Jun Wu Lab
@leo_jwu
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Stem Cells, Embryo Models, and Interspecies Chimeras. Weird is the new normal!
Dallas, TX
Joined August 2010
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Pinned Tweet
I am honored to receive the 2024
@ISSCR
Outstanding Young Investigator Award! This recognition is a testament to the hard work of my entire team. I owe a great deal to the exceptional collaborative research environment at
@UTSWNews
and unwavering support from the
@UTSWMolBiol
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Here is a video showing an adult rat-mouse chimera with a functional rat forebrain!
Two research teams successfully regenerate brain neural pathways
#inmice
using stem cells from rats. 🐀 🧵
@cellcellpress
@leo_jwu
@kkbaldwin238
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Cell division in the absence of DNA replication! Weird and interesting!
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A new story from the lab published in Nature today. We found an intriguing cell competitive interaction between primed PSCs among different species! Human (green) are actively eliminated by mouse (red) cells.
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We are excited to share our work on human blastoids as a model of pre- and peri-implantation human development (
@leo_jwu
,
@hon_lab
,
@leqianyu
,
@Yyyyyy1005
，
@jlduan
).
Article: News and Views: (1/10)
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A milestone paper in the iPSCs field! 👉Chemical reprogramming of human somatic cells to pluripotent stem cells
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So happy to know our human blastoid paper is highlighted in Nature cover today together with the iBlastoid study from Jose Polo’s lab
@MonashUni
. Beautiful cover design by the Polo lab! We also suggested a cover (right).
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Officially Tenured! Can’t say enough about how awesome my trainees without whom I can never get here! And how special this department, make me feel like home since the first day! And UTSW, for all the support!
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Contraction and expansion have been observed in cultured blastocysts from many mammals. We found human blastoids also underwent contraction and expansion.
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We are excited to share our new work on improving human blastoid models and using them to understand human peri-implantation development. (
@leqianyu
, Toshihiko,
@Yyyyyy1005
，
@jlduan
@deidre_logsdon
@CcrmResearch
@taotankm
,
@hon_lab
,
@yyreprod
,
@leo_jwu
) (1/12)
Large scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal crosstalk
#bioRxiv
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In a pair of studies published in Cell today, we used interspecies blastocyst complementation to study brain function and evolution. .
.
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Excited to share our latest paper on modeling post-implantation stages of human development into early organogenesis using stem cells! Big congrats to
@LLizhong
, Seiya, James,
@carlosapinzona
and collaborators
@hon_lab
and plachta lab!
19
31
148
First Ph.D student
@carlosapinzona
from the Wu lab successfully defended his thesis today! 🥳 Congratulations!🎉🍾🎈 Proud of you, Carlos! It is not easy to get a pass from such an all-star thesis committee (excluding me obviously 😂)!
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2
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A great preview article written by
@martinperaJAX
highlighting our peri-gastruloid work! And happy to know our paper is featured as the cover story of Cell! 👉 Seven days in the life cycle of Homo sapiens: Cell
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So excited about these two almost "back-to-back" milestone studies! Big congratulation to
@ZernickaGoetz
@jacob_hanna
and their trainees! Mouse embryos grown without eggs or sperm: why and what’s next?
2
15
109
Thrilled to share the publication of our latest review, "Hallmarks of totipotent and pluripotent stem cell states"
@CellStemCell
! A fruitful collaboration with Peng Du
@PKU1898
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Inter-species neural blastocyst complementation enables the generation of functional rat forebrain tissues in mice. The video shows an adult mouse with a rat forbrain.
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We are excited to share our work on bovine blastoids as an accessible in vitro model for studying bovine embryogenesis. This is a close collaboration with
@ZongliangJiang
lab. Congratulations to @
@carlosapinzona
, Yinjuan Wang,
@Yyyyyy1005
and all other authors! (1/n)
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I am honored to have my work recognized with the
@NYSCF
– Robertson Stem Cell Investigator Award! It is made possible by the great, collaborative research atmosphere at
@UTSW
; the unwavering support of the
@CRSM_UTSW
and
@UTSWMolBiol
; and, the hard work from the trainees!
We are delighted to announce the 2021 class of NYSCF - Robertson Investigators! Congratulations to
@DrShrutiNaik
(
@nyulangone
),
@leo_jwu
(
@UTSWNews
), Alex Pollen (
@UCSF
),
@lauren_orefice
(
@MGH_RI
),
@Neurrriot
(
@PrincetonNeuro
), &
@guo_lab
(
@YaleNeuro
):
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Embryo-like models shed fresh light on early human development
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I am excited to share the news that we have been selected as
#ASRMGrantAwardee
for the "Discovery and Innovation Grant"! Grateful for the hard work from the trainees who made this possible and the great research environment
@UTSW
!
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There is a serious underrepresentation of Asian awardees of United States biomedical research prizes despite many Asians are making transforming discoveries in science!
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In this
#50YearsofCell
celebration focus issue on Developmental Biology,
@fu_jianping
and I authored a perspective summarizing the prospects and challenges of developing human organs using embryo models and interspecies chimeras.
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Wu lab 2023 holiday party! Such a great night with delicious food, drinks and the fun werewolf game! Thank you all for making 2023 a special year and looking forward to more exciting journey ahead!
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Our new work on human blastoids and modeling maternal-fetal cross talk and others! Check out the tweetorial from a talented graduate student carlos!!!👇🏻👇🏻👇🏻
(1/n)Very happy to share that our our new protocol for the large-scale production of Human Blastoids from naïve human embryonic stem cells is out in
@CellStemCell
! This work was a collaboration with
@leo_jwu
@CcrmResearch
@deirdre_logsdon
@YYReprod
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We also prepared a cover to highlight both studies, which, unfortunately, was not selected. We're excited to share it with you here.
In a pair of studies published in Cell today, we used interspecies blastocyst complementation to study brain function and evolution. .
.
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40
163
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Our work on scRNA-seq of primate peri-gastrulation development is published
@Nature
! Congrats to all authors, esp
@jingleidi
, Jing, Haifeng, Luqing and
@LLizhong
! A wonderful collaboration with the labs of Hongmei Wang, Fan Guo and Xiangxiang Jiang!
9
9
72
Today the 2nd Ph.D student from the Wu lab Daniel Schmitz successfully defended his thesis! So proud of you and I am sure the future is bright!
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Interesting paper! Glad our human blastoid protocol worked for a different species and a different naive culture condition! Extended culture looks impressive but could benefit from more in-depth analyses.
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Excited to share our new work on artificial blastocysts generated from stem cells. Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures
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Thank you for highlighting our human blastoids and perigastruloids work! The key question next is what can we discover with these cool models.
It's that time of year!! 🎉We are so excited to announce our 2023 pick for Nature Methods' Method of the Year: methods for modeling development. Read the Editorial to find out why we chose this as our pick.
#moty2023
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It's official! Congratulations to
@carlosapinzona
and Daniel Schimtz! First PhDs from the Wu lab!
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So proud of
@LeqianYu
and
@Yyyyyy1005
Yulei Wei, the first generation of Wu lab trainees, who were the lead authors on the very first human blastoid paper! 👇🏻👇🏻Exited to dive into the dataset!
3D reconstruction of a gastrulating human embryo: Cell
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Our collaboration paper with
@TheBgiGroup
is now online! We performed scRNA-seq of early pig embryos and cross-species comparison with monkeys and humans, which revealed species-specific differences in early development!
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Super cool study on bat iPSCs and bat blastoids! Interesting platform to study interplay between pluripotency and endogenous viruses.
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A fruitful collaboration with
@JCIB_Lab_Salk
and
@taotankm
We found human extended pluripotent stem cells could contribute to chimera formation in monkey embryos cultured up to day 19-20
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Another preprint from the Wu lab this week, which is led by a talented postdoc Yingying Hu. Congrats to all the authors and collaborators who contributed to this study! We discovered the role of RNA sensing and innate immunity in interspecies chimerism!
3
10
55
Congratulations to all contributing authors! Especially
@carlosapinzona
@YinjuanWang
@Yyyyyy1005
! A great collaboration with
@ZongliangJiang
!
Our Bovine Blastoids paper is officially in press at
@CellStemCell
!
@leo_jwu
@ZongliangJiang
@YinjuanWang
@Yyyyyy1005
,
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Happy to share our new preprint on "Dissecting embryonic and extra-embryonic lineage crosstalk with stem cell co-culture"! This work is derived from a fruitful collaboration with
#taotan
lab and congratulations to all the authors involved!
2
14
55
Third PhD, and first MSTP student of the Wu lab Emily
@edbinshtok
has successfully defended her thesis! Really proud of you and hope the experience from Wu lab was positive that can fuel your passion for becoming a physician scientist!
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It's been 3 years since the start of Wu lab! So blessed with a productive and motivated crew. Despite the setback caused by Covid-19, we still managed to get one paper published, two papers accepted and one in revision! Looking forward to what 2021 will bring! Happy New year!
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Great to see our human blastoid protocol has been helpful to generate an advanced 3D in vitro human implantation model!
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Preprint alert! We have two collaborative papers out today on bioRxiv! In one study, working with Dr. Hui Yang's lab from CAS, we generated functional rat forebrain tissues in mice using an improved interspecies blastocyst complementation method.
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Happy to know our work on naive hPSC-blastoids was selected as runner-up for 2021 break through of the year!
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A Comprehensive Human Embryogenesis Reference Tool using Single-Cell RNA-Sequencing Data | bioRxiv
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The first demonstration of functional pluripotency for any primate species! More work to do but this work is important!
First live birth of a
#chimeric
monkey using embryonic stem cell lines.
Read more in
@CellCellPress
:
.
#ChineseAcademyofSciences
Qiang Sun, Zhen Liu, Miguel A. Esteban
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Our formative-like XPSCs paper is online! In this study, by modulating FGF, TGF and WNT signaling pathways, we generated intermediate PSCs from mice, horses and humans that show dual-competence for intra- or inter-species chimera formation and primordial germ cell specification.
New Resource online now CellStemCell: Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification
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Preprint alert from the Wu lab! A big shoutout to
@carlosapinzona
, Ryan, and the rest of the team! A fruitful collaboration with
@BanaszynskiLab
and
@PeterLyLab
! Dive into our detailed tweetorial below to learn more!👇👇👇
Have you ever wondered if the HUSH complex has roles outside LINE-1 silencing? I invite you to look at our story of how TASOR safeguards ESCs developmental potential. A collaborative effort
@PeterLyLab
@BanaszynskiLab
&
@leo_jwu
labs
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A great and balanced review of the recent advances in stem cell derived human embryo models by the one and only Janet Rossant! 👇🏻👇🏻👇🏻Why study human embryo development?
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Now that both functional sperms and eggs have been generated from mouse PSCs, I wonder whether these PSC-derived gametes are amenable for producing a live mouse on their own? Exciting work!
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Our interspecies PS cell competition paper is finally in print. Primed human (green) ES cells are actively competed out by mouse (red) EpiSCs during co-culture!
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Want to know the recent advances on interspecies organogenesis and blastocyst complementation? Check out our review!
The road to generating transplantable organs: from blastocyst complementation to interspecies chimeras
A Review by
@CanbinZheng
,
@edbinshtok
and
@leo_jwu
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It is important to recognize that embryo models are neither synthetic nor embryos! They are simply aggregates of cells in a dish to model some aspects of early development, and ALL embryo models have limitations!
#ISSCR
releases a statement on embryo models derived from human pluripotent stem cells.👇
#stemcells
#pluripotent
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It's a great pleasure to give a
@CRSM_UTSW
talk today! Thanks for the opportunity to present our work! The questions are excellent and thought provoking!
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So proud and happy for my friend Yuta Takahashi! Amazed to see how the methylation editing based on targeted insertion of CpG-free sequence to CpG island leads to transgenerational inheritance in mice!
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Excited about the opportunity to be supported together with
@kkbaldwin238
lab by CZI! We are taking an unconventional interspecies chimera approach to study neural circuits and brain function!
We’re excited to support 64 interdisciplinary teams that are taking innovative approaches to study fundamental
#neuroscience
+ neurodegenerative diseases. Read more about our second cycle of
@ChanZuckerberg
’s Neuroscience Collaborative Pairs Pilot Projects
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An important day for XENO-transplantation! Let's hope this works!
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Such a fun experience working with
@SJforKids
to explain our human blastoid model to a young audience!
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Despite the molecular and cellular similarities, human blastoids are not equivalent to human blastocysts. For example, in contrast to most blastocysts, blastoid outgrowths on endometrial stromal cells were modest.
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35
How cool is it to have your department chair sing with Willie Nelson!
An amazing night playing with Willie Nelson & friends! Thank you Annie, Willie, Micah and Mickey for your support of UTSW and our mission. Keep on rocking!
@UTSWNews
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Interesting paper! 👉 Induction of Meiosis from Human Pluripotent Stem Cells
A similar but different strategy has been used to directly induce meiotic entry in mouse ESCs! Check it out👇
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Thank you for the opportunity! Really enjoyed the discussions!
🚨 You won't want to miss next week's episode!
Dr. Jun Wu (
@leo_jwu
) from
@UTSWNews
is joining us to talk about modeling early mammalian development.
Check out his group's recent
@biorxivpreprint
on human
#blastoids
:
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Had a blast visiting MPI, MDC and BCRT in Berlin! So impressed with the exciting science going on here and made so many new friends and potential collaborators! And can’t have enough of Germany 🍺 🍻!
the Kraushar Lab had a blast hosting Jun Wu
@leo_jwu
@UTSWMedCenter
here at
@MPI_MolGen
in Berlin
breaking boundaries in the stem cell field, and engineering the future of developmental, evolutionary, and medical biology 🐁🐀🐎🐄🐒😀
🍻 from your friends in Berlin!
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Merry Christmas and happy new year! It’s been a productive year despite the challenges due to Covid! I am so proud and blessed to have such a motivated team! It has been so much fun exploring the unknowns!
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Another paper confirming our findings that human blastoids can be generated from naive PSCs I'd caution the comparative analysis of different blastoid datasets though (e.g., SmartSeq vs 10x), which can be misleading! Proper comparative analysis is needed.
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#ISSCR2020
fantastic talks from the Presidential Symposium! Especially our own
@Transactivator
! Can’t wait to share our new results tomorrow in “Early Development and Pluripotency - Interspecies Chimeras for Stem Cell Research”
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In another preprint study conducted in collaboration with
@kkbaldwin238
's lab, we demonstrated the remarkable potential of interspecies neural blastocyst complementation by enabling a mouse to "smell" the world with rat neurons.
2
6
31
Thrilled to be co-hosting the upcoming ISSCR webinar together with
@ashlee_m_hutch
on "Stem Cells for Species Preservation"! Curious about leveraging the latest stem cell technologies to protect endangered species? Join us for an exploration into the possibilities!
0
7
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A single-cell transcriptome atlas of human early embryogenesis (CS12~16) now available!
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2
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I will be speaking during Plenary Session II at Joint SDB-PASEDB Meeting. Please check out my talk if you're attending the event!
#2022SDB
#EvoDevo2022
- via
#Whova
event
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Thank you
@Mo_Li_KAUST
for highlighting our work on embryonic and extraembryonic stem cell co-culture, together with two recent stem cell human embryo models from
@MoEbrahimkhani
@Takashima_Lab
.
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models
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It is time to talk about (Evo-Devo) time! Excited to share our thoughts about timing in interspecies chimeras!
#EMBODevTempo
Are you a researcher looking at how time affects embryonic development?⏳ Submit your abstract now for our EMBO Workshop: 'Timing mechanisms linking
#development
and
#evolution
' taking place
@EMBLBarcelona
.
#EMBODevTempo
📩 Submit abstract by 20 Apr
🔗
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I'm thrilled about this upcoming webinar on stem cells for species conservation in just three days! It's free to attend, and we have an incredible lineup of speakers. Don't miss it!
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Happy to see an improved method for generating human blastoids from naive hPSCs and the demonstration of their utility for studying human implantation in vitro!
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Big congrats for Carlos and Daniel for passing their quals today! Great job!
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1
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Excited to be featured on
#PluripotencyDay
! Wish I was born on Oct 4th though.
Celebrate
#PluripotencyDay
with this episode featuring Dr. Jun Wu (
@leo_jwu
)!
He talks about developmental compatibility between species,
#chimeras
, and
#blastoids
.
🎧 Listen now:
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Congratulations to all authors and collaborators! 👇🏻👇🏻👇🏻
(1/n) Our findings demonstrate that by promoting cell survival, shortening hypoblast differentiation, and inhibiting key pathways like TGF-β via ALK5, Hippo, FGF-driven RAS-RAF-MEK-ERK, and Src signaling has significantly enhanced 5iLA-blastoid formation efficiency.
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An exciting study reporting a major progress toward the generation of stem cells with totipotent features through spliceosomal repression! I wouldn't call them totipotent stem cells though.
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I am looking forward to this symposium and excited to share our new results on integrated models of human embryo development!
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Self-organization of human dorsal-ventral forebrain structures by light induced SHH
0
8
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We commented on the advancement of blastocyst complementation for generating human mesonephoros in pigs! It will be interesting to combine chimeric approach and xenotransplantation approach in the future to overcome shortage of organ donors.
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Excited to participate in the discussion!
Get ready to embrace the exciting new episode of VGZT! 🎉🎉This time we will discuss the stem cell communications in embryloid models with
@leo_jwu
and the anterior-posterior patterning in
#sea_star
⭐️with
@FormeryLaurent
!🪄 Join on 18th Apr, 2:30 EDT/ 18:30 CET/ 16:30 UTC!!
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A fruitful collaboration with the Mori lab! A deep dive into the mechanisms regulating inter-species PSC competition! 👇👇👇
Ephrin Forward Signaling Controls Interspecies Cell Competition in Pluripotent Stem Cells
1
5
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Our collaboration paper with the Ross lab has been accepted! Derivation of sheep embryonic stem cells under optimized conditions
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Inspiring talks and a fun group of people! Will miss you all
#EMBODevTempo
looking forward to EvoDeVoTime 2.0
Say cheese. Thanks to all the participants, speakers, and organisers of
#EMBODevTempo
for a wonderful 3 days of everything timing in development and evolution! We hope everyone had a great time at sunny
@EMBLBarcelona
! ☀️🕶️
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Here is another video showing co-culture of human and mouse primed PSCs on micropatterned cover slide. Human (green) are eliminated by mouse (red) cells after 2-3 days.
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An important resource! 👇👇👇Spatiotemporal transcriptome atlas of human embryos after gastrulation
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An elegant study on human pluripotent stem cell competition, which in part explains why genetically variant hPSCs tend to overtake cultures!
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Thank you for validating our naive hPSC-blastoid model! We agree it is not perfect, which is the case to every first report. An objective and balanced, not biased, interpretation provided by your analysis promote a "healthy development of this emerging field"!
Extended analysis of blastoid cell composition reveal lack of trophectoderm in iBlastoids but not in Yu, Yanagida or Kagawa blastoids. We developed the Early Embryology Prediction tool based on neural networks to aid identification of lineage composition.
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What’s next for lab-grown human embryos?
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