Iannis Aifantis
@iannisaifantis1
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Cancer Research & Immunology. Professor & Chair, @NYUGSOM_Path @nyugrossman . Expressed opinions represent only Me/Myself/I. (Instagram: iannis.aifantis)
New York City, NY
Joined October 2015
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Pinned Tweet
Fantastic to see our melanoma TME paper focusing on the role of stress response in NK cell-mediated antitumor immunity. A heroic effort by our (ex) MD/PhD student
@HockemeyerKate
doing her clinical training by day and revisions by night!
@nyugrossman
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I came to USA
@DanaFarber
with $600 in 1999 on a J-1 Visa. My mentor (the great Harald von Boehmer) payed 1st month of my rent. Switched to H-1B Visa
@UChicago
. Became a citizen in 2015
@nyugrossman
. If I lived today in USA none of these would have happen
#ImmigrantScience
#Vote
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2022 ends with a bang...after years of work our immune single cell (CITE/TCR-Seq) mapping of adult and pediatric AML is our today
@NatureCancer
! The work was headed by two stars in the
#AifantisLab
,
@audrey_lasry
&
@BettinaNadorp
#leukemia
(1/5)
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618
#AndJustLikeThat
...before the turn of 2021, excited to see out
@Nature
today new work by
@PalanirajaT
in our lab connecting oncogenic signaling, tRNA biogenesis, amino acid availability and mitochondrial dynamics!
@nyugrossman
#leukemia
#AifantisLab
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Delighted to announce that
@glytsou
will stay in the NY area, as an Assistant Professor
@RutgersU
and
@RutgersCancer
, further focusing on
#mitochondria
&
#metabolism
in
#Leukemia
. That makes it 5/5 group leader/PI positions for the
#AifantisLab
in a year! Congrats Christina!!
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That is huge people! It’s the beginning of the end for COVID-19! It’s called Immunity...Reinfection could not occur in SARS-CoV-2 infected rhesus macaques | bioRxiv
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How are levels of surface CD19 regulated in normal differentiation and in response to
#CART
and
#BiTE
treatment? This is the focus of our brand new report at
@NatImmunol
identifying an
#RNA
binding protein controlling CD19 polyadenylation.
#Immunotherapy
20
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Our TET2/inflammation/tumor plasticity paper is out today at
@CD_AACR
! With a beautiful "Spotlight" by
@pietras_eric
and
@jdegregori1
, thank you both!! congrats to the key authors
@Maguillamot
@gcayanan1
@AnnaYeaton
and
@sanamloghavi
(to mention a few!)
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New
#AifantisLab
story out today at
@CellStemCell
. Impressive work by
@ewang2323
. Eric focused on AML differentiation and used surface antigen-guided
#CRISPR
and single cell ECCITE-Seq to identify new factors that control "stemness" of AML.
#singlecell
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Out today
@CellCellPress
our latest work on peptide:MHC class I expression & degradation and the discovery of a novel protein complex potentially important for T cell recognition in cancer. A great collaboration with
@jwang133
@nyugrossman
#Immunotherapy
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Congrats!!! I don’t care if it’s really “Chemistry” or if they needed a third awardee, the fact that we have 2 women attached to the prize it’s Amazing!!!
#WomenInSTEM
#WomenInScience
plus I was holding my breath for the last 3 years...🎉🍾
BREAKING NEWS:
The 2020
#NobelPrize
in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
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24K
48K
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(I hate Twitter humble-bragging, so I am going to simply...brag): 1000 citations today for one of the most exciting pieces of work that my lab was involved, our collaboration with
@rosslevinemd
at
@Cancer_Cell
proving the tumor suppressor function of TET2.
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5
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A kind gift from
@MiriamMerad
and
@SinaiImmunol
…Get Vaccinated!!! And close this Covid19 chapter forever!
#Immunology
#VaccinesSaveLives
#PostCovid
@nyugrossman
11
6
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Enjoy...an amazing "Hallmarks of Cancer" review by
@jc_balandran
and
@audrey_lasry
in our lab, out
@BCD_AACR
! We discuss the role of inflammation in normal and malignant hematopoiesis, from clonal hematopoiesis to full-blown myeloid leukemia.
#leukemia
7
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Today is my 15 year anniversary
@nyugrossman
and
#NYUPathology
! 10/01/06, joined as an Assistant Professor. Amazing colleagues and trainees and an huge amount of support/interactions with the Research community in New York City, the
#1
place to do science!
#NYC
#AifantisLab
#NYU
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Countries of Origin (other than US) of people in my lab: Greece (4), China (4), Spain, Russia (2), Italy (2), Ireland, Saudi Arabia, India, Israel, Australia (2), Germany. All of them science superstars with papers and funding to prove it...we need more Visas Mr. Miller, not less
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Very proud to see this work that started probably 7 years ago by
@PanosNtz
and
@artsinyc
out today at
@NatureGenet
as a cover article! it took the amazing effort by
@PalanirajaT
and Andreas Kloetgen (and several others) to complete this work.
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48
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Leukemia-on-a-chip: A beautiful ex Vivo model that can be used for the rapid screening of targeted therapies and CAR-T cells! From our lab,
@DrMattWit
led the effort with some brilliant work. Congrats to the team!
#aifantislab
@nyugrossman
@nyutandon
4
31
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A short commentary written with my
@nyugrossman
colleague
@DrBenNeel
out today at
@Cancer_Cell
. US research needs more (not less) immigrant scientists!
#Immigration
#immigrantscience
#ScienceTwitter
#research
@Vilcek
#NYUPathology
#PerlmutterCancerCenter
12
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it is exciting for a department chair to see that she/he picks the right young faculty and that they do well and succeed. I got a lot of good news recently
@nyugrossman
:
@RichPossemato
and
@ThalesPapaG
are now Associate Professors and Chris Park just got Tenure!
#NYUPathology
27
2
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Excited to share one more 2023 research story from our lab, out today
@CD_AACR
identifying
#Mitochondria
and
#Mitophagy
as a key regulator of Venetoclax and MCL1i resistance in AML. The work was led by
@glytsou
and
@xufeng_chen
...
@nyugrossman
(1)
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Important step by my institution
@nyugrossman
...the base postdoctoral fellow salary will be $70,000 and -of course- they have access to subsidized housing. Is it enough? Probably not, but is a solid and welcome step. NIH should help labs further increase salaries/benefits.
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12
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Proud to share our latest work, a collaboration with the lab of
@dstarczynowski
out now
@CellStemCell
. The paper describes a new way to control MYC activity with a competition between Ub/Ac at K148, regulated by the Ub ligase TRAF6
#MYC
#Leukemia
#CHIP
8
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Everybody in science (biology) is obsessed with open access publishing, pre publication servers, anonymous reviews and the rest but I don’t hear discussions about the ballooning of reviews, the incredible amount of requested experiments by reviewers...
10
27
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Excited to share our 1st study on the cross talk between inflammation and acute leukemia using (in this case) a novel TET2 mutant model. Conceived and executed by
@Maguillamot
-disrupted by Hurricane Sandy- and completed by
@AnnaYeaton
&
@gcayanan1
@nyugrossman
#AifantisLab
Now online in
@CD_AACR
: The Impact of
#Inflammation
-induced Tumor
#Plasticity
During
#Myeloid
Transformation - by
@AnnaYeaton
Geraldine Cayanan
@Maguillamot
@iannisaifantis1
and colleagues
@Perlmutter_CC
@nyugrossman
@nyulangone
#ClonalHematopoiesis
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Reason(s) for celebration for
#NYUPathology
: Drs.
@DrShrutiNaik
(DP2 NIH Innovator Award)
@ThalesPapaG
(Promotion, Associate Professor) and
@RichPossemato
(Promotion, Associate Professor)!! Proud to see our recruits doing amazing science! Amazing Dinner
@ClaroBK
@nyugrossman
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3
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Proud to present a 2nd
#AifantisLab
2023 contribution, an beautiful collaboration with
@kadochlab
spearheaded by
@Elena__Batti
from our side. The work demonstrates a central role for mSWI/SNF in the coordination of T cell activation and exhaustion...(1/5)
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21
168
Today’s Inauguration feels like a scientific manuscript that went through hell and 6 rounds of review/revision and ...FINALLY was accepted: you are more relieved than elated. You want to just go on with your life in peace!
#AcademicTwitter
#BidenHarrisInauguration
#DumpTrumpDay
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11
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Huge congratulations to one of the stars of Hematopathology,
@sanamloghavi
and a good friend and collaborator for recognized as a member of the 2022
@pathologistmag
Power List!
#hemepath
#pathology
#MedTwitter
22
11
156
Out today our 3D chromosomal landscape "evolution" paper in pediatric B cell leukemia (B-ALL). We report extensive Hi-C, ATAC- & RNA-seq on matched diagnosis/relapse B-ALL specimens. Work by the fantastic
@__YGhe
and
@SonaliNarang9
at
@NYUGSOM_Path
and
@nyugrossman
@NatureComms
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The work of
@DrMattWit
and
@bioigor
and our lab at
@Cancer_Cell
out today: an impressive single cell mapping of acute leukemia
#tumormicroenvironment
...for the ones that think that there are only solid tumor niches...
#aifantislab
@nyugrossman
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It is a pleasure to announce the launch of the Translational Immunology Center at
@nyulangone
. Excited to have as the Leader, one of our own
#NYUPathology
, Dr. Boris Reizis. The Center will build on the breath, depth and long tradition of immunology at our Institution. 1/3
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Today Stem Cell Research and Hematology lost one of their best and brightest,
@PaulFrenette
, the Director of the
@EinsteinMed
Institute for Stem Cell and Regenerative Medicine. Paul was an amazing scientist and a great mentor, collaborator and friend. We will all miss him dearly.
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14
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Excited to share our latest story from
#aifantislab
...Congrats to
@DrStass
and
@bioigor
who did an amazing work!
#singlecell
#hematopoiesis
#10xGenimics
. The bone marrow microenvironment at single-cell resolution
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“An Accidental Scientist” I love the title, so true! Thanks
@JExpMed
@Steph_JExpMed
and
@Teo_JExpMed
! Your journal is like home for me...actually my first PhD paper was at JExpMed almost 23 years ago!
#aifantislab
@nyulangone
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1
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Bittersweet feelings...Raja's (
@PalanirajaT
) last day in our lab after years of amazing work on 3D chromosomal organization and tRNA biogenesis. He is starting next week as an Assistant Professor
@MDAndersonNews
Good luck Raja! We will visit you in Houston...
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6
141
Street art in the East Village coming directly out of the newsfeed...
#Fauci
#FauciIsAHero
#COVID19
#StreetArt
#NYC
6
27
139
Only 131 hospitalizations yesterday in an NYC population of 8.5+M. Most likely 60%+ of them incidental. Get kids back to schools, people back to their offices, let people travel for business and pleasure. Go to your Gyms. Get your vaccines and you will be fine.
#EnoughIsEnough
Here’s a look at our
#COVID19
indicators for Friday, February 4:
• 16,494,653 vaccine doses administered
• 131 new hospitalizations
• 2,401 new cases
Get vaccinated:
Get tested:
More data:
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One more lab star this week...the incredible Raja (
@PalanirajaT
) accepted a junior faculty position at
@MDAndersonNews
/Division of Cancer Medicine! He has done amazing work on leukemia
#epigenetics
and tRNA bio-availability. Good luck in Houston Raja!
#AifantisLab
@NYUGSOM_Path
15
6
138
It is a pleasure to announce that
#NYUPathology
and
@nyugrossman
recruited Carla Nowosad (
@CarlaTheNove
), an impressive B cell immunologist, as Assistant Professor. She is a fellow
@victora_lab
+
@danmucida
@RockefellerUniv
(image from Nowosad et al. 2020
@nature
). Welcome to NYU!
4
11
134
Happy Bday to my friend, colleague and “partner in leukemia” Dr. Ross Levine!!!
@rosslevinemd
happy to wish him during today’s New York City leukemia meeting….that comes with a beautiful presentation on DNMT3A function in leukemia
@challenlab
5
4
132
I promise to not tweet anything about science all these days at
#ASH22
! I will however report from parties, restaurants and music clubs…Xo Xo
#GossipGirl
#hematology
13
4
128
Mama, I am coming Home 😀🙏
Greece to lift a seven-day compulsory quarantine for visitors from the European Union, the U.S., U.K., Serbia, Israel and United Arab Emirates as of April 19.
Visitors will still need to provide proof of vaccination or a negative Covid test from within 72 hours before arrival.
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An over-fed lab is a happy lab! Our first lab dinner since 2019! A lot more to come I hope!
#AifantisLab
#lablife
#greekfood
#postcovid
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Proud to see our latest story our today
@NatImmunol
! Impressive work by
@Maguillamot
identifying the Ub ligase degrading MYD88 and switches of inflammation! amazing collaboration with Luca Busino
@PennMedicine
.
#aifantislab
#inflammation
@nyulangone
7
19
120
Celebrating our first ever NK/tumor micro environment study that was just accepted for publication. Congrats to the impressive
@HockemeyerKate
and
@nkourtis
!! Beautiful art work by
@EmmaVIDALL
! Stay tuned for more soon!
#NKcells
#stress
#melanoma
#Cancer
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When you lab decides to remind you that the dreaded day is near…thank you all! You keep me busy and “young”.
#AifantisLab
#lablife
#TheEndIsNear
@nyugrossman
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for all
#SingleCell
fans out there, stay tuned: me and
@satijalab
we are putting together a 2021
@Fusion_Conf
on "Probing Human Disease using Single-Cell Technologies" Conference (
#FusionSCT
)
7
14
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6
2
115
Single cell biology AND a beautiful beach…cannot ask for more!
#FusionSCT
#SingleCell
#fusionconferences
#cancun
1
4
112
Registration now open! New Yorker's please come in person
@nyugrossman
! Everyone else, please follow us on Zoom! Supported by
@NYUGSOM_Path
...
#singlecell
#CancerResearch
#compbio
#leukemia
0
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113
Perfect day, light and temperature for a knockout photo shoot for the
#AifantisLab
!!! Pick your favorite photo and we will send you signed copies 😊📸
@nyugrossman
#lablife
#ScienceTwitter
12
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the discussion of Visas and
#ImmigrantScience
brings another question: why there are so few Americans that pursue careers in academic science? My lab currently employs 12 fantastic postdoctoral fellows, none (0) of them American. And this is not because we are not hiring...
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8
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There is nothing more exciting for a mentor to see trainees getting amazing faculty positions: Huge Congrats to Anastasia Tikhonova (
@DrStass
) for getting an Assistant Professor position
@PMResearch_UHN
, one of the best Cancer Centers in North America! Proud of you Anastasia!!
We are thrilled to welcome three exceptional scientists who will be joining our faculty later this year! They will be outstanding additions to our stem cell program and bring expertise in RNA-binding proteins, stem cell metabolism and stem cell niches.
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1
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We are
#2
baby!
@nyugrossman
is
#2
on the 2022
@usnews
list of best Medical Schools. I was never enamored by rankings but it is exciting to see that your hard work is recognized. And our
#NYUPathology
also sits on the Top5 this year! Back to work now...
0
5
103
Happy to see that the beautiful illustration by
@MyriamWares
made it to the cover of
@MolecularCell
Don't forget to take a look at the paper, an amazing collaboration with
@CKadoch
and her lab on the role of mSWI/SNF in T cell exhaustion!
@Elena__Batti
3
12
101
Last days in our lab for
@francescobcc
who returns to Italy to run his own independent Lab. Francesco will be joining the Pediatric Research Institute (
@cittadlsperanza
) in Padova. He will continue his work on 3D chromosomal organization in leukemia!
#AifantisLab
@NYUGSOM_Path
11
3
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Huge thanks to the
@TheMarkFdn
for the support! And to my collaborator and colleague here
@NYUGSOM_Path
Dr. Wang (
@jwang133
). The challenge is to target the STW complex and boost T cell recognition. (funny photo btw 🙂)
Congratulations to Jun Wang, PhD (
@jwang133
) and Iannis Aifantis, PhD (
@iannisaifantis1
), recipients of the
@TheMarkFdn
’s ASPIRE award for their trailblazing exploration of antigen presentation inhibitors in cancer immunotherapeutics.
Learn more:
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11
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97
Blood aficionados mark your calendars: The 1st ever
@Fusion_Conf
on Mechanisms & Targeting Leukemia (tentative title) coming May 2025 on the island of Crete, 🇬🇷 !! Organized by
@rosslevinemd
,
@LeeGrimesLab
& Me/Myself...stay tuned for more info!
#leukemia
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12
94
We would like to welcome our 2022 crop of Pathology Residents to
@NYUGSOMpathres
and
@nyugrossman
!! Excited to see you all here in July!
#Match2022
#pathmatch2022
#pathology
1
5
96
At
@NorthwesternMed
visiting the one and only Professor Nav Chandel, learning about ways to slow down my aging through mitochondria targeting…
3
0
94
Very proud to see that 2/3 of this year's
@GileadSciences
Research Scholar Awards in Heme/Onc went to trainees of our lab! The impressive Drs. Anastasia Tikhonova (
@DrStass
) and Maria Guillamot (
@Maguillamot
)! Congratulations to both!
@UHN
@nyugrossman
#aifantislab
#Leukemia
9
1
94
I guess in their ...free time the BioNTech team decided to also cure MS! Beautiful immunological analysis of the response in mouse models.
#RNA
1
10
93
A real tour de force from
@DrStass
in the lab published today at
@CellStemCell
reviewing the single cell revolution in stem cell niche biology...also important contributions from
@audrey_lasry
@rebeccajaustin1
#Aifantislab
@nyulangone
#stemcell
#singlecell
@10xGenomics
A new Review from
@iannisaifantis1
,
@DrStass
& Co provides a "Cell-by-Cell Deconstruction of Stem Cell Niches"
1
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2
16
93
Really impactful work by one of our
#NYUPathology
colleagues and the new Chair of Pathology
@NYUWinthropHosp
Dr. Amy Rapkiewicz. The power of Autopsy in the time of COVID19
#COVID__19
@nyugrossman
#autopsy
#pathology
6
30
90
A special moment today
@nyugrossman
with the “Master Scientist” Award for the incomparable
@DrBenNeel
!!! Ben is not only an amazing human being but also arguably the person most excited about science & research I’ve ever met. A true role model for all…
#CancerResearch
#Science
5
8
92
#AifantisLab
Holiday Dinner + after party. A lot of fun, 🇦🇷 Argentinian food and an impressive team of young scientists that make me proud! And for the Woke Mob out there: Yes, photo
#3
is tequila shots!
#ScienceTwitter
3
1
92
This is important...in the era of everybody calling themselves “immunologists”, these two really placed the foundations of the immune system...!
#immunology
Immune-cell pioneers win prestigious Lasker medical award
1
19
89
the evolution of an image: excited to have our work on the cover of
@Cancer_Cell
today. Illustration/art by Bianca Dunn (
@bianca_illustration
). Inspiration by
@DrMattWit
Nothing better than art to take our mind away these days.
#aifantislab
5
6
91
Congratulations to our colleague at
@NYUGSOM_Path
Dr. Shruti Naik (
@DrShrutiNaik
) for her promotion to the rank of Associate Professor! Its exciting to see your "junior" faculty doing such amazing research...Congrats Shruti!
@nyugrossman
14
6
90
NY State decided to remove the criteria for high complexity testing and basically anyone with advanced degree can work on the covid19 testing in our labs.
#aifantislab
already has volunteers!
5
23
89
The preprint of our extensive, Hi-C-based mapping of human T cell leukemia and the response to drug treatment is now out!
@4Dnucleome
@3D_Genome
@The3DGenome
@ArimaGenomics
@LLSResearch
#leukemia
#DNAlooping
1
34
89
Now LIVE: the inaugural "Biology and Therapy of Myeloid Malignancies Conference"
@Fusion_Conf
taking place May 14-17, 2025 on a beautiful Minoan coast in Crete, Greece. Huge thanks to co-organizer
@rosslevinemd
(and
@LeeGrimesLab
) !
#MyeloidMalignancies25
1
19
90
We would like to welcome
@MariaSirenko
to our lab, as a postdoctoral fellow! Maria did her PhD with
@PapaemmanuilLab
at
@MSKCancerCenter
focusing on
#singlecell
profiling and population genomics in Heme malignancies. Excited to have her with us!
#AifantisLab
@nyugrossman
4
4
88
For all fans of transcription, epigenetic and chromatin, the (amazing) final schedule for our Sep. 24th meeting is out! Register today! Coming to you courtesy of
@nyugrossman
and
@WeillCornell
#AifantisLab
#chromatin
#epigenetics
@4DNucleome
1
27
87
Thanks you guys for the Bday cake! Alcohol is coming tomorrow…😊
Let’s get the celebration started! Happy birthday
@iannisaifantis1
! May your special day be truly phenomenal! 🥳🎉🎁🎂
0
0
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17
1
89
Let the games begin!
#AifantisLab
summer dinner party heating up on a Manhattan rooftop!
#lablife
#science
@NYUGSOM_Path
#nyc
#rooftops
2
2
89
The
#AifantisLab
is proud to share the news that 2 of this year's
@ASH_hematology
RESTART awards went to a couple of the most talented people that passed from our benches:
@DrMattWit
and
@Maguillamot
!! Congrats to both and a big thanks to the Sponsor!
0
0
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After some sensational/alarmist pieces on
#COVID19
testing and vaccination, happy to see that
@nytimes
is hosting a beautiful article by two of the founders of modern immunology!!
@RMedzhitov
@VirusesImmunity
#VaccinesWork
#TCell
0
27
84
Such a pleasure of being part of a 150 year old tradition
@RockefellerUniv
celebrating the inimitable Anne Brunet (
@BrunetLab
) and her groundbreaking work on lifespan, aging and epigenetics.
#HarveyLecture
#aging
@Stanford
2
4
87
sorry Mom & Dad, I know that you haven't seen me in a year but we will have to wait a little bit more...you asked me why the most powerful country in the world has not flattened the curve? Oh, Don't get me started...
6
9
87
A beautiful contribution to our understanding of the immunogenicity of AML, with some intriguing findings on the role of oncogens, immunoediting and MYC. Part of the PhD Thesis of
@rebeccajaustin1
, now a postdoc in our lab. Congrats Rebecca and Team!
2
15
87
Our NYU Translational Immunology Center Website went live today! Exciting to see the dream of several of us, members of the
@nyugrossman
Immunology Community becoming a reality. We are accepting applications for Junior Faculty from all areas of Immunology!
3
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Targeting differentiation blockade in AML: New hope from cell-surface-based CRISPR screens: Cell Stem Cell
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Nothing more fun than working on ideas for a journal article cover. This is one for our upcoming 3D chromosomal landscapes of acute leukemia paper created by
@MollyFerg_Art
. YES these are TADs!
#4Dnucleome
#DNAlooping
#leukemia
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The excitement is palpable for the first In Real Life (IRL)
#AifantisLab
lab meeting! Presenters today,
@DrMattWit
and
@BettinaNadorp
@nyugrossman
#freedom
#ScienceTwitter
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I can clearly see 7 well separated populations here…a lemon 🍋 cake at the
#AifantisLab
created by Dr
@HockemeyerKate
!
#singlecell
#obsessions
#baking
#umap
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NYU Pathology is excited to host today the amazing
@bloodgenes
(aka V. Sankaran) in our first in person Research seminar!
#NYUPathology
@nyugrossman
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#ASH21
in Atlanta, Day 3: (arguably) the best Persian Food outside Tehran…at Delbar!
#iannis_eats
@ASH_hematology
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Mark your Calendars! The 2nd Single Cell & Disease
@Fusion_Conf
will take place in Cancun, February 2024! We are putting together a fantastic program and cant wait to see all the
#singlecell
community!
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Less than two weeks till our "Single Cell Mapping..." Symposium as part of our celebration for the 20 Years of the
#AifantisLab
. 1 day, 7 amazing speakers! Please come in person
@nyugrossman
or -if not in town- follow online. Registration is still open at:
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Academic research is dying. Research institutions are now merely training grounds for biotech/pharma personnel. We need advocacy, political pressure & bold solutions to keep young scientists with us. That is why we need voices like
@rosslevinemd
active!
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