Victora Lab
@victora_lab
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Laboratory of Lymphocyte Dynamics at @RockefellerUniv and @HHMINEWS . Opinions are Gabriel’s own.
New York, NY
Joined September 2020
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For anyone interested in our LIPSTIC (CD40 and universal) or K-tag mice, they are now available for registering interest at Jax.
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Happy to share our latest study using what we call “molecular fate-mapping” of serum antibodies to distinguish newly elicited from original antigenic sin (OAS) responses to flu and SARS-CoV-2 boosting in mice.
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This is an incredible honor, thank you
@HHMINEWS
. Couldn’t have done this without my wonderful lab!
⭐️ Big news! HHMI is investing $300+ million in 26 new
#HHMIInvestigators
from 19 US institutions. These top scientists will drive groundbreaking research in diverse fields, from neuroscience to immunology to structural biology & beyond. Welcome to HHMI!
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Out just now in
@ScienceMagazine
, our paper on the role Foxp3 (but not Tfr!) plays in ending the germinal center (GC) reaction. A heroic effort from
@jotraceyja24
, in collab with Wei Hu and Sasha Rudensky. 1/
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Happy to see this study out in
@Nature
! Massive effort by
@Arien_Schiepers
and also many collaborators, both from our lab and
@jbloom_lab
,
@PaulBieniasz
, and Norbert Pardi’s (U. Penn) groups.
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Online now
@nature
the final version of Sandra Nakandakari’s universal LIPSTIC paper! Thanks to
@MempelThorsten
and the other reviewers for their very useful input. *Special* thanks to
@KamphorstAlice
for stepping in to help us out!
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Vaccines are holding well against severe omicron in NYC. Impressive!
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Really happy to see this paper is out! It’s the brainchild of our dear postdoc Jonatan Ersching, who passed away in 2020. It’s not only a science story, but also the story of how we came together as a lab to finish what Jony started.
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For the B cell aficionados out there, check out our (
@NussenzweigL
& mine) latest review of the germinal center reaction in
@AnnualReviews
!
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Check out our latest
@biorxiv
describing a universal version of LIPSTIC technology for labeling cell-cell interactions. Led on our side by Sandra Nakandakari-Higa, in close collab. with computational biologists Sarah Walker &
@YuriPritykin
at Princeton.
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Congrats to our newest PhD Alex Barbulescu! Fantastic presentation and defense, a real masterclass on antibody-mediated feedback in germinal centers!
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Congrats to Dr. Tatsuya Araki, our first home-grown PhD! Beautiful presentation on the evolutionary aspects of B cell selection in germinal centers!
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Science is back!
Two years ago my father Cesar Victora refused the Brazilian Medal of Scientific Merit from the former guy in protest against his COVID denialism.
You can’t imagine how happy I am to see the current guy handing him that same medal now.
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Murphy’s correction to Mendel’s First Law: on breeding two heterozygotes you have 1/4 chance of generating each homozygote, unless that’s the genotype you want
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Our thoughts on B cell selection and affinity maturation towards commensals in the gut. Led by
@KevinWNg
and
@gp_donaldson
, with
@hobbs_alvaro
and Chris Wichmann. Thx to Fred Alt and Ken Murphy for commissioning this!
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Sharing two new preprints using our LIPSTIC technology to find DCs that prime CD4 T cells in two very different (and important) immune settings. This 🧵 is on a study led by
@AlexChudnovskiy
(🇺🇦🇺🇦) on the priming of a CD4 T cell response to cancer. 1/n
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Wow!
"A hyper-immune human subject was identified with a documented 18-year history of 756 immunizations to venoms spanning 2001 to 2018"
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Online now at
@ImmunityCP
@Arien_Schiepers
’ latest paper on secondary germinal centers and original antigen sin
Original🧵 here:
Online now: Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers
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Affinity maturation
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Great fun talking to the Immune crew!
Gabriel Victora
@victora_lab
joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues
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Congrats to my friend/neighbor/collaborator (Prof.)
@danmucida
on his tenure, well-deserved! To many more years of amazing science!🥂
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(GV) Not every day that you wake up to the news that your faculty mentor got the
@NobelPrize
.
Congrats Charlie, doesn’t get more well-deserved than that!
And go
@RockefellerUniv
!!
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“We observed that gd T cell subsets play contrasting roles in colorectal cancer: epithelial surveillance by steady-state IFN-g–producing cytotoxic gd populations help prevent tumor initiation, while intra-tumor gd T cells support tumor progression.”
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Bad omen for curiosity-driven basic science when a star institute like Skirball gets dismantled.
When will funders realize that translational science can’t happen without something to translate?
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However, this response is attenuated in heterologous boosting, in proportion to antigenic distance. The more removed the boosting antigen, the more it will engage new (non-OAS) B cell responses. This is good news for variant boosters!
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Nothing like a British "title" field to make you feel unimportant
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Briefly, we developed a new mouse genetics system where serum antibodies are fate-mapped with epitope tags, allowing us to distinguish antibodies produced by B cell clones expanded by primary vs. subsequent immunizations.
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For CoV-2 specifically, we find that Omicron (BA.1) S is sufficiently drifted from Wuhan S for variant mRNA vaccination to engage substantial new (non-OAS) B cell responses to escape epitopes that lead to better Omicron neutralization.
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First time I find out what someone in the lab is doing by tweet 😂
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Boosting macaques with the B.1.1.351 after two immunizations with WT CoV-2 induces strong serum neutralization against the variant strain. This is very good news!
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A thoughtful analysis of different models of GC selection and affinity maturation by Michael Meyer-Hermann, showing just how much we still need to learn
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Congrats
@LukaMesin
! Our lab would definitely not be what it is if you hadn’t joined us way back at the beginning. Can’t think of anyone more deserving!
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Just posted on
@biorxivpreprint
our new study on GC B cell proliferation mechanics. By Juhee Pae et al, in collaboration with
@shaleklab
,
@EfeyanLab
, Ari Melnick, and Michael Meyer-Hermann labs (with our deepest thanks). Here’s is the gist of it:
1/
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Our weekly SARS-CoV-2 screening program at
@RockefellerUniv
yields its first scientific results. Amazing effort by Bob Darnell et al.
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We hope our findings will shed light on the phenomenology of OAS and help us understand how variant boosters may overcome this barrier. We also hope to contribute to the ongoing debate over the merits of variant boosting (we think it’s a good thing).
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Question for immunology wonks: If you are primed with WT SARS-CoV2 vaccine then boosted with an E484K variant, which classical immunology effect do you expect to see?
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Joel had the openmindedness to take a young student with an undergrad in Music into the
@nyulangone
PhD program, I wouldn’t be here without him. Thanks Joel, and RIP.
The world has lost the great Dr. Joel Oppenheim. Dr. Oppenheim was the former Dean for Biomedical Sciences at
@nyugrossman
(1994-2014), and a giant that worked tirelessly to increase
#diversity
in graduate education across the US and at
@NYU
and
@nyugrossman
. I remember meeting
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Best memory B cell experiments ever!
Born
#OnThisDay
in 1923 was the "'grand dame' of immunology", Brigitte Askonas FRS. A leading figure in the field, her research centred on antibodies and their functions. She was also renowned as a scientific mentor. Find out more about her life and work:
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Check out our new lab website, updated after 3 years. Next update, 2024!
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COVID cases and deaths in Brazilian cities according to % Bolsonaro voters. Not too surprising, unfortunately.
From
@PedroHallal
’s column:
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Now out in print!
Pae,
@victora_lab
,
@LabMelnick
,
@coraline_mly
et al. show that, during clonal expansion, dark zone germinal center B cells enter cell cycle in the absence of direct signals from T cells, in a program that depends on the cell cycle regulator cyclin D3.
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The place to be next year 👇👇
I’m delighted to announce that I’ll be starting a faculty position at the Scripps Research Institute
@scrippsresearch
, in La Jolla, California, as a tenure-track Assist. Professor at the Dept. of Immunology and Microbiology, and Head of the Laboratory of Immune Longevity (LIL)!
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Thank you
@Hypothesisfund
, looking forward to working together!
Notwithstanding significant advances, the pandemic underscored how much remains to learn about the immune system.
#HFScout
@victora_lab
leads the charge on studying adaptive immunity & basic biology of how antibodies are generated in response to infection and immunization. 1/5
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Thanks
@RockefellerUniv
for highlighting our work!
The body's first blush with a pathogen shapes how it will respond to vaccines. Evidence from
@victora_lab
clarified how this phenomenon works, mechanistically.
#RockefellerScience
#yearinreview
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Great work from
@coraline_mly
and
@LabMelnick
in
@ScienceMagazine
, on how mutations in BTG1, an important DLBCL oncogene, affect germinal center dynamics by speeding up the positive selection process (in collaboration with Dr. Juhee Pae from our lab)
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We find that boosting repeatedly with the same antigen is subject to strong “primary addiction,” in that B cell clones engaged by priming strongly dominate subsequent boost responses.
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Happy to be a part of this initiative, many thanks to the organizers!
Looking forward to our next
#globalimmuno
talk this Wednesday February 10at 9am PST noon EST 5pm GMT by Dr. Gabriel Victora
Clonal Dynamics of the B cell response
LINK:
Meanwhile catch up with the amazing previous talks at:
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Mitchison's experiments are among the greatest classics in immunology, including the first demonstration of T cell help to B cells and the "antigen bridge"
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Important work from my friend Maria Curotto de Lafaille’s group on memory B cells in allergy. They identified IgG1 memory B cells in allergy patients that can quickly switch into pathogenic IgE producers. Check it out if interested in allergies!
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Waning effectiveness of the Pfizer vaccine against infection, but protection from hospitalization and death remain sky-high, even with a predominance of beta/delta.
In this 900,000-participant study in Qatar, vaccine effectiveness peaked at 77.5% in the first month after the second dose. The effectiveness fell to as low as 20% in months 5 through 7 after vaccination.
#Covid19vaccine
#IDTwttier
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Huge congrats to everyone, but especially to my good friends and colleagues from
@RockefellerUniv
,
@danmucida
@DanielKronauer
and Vanessa Ruta. Also to my awesome collaborator
@ematsen
. Well done and obviously well deserved.
HHMI News: We are proud to announce our 33 new
#HHMIInvestigators
. These individuals have the potential to make transformative discoveries over time and we look forward to seeing where their ideas lead them.
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Congrats
@deCarvalhoRenan
, making us proud!!
We are pleased to bring you the
@CellCellPress
paper of
#FacesOfCell
Dr. Renan V.H. de Carvalho (
@deCarvalhoRenan
), “Clonal replacement sustains long-lived germinal centers primed by respiratory viruses”
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GCs = squid game
hi there! are you mourning the loss of your antibodies, months out from getting your COVID vaccine? don't be—your absolute numbers might be down, but the average *quality* of the antibodies you have now is much higher than it was before. 1/
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(GV) Nice preview by
@PepperMarion
in
@nature
on one of my paper highlights of 2020, by
@TheBcellArtist
.
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Congrats to my PhD advisor
@MichaelLDustin
, newest member of the
@theNASciences
! Well deserved!!
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When we get sick with bugs, we make small tacks that latch on to the bugs and kill them. Though they aren’t great from the start, they get good with time. Real good tacks don’t let you get a bug more than once. We look at how these tacks are made and how they get to be so good.
Say what you work on, using only one-syllable words. My try: Some things go up. Some things go down. Some things go up and down, up and down, like that. I work on big groups of things that go up and down in sync, and ask, how can they do that? And how can they do it on their own?
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Congrats to Dr. Victora senior on his election as a foreign member of the
@royalsociety
!!
I cannot think of anyone more deserving of election to fellowship the Royal Society than my friend & colleague
@anjgoswami
- huge congratulations on this amazing honour!
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Fooling around with DALL-E 2 ()
“Painting of a mouse putting on lipstick in the style of Van Gogh”
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Porto Alegre, the city I was born in, is under water after the worst flood ever recorded there. And, as usual, it is the poorest people who are affected the most. Please donate if you can!
Those outside Brazil can also help the population affected by the climate catastrophe in RS. How to donate:
➡️ EuroZone
Standard Chartered Bank Frankfurt Bank
Swift: SCBLDEFX
Bank Account: 007358304
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Yep, this is happening. Complete with hiding the cause of death of treated patients that died to inflate their effectiveness numbers.
A Brazilian hospital chain tested unproven drugs on elderly COVID-19 patients without their knowledge as part of an effort to validate President Jair Bolsonaro's preferred 'miracle cure,' a lawyer for whistleblowing doctors told a Senate inquiry
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It never ceases to surprise me seeing this kind of thing making it to the top of the
@nytimes
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It’s unbelievable that we’re even talking about this
Our new map shows polio vaccination rates for NYC children 6 months to 5 years old. According to our data, 13.8% have not been vaccinated against polio. Polio is highly contagious. The most important way to prevent polio is by getting vaccinated:
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Huge congrats to
@Arien_Schiepers
!! 🥳🎉 Making us all proud!
Breaking news! We're announcing the names of the six laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2023! 🏆
Congratulations to all awardees and honourable mentions! 🎉 1/
➡️
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Congrats to our postdoc
@CarlaTheNove
, newest faculty member at
@nyugrossman
! Looking forward to great work on the gut B cell response coming from the Nowosad Lab!
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More from the tireless
@Arien_Schiepers
!
I am very excited to share the final story of my PhD, online now as a pre-print in
@biorxivpreprint
, where we dissect the opposing effects of antibody-feedback and memory T cell help on recall germinal centers (GCs). 1/n
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Kiss-and-run interaction
Sharing two new preprints using Labeling Immune Partnerships (including this one pictured
@victoralab
), or LIPSTIC technology, to identify DCs that prime CD4 T cells in two very different immune settings (a long🧵 1/n)
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This work was piloted by
@Arien_Schiepers
, in collab with
@PaulBieniasz
and
@jbloom_lab
labs, together with
@MarijevtWout
@AllieGreaney
@LukaMesin
@tylernstarr
and others. Also thanks to Norbert Pardi (U.Penn) and
@AcuitasTx
for custom-made mRNA-LNPs.
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Applications still open for the
@RockefellerUniv
's Exceptional Scholars Workshop, aimed at providing mentorship and leadership development for postdoctoral scientists of diverse and disadvantaged backgrounds.
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We miss Jony dearly, and I like to imagine that he would be as happy as we are to see this out. We dedicate this paper to him and his family!
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Pesquisador do RS que recusou homenagem de Bolsonaro recebe prêmio máximo da ciência brasileira | Rio Grande do Sul | G1
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For the 2-photon aficionados, check out our (Juhee Pae +
@jotraceyja24
) newest review/personal perspective on how to we and others used tricks to extend the capabilities of classic 2ph microscopy to image the germinal center at ≠ time scales.
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Chinese COVID-19 vaccine maintains protection in variant-plagued Brazil | Science | AAAS
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We apply this system to various settings, from simple hapten-carrier model antigens to SARS-CoV-2 Omicron boosts, passing through the original strains based on which T. Francis Jr. described the OAS concept.
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Congrats
@florsheim_eb
, looking forward to some amazing work!
2/ Awardee
@florsheim_eb
tackles a bold hypothesis linking dietary toxins + food allergies, which may uncover how neuroimmune interactions defend against harmful toxin-induced diseases. We're excited for what you'll discover! Congrats Dr. Florsheim!
@ASU
🙏
#HFScout
@victora_lab
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Finally, we dedicate this paper to Jonatan Ersching, brilliant postdoc and great friend, who we lost just last month. Jonatan’s early work on this study was key to getting it off the ground, and we will be forever thankful. We miss you Jony!
8/
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How to destroy an outstanding vaccination program
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Dados importantes para o Brasil, via
@VirusesImmunity
e
@carolilucas
. Sugerem que uma quarta dose da vacina da pfizer pode ajudar quem já tomou 2x corona e 1x pfizer a se proteger melhor da ômicron.
CoronaVac is an inactivated SARS-CoV-2 vaccine approved for use in 48 countries. In collaboration with the Ministry of Health in Dominican Republic, we tested whether CoronaVac (2x) + Pfizer booster induces neutralizing Abs to Delta and Omicron. (1/)
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Thanks to
@ircm_mtl
for hosting me, great time discussing science with you all. And very special thanks to the many trainees that showed up to the talk!
A fascinating conference ahead: on May 16 we welcome Gabriel D. Victora from
@victora_lab
, Laboratory of Lymphocyte Dynamics at
@RockefellerUniv
to talk about "Clonal and cellular dynamics of the antibody response"
#DrivenByLife
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