Thomas Kalil
@tkalil2050
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I am excited to announce the launch of Renaissance Philanthropy, with a phenomenal team including
@KumarAGarg
. Our goal is to help foundations and philanthropists promote a 21st century renaissance, fueled by advances in science, technology and innovation.
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My State of the Union proposal to use "demand-pull" approaches (Advance Market Commitments, milestone payments) for clean energy and climate solutions, building on success of NASA-SpaceX partnership and Operation Warp Speed.
.
@ENERGY
should equip the Office of Technology Transitions with the authority & budget to design a “demand-pull” intervention to accelerate U.S. industrial capacity to supply domestic clean energy and other necessary products. Read
@tkalil2050
’s proposal:
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Excited by the launch of Future House, a new research non-profit (funded by Eric Schmidt, inspired by his time at Xerox PARC) developing an AI scientist.
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Excited to be at No 10 Downing Street, where UK Government, Eric Schmidt, and Ken Griffin pledged to expand support for the UK Biobank. Some of the UK Biobank’s 500,000 volunteers were there as well.
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Senate Dems released their proposals on Appropriations bills, and it includes strong support for geroscience - making a direct attack on aging and increasing healthspan!
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$2 million in prizes for best ideas for market-shaping to solve problems in climate change and pandemic preparedness - with deadline of July 21, 2023. Supported by
@SchmidtFutures
@econD47
#econtwitter
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Congrats to
@stripe
for taking the lead on this. Also shout out to
@nanransohoff
at Stripe for her leadership, and Schmidt Futures Innovation Fellow
@Susan_Athey
for her help designing it. More companies should participate, launch AMCs in other sectors (steel, concrete, etc.)
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Everyone should read "Seeing Like a State" at least once. RIP James Scott.
𝗝𝗮𝗺𝗲𝘀 𝗖. 𝗦𝗰𝗼𝘁𝘁 passed away on July 19. He was a political scientist and specialist in Southeast Asia. He was a dissident within Political Science. Yet his books opened up lines of research on central issues, such as the exercise of power and resistance to power.👇
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Senate Appropriators just took important steps to increase funding for geroscience by the Defense Department, the National Institute on Aging (NIA), and ARPA-H. Appropriations bills still need to pass the House, but this is an important step forward. 1 of 5.
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Thrilled to announce that
@SchmidtFutures
and Ken Griffin are announcing $50 mn in support for additional Focused Research Organizations related to drug discovery and proteomics!
@Convergent_FROs
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I particularly want to thank
@ericschmidt
and
@wenschmidt
for their generous support. For more details see
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This article makes a strong case for polymaths and life-long learning - given that innovations and insights often occur at the intersection of two or more fields or disciplines.
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New Stanford President (Jonathan Levin) was involved in designing an Advance Market Commitment for a pneumococcal vaccine, which saved the lives of 700,000 lives in developing countries.
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DARPA’s new “Foundational Models for Scientific Discovery” program aims to explore, develop, and demonstrate an AI agent as an “autonomous scientist” that can use skeptical learning and reasoning to aid human scientists. For the solicitation – see
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Great WSJ piece on incentive prizes by
@bzcohen
. “To understand how federal agencies began giving out hundreds of millions of dollars through contests, you have to flash back to the 1990s, when a policy wonk named Tom Kalil read about Britain using incentive prizes centuries ago
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A thread on my interview with
@MartinBJensen
on Impetus Grants - the FAST grants of longevity research. H/t to
@tylercowen
@patrickc
and
@pdhsu
for providing the original inspiration!
#LONGEVITY
#aginggracefully
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UK Prime Minister just endorsed “different models of funding science … such as Focused Research Organizations” and provides £50 million to spur co-investment from philanthropists, including
@SchmidtFutures
. Exciting! See
@Convergent_FROs
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Excited that
@SchmidtFutures
is supporting the 2022 Bioautomation Challenge to accelerate progress in protein engineering!
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Congrats to FRO
@EvEBiotech
for their ambitious plan to map the “pharmome” – which will increase our ability to design drugs with fewer side effects, repurpose existing drugs, and design more effective drugs that target multiple pathways
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Thanks
@AdamMarblestone
! It's been a privilege to work with you on the BRAIN initiative, your seminal roadmap for scalable neural recording, and now Focused Research Organizations. Onward and upward!
Many of the most transformative ideas and people in science and technology today (and in supporting institutions) are still latent and blocked. Huge unlock and lever for positive change, led by the inimitable
@tkalil2050
and team. I've worked closely with this crew, and guarantee
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House appropriators call on NIH to launch an initiative in geroscience – (biology of aging), including "collaboration with the FDA, industry, and academia on the discovery and validation of biomarkers.” See draft report at
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Market-shaping can help solve big problems in climate change (clean cooling, green steel) and pandemic preparedness (faster detection, far UV-C light). The University of Chicago’s Market Shaping Accelerator announced the 39 winners of their competition!
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Q&A I did with
@FAScientists
on the opportunities to use AI/ML for science using the ���Common Task Method." Thanks for everyone who provided feedback and inspiration, including
@AdamMarblestone
,
@erika_alden_d
,
@DBBurkhardt
,
@D_R_Goodwin
.
#ai
#ml
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Biden policies are increasing the use of visas for STEM workers and entrepreneurs (O-1A, EB-2) by 30-55 percent. Immigration attorney Sophie Alcorn predicts these changes will result in “new technology startups that would not otherwise have been created.”
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Deep Science Ventures is launching a new PhD program, the Venture Science Doctorate, to put venture at the heart of research. It’s a 3-year, fully-funded PhD designed to provide solutions to key human and planetary challenges. Apply 👉
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Exciting Department of Energy RFI on how they might use “demand-pull” interventions like Advance Market Commitments, procurement, reverse auctions, for clean energy. Please retweet and encourage people and organizations with useful feedback to reply!
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Nice article in Politico on potential for geothermal to provide reliable carbon-neutral energy.
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Great opportunity to work with the amazing Heidi Williams (Stanford professor, leading expert on the economics of innovation) on meta-science - using experiments to improve S&T policy.
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My argument for a State of the Union initiative on geroscience - a direct attack on aging to increase healthy lifespan.
Geroscience research could one day delay diseases like Alzheimer’s – if the government is willing to promote the research, argues
@tkalil2050
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Do you want to learn how to design and manage an ambitious research program that is not a good fit for a company – but too big for a single academic research lab? Sign up for the BRAINS program! Congrats to Ben Reinhardt and Joshua Elliott for launching!
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The FY24 Labor HHS appropriations bill (signed by Biden) directs NIH to track geroscience research as a category! This is important because it is difficult for Congress to propose an increase in funding for geroscience in the absence of knowing what the current NIH baseline is.
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A great essay by
@erika_alden_d
and
@NikoMcCarty
on predictive ML models and biology! Delighted that Schmidt Futures and Griffin Catalyst are supporting work by Erika and her team at
@Align_Bio
to define and create “sequence to function” datasets.
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I love this quote from
@michael_nielsen
on the power of enablement. “T.E. Lawrence's life would briefly intersect some other person, sometimes for just a few minutes, and yet it would change the course of that person's life.
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The Institute for Progress just launched a new interview series, Statecraft, about how policymakers get things done. It’s a newsletter about how successful government initiatives happen, and a set of roadmaps for readers trying to get big things done.
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Thanks
@eric_is_weird
for your overly kind words! My team and I will work hard to live up to this. Thanks for all of your world-class ethnography of research institutions. It's foundational for "metascience as design practice" as suggested by
@michael_nielsen
and
@kanjun
.
When I try to explain Tom Kalil to people, the explanation I've settled on is:
"I'm not sure our generation has a Warren Weaver...but if we do it's probably Tom."
I'm very excited to see what this group gets up to
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Excited to see the launch of the Lean FRO, with support of the Simons Foundation, the Alfred P. Sloan Foundation, and Richard Merkin. This will advance the Formal Mathematics revolution by improving scalability, usability, and proof automation in the Lean proof assistant.
We are excited to share the news of the Lean Focused Research Organization (FRO): ! A new nonprofit dedicated to advancing the Formal Mathematics revolution, we aim to tackle the challenges of scalability, usability, and proof automation in Lean.
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Thanks to
@scientistsorg
for publishing my blog post on steps that policy entrepreneurs can take to increase the maturity of a policy idea. Pls let me know in comments what you would add - I'd like to make this a living document!
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@MarinaNitze
is what the Japanese call a "national treasure." There should be at least one Marina per important regional, national, and global problem, and there should be a Marina Academy so more people can grok Marina's mindset and skillset. Go Marina!
"Fundamentally, I wanted a veteran experience that didn't suck"
New Statecraft interview with
@MarinaNitze
on fixing the VA & foster care, and why agencies don't do user research
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This! And the full-suite of "demand pull" approaches - in addition to Advance Market Commitments, milestone payments, "contract for differences," and volume guarantees.
If we're going to spend $45B on supply chain resilience, we should at least make sure we can structure this support through Advance Market Commitments in addition to more traditional loan guarantee structures.
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I love this Nature interview with
@CultivariumFRO
co-founder Nili Ostrov - "The beauty of what science can do when urgently needed." FROs can combine the "public goods" aspiration of academia and the urgency and focus on results of startups.
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My episode of the Clearer Thinking podcast is out! To hear our conversation about policy entrepreneurs, market shaping, AI for Science, my amazing team in the Obama White House, and my current work with
@SchmidtFutures
, listen here:
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Therefore, the Committee urges the FDA to develop clearer regulatory pathways for emerging aging treatments and to provide an update on its progress in the fiscal year 2024 congressional budget justification
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Great essay from
@SGRodriques
on (1) the importance of universities for education; (2) the limitations of academia as the primary venue for early-stage research; (3) the need for more institutional experiments like FROs and other approaches.
#metascience
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Congrats to
@jamesfickel
and the large team who worked on identifying 12 concrete and actionable bottlenecks to increased healthspan.
This report is the months-long culmination of some of the brightest young leaders in the longevity field coming together to prioritize and detail the field’s top bottlenecks:
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Congrats to the
@acceleration_c
for landing a $200M grant from the Canadian government on self-driving labs! US GDP is 10X Canada's - worth exploring what a comparable initiative in the U.S. might look like. For a piece I wrote on AI for Science - see
We’re excited to announce that the Acceleration Consortium (
@acceleration_c
) at
@UofT
has received $200 million from the Canada First Research Excellence Fund (
@TIPS_SPIIE
) to further our work revolutionizing materials and molecular
#discovery
. Learn more:
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Check out Manu Prakash's project-based Frugal Science class at Stanford - with 50 slots for people around the world! Proud that Manu is a
@SchmidtFutures
Innovation Fellow, working on open-source, low-cost microscopy.
(1/n) 2023 begins with new hopes & dreams. Restarting our
#FrugalScience
global adventure this year with an invitation to global cohort of problem solvers. Here is invitation for global community to engage - come solve hard problems with us with a little bit of play.
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Congrats to the Open Reaction Database team for their work to create open data for chemistry, supported by
@SchmidtFutures
.
#AIforScience
We are happy to announce that the Open Reaction Database (ORD) has been awarded a grant as recommended by
@SchmidtFutures
, a philanthropic initiative founded by Eric and Wendy Schmidt. This grant will support the next phase of growth and adoption for the ORD, including:
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Congrats to Align to Innovate for launching a protein engineering tournament, supported by
@SchmidtFutures
and Ken Griffin. Register by May 1 to participate, and read the white paper here.
@Align_Bio
,
@erika_alden_d
,
#openscience
#aiforscience
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Congrats to
@CultivariumFRO
and
@Convergent_FROs
for this important progress on domesticating non-model organisms and growing the
#bioeconomy
. The world needs more FROs, and more philanthropists and governments should support them.
New tool from
@CultivariumFRO
: models to predict oxygen tolerance, temperature, salinity, and pH optima from a genome - without using pesky gene annotations. Very excited to share this resource. Quick explainer: 1/10
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Great work
@AlesFlidr
and
@Convergent_FROs
. More philanthropists should support work to dramatically improve our response to future pandemics - like making ubiquitous disinfection of the air in buildings a reality.
Far-UVC could save the day in the next pandemic if we make it cheap! Read this excellent piece of work by
@JasperGeh
and
@vivian_belenky
on how to get there. Lots of caveats in the report but this is Twitter :)
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Schmidt Futures has a program called Polymaths to encourage recently tenured scientists to explore a new field.
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@AndrewYNg
I'd love to see the "AI for Science" community generate dozens of ideas that could have the impact of AlphaFold2, and identify enablers for progress, e.g. better defined problems, open datasets, benchmarks, high-throughput experimentation, automation,
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In response to a request from Congress, NIH wrote a report on their current investments in geroscience, which could increase healthspan. Thanks to
@AFARorg
for their leadership on this important issue. See
#longevity
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Important editorial in Nature on the importance of open data for AI for Science. What is your "dream data set" that should exist but doesn't, and why?
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@JohnArnoldFndtn
Or maybe some scientists and engineers. The agencies responsible for economic and social mobility (education, workforce development, affordable housing, etc.) have little or no research capacity. Department of Labor has a $0 research budget.
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W00t!
#heatbeneathourfeet
Huge permitting reform news:
The Bureau of Land Management is giving geothermal energy exploration a categorical exclusion from environmental review under NEPA.
If you care about clean energy abundance, this is a massive win.
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Exciting to see the UK government launch a Contract for Difference for geothermal! The US should pursue something like this, building on the Department of Energy RFI, and leveraging the workforce, technical capacity and scale of the oil & gas sector.
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Thanks
@MartinBJensen
! I've learned a lot from you about aging biology, and am a huge fan of
@impetusgrants
, and your efforts to mentor the next generation of talent for the field!
I can't express the impact of
@tkalil2050
@KumarAGarg
better than this picture from
@ansonyuu
. So let me instead thank you for reinforcing in me an optimism that it's possible for a determined individual to improve even the state of even massive institutions and ecosystems, and
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I hope that this essay by
@michael_nielsen
and
@kanjun
inspires more metascience entrepreneurs, and more backers of metascience entrepreneurs! A must read.
New essay by
@kanjun
and myself, on improving the culture and social processes of science:
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Check out Homeworld Collective – the rapidly growing community seeking to leverage biotech to address climate change! If you are a philanthropist – consider providing funding for a Fast Grants for climate biotech.
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FRO on lowering cost of single-cell proteomics by 100X! Go
@slavov_n
and team at
@ParallelSqTech
!
Today, we announce ParallelSq Technology Institute (PTI):
@ParallelSqTech
PTI will develop scalable proteomic technologies for exploring proteome biology at unprecedented scale and resolution.
We will openly share tools & data to empower research🔓
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Go
@ilangur
and
@matthewclifford
- can't wait to see what you will do with ARIA!
We are optimists.
A future of flourishing humans with astonishing capabilities on a thriving planet is within our reach.
Hear more from
@ilangur
&
@matthewclifford
:
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Important announcement today of a $1 billion market-shaping initiative for clean hydrogen from DOE, with request for public input on the design. May this be the first of many!
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The Committee also urges the FDA to increase support for regulatory science that can inform these pathways, including collaborations with the National Institutes of Health, industry, and academia on the discovery and validation of biomarkers."
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Are you a life scientist with an idea for a "dream dataset" that could transform biology? Check out the Open Datasets Initiative - which has funding to develop automated, open source methods to generate the data, and submit your idea!
What is your dream dataset 📊? Announcing our Open Datasets Initiative 🎉 a new paradigm for funding💵, collecting🙌, and sharing 📂 large, high-fidelity datasets in the life sciences🧪🧬🧫. Make your dream dataset a reality today💡:
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Great op-ed from my younger, smarter, and more accomplished sister
@ariel_kalil
on ed tech's potential for improving student learning outcomes, including through parental engagement.
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Congrats to
@AISafetyInst
for this 8.5 million pound AI safety "fast grants" program. Thesis is that understanding the safety of models is not enough - also need to understand impact of models when deployed in a societal infrastructure.
We are announcing new grants for research into systemic AI safety.
Initially backed by up to £8.5 million, this program will fund researchers to advance the science underpinning AI safety.
Read more:
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Excited that
@SchmidtFutures
and
@Citadel
is supporting the Market Shaping Accelerator! We need more concrete proposals for market-shaping - like Advance Market Commitments for vaccines.
📢 Exciting news! 🚀 Today marks the official launch of the
@UChicago
Market Shaping Accelerator, led by
@UChi_Economics
' Michael Kremer,
@rglenner
, and
@dartmouthecon
's Christopher Snyder.💡Learn more:
#MarketShaping
#Innovation
#Economics
#EconTwitter
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Great essay from
@erika_alden_d
about why she launched the BioAutomation Challenge supported by
@SchmidtFutures
- and why a hybrid approach (cloud-based and in person) for life sciences makes sense.
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Congrats to the
@CultivariumFRO
team for progress on domesticating non-model organizations and growing the bioeconomy! This is why
@SchmidtFutures
is supporting
@Convergent_FROs
- and why more philanthropists should support Focused Research Organizations.
Today we start announcing
@CultivariumFRO
capabilities. First up, Possum, a toolkit to find functional plasmids for esoteric microbes.
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and thought: Why isn’t the U.S. government doing this?” Congrats to everyone who worked for President Obama on incentive prizes, including Robyn Steffen,
@cristindorgelo
, and
@jenngustetic
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Great list
@JacobTref
. These are all thoughtful ideas. I am happy to spend some time on the "FDA application track for NTDs." It's difficult for me to imagine that there is a compelling argument against this - particularly if it is opt-in for the developer.
Thank you
@tkalil2050
and
@ashishkjha
for the prompt to reflect. (Interested whether you agree/disagree with my suggestions!)
The list leans on ideas developed by many others, e.g.
@dave_ridley
@JBayNishi
@RethinkPriors
@CGDev
(
@JustinSandefur
see if you can spot your hyperlink)
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Great work by my smarter sister
@ariel_kalil
! She's using behavioral insights, digital tools and rigorous evaluation to increase parental engagement and strengthen math skills for children.
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My proposal to increase investment in the "digital transformation of science" - not only AI but high throughput experimentation, simulation, etc. This could accelerate the pace of discovery, increase reproducibility, allow researchers to focus on design of experimentations.
A $1B AI for Science Initiative can accelerate the pace of scientific discovery and leverage America’s strengths in robots, simulation, and artificial intelligence to improve technical capacity, writes
@tkalil2050
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Congrats on your new role as leader of DARPA's Biological Technology Office,
@mkoeris
! Can't wait to see what you and your team will accomplish.
I think you can also put something else in the middle - maybe something with 5 letters...
Joking aside - I do very much appreciate what
#FRO
#focusedresearchorganizations
have to offer the nation and the world. Kudos
@SchmidtFutures
for supporting those!
CC
@tkalil2050
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Mobilizing the research community and philanthropists to make it happen. So, how might we create a three-sided marketplace between (1) strategists for a given field; (2) a community of researchers and innovators; and (3) philanthropists.
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Congrats to the phenomenal scientists leading this effort like
@SGRodriques
and
@andrewwhite01
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So proud of my sis
@ariel_kalil
for her work on this critical issue!
What strategies increase parental engagement in children’s early education? In one
#RCT
,
@POreopoulos
@ariel_kalil
found that tools like goal-setting, reminders, & social rewards more than doubled the time parents spent reading to their children.
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It notes that “discovering and validating biomarkers for aging would significantly improve the efficacy of interventions," and epigenetic reprogramming could "delay the entire panoply of age-related diseases.” See page 136 of 5 of 5.
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DARPA is looking for ideas on the use of AI to help adult learners master complex topics - like cybersecurity.
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if you want to build an AI scientist, you have to create real, useful science tasks and evals, not evaluate the model on scientific equivalent of Trivial Pursuit. Congrats to
@SGRodriques
and
@FutureHouseSF
!
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For the FDA - the committee states: "The Committee understands that aging processes begin at birth and appear to be causal contributors to multiple disorders and diseases from childhood to advanced old age.
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Recent advances in geroscience suggest it is possible to prevent and treat a wide range of these disorders and diseases, including Alzheimer’s, cancer, cardiovascular diseases and many others, by slowing or reversing certain genetic, molecular, and cellular hallmarks of aging.
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Beautiful, moving TED talk by my friend and White House colleague Maya Shankar. Wise words on dealing with unexpected change by transforming what we are capable of, what we value, and how we define ourselves.
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It’s also full of interesting stories, like how the US extracted weapons-grade uranium from post-Soviet states, or saved more than 20 million lives in Sub-Saharan Africa. To subscribe, see
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Despite the enormous promise of this field, private sector investment is limited by a lack of clinical or surrogate endpoints which would demonstrate that an intervention is safe and effective.
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Great article from
@AsimovPress
on Cultivarium - a Focused Research Organization.
@Cultivarium
seeks to "democratize access to extraordinary microbes" - which can lead new biotech tools and antibiotics. We have only discovered 0.001 percent of all microbes!
@Convergent_FROs
Many of biology's most important discoveries—including antibiotics and enzymes for PCR—came from "weird" microbes.
Science might move faster if we studied more diverse organisms, but most can't be grown in the lab. This is the story of
@CultivariumFRO
's effort to fix that.🔻
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Thanks to
@seancaptain
with Worth magazine for a great interview on what my
@RenPhil21
team and I are doing to increase the level and ambition of science and technology philanthropy!
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Congrats to
@darshaksanghavi
at
@ARPA_H
for launching a “pay for success” program to improve health outcomes such as maternal health, opiod use, heart attack/stroke, and alcohol-related harms. For details, see
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@NHGRI_Director
@NIH
@genome_gov
@AllofUsResearch
Exciting! What do you think the US can learn from the UK Biobank, which has made data available to 30,000 researchers (globally) in industry and academia?
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Great interview with the amazing
@KumarAGarg
- a force for good!
“There’s a lot more in the world that is fixable, changeable, shapeable than people realize.”
Schmidt Futures VP of Partnerships,
@KumarAGarg
, shares his optimism towards solving hard problems.
Watch the full interview with
@RoadtripNation
:
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@patrickc
@albrgr
@timhwang
Agreed! Lant is advising several NGOs working to implement some his ideas on labor mobility (Labor Mobility Partnership) and economic growth in developing countries (Growth Teams) that deserve more funding.
@sherylsandberg
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The UK Biobank has become an important engine of discovery for the global biomedical research community. I hope other philanthropists, foundations and companies will increase their support for the UK Biobank – the UK Government is prepared to provide additional matching funds!
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See a call for white papers on "self-driving labs" to accelerate materials discovery! Prizes for the best ideas! Thanks to
@acceleration_c
for organizing this.
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Very exciting opportunities to work on scientific moonshots with the amazing
@Convergent_FROs
team!
Excited to be growing the core CR team!
We aim to launch 10-20+ moonshot science projects over the coming yrs, and will need exceptional people with the right mix of ‘crazy’ and ‘grounded’ to accelerate our core org + FROs across ops, talent search, etc.
5 roles open now 👇
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