National Human Genome Research Institute
@genome_gov
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Funding research at the forefront of genomics to improve human health. Formerly the Human Genome Project. https://t.co/4hdQRFkFNU
Bethesda, MD
Joined December 2010
Sex and gender are multifaceted and variable — and not as binary as researchers once thought.
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Just for fun Friday: a double helix parade!
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WE NEED TO STOP SEEING OURSELVES AS HAVING JUST ONE COMPLETE REFERENCE GENOME BUT INSTEAD HAVING A COLLECTION OF GENOMES WHERE EVERYONE’S DIFFERENCES ARE REPRESENTED. THAT’S WHY RESEARCHERS ARE WORKING TO CREATE A PANGENOME.
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Happy Birthday, Rosalind Franklin! We celebrate her work and influence in science. Thanks to her, we have the historic Photo 51, which revealed that DNA has a double-helical structure!
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I’M WONDERING WHEN WE WILL STOP SEEING OURSELVES AS HAVING JUST ONE COMPLETE GENOME BUT INSTEAD HAVING A COLLECTION OF GENOMES WHERE EVERYONE’S DIFFERENCES ARE REPRESENTED.
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When Human Genome Project researchers announced that they had successfully completed sequencing the human genome, it was only about 92% complete. There were still hundreds of gaps or missing DNA sequences. Why was it so difficult to complete the sequence? Let’s break it down!
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When Human Genome Project researchers announced they had successfully completed sequencing the human genome, it was actually only about 92% complete. Now, researchers have finally got that last 8%!
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Scientists in the Telomere-to-Telomere (#T2T) consortium have published the first complete, gapless human genome sequence. This can lead to a better understanding of our genomic variations and provide insight for missing heritability and human disease.
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Understanding the function of an entire genome is no easy task! Most genes likely have more than one function and behave differently depending on context.
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|￣￣￣￣￣￣￣￣|.| |.| Genomic studies |.| should represent |.| human diversity |.| |.|＿＿＿＿＿＿＿＿| . (\__/) || . (•ㅅ•)|| . / づ.
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RNA IS JUST AS IMPORTANT AS DNA!!!
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JUST WONDERING IF THIS GENOMIC STUDY USES DATA THAT REPRESENTS DIVERSE HUMAN POPULATIONS. IF NOT, TRY AGAIN.
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Eugenics is an immoral and inaccurate theory that the genomics community is continuously working to debunk. Let’s break down how it came to be in the first place. (Thread).
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When Human Genome Project researchers announced they had successfully completed sequencing the human genome, it was actually only about 92% complete. Now, researchers have finally got that last 8%!
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Sigh. You’ve disappointed Miranda Priestly. Looks like you’re not going to Paris this year.
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When you’re trying to advance genomic medicine to help all populations, but you can only find data that come from people with European ancestry.
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.@Genome_gov researchers have assembled the first, fully complete human #YChromosome sequence! This sequence reveals genetic factors with implications for fertility. (Thread)
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Scientists have completed all of the missing gaps in the human genome, but using one sequence to study all humans cannot possibly represent everyone!
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The Human Genome Project finished drafting the first nearly complete human genome sequence in 2003. It was about 92% complete, with over 150,000 gaps of DNA left to be sequenced. Now, the #T2T consortium has finished sequencing that last 8%!
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RNA is…complicated. If it’s not confusing enough that there are many types of RNA, some RNA molecules also fold into different shapes that help their stability and functions. Not to worry! We break it all down for you in our new fact sheet:
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#T2T researchers after completing the Y chromosome sequence, which was the most difficult one to complete and needed special technology.
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Genetics and genomics play critical roles in health and disease, but what’s the difference between the two? Why are both important for our health? Learn more in our genetics vs. genomics fact sheet!
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Roses are red.Violets are blue.Genomic data should be diverse.For the results to be true. Happy Valentine's Day!
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Understanding the function of an entire genome is no easy task! Most genes likely have more than one function and behave differently depending on context.
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Genetics and genomics play critical roles in health and disease, but what’s the difference between the two? Why are both important for our health? Learn more in our genetics vs. genomics fact sheet!
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Y chromosome being annoyingly proud of the many, many repetitive regions in its DNA sequence.
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As part of #DNADay23, we celebrate Rosalind Franklin for her work and influence in science. Thanks to Franklin, we have the historic Photo 51, which revealed that DNA has a double helix shape!
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HE SAID YOU CAN’T USE ONE REFERENCE GENOME TO STUDY EVERY DIVERSE POPULATION.
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We are getting ready to share some BIG genomics news with you tomorrow, and we are so excited. This is what dreams are made of.
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Using one reference genome to study all humans isn’t fetch at all. It cannot possibly represent everyone! That’s why researchers are working to create a “pangenome,” a collection of complete genomes in which everyone’s differences are represented.
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Our complete misery and disappointment when your genomic study doesn’t use data that represents diverse human populations.
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Us ready to call out researchers for the lack of diversity in their genomics studies.
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Not Wordle, just a double helix. 🟩⬜️⬜️🟪🟪🟪⬜️⬜️🟩.⬜️🟩🟪⬜️⬜️⬜️🟪🟩⬜️.⬜️🟪🟩⬜️⬜️⬜️🟩🟪⬜️.🟪⬜️⬜️🟩🟩🟩⬜️⬜️🟪. Researchers sequence DNA by solving it like a massive puzzle! They look at the DNA sequence in hundreds or thousands of fragments that they must put back together.
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Until now, genomics research has been mostly based on people with European ancestry. But that is just one ancestral group! Research should be based on everyone’s DNA.
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Scientists have completed all of the missing gaps in the human genome, but using one sequence to study all humans cannot possibly represent everyone!
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Reading about genomic variants to learn more about how unique and special I am.
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As research into genetics and genomics advances, scientists need to work to dismantle and confront ableism, eugenics and racism, which still exist at the NIH, in science and in society.
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Reading about genomic variants to learn more about how unique and special I am.
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#HappyBirthday to the "Mother of Modern Medicine," #HenriettaLacks. Her cells contributed to numerous medical discoveries and helped to evolve bioethical policies. Today, we honor her legacy and lasting impact. #TwitterThread.
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May the 4th be with you today! 🧬
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Researchers from the @genome_gov-funded Human Pangenome Reference Consortium (@HumanPangenome) have completed a collection of new human reference genome sequences that much more accurately reflect global diversity!
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Until now, genomics research has been mostly based on people with European ancestry. But that is just one ancestral group! Research should be based on everyone’s DNA.
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To have genomics research that’s gold-metal worthy, we need to look beyond having one human genome sequence! One sequence can’t possibly represent everyone’s genomic diversity.
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The Human Genome Project finished drafting the first nearly complete human genome sequence in 2003. It was about 92% complete, with over 150,000 gaps of DNA left to be sequenced.
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When Human Genome Project researchers announced that they had successfully completed sequencing the human genome, it was only about 92% complete. There were still hundreds of gaps or missing DNA sequences. Why was it so difficult to complete the sequence? Let’s break it down!
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Using one reference genome to study all humans doesn’t quite work. It can’t possibly represent everyone! That’s why researchers are working to create a “pangenome,” a collection of genomes in which everyone’s differences are represented.
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#HappyBirthday to the Father of Modern Genetics! Thanks to Gregor Mendel's pea experiments, we now understand how heredity is transmitted. #hbd #photooftheday #birthdayboy #july #genomics #genetics #Repost
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Genetics and genomics both play roles in health and disease, but what’s the difference between the two? Why are they both important for our health? Learn more about the key roles each plays in our genetics vs. genomics fact sheet!
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Why did we need to update the human genome reference sequence? When it was created during the Human Genome Project, around 70% of it came from only one person with blended ancestry, which includes African, European, Admixed American, East Asian and South Asian ancestry.
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Until now, genomics research has been mostly based on people with European ancestry. But that is just one ancestral group! Research should be based on everyone’s DNA!
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Just making sure you are getting informed consent from participants in your research study.
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Researchers cannot read all 3 billion base pairs of the human genome from end to end. First, they must determine the sequence of random pieces of DNA. Then, they use those smaller sequences to put the whole genome sequence back together!
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Fren, I am hearing much about the Human Genome Project, but I am wondering if you are familiar with the Dog Genome Project at @genome_gov? A dog’s genetic blueprint is so similar to humans that researchers can compare them and gain new insights about dog and human health!
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Me showing top genomicists and researchers the meme I plan on using to talk about their latest work.
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Me intensely explaining to everyone that #DNADay23 is a big deal because it’s the 70th anniversary of the discovery of the double helix and 20 years since the Human Genome Project was completed.
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Happy Thanksgiving! We are thankful for the opportunity to talk about how cool genomics is with you all the time. Our family might get annoyed at us for talking about it too much, but that won’t stop us!
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Scientists have discovered that the New Guinea singing dog (yes!) thought to be extinct for 50 years, still thrives in the Highlands of New Guinea. This opens new doors for protecting a remarkable creature that can teach us about human vocal learning.
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This month would have marked the 100th birthday for the "Mother of Modern Medicine," Henrietta Lacks! Her cells contributed to numerous medical discoveries and helped to evolve bioethical policies. Today, we honor her legacy and lasting impact. #fbf
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GENOMIC STUDIES SHOULD USE DATA THAT REPRESENT DIVERSE HUMAN POPULATIONS!!
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Biological pathways trying to send signals in your body so your pupils expand in the dark.
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Sigh. You’ve disappointed Miranda Priestly. Looks like you’re not going to Paris this year.
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Happy Birthday, Rosalind Franklin! A pioneer in the field of #genomics -- we stand on the shoulders of giants.
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I’M WONDERING WHEN WE WILL STOP SEEING OURSELVES AS HAVING JUST ONE COMPLETE GENOME, BUT INSTEAD HAVING A COLLECTION OF GENOMES WHERE EVERYONE’S DIFFERENCES ARE REPRESENTED.
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Even though 99.9% of our sequences are the same, there are slight differences in each person. These differences are called genomic variants. Out of the 6 billion letters in our genomes, each of us has around 4 to 5 million genomic variants!
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The Human Genome Project finished in 2003 with an almost “complete” first draft of the human genome sequence. It was about 95% complete — with over 150,000 gaps of DNA left to be sequenced. Scientists are closing these gaps, with only about 100 left!
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GENOMICS STUDIES SHOULD REPRESENT HUMAN DIVERSITY
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Good morning. Are you trying to learn the basis of how genomics works, or are you wanting to keep up with the latest sequencing technology? Either way, our newly updated Talking Glossary has you covered! Take it all in and become an expert.
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Genetics and genomics both play roles in health and disease, but what’s the difference between the two? Why are they both important for our health? Learn more about their differences and importance for our health in our Genetics vs. Genomics Fact Sheet!
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We’re still in our BRAT summer by sharing our new RNA resources! Improved understanding of RNA over the years has led to huge developments, such as creating a COVID vaccine that saved millions of lives. Learn more in our new fact sheet!
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There’s no wrong time or place to remind people that it’s time to stop seeing ourselves as having one complete human genome reference! One genome sequence can’t possibly represent everyone’s diversity.
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Only 2 out of 3 were cool.
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Genetics and genomics play critical roles in health and disease, but what’s the difference between the two? Why are both important for our health? Learn more in our genetics vs. genomics fact sheet!
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Do you know why we started the Human Genome Project?. To reveal that we're a 99.9% match.
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Happy Birthday, Rosalind Franklin! We celebrate her work and influence in science. Thanks to her, we have the historic Photo 51, which revealed that DNA has a double-helical structure!
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POV: You’re a cell that has to read the genetic code written in DNA so you can produce the molecules you need.
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No funny Friday, but an inspirational one. Here's to Dr. Rosalind Franklin.
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Uh oh. Harper noticed that your genomics study does not use data that represent diverse human populations. Looks like her vacation is off to a rough start.
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How do researchers find genomic variants associated with complex diseases? They study the genomes of groups of people who have the same disease and compare them to the genomes of people who do not have that disease. Learn more:
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There’s no wrong time or place to remind people that it’s time to stop seeing ourselves as having one complete human genome reference! One genome sequence can’t possibly represent everyone’s diversity.
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To understand genomics, we first need to understand DNA, a chemical compound that contains the instructions needed to direct the activities in the cells of all living organisms!. DNA molecules are made up of two twisting, paired strands, a structure that’s called a double helix.
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Us not taking your research seriously until your study is inclusive and represents all human genetic diversity.
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Reading about genomic variants to learn more about how unique and special I am.
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Scientists currently use one reference genome as a guide to study humans, but one reference genome can't represent everyone! Now, researchers have created a “pangenome,” a collection of complete genomes in which more human populations and their genomic variants are represented.
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Today's Google Doodle honors the pioneering biochemist and Nobel Laureate Har Gobind Khorana who deciphered DNA and wrote the dictionary for our genetic language.
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Using one reference genome to study all humans isn’t fetch at all. It can’t possibly represent everyone! That’s why researchers are working to create a “pangenome,” a collection of complete genomes in which everyone’s differences are represented.
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Can’t sleep? No time to write an entire new album? No problem, you can spend that time learning about genomics! Our Talking Glossary of Genetic and Genomic Terms is available for you to read any time of day, even m i d n i g h t.
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Are you all ready for the greatest thing to happen this month?? We are talking about DNA Day on April 25 of course…😉. Check out all of the places that are having DNA Day events and get involved!
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One complete and accurate human genome sequence down! Literally hundreds to go…
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