Peggy Goodell
@Goodell_Lab
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The Goodell Lab. Hematopoietic stem cells, epigenetics, DNA methylation. Chair, Dept of Mol Cell Biology at Baylor College of Medicine. Tweets my own.
Houston, Texas
Joined March 2012
I am extremely excited to announce that I will become Chair of the Molecular and Cellular Biology department of @bcmhouston as of October 1. Fantastic department that I hope to grow and diversify into multiple areas of basic science. Will be recruiting (more soon)! #cellbiology.
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The lab recently passed its 25th b-day! They surprised me today w/ a party including alumni videos, lab swag, and more. So fortunate to have wonderful current and former trainees and staff. Deeply grateful to them all!
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The Dept of Molecular and Cellular Biology @bcmhouston marks its 50th anniversary today! 🎉 🍾 It was the first Cell Biology dept in the country!
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We are all walking mosaics of genetically distinct cells. Every cell acquires around one mutation each division after fertilization, resulting in a vast amount of genetic diversity across all the cells in our bodies by the time we are born.
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Getting ready for my #ISSCR2020 talk around midnight my time. Happy to see an international live audience! Honored by the Tobias award from @ISSCR!
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Excited to share our work investigating the role of the chromatin remodeler SRCAP in clonal hematopoiesis (CH) via DNA repair and epigenetic regulation - now out in @CellStemCell! Project led by @ChunWeiChen7. Great collaboration with @adamssperling.
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Excited to share our latest study on #DNMT3A identifying a new chromatin reader domain in the N-terminus that is essential for post-natal life.
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Truly honored by this award! I feel so fortunate to have had so many fantastic trainees over the past ~25 years! Thank you all!. I’m deeply grateful to the hematology community for recognizing and supporting our work. Thanks also to the funders for believing in us!.
Very excited to see the boss @Goodell_Lab present her Don Metcalf award lecture at #ISEH2023 introduced serendipitously by one of her first trainees and current @ISEHSociety Vice President Shannon!
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📢 Happy to announce our new review on stem cell #aging! We integrate traditional concepts/hallmarks of aging with emerging data on somatic evolution and stem cell competition. @NatureAging .
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Huge honor to be recognized w/ this award! ISEH helped me grow as a scientist and mentor- v grateful for the support of this community over the years. THANK YOU ALL!.
Congratulations to our ISEH 2023 Society Scientific Award Winners! This week on #SimplyBlood we celebrate the achievements of this year's awardees: @Goodell_Lab, @dstarczynowski, and @Nina_CabezasW 👉
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Who will win? Modeling cell competition in clonal hematopoiesis! #TET2 #DNMT3A #TP53 ? Come see poster 3857 by K Wohlan on Monday #ASH22! Collaboration w @TheKingLab @NakadaLab @Yun_Nancy_Huang and many others.
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Winning stem cells. Our paper on clonal selection of HSCs in the context of chemotherapy is out in @CellStemCell. PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy @bcmhouston @MDAndersonNews @sangerinstitute @CAGTHouston
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Great to collaborate again with @challenlab on a new review of Clonal Hematopoiesis #CHIP #CH. It is an introduction to a review series in @bloodjournal on CH. We focused on the mechanisms driving CH, emphasizing the opportunities for more research.
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Recruiting faculty to the Dept of Molecular and Cellular Biology at Baylor College of Medicine in Houston! Recruiting broadly in cancer and cell biology. Apply by Nov 1, 2023. @BCMhouston.
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Happy to see this out and proud of @YungHsin_Huang for a herculean effort. #DNMT3A mutations are common in heme malignancies, clonal hematopoiesis, and @TBRSCommunity. Many variants of uncertain significance we wanted to understand.
From the January issue: Systematic profiling of #DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor by @YungHsin_Huang and @Goodell_Lab of @bcmhouston.
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Recruiting faculty @bcmhouston! Multiple assistant prof positions in the MCB dept AND the Stem Cell Cntr! Looking for expertise in #epigenetics #generegulation #cellbio #synbio #organoids #stemcells… . Why consider BCM? Read on.
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We are hiring a new Director of the Human Stem Cell Core @bcmhouston. Great opportunity to run a well-supported Core in an excellent environment and become a faculty member of the Molecular and Cellular Biology Dept. Join us! . Please RT!
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Great to participate in the #ASH22 career development lunch with the next generation of hematologists! Great convo about career choices, paths to get where you want, and things to do to be prepared! (Write, write write!). Thanks for attending!
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Congrats to @BMSplice for an outstanding thesis defense! So proud. Thanks to great colleagues on committee @chasz43 @Catic_Lab @twestbrooklab @ABertuch. Joyous day in academic science.
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Honored to be part of this interesting podcast series!.
Check out the new episode of our #Epigenetics #Podcast! We chatted with #StemCells expert Peggy Goodell @Goodell_Lab from @bcmhouston about her work on the role of #DNAmethylation in #stemcell differentiation. Listen now:
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This will be a classic paper, shaping the way we think about hematopoiesis and #Cancer. Mapping #mosaicism during development. A tour de force, using patient samples, tons of sequencing, and deep and thoughtful analysis of lots of data.
Delighted to share my research group's latest study, published today @Nature 👉where we trace the life histories of blood cancer development in patients @sangerinstitute @SCICambridge @Cambridge_Uni.
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Thank you! Huge honor to help open #AACR24 !.
@Goodell_Lab delivers exceptional lecture on CHIP during #plenary session. Fantastic summary slide. Definitely one to watch on virtual platform if you were unable to attend. #AACR24 @AACR
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Great Ham-Wasserman lecture at #ASH21 by Andreas Trumpp from @hi_stem_lab. HSC biology to clinical-translation. Recognizing former trainees, collaborators, and colleagues in the journey. Congrats!
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Frida Kahlo – interested in medicine – was gifted this #microscope by her father. Apparently, she frequently traveled with it. Later turned to art. #SciArt
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Pure joy to run into one of my “twitter” (s)heros at #ASH23. Awesome content, energy, education, (s)hematology…❤️ @sanamloghavi
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Out today from the lab @NatureAging reporting TET2 mediated spatial relocalization of heterochromatin in aged HSPCs A great collaboration with @Goodell_Lab @ZhouLaboratory.
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Honored to spend 2d at @UW and the @fredhutch as the Clem Finch Visiting Prof hosted by the ever thoughtful Jan Abkowitz, and hearing about great science from @bradleybio @JShendure @Doulatov_lab @scwlee33 and the inimitable @HarmitMalik and others! Thanks all for a great visit!
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Excited to be heading to #ASH21 to see great #hematology research and seeing colleagues- starting w 2 of MDACC’s finest @RobJenqMD @jmolldrem !
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So pleased to share this story! Thanks especially to student @YungHsin_Huang for his persistence and to many lab members and collaborators!.
I am so excited to share our efforts published in Cancer Discovery! We systematically profile DNMT3A variants in enzyme activity and protein stability and uncover that a large portion of variants leads to instability mediated by E3 ubiquitin ligase adaptor DCAF8.
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Great to see all the colleagues from @bcmhouston and @MDAndersonNews on the way to #ASH23! @TheKingLab @NakadaLab
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Differences in baseline hematopoiesis in the context of germline DNMT3A mutations in patients —> possible insights for age-related clonal hematopoiesis. .
Our latest work describing the impact of germline DNMT3A mutations on hematopoiesis
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Inspiring day meeting w families from the @TBRSCommunity, sharing research and hearing their questions and concerns. Made #DNMT3A bracelets!
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Faculty positions are available at the Stem Cells and Regenerative Medicine Center at Baylor College of Medicine in Houston! We will start reviewing apps October 15. #stemcells @bcmhouston . Why consider BCM for launching your academic career? Read on. .
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Super excited to share this recent work- driven by the inimitable @BMSplice!.
Thrilled to share @Goodell_Lab’s latest work on a new role for DNMT3A in stem cell activation via coordination of RNA splicing in @naturecellbio 🧵below (and read here: .
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@jkpritch @bcmhouston is planning for multiple searches, including for my department of Molecular and Cellular Biology, so stay tuned. I’m super excited about the opportunity to recruit exceptional candidates!.
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#DNMT3A brain trust at #ASH18 Don’t miss their great paper showing patients with loss of MBD4 develop #AML with hundreds of coexisting DNMT3A mutations. In vivo #Evolution in hyperdrive. @ianjmajewski @MathijsSanders
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Multiple faculty positions available in the Dept of Molecular & Cellular Biology at Baylor College of Medicine in Houston! Broad basic science recruiting in Mol & Cell. Biol. App review start Nov 8. #cellbio @BCMhouston @ASCBiology . Why consider BCM.
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#FluorescenceFriday -flow cytometry counts too, right? Excited to start up our new 5-laser @CytekBio instrument! Just Ab titration today but stay tuned.
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Mutant NPM1 Maintains the Leukemic State through HOX Expression: Cancer Cell
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Please give a warm Twitter welcome to @XiChenLab who just joined. -Fantastic faculty member in MCB department @bcmhouston. Beautiful new @NatureCellBio paper on protein QC in #HSCs! Congrats!.
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Excited to talk about career development and #leadership tomorrow, hosted by @ISEHSociety!.
🚨 Last call to sign up to join tomorrow's live webinar hosted by the Junior Faculty Committee featuring @goodell_lab and @johnstonericky. Register for free today!
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Congrats to @TrowbridgeLab for this award! Well deserved! Jennifer is universally respected and appreciated in #hematology for her combo of great science and sunny personality. 👏👏👏.
The #ISEH2020 Janet Rowley Award Winner is Jennifer Trowbridge! @TrowbridgeLab studies cell fate regulation within the hematopoietic system with a current focus on the epigenetic regulation of hematopoietic stem cells and progenitor cell lineage commitment
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NPM1c functions in the nucleus- #ASH22 reunion w/ @therealDrGundry @BrunettiLab @Gandhar_Datar. Don’t miss Gandhar’s talk today at 4:30 (session 602) to hear Chapter 3!
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We are very excited to welcome you as our newest faculty recruit to the stem cell center @bcmhouston! Can’t wait to have you join us here!.
Thrilled to share that I will be starting my lab at the STaR center @BCMhouston this fall. We will be studying how post-transcriptional and epigenetic mechanisms govern cell fate decisions [. Will be hiring soon!.
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So proud of @1indaz who defended her PhD thesis today w flying colors! #ppm1d ! Great lab leader! First part of #doubledoc!.
Another amazing alum of @Goodell_Lab @CAGTHouston.
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#grateful for this fabulous @ASH_hematology community where our trainees can come to learn, be inspired, network, and contribute. #ASH22
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Great to end Boston visit by jogging my old route from Postdoc days @WhiteheadInst. Beautiful October day. Little changed but density of Kendall square and my running speed.
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Proud to be at HHMI where @MoralesMantilla from the @TheKingLab was just inducted as a new Gilliam Scholar! 2018 Gilliam Scholar @jaime_m_reyes from my lab also here! @HHMINEWS @CAGTHouston @bcmhouston
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Great talk today by @gur_ola on #DNMT3A in #Leukemia while visiting @CAGTHouston. Currently @UFHealthCancer, formerly with @rosslevinemd
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Fantastic @Nature paper from colleague Ben Deneen. Native mouse glioblastoma model w/ in vivo screen IDs PIK3CA driver variants, cross-talk between tumor cells and neurons. Contribution from GPC3. #gliomaNS @CAGTHouston @BCMFromtheLabs .
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Fantastic new work on clonal hematopoiesis and progression to leukemia w additional environmental factors! 🤩 #TET2 biallelic muts, resistance to cell death, UV exposure… Soup-to-nuts read. Congrats all! Will be a classic. 👏👏👏.
Thrilled to share our latest work out today @Nature . A collaborative effort with many great, super smart colleagues, especially @gryfyndor @hovestadt @vangalenlab :
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Inspirational tweetorial for those into clonal hematopoiesis/ tAML. Great explanation, data, GIFS, and enthusiasm. Need more rock concert road-trips! #PPM1D #DNMT3A.
❓💉How does chemotherapy affect healthy cells in the blood? Our preprint “The evolution of hematopoietic cells under cancer therapy” just out in biorXiv! From @bbglab & @hematosantpau 👉🏾 @a_cortesbu @fmuinos Marta Abel @nlbigas & yours truly. Tweetorial👇🏾.
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So fortunate to have had these 4 train me to be a good PI!.
@Goodell_Lab reunion for @TheKingLab invited seminar @WUSTLmed @baldridge_lab @SouroullasLab
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Got to meet one of my heroes in the bio-science Twitterverse @atulbutte at the @theNAMedicine meeting!
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It’s an honor to be presenting today at @pmcancercentre. Great to meet one of the #AML heroes, Mark Minden, and see the original 1992 karyogram of OCI-AML3 with mutated #NPM1!
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Fantastic new work from @jaiswalmdphd et al on clonal hematopoiesis! #DNMT3A still stands apart! TCL1A promotes expansion of TET2 mut clones. TCL1A is the new mystery! Congrats all!.
Clonal hematopoiesis is an expansion of blood stem cell clones caused by mutations in a recurrent set of genes. Our paper on factors mediating expansion of these mutant clones is published today. Thread below. .
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Our JoVE protocol for fast and efficient CRISPR/Cas9 gene editing of hematopoietic stem cells has been published! starring @lorebrun83 and @koston7.
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Check out the fancy CRISPR KOs and K-ins to generate new B-ALL cell line models with patient-relevant Ikaros isoforms. New insights into therapy resistance + potential vulnerabilities. Congrats to @RachelRau3 and superstar team!! #SAMHD1 #IKZF1.
Congratulations to Jason Rogers, Rohit Gupta, @Cajohnson23, @GeraldoMedrano and so many lab members past and present for getting this across the finish line with tremendous support from @Goodell_Lab. Thx to @BloodAdvances for publishing our work!.
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Congrats to @jaime_m_reyes for a successful thesis defense! So proud! . First thesis party 🎉 w 🌮 and choco-flan! 😋
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Happy to be at #ASH21 in person, but the poster session is missing the buzz and intensity of years past. 😥 Maybe next year…
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Running into colleagues heading to #ASH2018 at the gate! @kyudehking @Yun_Nancy_Huang and Daisuke Nakada. Looking forward to hearing some great hematology research!
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Our review on targeted DNA methylation and de-methylation using #CRISPR, ZFs & TALENs is out. History + strengths/limitations of several tools. Some great options, but room for improvement! #DNMT3A. Thanks Yong Lei and @YungHsin_Huang and @GenomeBiology.
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Cell-cell competition in development and disease- our @KeystoneSymp meeting starts in one month in Tahoe! Revolutionizing concepts of #aging, #cancer, and #development. Still time to register; bring a poster! Model organisms to humans. Great speakers!
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We fulfilled the Goodell lab tradition too! What a great team!
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Great story about the human side of early BMT. Good reminder of why we do what we do and how far the field has come. #hematology #HSC #stemcells.
In 1971, Chris Lundy had minute odds of survival. He is now the longest living BMT recipient at the Hutch.
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MCB dept Halloween party! 1st place pumpkin by @Kaochar2 lab (Dia de los muertos), 3rd by @JVanNostrandLab, a pumpkinoid model of metastasis w fluorescent subclones by @RoartyLab, and others.
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Great to have @SJMorrison give great feedback on the work of @queserachiraag from our lab at #CSHLSYMP23 on Stem Cells! @cshlmeetings
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Great intro by the incomparable @jyoti_nangalia for the #TP53 abstract at the #ASH21 plenary session. Just wish she was here in vivo! Rocking In red!
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Awesome new paper! Something for those interested in #DNMT3A inflammation, interferon gamma, AML, epigenetics of cancer x environment, DNA methylation!.
Please see our new manuscript in @BCD_AACR describing mechanisms which provide DNMT3A-mutant HSCs a competitive advantage in inflammatory conditions. See virtual poster LB555 from @ChristineRCZ #AACR2022 for additional details!.
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Prepping for #ASH20 was a bit different this year- nice not to worry about what 👠👢🥿👟 to bring to survive the miles! #ASHfashion. And I sure miss the badge ribbons. .
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What is the straw that breaks the back of clonal hematopoiesis and drives malignancy development? Great perspective for a talk by @zxtzhangqian from @VAInstitute at #KSCellComp
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Nice work by Indranil Singh @cancer_curious presented at #stemcellniche2023. His impassioned presentation would make @AlejoFraticelli proud!
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And fabulously presented abstract by @AlbaRMeira from @AdamMead lab dissecting the impact of #TP53 mutations at the single cell level in MPN. Complete story- look forward to seeing in print! #ASH21
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A monumental review about #DNAmethylation! Traces key insights with fantastic figures, summaries, and outstanding questions. Highly recommend for both novices and aficionados.
What does DNA methylation do again? Our answer in 32 short pages. Excited to finally get to share a true labor of love Nina Bailly and I worked on together throughout the pandemic, a swan song to my PhD and time in Germany.
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Congratulations Nancy! @Yun_Nancy_Huang ! Well deserved huge honor! For her contributions to cancer #epigenetics.
TAMEST is pleased to announce Yun Nancy Huang, Ph.D., Associate Professor, @TAMHSC_IBT, as the inaugural recipient of the Mary Beth Maddox Award and Lectureship.
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Congrats Ross! So well deserved! Such a generous colleague with infinite energy, always sharing ideas. Making a real impact on the field and on #AML, always thinking of patients.
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Beautiful work on TET2 in heart development showing its loss affects long-range contacts. Congrats @Yun_Nancy_Huang and @jmartinlab!.
Please check out our new collaborative paper with Nancy Huang’s group looking at Tet function in heart development
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@challenlab Thank you Grant! I was so fortunate to have you in my lab! All my trainees have helped me- motivating, inspiring, teaching. what a great journey and privilege for me!.
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Amazing comprehensive data that will shape the way with think about natural #aging. Dont miss incredible animated illustrations! #SciArt.
I am incredibly excited to share our preprint ‘Somatic mutation rates scale with lifespan across mammals’In this paper we provide an unprecedented description of somatic mutation across mammals. An illustrated tweetorial…[1/17]
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Thank you! Great meeting- inspiring talks and great interactions. Lots of motivated trainees.
Great talk on clonal hematopoiesis by @Goodell_Lab at #FASEBSRC #HematologicMalignancies conference. They are also recruiting new lab members!
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Welcome to Twitter Daisuke! … while @bcmhouston coffee corner is still closed, you can catch up here with @TheKingLab @Yun_Nancy_Huang @DrKTakahashi @GetYourChorion @gorelicklab @JLeeLab @ronparchem @JeffMRosen @jmartinlab @Catic_Lab @DrPaulKlotman @mdickinson31 and many others!.
Hi everyone, figured better be late than never!.
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I hope to promote a collaborative environment that.continues to support discoveries that impact health.and a positive place to work that values mentoring,.diversity, and scientific integrity. Join us! Recruiting at all levels.
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Talk prep with pre-recording was nerve wracking - but our scientific session was great! And the lively panel discussion with @bloodgenes and others brought it to life! #ASH20
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It has been an honor to lead the dpt over the past ~3 yrs and to bring in new faculty working in cancer signaling & metabolism, chromatin regulation, stem cell biology and structural cell biol. @JVanNostrandLab @DiStefano_Lab @KylePEagen and Pengxiang Huang.
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Really exciting work exploiting the ability of #DNAmethylation patterns to classify cell types. Allows sensitive detection of tumor cell DNA within the complex mixture of cells/DNA in blood. New potentially transformative approach to early diagnosis.
This thread provides a brief explanation of our recent @nature paper by co-first author Ankur Chakravarthy. ‘Sensitive tumour detection and classification using plasma cell-free DNA methylomes’.
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3D genome- great talks by @blobelgroup @elisa_oricchio and @erezaterez. Broad concepts and impact for malignant and nonmalignant hematology. Repeats at 4:30 today. #ASH19.
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Thrilled to welcome Josh Riback to the Department as a new Assistant Prof this summer!.
Excited to confirm that I am starting @RibackLab joining the department of MCB @BCMHouston with support from @CPRITTexas! We'll be hiring, so if you're interested in bridging the biology and physics of Biological Condensates, please get in touch!
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Fantastic plenary by Hind Bouzid from @jaiswalmdphd lab on CHIP and protection from Alzheimer’s! #ASH21
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@AlejoFraticelli Well, as much as I love hematology, I would consider one of the super-awesome PIs who have recently joined my department @bcmhouston!. @DiStefano_Lab, @BenhamPyleLab, @JLeeLab, @JVanNostrandLab,@SuperSciJew, @KylePEagen, Pengxiang Huang, or @AreyLab, @GetYourChorion, @hodgeshc.
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Planaria hold the answer to immortality? Sorting neoblasts with Hoechst, imaging and 3D reconstruction, and the lab acknowledgements by drone. Incredible talk by @Planaria1 during #KSCellComp. @KeystoneSymp
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#HappyHalloween Fun with @TheKingLab and Daisuke Nakada's lab. @bcmhouston @CAGTHouston @jaime_m_reyes @BMSplice
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Cell Competition in Development and Disease -Keystone conference! Feb 24-28, 2019 in #Tahoe. Deadlines: short talk abstracts: Nov 28, early reg: Jan 8. Topics -Competition in Development, Germline, Cancer, Evolution, Tissue Mosaicism, Aging @KeystoneSymp
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Amazing talks today at the McLean lectures @bcmhouston by @LugerLab and @SteitzLab ! Both featuring history of the field and inspiration for the future!
So excited to hear not one but TWO fantastic #WomenInSTEM talk about their ground-breaking research at our 49th Annual McLean Lectures! @SteitzLab @LugerLab @bcmhouston #RNA #NucleicAcids #Histones because you know it's ALL ABOUT THAT BASE! (see: .
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Amazing #clonal-evolution, #breastcancer, exquisite spatial info. Congrats on beautiful work!.
Want to *see* how a tumour has evolved and grown? And also how different clones acquired characteristic transcriptional and histopathological features? . Hold on, that's magic. No, it's our new preprint by @LucyYat47076319 and @MatsNilssonLab 1/9 .
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