Cell Stem Cell
@CellStemCell
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A monthly journal at the forefront of stem cell science and policy. Posts & opinions from Editor-in-Chief, Dr. Sheila Chari
Cambridge, MA
Joined June 2009
Metabolic regulation of the hallmarks of stem cell biology by Jackson (@__btjackson) and Finley (@lydfinley). Collection highlight from Cell Stem Cell.
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Harnessing synthetic biology to engineer organoids and tissues
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Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging by Ling Liu at @StanfordMed et al. High-quality paper handpicked by the @CellStemCell editorial team
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Hallmarks of totipotent and pluripotent stem cell states
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New Review online now CellStemCell: Programming hydrogels to probe spatiotemporal cell biology
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Our May issue is live! Featuring a Reviews Focus on Biomaterials and their applications in #StemCell biology, #TissueEngineering, and #RegenerativeMedicine from @JenniferALewis1, @TejalADesai, @BurdickLab, & @fu_jianping. Cover art from @saratysonart
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Metabolic regulation of the hallmarks of stem cell biology
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Our Jan 2023 issue is live! The cover features a gene therapy strategy from @Ken_Poss_Lab using zebrafish enhancers to target injury sites in small and large mammals & improve heart #regeneration. Read this & more here👉
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New issue alert! See exciting studies including our cover article on gene-edited hypoimmune islets that can reverse diabetes on transplant in an allogeneic non-human primate from Shrepfer lab @Sana_Biotech. Plus, the latest in our Hallmarks series from @leo_jwu!
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Over the past year, we've featured 71 early-career researchers who discussed their research and the COVID-19 pandemic's impact on their labs & lives. We mark the closing of this article series with interviews and essays from some of the participants.
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Cancer stem cell mimicry for immune evasion and therapeutic resistance
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Our April installment of Mentoring the NextGen features Fiona Watt @Cambridge_Uni. Great suggestions on who to seek as alternative mentors, what you get from putting yourself in a mentor's shoes, managing failures and breaking through the old boys club.
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Sox9-coordinated cellular neighborhoods generate fibrosis
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Online Now! Autofluorescence is a biomarker of neural stem cell activation state #stemcells.
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A mechanical niche promotes the rejuvenation of blood stem cells
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New issue alert! The cover paper reports generation of humanized mesonephros from hiPS in chimeric pigs. Other highlights include blastoid models of human development (incl pre-implantation to early gastrulation), reconstitution of proximal and distal
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Trained immunity in the bone marrow: Hub of autoimmunity
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New paper alert: Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development. From @ZernickaGoetz @MZG_Lab and colleagues-
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A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals by @JorgeLazaroF et al. High-quality paper handpicked by the @CellStemCell editorial team
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Our August issue is live! The cover features a Technology article from @milicaruoft lab. The authors create patent, stable and perfusable microvasculature in cardiac tissue for organ-on-chip by integrating hiPSC-macrophages into their system.
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Happy New Year! We're ringing in 2024 with lots of great papers and an exciting Reviews series on the Hallmarks of Stem Cells! Check out the flagship Review from @HansClevers & Joep Beumer on Hallmarks of stemness in mammalian tissues. More to come!
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Making blood from iPSCs: Reaching for the most sought-after prize
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Decoding aging-dependent regenerative decline across tissues at single-cell resolution
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New Article online now CellStemCell: Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis
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A new Review from @iannisaifantis1, @DrStass & Co provides a "Cell-by-Cell Deconstruction of Stem Cell Niches"
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Dawn of development: Exploring early human embryogenesis using stem cells
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Getting physical: Material mechanics is an intrinsic cell cue
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New Short Article online now CellStemCell: SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF-barrier in human brain organoids
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Online Now! Decoding aging-dependent regenerative decline across tissues at single-cell resolution #stemcells.
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Online Now! Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation #stemcells.
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Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
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Online Now! Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids #stemcells.
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Our latest issue is out! Featured on the cover, two papers from the Tabar & Studer labs set the stage for clinical study of hPSC-derived dopaminergic neurons for Parkinson's disease patients in the US.
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Online Now! Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging #stemcells.
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Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation
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TGFB1 induces fetal reprogramming and enhances intestinal regeneration
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OurJune issue features several exciting studies on stem cell models of human development, showing hESCs make trophectoderm & can be used to create blastoids. The cover art by Misaki Ouchida plays on the etymology of "placenta" which is “cake” in Latin.
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Online Now! A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS #stemcells.
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Online Now! Highly cooperative chimeric super-SOX induces naive pluripotency across species #stemcells.
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Early human development and stem cell-based human embryo models
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New issue alert! The cover from @Goodell_Lab features their paper on SCRAP mutations in clonal hematopoiesis and how epigenetic dysregulation and DNA damage repair combine to "superpower" mutant HSC clones. Check this out and more:
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New Short Article online now CellStemCell: A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
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CRISPRi/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity
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Genetic reporter for live tracing fluid flow forces during cell fate segregation in mouse blastocyst development
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Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
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New Article online now CellStemCell: Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder
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From stem cells to regulatory T cells: A tale of plasticity
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Online Now! Inflammation-induced epigenetic imprinting regulates intestinal stem cells #stemcells.
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Inflammation-induced epigenetic imprinting regulates intestinal stem cells
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Pluripotent stem-cell-derived therapies in clinical trial: A 2025 update
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Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation
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Online Now! Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis #stemcells.
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Online Now! Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths #stemcells
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A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate
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New Article online now CellStemCell: Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells
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Maintenance of high-turnover tissues during and beyond homeostasis
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New paper from Franklin Lab @SCICambridge: Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells: Cell Stem Cell
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The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids
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The third installment of our Mentoring the Next Generation series goes with our bioengineering theme! @MIT's Robert Langer shares his thoughts on the power of positive reinforcement, co-mentoring, and following your own mind and heart.
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Happy New Year! To start off 2019, our January issue has a Reviews feature on Stem Cell Mechanisms of Cancer. Access to the 5 reviews and perspectives are free through the end of the month.
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Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells
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Online Now! Human pluripotent stem cell-derived organoids repair damaged bowel in vivo #stemcells.
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Online Now! Marmoset and human trophoblast stem cells differ in signaling requirements and recapitulate divergent modes of trophoblast invasion #stemcells.
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New Article online now CellStemCell: Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing
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Online Now! Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts #stemcells.
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November 2018 marks the 20th anniversary of the paper that reported the initial human embryonic stem cell derivations and launched the field of human pluripotent stem cell research. Ludwig et al reflect on the impact of this groundbreaking achievement.
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Online Now! Bioengineered human colon organoids with in vivo-like cellular complexity and function #stemcells.
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Collection highlight from @CellStemCell: Biomaterials to enhance stem cell transplantation from Bhushan Kharbikar, Priya Mohindra & Tejal Desai @UCSF @GradDivision @UCSF_BTS.
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Online Now! Analyzing embryo dormancy at single-cell resolution reveals dynamic transcriptional responses and activation of integrin-Yap/Taz prosurvival signaling #stemcells.
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Online Now! Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques #stemcells.
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Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models
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Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging
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Promises and challenges of organoids: From humanized to human derived
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Online Now! Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms #stemcells.
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Collection highlight from @CellStemCell: Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation.
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A new paper from @studerl Lab reports on."A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes"
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New from @SeanM_Wu & Co: Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes
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We interview Elaine Fuchs @RockefellerUniv in the latest #Mentoring the NextGen! She has great advice on how to identify trainees that will flourish, building confidence by "taking a back seat" at group meetings, & how small acts of encouragement add up.
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Janet Rossant is next in the latest edition of our Mentoring the Next Generation series! She shares her advice on bringing out the best in trainees, asking the tough questions, and how post-docs and young faculty should approach new phases in their careers.
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Next up in our mentoring the next generation series Dr. Connie Eaves @EavesLab tells us about her philosophy towards mentoring, the value of a peer network and her advice on how couples who work together can do so productively!
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New Article online now CellStemCell: Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Human Developmental Hematopoiesis
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A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice
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New Resource online now CellStemCell: Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids
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New Review from Taimoor Qazi, Michael Blatchley, Matthew Davidson, Megan Cooke, Kristi Anseth & Jason Burdick, Programming hydrogels to probe #spatiotemporal cell biology @Penn @CUBoulder
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New Article online now CellStemCell: Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models
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CAR macrophages tuning the immune symphony of anti-cancer therapies
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