positions have...

Transition metal-catalysed functionalizations of inert C–H bonds to construct C–C bonds represent an ideal route in the synthesis of valuable organic molecules. Fine tuning of directing groups,...

Direct catalytic transformation of C–H bonds to new functionalities has provided a powerful strategy to synthesize complex molecular scaffolds in a straightforward way. Unstinting efforts of the...

Nitrile or cyano compounds are an important part of structural motifs in dyes, agrochemicals, medicinal compounds, and electronic materials. Also, aryl nitrile is an important intermediate in the...

Overriding the preference for favorable proximal metalation by ortho-directing amide group, a pyrimidine-based directing group (DG) has been demonstrated for diverse remote meta-C–H functionalizati...

Artificial metalloenzymes have been recently established as efficient alternatives to traditional transition metal catalysts. The presence of a secondary coordination sphere in artificial metalloen...

Lactones comprise a class of valuable compounds having biological as well as industrial importance. Development of a methodology to synthesize such molecules directly from readily available materials...

The late-stage functionalization (LSF) of pharmaceutical and agrochemical compounds by the site-selective activation of C–H bonds provides access to diverse structural analogs and expands synthetic...

Rhodium catalysis has been extensively used for ortho-C–H functionalization reactions, and successfully extended to meta-C–H functionalization. Its application to para-C–H activation remains an unmet...

Controlling remote selectivity and delivering novel functionalities at distal positions in arenes are an important endeavor in contemporary organic synthesis. In this vein, template engineering and...

Deuterated and tritiated analogs of drugs are valuable compounds for pharmaceutical and medicinal chemistry. In this work, we present a novel hydrogen isotope exchange reaction of drugs using...

An orthogonal selectivity for distal meta-C–H activation of benzophenone is acheived by overriding the inherent proximal ortho-selectivity through a template assisted metalation approach. This...

Unactivated olefins usually react poorly in conventional alkenylation reactions. Their introduction via C–H activation is limited to aromatic acids. Herein, we disclose a C–H functionalization...