Electrooxidative cobalt-catalyzed C–H activation selectively produces C-stereogenic, P-stereogenic, and atropisomeric compounds.

Nature Catalysis - C–H activation in organic chemistry usually relies on precious and toxic transition metals. Now it is reported that a sustainable photo-promoted iron-catalysed aromatic...

Nature Reviews Methods Primers - This Primer provides an overview of the best practices for C–H activation as well as key advances in asymmetric, photoinduced and electrocatalytic-mediated...

Nature Chemistry - Despite the importance of C–H methylation in medicinal chemistry, the application to densely functionalized complex molecules remains a challenge. Now, a novel...

Iron catalysts represent an economically attractive tool for C–H activations because of their low costs and low toxicities. Despite an exponential increase of interest in this area, detailed mechan...

Multicomponent domino reactions via electrochemical annulations have emerged as a robust strategy for the rapid assembly of heterocyclics. Herein, an electrochemical annulation via a [1 + 2 + 1 + 1]...

Rhodium(III)-catalyzed enantioselective C–H activation has emerged as a powerful tool for assembling enabling chiral molecules. However, this approach is significantly hampered by the cumbersome...

The merger of rhodium catalysis and electrochemical synthesis enabled the exclusive access to the C7−H electro-alkenylation of indoles.

The cobaltaelectro-catalyzed C−H activation was devised to access molecules with central and axial chirality with up to >99 % enantiomeric excess and >20 : 1 diastereomeric ratio. The cobaltaelectr...

The visible light-induced C–H arylation of azoles has been accomplished by dual-catalytic system with the aid of an inexpensive ligand-free copper(i)-catalyst in combination with a suitable photore...

Enantioselective palladaelectro-catalyzed C–H alkenylations and allylations were achieved with easily-accessible amino acids as transient directing groups. This strategy provided access to highly...

A secondary phosphine oxide (SPO)-nickel catalyst allowed the activation of otherwise inert C–F bonds of unactivated arenes in terms of challenging couplings with primary and secondary alkyl Grignard...

Electrosynthesis represents an increasingly viable platform for molecular synthesis; this volume presents the key concepts, strategies, and latest advances.

The oxidative intermolecular nitrogenation of C(sp3)–H bonds represents one of the most straightforward strategies to construct nitrogen-containing molecules. However, a sacrificial chemical oxidant...

Catalyzed C–H activation has surfaced as an enabling tool for molecular assembly, with a plethora of translational applications. The enormous developments toward the utilization of ubiquitous C–H...

The development of novel catalysts for C–H activation reactions with increased reactivity and improved selectivities has been attracting significant interest over the last two decades. More recently,...

Palladium-catalyzed C−H arylation of tryptophan-containing peptides with readily accessible and modular arylthianthrenium salts was investigated. The modular nature of this arylating agent allowed...

Light-enabled ruthenium-catalyzed C−H activation enables direct arylations at room temperature. Biscyclometalated ruthenium intermediates were identified as photoredox catalysts through a metal-to-...

Asymmetric ruthenium-catalyzed C–H alkylations were enabled by a chiral C2-symmetric carboxylic acid. The mild cooperative ruthenium(II) catalysis set the stage for the assembly of chiral tetrahydr...

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Nature Communications - A highly efficient stereoselective C−H alkylation of indoles with aryl alkenes is achieved by sustainable iron catalysis, leading to atropoenriched and enantioenriched...

A formal C(sp2)−H alkylation via the dibenzothiophenylation/nickel-catalyzed eXEC sequence is presented. The first activation step selectively gives aryldibenzothiophenium salts, which are subseque...

Enantioselective electrocatalyzed transformations represent a major challenge. We herein achieved atropoenantioselective pallada-electrocatalyzed C–H olefinations and C–H allylations with high...

The iron-catalyzed hydroarylation of allenes was accomplished by weak phenone assistance. The C–H activation proceeded with excellent efficacy and high ortho-regioselectivity in proximity to the...

Here, Wei et al. describe an iron(III) complex as an inexpensive and effective photocatalyst for the photoelectrochemical functionalization of hydrosilanes and hydrogermanes with chemo-selectivity....

The late-stage fluorescent labeling of structurally complex peptides bears immense potential for molecular imaging. Herein, we report on a manganese(i)-catalyzed peptide C–H alkenylation under...

A ruthenium(II)/phosphine catalysis system enabled versatile meta-arene C−H glycosylation by σ-activation. Thus, easily accessible glycosyl bromide donors furnished 1,2-trans C-aryl glycosides via...

The ruthenium-catalyzed remote-difunctionalization of nonactivated alkenes for double meta-C(sp2)−H/C-6(sp3)−H transformations was achieved by metalla-hydrogen atom transfer (MHAT) and σ-activation,...