Stephen Tang
@stephentang23
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MD-PhD student @ColumbiaMed | @SternbergLab | Gene editing and RNA biology
New York, NY
Joined June 2020
Thrilled, and also in a bit of disbelief, to see our paper featured on the cover of @ScienceMagazine! "Finding Neo" wasn't easy, but we just kept swimming (read: stared at a sequence of DNA) until the Eureka moment hit.
The central dogma of molecular biology states that genetic information flows from DNA and RNA to protein, with reverse transcription converting RNA to DNA. In the pursuit of understanding how bacteria defend themselves from viral infection, two groups have found alternative pathways to making genes from RNA that did not previously encode proteins. Learn more this week in Science:
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@srviswanathan @NatMetabolism @LironBarPeled @DanaFarberNews @jiaoli43141960 @Sadagopan_A @DrPrateekKhanna @YasminLaimon @Cary_Weiss @m_achom @DrChoueiri @LabSignoretti @DanaFarber_GU Congrats Srini, Jiao, and the whole team!
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Thanks to @IlyaOsterman and @SorekLab for beautifully highlighting our recent paper! And congratulations to @maxewilkinson and @zhangf on their paper, which nicely agrees with and complements our findings.
Tricking phages with reverse transcription @IlyaOsterman summarized the beautiful discoveries from the labs of @SternbergLab and @zhangf, who showed how bacteria defend against phages by expressing a protein that is not really encoded in their DNA
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@fdemiguelsdp @ScienceMagazine Hey Fernando, great to hear from you! Thanks and hope you're doing well!
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Congratulations to @srviswanathan and all authors on their new study, which uncovers a genetic basis for sex differences in tRCC!
Our study on sex differences in Xp11 translocation renal cell carcinoma is out @CellCellPress! We ascribe a genetic basis to the female bias in tRCC, which is driven by a translocation of the TFE3 gene on the X chromosome. w Zhang lab @danafarbernews 🧵1/
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RT @ScienceMagazine: Researchers report in Science that infected bacteria surprisingly fight back with “hidden” genes that halt cell growth…
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Huge thanks to all co-authors for their contributions! And in case you missed the news, @shsternberg was just named an @HHMINEWS Investigator, which means the lab is hiring and gearing up to tackle a new wave of high-risk, high-reward projects. Reach out to Sam if interested!
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Congratulations to @shsternberg on being named an HHMI Investigator — a tremendous achievement appropriate for a tremendous mentor and scientist!
⭐️ Big news! HHMI is investing $300+ million in 26 new #HHMIInvestigators from 19 US institutions. These top scientists will drive groundbreaking research in diverse fields, from neuroscience to immunology to structural biology & beyond. Welcome to HHMI!
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Congratulations to @rzedaveinyte on her new article out today in @ScienceMagazine! It's a beautiful story about a single RNA molecule that wears many hats, from mRNA to self-splicing intron to guide RNA.
We're excited to see our recent work on multi-functional transposons now in press. Nucleases and guide RNAs and catalytic introns, oh my! See the links and original thread below, for more...
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When it comes to mobile genetic element biology, anything is possible - including RNA-guided transcription factors. Congrats to lead author @TannerWiegand on a beautiful new story, out today in @Nature!
Check out the latest story from the Sternberg group: phages coopted transposon-encoded nucleases (TnpB) and repurposed them for regulation of host genes! Thrilled to see this work in print, & a huge thanks to my amazing co-authors!!
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RT @MDMlab_Paris: New preprint: In a fun collaboration with the @SternbergLab, we reveal the evolutionary origin of eukaryotic RNA-guided R…
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Congrats to @zwalsh96 and @BizarMd on their work developing a powerful new base editor screening approach to identify T cell variants with improved anti-tumor activity!
Very happy to share some of my PhD work, published yesterday in @NatureBiotech. Especially thankful for truly exceptional mentorship from my PI, @BizarMd, who encouraged me to leverage powerful gene editing tools to ask some exciting questions bridging immunology and genetics
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Many thanks to @ewencallaway @nature for highlighting our recent work on a reverse transcriptase that creates de novo genes!
“This is crazy molecular biology. I would have never guessed this type of mechanism existed” Bacterial defensive systems scramble the standard workflow of life
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