Waser Group
@LcsoLab
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Driven by Passion for Chemistry Organic Chemistry Lab @EPFL_CHEM_Tweet @EPFL_en @NCCR_Catalysis @SNE_ChemBio
EPFL, Lausanne, Switzerland
Joined March 2015
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Interesting: In the new manuscript template
@angew_chem
, you should now add the references cited in the SI in the main manuscript. An excellent move to give more credits to researchers developing useful synthesis procedures and providing good characterization data!
14
79
645
A full year of total synthesis problems! 🧪Check our website to find them all! More than 120 organic chemistry exercises and more to come in 2022!
#LCSOSynthesisProblem
@EPFL_CHEM_Tweet
#TotalSynthesis
Take a look:
1
71
377
Happy Friday everyone! What's your plan for the week end? Ariel's gonna relax in her lab hot tub with her friends! (Sound on 🔊)
#FridayMotivation
#Chemistry
#RealTimeChem
#phdlife
7
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337
Welcome back to Helena 🇪🇸 who joined the group as PhD student! All the best !
6
3
235
Shaky Friday everyone! Oh baby, when you talk like that, You make a chemist go mad!💃🧪
#Science
#Chemistry
#phdlife
#FridayMotivation
#RealTimeChem
@shakira
@EPFL_CHEM_Tweet
Sound on 🔊
5
20
210
A full year of total synthesis problems! More than 20 syntheses added to our collection of synthesis exercises! Check our website to find more than 140 organic chemistry problems!
#LCSOSynthesisProblem
@EPFL_CHEM_Tweet
#TotalSynthesis
Take a look:
1
31
198
Happy Friday everyone! Don't forget to keep your head out of the water (literally)!
2
24
175
From
@chemrxiv
to
@J_A_C_S
! The work of
@TinVTNguyen1
,
@ABossonnet
and Matt on the Photocatalyzed [2σ + 2σ] and [2σ + 2π] Cycloadditions for the Synthesis of Bicyclo[3.1.1]heptanes and 5- or 6-Membered Carbocycles is now out, thread of a long story 1/4
6
12
172
Today, Jerome has been promoted to full professor of organic chemistry
@EPFL_CHEM_Tweet
@EPFL_en
by the ETH Board!
33
8
151
Welcome to Adriana 🇮🇹 (
@adriana_faraone
) who joins the group as Postdoctoral researcher ! All the best!
0
0
137
How to activate carbonyl cyclopropanes for cycloadditions with light only? Look at the preprint
@ChemRxiv
of Tin
@TinVTNguyen1
and Andre
@ABossonnet
for access to cyclopent(a)enes and bicyclo[3.1.1]heptanes as meta-substituted benzene bioisosters!
3
10
137
Bloomy Friday everyone! 🌸
Will you find the perfect caption for this video?
#phdlife
#Chemistry
#OrganicChemistry
#FridayMotivation
@buchilabeqpt
@EPFL_CHEM_Tweet
#spring
10
13
134
It is out! Elusive sigma-type cyclopropenium equivalents accessed via a new hypervalent iodine reagent (CpBX), and gold-catalyzed reactions thanks to the huge work of Xiangdong
@Xiangdong__Li
with computation from Mat
@mdwodrich
now in
@NatureChemistry
4
9
133
A full year of total synthesis, retrosynthesis and mechanistic problems!🧪Check out our website to find them all! More than 160 organic chemistry exercises and more in 2024!
#LCSOSynthesisProblem
@EPFL_CHEM_Tweet
#TotalSynthesis
#Chemistry
Take a look:
1
18
130
Challenged by a first year student on the mechanism of the Mitsunobu reaction. In the second step, why the carboxylate does not attack the phosphorous, it looks more nucleophilic...
9
10
129
From
@ChemRxiv
to
@ChemicalScience
! The final version of the work of Stefano on the annulation of BCBs with dienes has now just been published!
5
8
127
It's time to
#BreakTheBias
in Science too. We are very proud to share with you the picture of our talented Women of the LCSO on the international women's rights day! Let's celebrate together the incredible work done by women in
#Chemistry
👩🔬
#IWD2022
#WomenInSTEM
#WomensDay2022
3
11
123
You want to learn more about the late stage functionalization of peptides and proteins with hypervalent iodine reagents?
Have a look at the mini-review of Emmanuelle and Elija just accepted
@angew_chem
!
1
21
123
New labs, new picture! Here are all LCSO actual members from around the world🇨🇭🇫🇷🇮🇹🇪🇸🇩🇪🇱🇻🇺🇦🇨🇳🇯🇵🇻🇳 What a view! 🏔️
@EPFL_CHEM_Tweet
#phdlife
#alpes
#Chemistry
@unil
1
3
119
Have a look at the work of Vladyslav
@Vlad__Smyrnov
on accessing cyclopropeniums via a radical-polar crossover approach in
@angew_chem
. Our work complete recent breakthroughs of
@MarcosGSuero
and
@SmwhLab
to make cyclopropeniums more accessible.
1
13
116
New way to functionalize peptides/proteins : Nina
@NDeclas
now developed the first method for tyrosine functionalization with EBXs, with already first applications with
@matile_group
and
@PStallforth
(more in the thread) now available
@ChemRxiv
2
15
112
How to get two alkaloid scaffolds by combining indoles and aminocyclobutanes just by changing the temperature?
Have a look at the work of Emma
@EmmaGabRobert
with preliminary results of Vincent and calculations by Matt now accepted
@angew_chem
1
12
111
From
@ChemRxiv
to
@J_A_C_S
our work on catalytically formed auxiliaries is now published! A great teamwork of
@Luca_Buzzetti
@pacans94
and Phill. Also a major milestone for the project
#SeleCHEM
@ERC_Research
The work of
@Luca_Buzzetti
,
@pacans94
and Phill making the best out of two worlds is now on
@chemrxiv
: we exploit
#asymmetriccatalysis
to forge a
#chiralauxiliary
, which is then used to control asymmetric hydrogenation to access chiral amino alcohols.
5
2
73
6
7
109
From
@ChemRxiv
to
@angew_chem
the work of Stephanie
@steph_ge_amos
, Diana and Franck
@FranckF1476
@EPFL_CHEM_Tweet
@NCCR_Catalysis
on the direct photoexcitation of ArEBX reagents is now accepted for publication
3
12
106
Nice diner yesterday night at the
#IASOC
2022:
@anatmilo
,
@MatthewGaunt8
,
@CarreiraGroup
,
@Schoenebeck_Lab
and
@MartinLab_ICIQ
had dinner with
@TinVTNguyen1
,
@EmmaGabRobert
and Christine from LCSO!
0
4
106
What happens when you irradiate carbonyl cyclopropanes with light? The outcome depend on the substrate, but always via a biradical: if you are curious look at the preprint
@ChemRxiv
of Tin
@TinVTNguyen1
André
@ABossonnet
Duncan
@DuncanBrownsey
and Matt
1
10
107
The work of
@Xingyuu_Liu
on the gold catalyzed macrocyclization of peptide-EBXs to make fluorescent macrocycles is now in
@J_A_C_S
A great collaboration with Wei
@LCBM_EPFL
@Beatfierz
and Nathan
@LabRadenovic
within project SeleCHEM
@ERC_Research
3
12
103
Now Helena showing how you can separate chlorophyll from carotene by column chromatography
0
6
102
The work of Nieves
@Nieves_P_R
@NCCR_Catalysis
on the Cu-catalyzed enantioselective 3-component reaction of nucleophiles, diazo compounds and EBX reagents is now accepted
@angew_chem
!
5
14
101
We are happy to welcome 4 master students this semester! Say hello to Elodie 🇫🇷 Leander 🇩🇪 Trinh🇻🇳 and Olha 🇺🇦
5
0
98
When two long stories end up happily at the same time: the work of Tin
@TinVTNguyen1
/Matt and Nina
@NDeclas
(with beautiful collaborations with
@matile_group
and
@PStallforth
) are now both accepted
@ChemicalScience
2
11
98
Oops!.. we did it again!
#LCSOSynthesisProblem
is back with the total synthesis of (-)-Cajanusine by
@KBrownLab
in 2020 in
@J_A_C_S
!
#TotalSynthesis
@TotalSynthesis
#Chemistry
Take a look:
Original paper:
0
8
94
Xingyu
@Xingyuu_Liu
with the help of Olha and Adriana
@adriana_faraone
developed new non-natural amino acids containing a EBx reagent for solid and solution phase peptide synthesis, leading to new ways towards macrocycles, now accepted
@angew_chem
3
10
96
Happy New Year! Wrapping up 2023 with a compilation of the best views we got last year from the lab! Can't wait to see what 2024 brings us ✨🏞️🇨🇭
@EPFL_CHEM_Tweet
@EPFL
0
5
93
From
@ChemRxiv
to Org. Lett.
@JOC_OL
the work of Diana
@diacavalli
@EPFL_CHEM_Tweet
@NCCR_Catalysis
on the synthesis of lactones via an organic-dye catalyzed alkynylative cyclization is now published in its final form
1
12
93
New month, new PhD! Welcome to Christine 🇫🇷 who joined us yesterday from
@enscmchimiemtp
! Best of luck!
1
1
91
Congrats to Christine for passing her first year candidacy exam yesterday!
4
0
90
the work of Elija and Javier
@DeCerrajeria
on new hypervalent iodine reagents for cys-cys and cys-lys peptide stapling has now been accepted
@angew_chem
1
16
90
Our first publication of the year from Christine and Emmanuelle is just accepted in OL
@JOC_OL
: A Polonovski strategy for the synthesis of non-natural amino acid and peptide derivatives
0
8
89
How to introduce simultaneously an azide and an alkyne onto an alkene? Look at the photocatalytic radical-polar crossover approach of Julien just accepted
@ChemicalScience
!
@EPFL_CHEM_Tweet
@NCCR_Catalysis
2
7
88
The work of Ashis
@ashisdas283
Luca
@Luca_Buzzetti
and Mikus
@pacans94
on catalytically formed chiral auxiliary via hydroalkoxylation is now accepted
@ACSCatalysis
as part of project SeleCHEM
@ERC_Research
and
@NCCR_Catalysis
2
14
88
How to access highly substituted spirocyclopropanes? Look at the semipinacol rearrangement approach of Vladyslav
@Vlad__Smyrnov
just accepted in OL
@JOC_OL
!
0
5
87
Amazing that such reagents are stable: Benziodoxolones bearing primary unprotected amines reported by Marques and co-workers in OL
@JOC_OL
2
10
86
Jerome
@LcsoLab
and Bill
@morandilab
are happy to announce the Swiss Summer School 2021 (including Bob Grubbs
@catalysis_eth
@CoperetGroup
@anatmilo
@HysterLab
@EvaHeviaGroup
and great industry colleagues), supported by
@SwissChemistry
@NCCR_Catalysis
0
22
86
Today it was the turn of Jerome to present the work of the group in the ring opening of strained rings at the Thinking out of the Ring workshop at the
@lorentzcenter
1
2
86
Organic seminars starting again
@EPFL_CHEM_Tweet
with Prof Ruben Martin
@rmartinICIQ
@MartinLab_ICIQ
from ICIQ
@ICIQchem
0
2
85
Great day
@LcsoLab
with two major hypervalent iodine projects from
@ERC_Research
SeleCHEM accepted
@angew_chem
! First a new method for the synthesis of heteroatom-substituted trifluoromethylated alkenes from VBXs developed by Tobias
@TobiasMilzarek
1
8
85
Organic chemistry Seminar today
@EPFL_CHEM_Tweet
with Prof David Procter
@GroupProcter
from Manchester University
0
0
81
Have a look at the room temperature [4+2] cycloaddition on benzene rings discovered by Durga
@durgahari001
Guillaume and Artem
@Artem_Tsymbal
with computation
@mdwodrich
and beautiful crystal structures of Rosario and Farzaneh just accepted
@angew_chem
1
3
83
Bis(trifluoromethylated) ethynyl benziodoxoles are useful reagents, yet their synthesis is cumbersome: now Nieves
@Nieves_P_R
, Tobias
@TobiasMilzarek
and Xingyu
@Xingyuu_Liu
developed a practical one-pot protocol directly from iodine(I)
@ChemCommun
0
15
80
What about some crystals to finish the week?💎Would you be able to guess which chemical is crystalized?
#LCSOCrystalChallenge
Send us your nicest crystals!
More to come next Friday!
#Chemistry
@EPFL_CHEM_Tweet
#Crystal
#Science
@RealTimeChem
5
3
81
The ultimative EBX synthesis by Julien: it is so efficient that you can directly perform alkynylation reactions in the same pot without need for isolation or purification now available
@JOC_OL
1
8
80
Welcome to Daphne 🇧🇪 and Clément 🇫🇷 who joined LCSO as master students! Best of luck!
0
1
77
First publication in 2022: Mikus
@pacans94
extends the Catalytically Formed Chiral Auxiliary concept from hydrogenation to cyclopropanation and epoxidation, just accepted
@angew_chem
part of project SeleCHEM
@ERC_Research
and
@NCCR_Catalysis
0
8
78
The work of Abhaya
@MishraAbhayaK
, Romain and Durga on the first amphiphilic EBX reagents is now accepted
@angew_chem
! With them we can mimic the biological lipidation process in pure water/buffers to increase the lipophilicity of peptides.
2
1
77
How to access more substituted aminocyclobutanes? Have a look at Emma's
@EmmaGabRobert
strategy based on a Ficini reaction/hydrogenation sequence now accepted
@ChemEurJ
0
3
77
This week in
#LCSOSynthesisProblem
Josh challenged us with the synthesis of Pleuromutilin by Pronin
@UCIChemistry
in
@J_A_C_S
!
#Chemistry
#TotalSynthesis
Take a look:
Original Paper:
1
17
76
0
10
77
The preprint
@ChemRxiv
of Stephanie
@steph_ge_amos
and Stefano on the photocatalytic Umpolung of enol ethers and enamides for the synthesis of amino alcohols is now accepted
@ChemicalScience
2
6
75
It is always a pleasure to see the use of hypervalent iodine reagents for alkynylation continuing to grow! Eliott
@LeDu_Eliott
has now reviewed the recent progress since 2018 in
@ChemCommun
1
10
74
Next work of the tether team
@LcsoLab
@NCCR_Catalysis
@ERC_Research
: Ashis
@ashisdas283
, Thomas
@TRossolini
and Stefano report in OL
@JOC_OL
the first Pd-catalyzed aminoacetoxylation of alkenes using N,O-acetal tethers:
4
9
73
Pierre challenged us last week for the
#LCSOSynthesisProblem
with the Total synthesis of Ladderane Phospholipid by Burns in
@J_A_C_S
!
@TotalSynthesis
Take a look:
For original paper:
0
15
76
If you want to start your independent career
@EPFL_CHEM_Tweet
and
@NCCR_Catalysis
as an assistant professor, the deadline for application is approaching! (October 15)
1
35
74
Second, the peptide-EBXs from Xingyu
@Xingyuu_Liu
(previously on
@ChemRxiv
) also accepted
@angew_chem
! A huge work
@ERC_Research
including thiol functionalization, photocatalyzed macrocyclization and binding studies with Heinis group
@EPFL_CHEM_Tweet
1
8
74
Full room for the green and sustainable chemistry scs award lecture of Xile Hu
@HuLab_EPFL
@EPFL_CHEM_Tweet
@SwissChemistry
3
7
73
No new data, but a reminder that we have benziodoxol(on)e stability data on our website: useful if you want to work with these reagents!
If you have additional data on benziodoxole stability, we would be very happy to add it also!
0
9
73
This one was found by "accident": have a look on the preprint
@ChemRxiv
of Vladyslav
@Vlad__Smyrnov
and the two master students Antonin and Leander on the platinum-catalyzed isomerization of cyclopropenes to 1,3-dienes
1
8
74
The work of Pierre
@PierrePalamini
@NCCR_Catalysis
and Emmanuelle on the carboazidation of dehydroalanines using a iron catalyst is now published in OL
@JOC_OL
! This method gives access to unique alpha-azido amino acids derivatives.
1
7
72
The work of
@Luca_Buzzetti
,
@pacans94
and Phill making the best out of two worlds is now on
@chemrxiv
: we exploit
#asymmetriccatalysis
to forge a
#chiralauxiliary
, which is then used to control asymmetric hydrogenation to access chiral amino alcohols.
5
2
73
Congratulations to Julien Borrel for becoming the 26th doctor of the group! Wish you all the best for the future! 🎉
0
0
72
How to activate DA cyclopropanes with only one ester group for annulation with indoles? Check the solution of Vincent and Emma just accepted
@ChemicalScience
1
6
71
Oleksandr S. Liashuk (from Grygorenko group
@DrGregor2
@KyivUniversity
@EnamineLtd
) during his PhD exchange
@LcsoLab
developed the first photochemical [2+2] cycloaddition of alkynyl boronates, now just accepted
@ChemEurJ
!
0
4
71
Tether chemistry alert: the work of Helena
@helsoleav
, Mikus
@pacans94
and Lucas on endo vs exo selective carboamination of propargylic alcohols is now accepted
@angew_chem
@EPFL_CHEM_Tweet
@NCCR_Catalysis
1
4
71
Xile Hu
@HuLab_EPFL
@EPFL_CHEM_Tweet
@NCCR_Catalysis
just received officially the green and sustainable chemistry award
@SwissChemistry
1
2
69
Congratulations to Xingyu Liu
@Xingyuu_Liu
for becoming the 27th doctor of the group! 🎓 We wish you all the best for the future!
1
0
70
Only 3 days left to apply to the open joined PhD position
@LcsoLab
@Beatfierz
@EPFL_CHEM_Tweet
to make an impact in chemical biology using hypervalent iodine reagents! RT welcome.
3
32
67
Do you want to learn more about the activation of aminocyclopropanes via radical intermediates? Have a look at the review of Ming-Ming
@mingming0629
and Tin
@TinVTNguyen1
just published
@ChemSocRev
!
2
10
68
First organic seminar live since more than 18 months
@EPFL_CHEM_Tweet
with prof. Louis Fensterbank
@IPCM_Sorbonne
!
0
3
67
Finally out! The direct ethynylation of peptides of Romain and Raj
@RajNand1985
and extended to antibodies in collaboration with
@CharlotteSornay
@ChaubetGuilhem
@BFC_UMR7199
and proteomics with Adibekian lab
@scrippsresearch
is now accepted
@angew_chem
2
10
67
After 15 years LCSO, some Alumni statistics, first for PhD and postdoc (
#33
): 79% are now working in industry and 21% in academia. Most of them in chemical industries, but only 5 companies employ more than one alumni. We have a strong and diverse chemical industry in Switzerland!
1
2
65
EBX strikes again! Have a look at the first synthesis of alkynylated azadipeptides by Eliott
@LeDu_Eliott
and Julien now as preprint
@ChemRxiv
(for more background on azapeptides, see the great work of the Lubell group and
@theProulxlab
)
3
7
65
Second preprint
@ChemRxiv
this year from
@LcsoLab
: Nieves
@Nieves_P_R
presents her results on enantioselective 3CR reactions of EBx, fluorinated diazo compounds and nucleophiles!
1
6
66
Next organic seminar
@EPFL_CHEM_Tweet
today with Prof Armido Studer from the University of Muenster
0
2
66
Organic seminars are back
@EPFL_CHEM_Tweet
! First Prof Paolo Melchiorre
@Melchiorre_P
! (Sadly our big beamer doesn’t start, hopefully we can fix it soon)
1
2
66
Swiss summer school in catalysis and sustainable chemistry starting now in les Diablerets with a special career session with the support of
@SwissChemistry
and
@NCCR_Catalysis
2
5
64