Lee Grimes Lab
@LeeGrimesLab
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Joined July 2018
News Flash. After decades of work to unlock hematopoiesis, marrow failure and leukemia, I can no longer be fired simply because of who I love. Thanks Supreme Court.
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🚀 Launching our #SingleCellAtlas: a deep dive into human bone marrow with paired CITE-seq and high-dimensional flow cytometry! Led by @XuanSeanZhang and @annie_song_b published in @NatImmunol. 1/3.
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Delighted to serve as the first basic investigative research councilor on ASH Executive Committee! .
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This is team science! 🤝 A big shoutout to @LeeGrimesLab, @Krauselab_Yale, @PittTweet (Singh lab) & @CraigTJordanLab. Funded mostly by an RC2 grant from @NIH, @NIDDKgov, @ShilpaH75. Kudos to @BioLegend, @CytekBio & Curiox Biosystems for their support with prototype products! 3/3
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WOW. Its already time to start planning for #MyeloidMeeting24 .HOLD THE DATES: May 20-24, 2024.We will go back to the same venue and hotel.
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AGENDA IS NOW LIVE for the 13th International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia. 👉 Its going to be amazing! 👈.Menu links are coming soon.
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Myeloid progenitor production is just random in the marrow. right? Not so! See Dani Lucas’ lab manuscript on BioRxIV.
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Registration now open for "live and in person".13th International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia.MAY 23-26, 2022.Unpublished work ONLY
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NEW at the 13th International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia. Send in your HOT unpublished abstract for a poster, get selected for a short talk, and we pay your hotel bill!
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Get your intellectual and culinary appetites ready. The meeting begins tomorrow with LEMONADE at noon. #MyeloidMeeting22
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MYELOID2024 basic schedule information now live (start and end times) .No menus yet!.
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Congratulations @theclotthickens, for the first submitted abstract to be awarded a short talk at the 13th International Workshop on Myeloid Stem Cells and Leukemia. We are paying your hotel bill Dr. Machlus!. If anyone has not yet registered, the cost of doing so increases soon.
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How do HSC integrate stress? Here is amazing work by Jose Cancelas' lab showing how Scribble links cdc42 to Yap/Taz signaling to control HSC function and cell fate.
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Check out our digital resource for everyone in #hematology! Visualize any gene and surface marker on 80+ cell states from >400k human HSPCs from donors spanning race and sex. Check the Infinity Objects for isolation strategies of your cell of interest. 2/3.
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Note that @nsalomonis recorded a tutorial on how to use the Human CITE-Seq Bone Marrow Atlas Portal. Check it out via @YouTube.
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Beyond sad at the passing of Paul Frenette, who was an amazing scientist, great mentor and excellent dinner companion. We will miss his presence in the field, both personally and scientifically.
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AGENDA is now live for MYELOID2024.Check out 81 unpublished stories!.
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First PhD in the program in Biomedical Informatics defends today with 10 papers! Congratulations @EricaDepoBMI and your mentor @nsalomonis.
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Beautiful work by @DanielL84885058 Dani Lucas lab. These gorgeous pictures of the bone marrow could be framed! @nsalomonis and I had a great time helping. Read the story here
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MYELOID2024 registration opening soon. If you are a speaker or someone who pre-registered, you will be getting an email link to the registration website. Registration will open for everyone after January 1st.
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Isle of Capri. Three Italian postdocs thanked @EatWellTweets for getting Italian food right. #MyeloidMeeting22
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A number of new NIH grants just starting or coming soon means we have space for new postdocs. Training possible in both hematology/oncology and informatics. How does that work? You can watch a synopsis of our recent Nature paper for the next 48 hours at:
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The Taub Foundation asks “what should the future of MDS research be?” Steve Gore hosts a 1 hour discussion at #MyeloidMeeting22
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#ASH21 Apple Watch wants to know if I am starting a workout every time I walk between sessions at ASH.
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Less than 24 hours to the start of MYELOID2024.Looking forward to seeing everyone.
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thanks in advance spirits expert Rachel Moore @GinnyTonicCincy for running the speakeasy lounge bourbon tasting at "39.0976° N, 84.5113° W:.The End of the South" for #MyeloidMeeting22
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Looking for a postdoc that trains you in hematopoiesis, leukemogenesis and informatics? How about figuring out the function of new leukemia oncoproteins?.
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Which clusters are the best ones? How would you find out? @FrankLI55917967 @nsalomonis use Game Theory and cluster stability to figure that out for you in "scTriangulate". Help from me, @annielovesveg and @bulbgod Check it out:
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U.S. News: Best Children's Hospitals Honor Roll. 1. Cincinnati Children's Hospital Medical Center. 2. Boston Children's Hospital. 3. Texas Children's Hospital, Houston. 4. Children's Hospital of Philadelphia.
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WHOA! . at CAPACITY already. has already reached initial capacity limits. If you have a KILLER unpublished story and want a short talk email me. No promises, but I hate to see good stuff shut out.
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new splicing neoantigen tool "SNAF" from @FrankLI55917967 and @nsalomonis is now online at Science Translational Medicine. B cell or T cell antigens.
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CCHMC Division of Immunobiology is hiring faculty (at all ranks). Applicants should send a CV, 2-page research plan, and contact information for three.references to Immunobiology@cchmc.org by March 1st, 2024.
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@AlejoFraticelli The most important thing is to figure out the experiment that would kill the project (if X is not true, then the whole thing fails). As Shalin states "beg, borrow and steal (from other funded projects)" to get THIS key experiment done.
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@LeeGrimesLab, @nsalomonis and @KyleFerchen are excited to announce the publication of our new #Bioinformatics application! #pyInfinityFlow, enables combination of overlapping Flow Cytometry panels, unlocking the potential to profile more features across millions of cells (1/7).
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Major change at MYELOID2024.LOTS of short talks from submitted abstracts!.Agenda soon.
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Congratulations to @ImmunologyAAI on hiring the first @LeeGrimesLab grad student (its been a minute) as their new CEO. She is going to do an amazing job.
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Welcomed to UPenn by snow!.Thanks for the invite and weather @bowman_rl .Can’t wait for an exciting day!.@PennMedicine @ChildrensPhila
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How do adult hematopoietic stem cells remember that they have divided? .Just ask @MarieDo95228975 . with help from us and @nsalomonis. via @LinkedIn.
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New story from @SaraMeyerLab ! .new twist on inflammatory signaling in leukemia. DOI: 10.1158/1078-0432.CCR-22-1598.
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Wow @JianXuLab "an integrative approach to systematically identify and characterize noncoding regulatory variants with functional consequences in human hematopoietic malignancies" Very cool. and they highlight one of GFI1's friends. PER2. DOI: 10.1158/2159-8290.
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Visiting ABRCMS to have conversations with the next generation of scientists .
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@haas_lab @NatureCellBio @ChrBcc @larsplus @cnombela @LarsMSteinmetz Congratualtions Simon. We liked it so much we wrote a News and Views about it.
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Gerhard Richter "Tulips" 1995.Jonathan Anderson's "Loewe Fall" 2023.MYELOID2024 .see it now:
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MYELOID2024.Due to problems with our registration vendor (now fixed), the deadline for early registration is extended to 3/7/2024. Registration link:
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MENUS are NOW LIVE for the 13th International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia.
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YES!!👉"Conceptually, the identification of discrete cell populations by multiple complementary markers and methods supports a model wherein hematopoietic differentiation proceeds through a series of discrete meta-stable states, rather than being a continuum" @kathrinbernt.
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I pledge to continue opposing racism & hate. I pledge to encourage & train the next generation of scientists, with the hope that they will be more diverse. I will recognize that diversity extends beyond race, religion, and gender identity. I will value diversity, and listen.
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New work by a team including our own Gang Huang reports the efficacy of ruxolitinib for COVID19. small number of patients, but those on drug did not die. More from this approach coming soon from other arenas. Check out Gang's report in JACI.
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Multi-omics single-cell analyses of genetic disease models demonstrates the dominance of cell states in integrating the impact of mutations via @LinkedIn.
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American Hematology peeps. If your Hematology-focused R01 proposal was scored but not funded in the last 18 months check out ASH Bridge Award. Due Nov 2!! @ASH_hematology.
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Congrats to grad student Kyle Ferchen on an ASH abstract achievement award. Poster 1216 TODAY #ASH22.
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If you are trying to register and having trouble, we are working on it with the web service provider!.Meantime, the deadline for the registration price increase will be moved a week (to Feb 7th) to alleviate any stress.
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Age-associated epigenetic reprogramming may form a predisposing condition for the development of age-related AML. via @LinkedIn.
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Lab peeps at Python class.The guy in the green shirt is the instructor - but you knew that.
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Check out our latest article: cellHarmony: Cell-level matching and comparison of single-cell transcriptomes (now online at NAR) via @LinkedIn.
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Registration for MYELOID2024 will close on Friday. If you feel inspired to attend after looking at the AGENDA, better hurry up.
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WOW!.So proud of “scientific little sister” @mebottazzi for developing a cheap-to-make patent-free COVID-19 vaccine and distributing it to the world.
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Scientists: Support for the innovation engine of American science: immigrants - Sign the Petition! via @Change.
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@EatWellTweets is already hard at work for #MyeloidMeeting22. Thanks Renee Schuler and team!❤️🧡💛💚💙💜🤎🖤🤍💗
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@LeeGrimesLab has an immediate opening for an NIH-funded postdoctoral research fellow to study.myeloid hematology/oncology. Dual training in bioinformatics with @nsalomonis lab possible.
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New Nature Article by my colleague @richardalang1. Violet-light-sensitive neuropsin OPN5, expressed in light sensing neurons in the hypothalamic preoptic area, modulates the heat-generating capacity of brown adipose tissue. Congrats Lang lab!!.
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