Yuancheng (Ryan) Lu
@Y_Ryan_Lu
Followers
5,196
Following
1,036
Media
82
Statuses
459
I study the biology of aging and its reversal | @LSRFdtn & @AFARorg postdoc at Whitehead-MIT in @JswLab | Biomed PhD @Harvard in @DavidaSinclair lab
Cambridge, MA
Joined July 2013
Don't wanna be here?
Send us removal request.
Explore trending content on Musk Viewer
Sánchez
• 1357785 Tweets
THE LOYAL PIN THE KEY WITNESS
• 749845 Tweets
El Rey
• 621896 Tweets
Paiporta
• 492974 Tweets
ベイスターズ
• 391315 Tweets
#BrazilGP
• 271314 Tweets
Chelsea
• 233256 Tweets
横浜優勝
• 231808 Tweets
Senna
• 188891 Tweets
Reyes
• 172243 Tweets
Franco
• 167211 Tweets
Hamilton
• 166782 Tweets
Colapinto
• 114251 Tweets
Norris
• 113911 Tweets
Verstappen
• 111170 Tweets
Manchester United
• 102994 Tweets
Casado
• 62643 Tweets
Stroll
• 62348 Tweets
Trabzonspor - Fenerbahçe
• 62039 Tweets
#BrazilianGP
• 60912 Tweets
Espanyol
• 57343 Tweets
TIMELESSLY WITH JAEHYUN
• 52357 Tweets
#MUNCHE
• 49298 Tweets
Hakem
• 45891 Tweets
推しの日
• 44068 Tweets
Sainz
• 40094 Tweets
#TSvFB
• 35250 Tweets
Dani Olmo
• 31099 Tweets
Ocon
• 29302 Tweets
Faul
• 28090 Tweets
Mert
• 26459 Tweets
Ozan
• 19343 Tweets
Garnacho
• 18231 Tweets
Rashford
• 17404 Tweets
Ugarte
• 15631 Tweets
Solanke
• 15320 Tweets
Caicedo
• 13836 Tweets
Alpine
• 13344 Tweets
Pinned Tweet
My PhD work from
@davidasinclair
lab with our amazing collaborators has come out today, indicating that in vivo reprogramming can recover the youthful epigenetic information within injured or aged cells and allow optic nerve regeneration and vision restoration. Feeling blessed!
A Nature paper reports that neurons in the eyes of mice can be reprogrammed to a more youthful state in which they re-acquire the ability to regenerate and restore vision.
9
147
646
50
83
683
It feels bittersweet to finish my last week in
@davidasinclair
lab. I was so lucky to find this dream match in the 4th rotation and start an incredible 6y journey with some low lows and high highs🍾. Now onto the next chapter with
@JswLab
to keep learning and growing💪. Excited!
16
4
297
Happy 52nd birthday to my PhD mentor
@davidasinclair
who still looks like in his 30s and probably never wasted a minute, even at a Friday night before his birthday. Thanks for being an inspiration to me, and maybe to the little boy in the back as well 😁
4
3
254
I became Dr. Lu on May.4th.2020 🎓Feel blessed.
#HarvardPhD
#Sinclairlab
#AntiAging
#InVivoReprogramming
19
1
197
Beautiful
@NEJM
illustration and review of our work
@nature
on age reversal and vision restoration.
@davidasinclair
@Harvard
3
29
158
Delving into our newly released result, a thread:
Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma: A year-long functional tracking of in vivo partial reprogramming demonstrates safety and efficacy. Work from
@margaretekarg
@YuanchengLu
@davidasinclair
@bruce_ksander
2
7
52
12
20
115
Interesting in vivo reprogramming paper, the effect is predominantly driven by Myc (Sup.Fig1 and …), but OSK was needed to rejuvenate the heart and unleash the Myc driven effect. Heart seems even harder to regenerate than neurons!
7
25
102
I am a huge fan of Elon, but disagree with him on this one. There is no reproduction incentive for fruit flies to evolve a longer lifespan. And none of previous breakthroughs in our healthcare was targeting aging. We need one to explore outer space - I am optimistic about it.
11
3
99
2yrs ago on this date, I had the 1st big result in my career. It was one ray of light shed on me after 4yrs of darkness/struggle in PhD. I celebrate this date as an anniversary. It reminds me to keep humble, and remember the unmatchable joy of making discoveries when exhausted.
6
0
86
This unifying piece of “The Information Theory of Aging” took us 3 years to craft, with valuable input from reviewers & editor
@NatureAging
. Thrilled to share it today! Check out David’s thread and grab a free copy:
3
12
75
It is really exciting time for rejuvenation research. The field is blooming.
6
4
79
Dear Michael, I still cannot believe you have gone from us this suddenly. You are the most generous person I have met, you are like my second dad. You trained me into the scientist I am today, I can only pass on your legacy. I love you Michael!! Rest In Peace🙏
5
1
70
A very cool tool for epigenetic editing!
Introducing CRISPRoff: a new, reversible CRISPR method that can control gene expression while leaving the underlying DNA sequence unchanged. Designed by Jonathan Weissman
@JSWlab
,
@jamesknunez
,
@LukeGilbertSF
, and collaborators. Read more:
2
27
101
0
7
69
The discovery of nerve regeneration was on Jun.28.2018, only a little less than five years ago. Still remember the feeling in the microscope room vividly. Great efforts from
@lifebiosciences
@MGH_RI
team, now it’s one step closer to clinic to help patients🤞
Epigenetic reprogramming is a new frontier. This day comes after many years of work by
@lifebiosciences
,
@MassEyeAndEar
& my lab
@harvardmed
to develop safe age reversal technologies to reset old, damaged tissues. Image: mouse nerves regrowing (Lu, 2020
@Nature
) 4/
7
30
328
6
7
52
Glad to see this new preprint from
@rejuvenatebio
using the same strategy we reported previously - dual AAVs to express OSK - to achieve lifespan extension in 2y-old WT mice without any teratoma observed: remaining lifespan was DOUBLED🤩
3
12
53
What can I say besides THANK YOU!
@nature
@TeeHeemels
@davidasinclair
@harvardmed
& our artists, collaborators.
4
0
51
In this article we highlighted the potential of harnessing epigenetic reprogramming to treat a leading cause of irreversible blindness- Glaucoma. with
@davidasinclair
& Meredith Ksander & Bruce Ksander
Could reversing the age of RGCs restore youthful function that would rescue vision lost because of
#glaucoma
? A recent study sought to answer this question.
1
15
93
1
15
51
Deeply honored to be selected as a
@LSRFdtn
fellow and congrats to other awardees. I am grateful to the generous support from my sponsors and amazing mentors
@davidasinclair
@JswLab
@bruce_ksander
&Zhigang He, and my colleagues who kindly helped along the way!
Finally! It's been hard to keep this under wraps until August 1st. We are excited to announce our 2022 awardees. Our entire current awardee group is listed on our website:
#lifescience
#postdoc
#earlycareer
#funding
#basicresearch
,
#postdocfunding
,
#award
3
11
50
10
2
48
Something we’ve been waiting for.
Our new article reveals that gene therapy-mediated partial reprogramming extends lifespan and reverses age-related changes in aged mice, showcasing lifespan extension in wild-type animals through in vivo reprogramming.
@eskamoah
@cc_biology_
@rejuvenatebio
12
59
209
2
5
44
Remembering Michael in a talk at CSHL “Mechanisms of Aging” conference has been on my To Do List the past two years. Today I crossed off this task. ps: That was him presenting in the same conference room in the first pic.
4
3
44
And we were fortunate to have our paper featured on the cover, and accompanied by a News & Views from
@hubermanlab
0
4
40
9 years since mCiPSC: hCiPSC.
2
10
41
Is ending aging possible? I guarantee you won’t be disappointed by this book “lifespan” from my mentor/great aging scientist
@davidasinclair
and the talented writer
@mdlaplante
. Huge honor for me to be a part of it. Here is the link to order
2
3
38
A touching msg today from a girl who suffers congenital glaucoma: she got abandoned and then adopted to US, got treated & became a science writer, but she still couldn’t drive etc. She has been waiting for a restoration therapy for life. Stories like this fuel me when exhausted.
2
2
37
One ray of light after four years of darkness, end up with this prerprint. Thanks to all my great co-authors/labmates, especially my PhD mentors Michael Bonkowski and
@davidasinclair
, also my dear family and wife. This is a start.
Reversal of ageing- and injury-induced vision loss by Tet-dependent epigenetic reprogramming
#bioRxiv
1
8
25
2
7
32
It was great honor to meet 2012 Nobel Laureate Shinya Yamanaka, who invented the method to generate iPSC. I showed him our paper and briefly described the story, he was impressed and very interested in the potential of in vivo reprogramming:
1
4
32
Super excited to see the launch of Nature Aging. It will definitely encourage more brilliant minds getting into this field.
We're excited to launch
@NatureAging
today! The content of our first issue, "Aging in Unity", reflects the diversity of all communities working on aging: biologists, clinicians, social scientists, civil society and industry. Free to access for all here:
2
146
426
0
5
32
This supports that the rejuvenation happens first during reprogramming, and is separable from the pluripotency: even the cells get over-reprogrammed and lose cell identity transiently, no worry! They can regain their identity and get an even greater extend of rejuvenation.
1
7
30
Visited
@salkinstitute
@scrippsresearch
at the end of 2022, a trip overdue for 2.5 yrs. 2023 is a new start 🙏 ps: pointing at lab space of two great scientists I favor
@ardemp
@xinjin
in photo 2.
3
0
31
Proud to join the Editoral Board of Cellular Reprogramming and run its Twitter account in my spare time! Give it a follow to keep up with reprogramming related research!
Hello Twitter World! We are officially here. Stay tuned for all the exciting research and event update related to Cellular Reprogramming, arguably the most fascinating process in biology😉
1
1
11
1
1
29
To our surprise, extending the OSK treatment to 8 weeks fully restored the once lost vision in glaucomatous eyes, and this was also achieved with a Dox-induced AAV version that is clinically favorable.
1
0
25
Great and fun time ahead in this exciting field. Congrats to everyone involved including my co-authors Steve Horvath and
@DrMorganLevine
!
With today’s launch of Altos Labs, we celebrate this community of leading scientists, clinicians, and industry leaders. We are excited to pursue cellular rejuvenation programming to restore cell health with the goal to reverse disease.
29
136
666
0
0
23
“Our ability to make the most out of uncertainty is what creates the most potential value.”
0
0
25
Congrats to
@davidasinclair
and
@mdlaplante
, the Chinese version of Lifespan is out and becoming super hot! Great popularization for aging science. Friends were reading it before I knew it. The translation is well-done!! How did they even figure out our Chinese name correctly?😄
1
2
24
Game changer for DNAm clock analysis. Work from my previous baymate
@patrick_griffN
at
@davidasinclair
lab🎉
0
2
23
Congrats on the paper and the beautiful cover!
@AlexandreTrapp
@gladyshev_lab
Our December issue is live! Read about conferences in 2022,
#longevity
-ready cities,
#senolytic
vaccination,
#COVID
-19 and mental health,
#telomeres
and
#AD
, muscle
#regeneration
, a new approach to estimate
#epigenetic
age in single cells and more
2
30
98
1
1
24
First Whitehead retreat at Waterville since pandemic. Gorgeous place and a lot of cool science.
1
2
21
My first ARVO meeting is full of fun. Many exciting sciences and new friends. See you all at Seattle next year.
#ARVO2023
1
2
20
🙏
0
0
20
Congratulations! Proud of my first intern student Doudou. Well-deserved.
✨Big news!✨
@BrownMolBio
student Doudou Yu was just awarded a prestigious F99/K00 from the NIA to continue her work on hypothalamic aging. Congratulations Doudou on this well-deserved award!🎉⭐️🧬
7
4
86
0
1
21
Q: What’s the secret of productive research from Boston? A: Scientists don’t have much else to do in winter. 😂Wisdom from
@pdhsu
, I see no lies.
2
0
20
My PhD work with
@davidasinclair
, Zhigang He,
@bruce_ksander
and colleagues utilized dual AAVs to express OSK, effectively rejuvenating retinal ganglion cells and restoring 40% of lost vision after one month of treatment in microbead-induced glaucoma: .
A Nature paper reports that neurons in the eyes of mice can be reprogrammed to a more youthful state in which they re-acquire the ability to regenerate and restore vision.
9
147
646
4
5
19
I am extremely lucky to have great mentors like
@davidasinclair
and late Michael Bonkowski during my PhD. Forever grateful.
@PoHienEar
@nature
@YuanchengLu
Thanks Po. I'm so very proud today of
@YuanchengLu
, our lab members, and our world-class collaborators
2
1
15
0
0
20
This daylight saving thing makes so much sense. Can we just stick with it and not switch back ever?
1
0
19
A chance to educate and influence 1.4 billion people, how exciting!
LIFESPAN: Mandarin edition. When Matt and I released Lifespan, just before the pandemic, our predictions — aging as a disease, emergence of a new virus, telehealth, home testing, biosensors, age tests & age reversal — were merely predictions. Not anymore. What’s next? Lifespan 2
35
60
624
1
0
19
Had fun representing
@davidasinclair
lab, to share what we have achieved to our Harvard colleagues.
3
1
17
Will always brought us HEAT fans joy and energy, and we were lucky to have him by our side at our favorite life moments! A kind and special human being! Great to meet you again at HOF.
Remember this couple from China who credits their love of Dwyane Wade for help bringing them together? They surprised him at his Legacy celebration with their son named after him Raymond Wade.
Well, they came to his HOF enshrinement. Little Raymond Wade is growing up fast ❤️
5
57
550
1
1
19
My student caught me dancing on the chair. Yea there was some good news today.
1
0
17
We previously reported
@Nature
the acceleration of the aging in mouse retina neurons due to trauma injury. Dr. Joe Rizzo,
@MadhuraShah2
,
@DrenusheKV
, and us delved into supporting human clinical cases and the potential of epigenetic rejuvenation to treat various nerve injuries.
The Role of Epigenetics in Accelerated Aging: A Reconsideration of Later-Life Visual Loss After Early Optic Neuropathy
0
1
6
2
5
18
Comprehensive paper from Serrano group and
@ReikLab
, showing that one week of OSKM induction in 1y-old-mice rejuvenates DNAm and transcription patterns in multiple internal organs and even restores several serum metabolites.
#invivoreprogramming
0
10
15
So impressed! Great summary and discussion for our paper, worth a look if interested.
In my latest video I cover the eye-opening ;) study by
@YuanchengLu
at the
@davidasinclair
lab --> Reversing aging through cellular reprogramming!? via
@YouTube
#epigenetics
#aging
#longevity
#scicomm
#AcademicYouTube
4
7
33
0
2
17
This study spanned several years and owes its completion to the collective efforts of the team. Kudos to all co-authors for their significant contributions!
1
0
17
@davidasinclair
@gofundme
Dear Michael, I still cannot believe you have gone from us this suddenly. You are the most generous person I have met, you are like my second dad. You trained me into the scientist I am today, I can only pass on your legacy. I love you Michael!! Rest In Peace🙏
0
1
15
Aaron, I am impressed by your understanding of our research at this age, you got the big picture, better than I was 15. Keep up the good work! Typo: Sox2 not Sox3
2
1
16
Today marks 1y since Michael’s passing. In memory of him, yesterday we went to Winthrop, his favorite 🎣 place, and eat at where he enjoyed getting takeouts. I am proud we have gone through this year together while carrying precious memory of him. He is forever in this way.
Dear Michael, I still cannot believe you have gone from us this suddenly. You are the most generous person I have met, you are like my second dad. You trained me into the scientist I am today, I can only pass on your legacy. I love you Michael!! Rest In Peace🙏
5
1
70
0
1
16
These two methods will be nicely complementary to each other.
Sorry senolytics, "reprogramming" is officially the shiny new object in geroscience. You had a good run.
9
3
97
9
0
14
Terrific effort by
@MartinBJensen
and
@LNuzhna
and others to support aging research in a paradigm shifting way! Please consider donating!
0
3
15
So yea this was us waiting in the line out of the now famous Rm 257, after police kicked out the standing audience. We actually got in before talk of Juan Carlos and met up finally. Encouraged to see epigenetic rejuvenation topic is attracting brilliant minds. A memorable
@ISSCR
!
0
0
15
Such great news for Science and Humanity! My son witness his first, and the most important election in history.
#PresidentElectJoe
0
0
14
Michael, I know you must be incredibly proud today up there. I can smile thinking that our Nature completes your CNS journal collection. Miss you a ton bro.
Dear Michael, I still cannot believe you have gone from us this suddenly. You are the most generous person I have met, you are like my second dad. You trained me into the scientist I am today, I can only pass on your legacy. I love you Michael!! Rest In Peace🙏
5
1
70
0
0
15
I am willing to review papers, folks in aging and eye research community
@aginghighlights
and editors at
@NatureAging
@AgingCell
@NeuroCellPress
@Cell_Metabolism
@NatureComms
@GlaucomaOrg
, please reach out.
0
0
14
Few questions remained to be answered: 1. What’s the maximum extent of recovery that can be achieved? 2. How long is vision improved by continuous OSK? 3. How stable is a single cycle of in vivo reprogramming?
1
0
14
@realNathanCheng
@KKajderowicz
@OnDeckLongevity
@michellebkwok
@adanguyenx
@janechuprin
@ArtirKel
Why not? Haha. What time on Friday?
2
0
13
My colleague, collaborator and dear friend Xiaojie has been a great inspiration to me! So proud of you Xiaojie! Consider joining his lab if you are interested in machine learning, single cell, and spatial genomics 🚀
I am profoundly humbled and excited to officially announce that I will start my independent lab at Stanford this Dec. 16th. Growing up as the son of farmers in a remote village in China and facing the loss of my father at an age of 10, this journey has been anything but easy.
188
145
3K
1
0
13
Proud of my ex-intern student
@doudou_yu_
, who played a critical role in our nerve regeneration discovery, now had her first author paper from
@TheWebbLab
featured on Nature Aging. Congratulations!🎉
Interested in how the hypothalamus ages? Check out our new study in
@NatureAging
. HUGE congrats to co-authors
@KHajdarovic
and
@doudou_yu_
!
5
37
170
0
0
13
Congratulations
@patrick_griffN
!
Our latest paper is out - a new method called "TIME-Seq" to measure biological age for just a few dollars. Great work Patrick Griffin!
@NatureAging
Free download
37
148
812
0
0
13
@dhakal_rasik
@davidasinclair
Great question, more work is needed, but here is our hypothesized mechanism: In the presence of OSK, the PRC2 complex recruits TET to specific sites (e.g. H3K27me3 enriched) in the genome and induces active demethylation, while adding methylation by DNMTs should be involved too.
0
3
12
It highlights the therapeutic potential of rejuvenating gene therapies using OSK, not only for glaucoma but also for other ocular and systemic injuries and age-related diseases.
2
0
13
Delighted to announce the Arc Institute
@arcinstitute
, a new, independent scientific institution dedicated to the study of complex human disease. Working with our partners
@UCBerkeley
@Stanford
@UCSF
, our mission is to accelerate progress in biomedical research and therapeutics.
78
173
1K
0
0
12
We are confident this improvement is not due to spontaneous vision recovery as this glaucoma model has been widely used and no observation of recovery was observed. We then continued monitoring the AAV-treated groups.
1
0
12
To address these, led by
@margaretekarg
and
@bruce_ksander
, partially funded by
@lifebiosciences
, we conducted to our knowledge the first year-long functional tracking of in vivo reprogramming with either continuous OSK or cyclic OSK in RGC, reading by an objective vision assay.
1
0
11
Wisdom from Nobel Laureate “Most great discoveries start with an unexpected result and a receptive mind.”
0
2
11
The GoFundMe page for helping Michael’s family. He has two young sons just lost their dad.
0
0
11
Blessed and thankful🙏
Raymond Wade Lu meet
@DwyaneWade
.
This baby was named after D-Wade and they got to meet ❤️
62
1K
10K
1
0
11
Held Spark for 7 months, sold all I have two weeks ago at $48. Now the stock could be double Monday. Lesson: Believe in what you believe and never doubt. Easy to say but hard to do.
1
0
11
This was the NC paper I tried to cite:
0
0
11
Finally someone tested if GHR KO in adult still extends lifespan. Looks like the lifespan benefit of messing up GHR/IGF-1 pathway is mostly awarded at early age. The trade off was to have a smaller body size and it doesn’t seem appealing in this society.. Better solution needed!
More notable result is that GHR KO at 6mo does NOT extend
#lifespan
in male mice, and effect in females is much smaller than from-birth mutation.
Different explanations possible, but one is that biological wiring during development drives much of the GH effect on lifespan.
2
2
30
2
3
11
The DOX inducible AAVs were profiled by Nasrin Refaian; after DOX withdrawal, it takes about 4 wks and 6wks respectively for OSK mRNA and protein to go away.
1
0
10
You can’t miss this awesome book about aging! I have seen how hard
@davidasinclair
@mdlaplante
working on it. Hug congrats! I need you two signing a copy for me.
2
0
10
Together with our other results
@nature
, these results indicate that the eye, particularly in the context of this glaucoma model and retinal neurons, represents an
ideal system and condition to evaluate the efficiency and safety of novel interventions to rejuvenate tissues.
1
0
10
This is wonderful.
Please RT!
Putting our 💰 where our mouth is, Norn Group is launching a new program to help talented foreigners reach the US and contribute to
#longevity
research. We need a half/full-time Ops lead to plow through obstacles. Apply here (more info below):
3
31
86
0
0
10
A method enables simultaneous analysis of single-cell lineage, gene expression, and spatial organization in the same tissue! Congrats for this beautiful work.
So excited to share our publication today! Working with the awesome
@markwbudde
, A. Granados, and other brilliant minds in the
@ElowitzLab
, Lois Lab, and
@LongCai_Lab
, we developed a synthetic recording system to image single cell lineage history.
9
79
341
0
2
9
This one hit many of us hard. Jay was one of my favorite scientists in the aging field since our first interaction 5yrs ago. He taught me a class on mechanism of aging and gave me advice anytime I need, including one just before his relocation. We lost a great great soul today.
Can’t believe it. Our buddy, Jay Mitchell, a young professor who helped figure out why fasting is healthy & how to treat rare diseases in kids, just passed away. A huge loss to the aging field. I’ll miss you, man.
78
23
653
0
0
9
Wonderful recognition but not surprised. Proud of you Kat!
Extremely grateful to be chosen as a 2023
@PDSoros
Fellow!!!
Thank you to my amazing science mentors across career stages!
@MIT
(
@mitbrainandcog
+
@WhiteheadInst
):
@Hrvatin_Sinisa
/
@JSWLab
/
@YuanchengLu
/
@HeatherKPhD
@Harvard
:
@_emmarosewest
/Connie Cepko
@Cornell
:
@CornellBirds
40
15
244
1
1
8
Congratulations
@AndreaCipr83541
@mahdi_moqri
@SunMaybury
Ryan Rogers Hammond,
@davidasinclair
& Vittorio Sebastien and all. A great summary and a beautiful piece to read.
Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
1
11
31
1
0
9
During my talk, I shared the scientific wisdom from James Watson.
0
0
9
That’s so exciting! I am sure I will be submitting one to it in the future!
Nature Aging is open for submissions!
Chief Editor: Sebastien Thuault
(unrelated, Picasso's self-portraits at different ages)
3
54
174
0
0
9
1. Ceasing OSK after 8 wks maintains improved vision at a level similar to healthy eyes for an additional two months before a slight decline. 2. Sustained OSK expression beyond 8 wks enhanced vision even more, which was maintained at a healthy state thereafter.
1
0
10
Literally in tears of joy right now. Fight through all stress and doubts from outside, sometimes even from ourselves, but keep standing straightly! Unreal feeling!
After all the hard work and repeated failures you experience as a young scientist, moments like this make it all worthwhile:
13
6
85
1
0
8