Delighted to share the preprint of our latest work: 👆Therein we describe the engineering of a new CRISPR-based method that functions in eukaryotic cells, Transcription-associated Cas9 Targeting (TraCT). Summary 🧵 below [1/9]

Proud to present, "Engineered transcription-associated Cas9 targeting in eukaryotic cells", #CRISPR #research online now @NatureComms via @SpringerNature: Grateful to all co-authors and other contributors! Main text PDF shortcut:

RT @dbikard: 1/ 🧵 Thrilled to share work of @EligoBio just published in @Nature ! We show proof of principle results of efficient base edit…

RT @dbikard: 15 years after doing my PhD on integrons with @amazeld, I'm thrilled to see my old and new interests united with the exciting…

RT @stephentang23: I am delighted to share the newest work from the @SternbergLab, in which we discover RNA-templated gene creation as a me…

RT @amer_hossai1: Excited to share my latest work from the @MarraffiniLab, in collaboration with @PhoebeARice, now online @Nature!! https:…

@jakob_tr Excellent sleuthing! Long wondered if the 81bp deletion in “xis” (now ith-2) from the -S2 mutant of NM4 arose in-frame to preserve a function, given no obvious induction/plaque phenotypes(. Perhaps the remaining N-term of ith-2 sufficiently inhibits Tha-2?

RT @SternbergLab: New pre-print from the Sternberg Lab! Transposon-encoded nucleases (TnpB/IscB) gave rise to the CRISPR-associated protein…

RT @DarkMatterDNA: Our latest work now in @Nature. Check out what else we're doing at

RT @jwmodell: Check out our new paper showing how CRISPR-Cas9 systems fight back against phages with anti-CRISPR proteins!

Major thanks all around to the @JefBoeke and Noyes lab folks who contributed to this work!! Check out the preprint for many more details! [9/9]

RT @norapyenson: Can the simplest living things coexist 🏘️ in the face of competition? We found that bacterial viruses (phages) could eas…