Joshua Modell
@jwmodell
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Assistant Professor of Molecular Biology and Genetics @ Johns Hopkins School of Medicine
Baltimore, MD
Joined September 2014
RT @NatureMicrobiol: OUT NOW š¦ Prediction of strain level phage-host interactions across the Escherichia genus using only genomic informatiā¦
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RT @alexjmeeske: Many bacteria have >1 CRISPR system, and they affect each other! @shallymarg found a 3-way interaction that leads to primeā¦
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Cas proteins in disguise?? Halloween came early this year! šš„ø
The final version of our paper on anti-CRISPRs "in disguise" as Cas proteins is out today in Nature! Congrats to Mark, Edith and the whole team!
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RT @SternbergLab: We're excited to see our recent work on multi-functional transposons now in press. Nucleases and guide RNAs and catalyticā¦
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RT @NilsBirkholz: šš» I'm absolutely glee-ridden to finally see our study on the RNA- and DNA-binding anti-CRISPR repressor Aca2 published iā¦
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Marieās paper is out! We previously showed that Cas9 represses its own promoter to avoid autoimmunity. Marie now shows that this repression generates a mutant subpopulation of CRISPR-Cas overexpressors that expand and contract in response to phage pressure.
OUT NOW š A dynamic subpopulation of CRISPRāCas overexpressers allows Streptococcus pyogenes to rapidly respond to phage @marie_stoltzfus @jwmodell
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RT @stephentang23: I am delighted to share the newest work from the @SternbergLab, in which we discover RNA-templated gene creation as a meā¦
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RT @jrpenades: Led by @jakob_tr and @quiles_nuria, with @lasa_lab, we show that prophages utilise noncontiguous operons to balance immuniā¦
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Really beautiful work describing the gatekeepers of phage nuclei!
New preprint from the lab, led by outstanding student Claire Kokontis! (@CKokontis) In this work Claire et al. discover Imp1-Imp6, phage proteins required for the selective import of proteins into the jumbo phage nucleus! Imp1 (below) is the special one.
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RT @joeBondyDenomy: The phiKZ jumbo phages build a protein based nucleus to protect their DNA(!), but what do they do before the nucleus isā¦
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RT @mike_tilapia: Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximitā¦
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RT @RockLabTB: Ever wonder why drug-resistant Mycobacterium tuberculosis is less fit than drug-susceptible Mtb? And how the bacterium can eā¦
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