Scripps Research
@scrippsresearch
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Scripps Research is one of the world's largest, private, non-profit biomedical research organizations. We are Science Changing Life.
La Jolla, CA
Joined September 2012
Congrats to Prof. Jeff Kelly for receiving the Stein & Moore Award from @ASBMB and The Protein Society, which honors his high-impact contributions to #proteinscience. His work on protein folding and misfolding has led to new therapies for amyloid diseases.
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Congratulations to Scripps Research’s Ardem Patapoutian, who has been awarded the 2021 #NobelPrize for Physiology or Medicine. Patapoutian wins the award jointly with David Julius, for the discovery of receptors that sense temperature and touch @ardemp
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#OnThisDay, we honor the distinguished legacy of Ellen Browning Scripps. Her visionary $300K endowment (over $4-5M today) to the Scripps Metabolic Clinic laid the foundation for Scripps Research to become one of the world’s leading scientific research institutes.
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Duplicate images? Almost. This past weekend saw K. Barry Sharpless receive his #NobelPrize at the awards ceremony in Stockholm – the same honor he experienced around this time over 20 years ago. #doubleNobel
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Two-time #NobelPrize winner K. Barry Sharpless descends to a round of applause as he arrives on campus and celebrates the news with the Scripps Research community. 👏
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In recognition of his trusted voice in science, especially amidst the #COVID19 pandemic, @EricTopol will receive the Gold Foundation Medal. He is honored alongside Dr. Anthony Fauci, Dr. Wayne Riley and hundreds of courageous healthcare workers @GoldFdtn
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"I grew up in Lebanon, and I pretty much fled to the U.S. when I was 18. I think it has had a huge influence on me. You know, growing up in a war-torn country, I couldn’t even imagine having a career in science." @ardemp speaks to @sciam & @tanyalewis314
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“Click chemistry”—a term Sharpless coined— refers to the LEGO™-like ease of fitting modular chemicals together to form complex molecules. The ingenious platform has transformed how scientists approach drug discovery, bioimaging and more #NobelPrize
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Scripps Research's @ardemp arrives in Stockholm with the other laureates ahead of the #NobelPrize ceremony. With @NobelPrize
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Professor K. Barry Sharpless is only the fifth individual to have ever been awarded two lifetime Nobel Prizes. 2001 and 2022.
Barry Sharpless has just become the fifth individual to be awarded two Nobel Prizes. He follows in the footsteps of double #NobelPrize laureates John Bardeen, Marie Skłodowska Curie, Linus Pauling and Frederick Sanger. Sharpless was awarded the chemistry prize in 2001 and 2022
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The @EngleLab has engineered a novel nickel-catalyzed reaction to create unique, customizable polymers. Findings in @NatureSynthesis suggest enhanced drug delivery and energy storage, offering a more #sustainable approach to polymer production. More:
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“Often times these prizes are given to one or two people, but I want to emphasize that there's a whole field of people working in this area. Specifically in my lab, there’s a big group of young, enthusiastic, smart scientists, grad students & post docs who actually do the work."
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We are delighted to announce that Scripps Research's Prof. K. Barry Sharpless has been named winner of this year's #NobelPrize for Chemistry, for the development of click chemistry and bioorthogonal chemistry. Congratulations to all three winners!.
BREAKING NEWS: .The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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Congratulations to chemist Prof. Phil Baran, who has been awarded the 2022 Danisco Foundation Science Excellence Award from @IFF. Baran is recognized for advancing science and technology relevant to the future of food, nutrition, and health @BaranLabReads
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The Scripps Research Translational Institute, led by @EricTopol, has received $46.8 million in renewed funding over 7 years from @ncats_nih_gov. This will support continued progress in transforming human health through tech-focused innovations @ScrippsRTI
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With pioneering #chemistry that has transformed fields ranging from drug discovery to materials science, Prof. Jin-Quan Yu will be the inaugural holder of the Bristol Myers Squibb Endowed Chair in Chemistry @bmsnews @YulabJin
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Rapid testing may be one of the most under-utilized tools in the arsenal against the #coronavirus. @EricTopol & @danieloran explore in @statnews #rapidtesting.
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In controlled lab experiments, Profs Hyeryun Choe and Mike Farzan show that a #coronavirus mutation (in this spike) allows it to infect more cells. If this variant causes greater infectivity in people, it could explain differences in severity of outbreaks
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We mourn the passing of Richard Lerner, MD, a scientific pioneer who developed technologies that had a major impact on science and medicine, and who played a critical role in shaping Scripps Research and San Diego’s burgeoning life sciences sector.
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#cancer needs oxygen to survive, which is why tumors readily sprout new blood vessels. Prof Xiang-Lei Yang’s lab has now discovered a way to prevent this process by inhibiting #HIF and #VEGF signaling @PLOSBiology
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The labs of @liye_tsri and Ben Cravatt have made the impossible possible – developing a new method called CATCH, which allows the imaging of specific drugs in tissue to reveal where the compounds are acting in the body @CellCellPress
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We are excited to partner with iconic actor @alanalda and the Alda Communication Training Company, empowering scientists and medical professionals to convey complex topics to the public with #ClearAndVivid #communication @AldaCenter @alda
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Prof. Jin-Quan Yu has been awarded the 2024 Max Tishler Prize, Yamada-Koga Prize, and Henry J. Albert Award. His trailblazing C–H activation research is reshaping chemistry, with vast implications from drug discovery to material science. More at:
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The lab of @AhmedHBadran has expanded the genetic code by incorporating non-canonical amino acids using four-nucleotide codons. Published in @NatureBiotech, this method enhances #proteinsynthesis precision for drug discovery. More:
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Today, the Calibr division of Scripps Research announce promising preliminary data from the first-in-human Phase 1 clinical trial with switchable CAR-T cell therapy. The trial studied the cell product (CLBR001 + SWI019) in patients with B cell malignancies
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Congrats to our EVP @EricTopol, who is included in the 2024 @TIME #TIME100Health list! The list recognizes the impact, #innovation, and achievement of the world’s most influential individuals in #health. 🎉🌟
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Congrats to prof. Ryan Shenvi for being awarded the 2024 Mukaiyama Award from the Society of Synthetic Organic Chemistry, Japan. Shenvi is recognized for his contributions to synthetic organic chemistry, notably in complex synthesis. Read more at:
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Prof. Chi-Huey Wong is awarded this year’s Tetrahedron Prize for Creativity in Organic Synthesis. Wong’s discoveries have shaped our understanding of complex carbohydrates and glycoproteins, and their role in physiology and disease. @TetrahedronChem
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Congratulations to @DonnaBlackmond, who has been awarded the 2023 James Flack Norris Award in Physical Organic Chemistry from @AmerChemSociety.
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"The singular and momentous advance in life science that demonstrates the power of AI" - @EricTopol on the ability of #AlphaFold to predict the structures for nearly all catalogued proteins known to science ~200 million @DeepMind.
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Scientists in @Shenvi_Lab have found a streamlined method for synthesizing compounds found in the bark of trees in Papua New Guinea, which are known for their #hallucinogenic effects and could form the basis of new neurological treatments @ScienceMagazine
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As a leader in the field of natural product synthesis, Scripps Research chemist Prof. Ryan Shenvi has been named among the nation’s rising stars as a 2020 finalist for the prestigious Blavatnik National Awards. Good luck Ryan! @Shenvi_Lab @BlavatnikAwards
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Congrats to Prof. Benjamin Cravatt for receiving the 2024 Bristol Myers Squibb Award for Enzyme Chemistry from the @ACS_DivBioChem. His work in activity-based protein profiling revolutionizes treatments for neurological disorders and cancer. 🎉🌟 More at:
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#ICMYI: Scripps Research EVP @EricTopol made the @TIME #TIME100Health list! A leading physician-scientist, Topol pioneers in individualized medicine—using digital and genomic tech for improved healthcare. More:
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Scripps Research receives a major award from @NIH to lead key programs in the @AllofUsResearch Program. The Participant Center, directed by @EricTopol & @julialmv, makes the program more accessible to participants & adds new data collection capabilities
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Congratulations to Prof. Dale Boger, who has received the #TetrahedronPrize from @ELSchemistry for creativity in organic #chemistry. Discoveries from @BogerLab include durable antibiotics, novel ways to treat chronic pain & an experimental #cancer vaccine
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Scripps Research's @ardemp details his life story and explains the groundbreaking work that led to him being awarded the #NobelPrize in Physiology or Medicine in 2021. Dive into the full video and Q&A in our latest Scripps Research Magazine feature
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With promising preliminary results in patients with B cell malignancies, Calibr’s “switchable” chimeric antigen receptor T-cell (sCAR-T) therapy platform is the 1st step towards development of a universal, more versatile, and safer approach to cell therapy
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US benefits tremendously from those who come from abroad to offer their intellect, talent & energy. We strongly oppose the order blocking H-1B & other work visas. We extend gratitude & support to international scholars contributing so much to science & culture at Scripps Research.
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The Jin-Quan Yu Lab has developed a method to create ‘gamma chiral centers’ on carboxylic acids, published in @ScienceMagazine. This could revolutionize #drugdesign by enhancing the ability to build complex pharmaceutical #molecules. More:
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Prof. Keary Engle has been awarded the 2023 Leo Hendrik Baekeland Award from @AcsJersey. Engle is recognized for his accomplishments in pure and applied chemistry, as well as the creativity and leadership displayed in his approach to research. @EngleLab.
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Starting soon! Register for free and tune in at 1pm PT.
Tune into our free #FrontRow lecture this Wednesday (1pm PT). @tajayiMD will show how clinical scientists are using smartphone and other digital technologies to revolutionize #MaternalHealth and reduce population disparities. Register here:
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Congrats to Keary Engle, PhD, Dean of Graduate & Postdoctoral Studies at Scripps Research, on receiving the 2025 Arthur C. Cope Scholar Award. @EngleLab’s work on metal-catalyzed reactions advances organic chemistry for faster, sustainable synthesis. More:
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Some scientists suggest #omicron may have evolved in the immunocompromised, while others suggest it may have developed after passing back into animal species. Prof. Kristian Andersen discusses in @statnews @helenbranswell
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Congratulations to Scripps Research’s @xinjin, who has been selected for this year’s prestigious 35 Innovators Under 35 list by MIT’s @techreview. Jin is recognized for her development of gene-editing tools to understand the origins of #autism #TR35
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"I went into Barry's office to say congratulations, and he went to the blackboard. All of a sudden, he's giving me a lecture about sulphur chemistry." - Vice President Jamie Williamson, pays tribute to #Nobel laureate K.Barry Sharpless. Highlights from the prize toast on campus.
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Chemists from @BogerLab have devised the first general method for synthesizing a family of compounds called 1,2,3,5-tetrazines, which hold great promise for making pharmaceuticals, biological probes and other chemical products @ACSPublications
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The Scripps Research community mourns the passing of Michael Oldstone, MD, esteemed virologist and professor emeritus, who helped establish the viral pathogenesis field and shaped our understanding of host immune responses
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Two Scripps Research faculty are recipients of this year’s Baxter Young Investigator Awards. @nani_grotjahn who studies mitochondrial stress and @xinjin who focuses on neurodevelopment and autism. Congratulations Danielle and Xin!
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Congratulations to glycobiologist @HuangMia,who has been awarded the 2023 Research Fellowship in Chemistry from the @SloanFoundation. Huang is recognized for her research on glycans and their role in stem cell biology and cancer. #SloanFellow.
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Pioneering biochemist Jeffery Kelly has been awarded the Breakthrough Prize in Life Sciences 👏 The award recognizes Kelly’s work elucidating the molecular basis of neurodegenerative and cardiac transthyretin diseases @brkthroughprize #BreakthroughPrize
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Congratulations to Prof. Benjamin Cravatt, who has been awarded the prestigious #WolfPrize for pioneering innovative protein-based technologies that have gone on to shape anti-cancer drug discovery @WolfPrize_ @grobbins.
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With diverse expertise ranging from protein engineering to mitochondrial stress and autism, we welcome three new members of faculty: Ahmed Badran, PhD; Danielle Grotjahn, PhD; and Xin Jin, PhD @AhmedHBadran @nani_grotjahn @xinjin
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“Growing up, my idea of a scientist was from the cartoon Dexter’s Laboratory.” Despite pressure to follow a more traditional career, Huang pursued research to become an expert in #glycobiology. Science with a view @HuangMia #WomenInSTEM #WomenInScienceDay
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Congratulations to Scripps Research chemist @hanzyduzit who has been awarded a prestigious @SloanFoundation Research Fellowship for his work using enzymes to make challenging #anticancer, #antiinflammatory and #antimicrobial compounds #SloanFellow
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We welcome Yuzhong Liu to Scripps Research, who will join the Department of Chemistry to develop improved vaccines and medicines using synthetic biology. Learn more about her research:
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Congrats to Benjamin Cravatt, PhD, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Research, on receiving the 2024 Heinrich Wieland Prize. His work on disease-causing proteins and activity-based protein profiling is advancing drug discovery.
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"Ending Alzheimer's". Living longer does not always mean living better. Scripps researchers are changing that as they pursue a cure for Alzheimer’s. Give now to support this life-saving work: #AlzheimersDisease
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The recent @NatureMedicine paper by @K_G_Andersen and colleagues on the origins of the novel #coronavirus receives unbelievable attention online and in the news, speaking to its impact #2019nCov #COVID19 @altmetric
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In a new @Nature study, Prof. Ryan Shenvi (@Shenvi_Lab) demonstrated how computational tools and predictive modeling could synthesize 25 picrotoxin—complex plant molecules that could inform drug discovery for brain diseases. More:
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Congratulations to @nani_grotjahn, who has been named a 2023 Pew Scholar in the Biomedical Sciences. The award will support Grotjahn’s study of how cells assemble the molecular machinery that governs programmed cell death @pewtrusts
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In huge effort involving @IAVI, @fredhutch & @NIH, scientists in Prof. William Schief’s lab have revealed promising results in the first-in-human clinical trial of a novel #HIV vaccine. Targeted response achieved in 97% of those vaccinated.@ScienceMagazine
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In collab w/ @IAVI, researchers led by Prof. William Schief have confirmed a novel #HIV #vaccine approach in the first human clinical trial. Vaccine works to prime the #immunesystem as the first stage in the production of broadly neutralizing #antibodies
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Thanks to the pioneering work of prof. Chi-Huey Wong spanning over 40 years, the field of #glycobiology came to be. Knowing how cellular sugars operate has since led to medicines for #influenza, #cancer & #HIV. Learn more in the Scripps Research Magazine
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Congratulations to Jin-Quan Yu, PhD, who has been elected to the prestigious American Academy of Arts and Sciences. Yu has broken down barriers in organic synthetic chemistry to create versatile compounds with enormous public benefit. #sciencechanginglife.
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Congratulations to Scripps Research Professor K. Barry Sharpless for being awarded the Sir Derek Barton Gold Medal from the Royal Society of Chemistry! . Read more: @RoySocChem #RSCPrizes #chemistry #clickchemistry
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Prof. Keary Engle of the @EngleLab is the new Dean of Graduate and Postdoctoral Studies at Scripps Research, leading the @ScrippsGradPrgm. An alumnus, Engle brings personal experience and is committed to mentoring future researchers. More:
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Could intranasal #vaccines be the way to go to more effectively prevent #COVID19 spread, versus shots in the arm? @danieloran and @EricTopol explore for @sciam
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By hijacking enzymes from bacterial strains in Scripps Research’s Natural Products Discovery Center, Profs. Hans Renata & Ben Shen have been able to make complex, medicinal molecules that are usually only obtainable from plants @ScienceMagazine @hanzyduzit
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Scripps Research's Prof. Dennis Burton and colleagues are looking for #COVID19 survivors who are willing to donate blood to screen for #antibodies. Help us to develop a potential #antiviral against the #coronavirus @UCSD @grobbins @sdut.
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We welcome Alejandra Mendoza to our growing faculty, who will join as an assistant professor in the Department of Immunology and Microbiology. Mendoza’s lab will illuminate the interwoven circuits that drive inflammation, pain and immunological diseases
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No more #flu shot? Scientists at @scrippsresearch @WCMpeds @UChicago @ScienceLife have identified a new Achilles’ heel of influenza virus, making progress in the quest for a universal flu #vaccine.
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Prof. Ryan Shenvi, PhD, has won the 2024 A.R. Katritzky Junior Award by @ishc1967. His work in chemical synthesis and catalysis has greatly impacted medicine, agriculture, and materials science. @Shenvi_Lab continues to explore complex metabolites. More:
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175 years since first use of #ether, but the way general #anesthesia works has remained a mystery, until now. Scott Hansen and Richard Lerner labs show that the compounds rearrange the lipids in cell membranes, leading to unconsciousness @PNASNews
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Elegantly mixing art & science, researchers in the Center for Computational Structural Biology have produced the very first 3D model of an entire cell, representing a new way to visualize cellular environments in health and medicine @MartinaMaritan #sciart
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Congratulations to Scripps Research’s Ben Cravatt for winning the prestigious Jeremy Knowles Award from the Royal Society of Chemistry. Wonderful recognition of Ben’s pioneering work and overall contributions to the chemical sciences.
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Scripps Research’s @YulabJin have developed a new method for the easy, versatile synthesis of molecules called lactones, which could boost industries from pharmaceuticals to plastics @ScienceMagazine
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Scripps Research Prof. Jin-Quan Yu has received the 2024 Award for Creativity in Molecular Design and Synthesis from the @AmerChemSociety. Yu’s work in C-H activation drives molecular innovation and advances #drugdiscovery across industries. More:
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In a synthetic chemistry feat reported in the journal @Nature, Scripps Research scientists devise a method for C-H activation of alcohols.
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"We should probably prepare for this being the predominant lineage in most places in the United States by March." A new analysis led by @K_G_Andersen projects continued spread of #B117 #SARSCoV2 variant, which could lead to increased strain on healthcare
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Prof. Jefferey Kelly has received the 2023 Wolf Prize in Chemistry. It recognizes his research developing therapeutic strategies that amend toxic misfolded proteins that aggregate in the body—a hallmark of many diseases, including Alzheimer’s @WolfPrize_
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Scripps Research chemist Prof. Ryan Shenvi has been awarded the A.V. Rama Rao Award in Organic/Bioorganic #Chemistry by @ChemResSocIndia. @Shenvi_Lab is being recognized for his work in chemical synthesis and #catalysis. More at:
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From #inflammation, to #arrythmias and impaired blood flow, the effects of #COVID19 on the #heart are becoming a growing area of concern. @EricTopol details in @ScienceMagazine #SciMagPerspective #SARSCoV2.
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Congratulations to Scripps Research neuroscientist @xinjin, who has been named the recipient of the 2022 Early Career Investigator Award from the International Society for Autism Research (INSAR) @AutismINSAR
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Congratulations to Prof. Chi-Huey Wong for the Robert A. Welch Award in #Chemistry. Wong is recognized for his instrumental work over the past three decades on carbohydrates in active immunization & treatment of cancer & infectious disease @WelchFoundation
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In a tribute to Richard Lerner in @ScienceMagazine, current Scripps Research President & CEO, Peter Schultz, reflected on Lerner's remarkable creativity in bridging fields of chemistry, immunology & medicine, generating a legacy of scientific enterprise
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Vaccine candidate from @Novavax shows promise in ongoing clinical trials. Now, structural mapping from the Ward Lab shows the #coronavirus spikes keep the desired shape in this #vaccine, which should help stimulate appropriate #immune responses @WardLab1
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An institute’s faculty should be recognized not just for their independent research, but also their commitment to education and mentorship. Congratulations to chemist Keary Engle for winning the Camille Dreyfus Teacher-Scholar Award. @EngleLab
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Two studies from Prof. Bill Schief’s lab & collaborators describe an approach to design a custom HIV vaccine that can coax the immune system to produce the right broadly neutralizing antibodies in a stepwise manner @ImmunityCP @ragoninstitute @moderna_tx
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We’re pleased to welcome back @ScrippsGradPrgm alum @IanSeiple as a professor of chemistry. His work advances synthetic routes to complex molecules, like antibiotics to address antimicrobial resistance, and expands into cancer and aging research. More at:
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A study in @nchembio by Prof. Benjamin Cravatt and @YuanjinZhang1 developed “‘paralog-hopping”’ to target the #cancer protein CCNE1 by pinpointing a druggable site on its twin CCNE2. Targeting cryptic drug-binding pockets could advance cancer therapies.
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The @YulabJin lab has streamlined the complex creation of saturated heterocycles, which are essential in many FDA-approved drugs. This innovation is pivotal for quicker, more efficient drug development. More:
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The Wolf Foundation awarded Cravatt the prize for “developing activity-based protein profiling, which has emerged as a powerful and widely used chemical proteomic strategy to characterize enzyme function in native biological systems.” @WolfPrize_
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Congratulations to Professor Sandra Encalada for receiving $4.1 million from NIH to advance her work on #prion diseases! The research could also help better understand additional neurodegenerative diseases. #neuroscience #brain.
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Scripps Research is home to some of the world’s leading chemists, who advance our ability to design and produce molecules, develop life-changing therapies, and tackle global sustainability challenges. Learn more:
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