Sternberg Lab
@SternbergLab
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Sternberg Lab at Columbia University
New York, NY
Joined October 2017
@dbikard Thanks David! And congrats on the in situ base editing study from a few days back... it was immediately shared and discussed around the lab Slack!
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Check out our latest work now 'in print,' on an evolutionary path -- parallel to CRISPR-Cas -- that led to the recurrent emergence of RNA-guided transcription factors. A great piece of detective work led by @TannerWiegand, with major contributions from many others in the lab!
Check out the latest story from the Sternberg group: phages coopted transposon-encoded nucleases (TnpB) and repurposed them for regulation of host genes! Thrilled to see this work in print, & a huge thanks to my amazing co-authors!!
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We would have never guessed this mechanism either, and we continued to question it until the data convinced us beyond a reasonable doubt! Thanks to @ewencallaway for featuring our recent preprint on an antiphage immune system that turned out to be a molecular biology playground.
“This is crazy molecular biology. I would have never guessed this type of mechanism existed” Bacterial defensive systems scramble the standard workflow of life
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In a new preprint from the lab, @stephentang23 et al uncover a remarkable mechanism of antiviral immunity mediated by bacterial reverse transcriptase enzymes. Check out the thread below for more!
I am delighted to share the newest work from the @SternbergLab, in which we discover RNA-templated gene creation as a mechanism of antiviral immunity. This is a story for anyone who loves molecular biology, and one that repeatedly left us in disbelief.
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What's neat is that, using a bioinformatics approach, Han @altaetran et al. recently found putative examples of even more TnpB domestication events, including associations with transcriptional activators! Maybe we'll need a new name for those 😁
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