@DrMarkOng Gastric signet ring cell carcinoma?

@HENRYY_MD @RACARR51 @mccalmo @david_terrano @tonitatirado @MarcelaSaebL @et565 @DrGeeONE @kis_lorand @gonzadetoro @ChristineJKoMD @SGottesmanMD @VHNguyenMD @TristanRutland7 Follicular (infundibular) SCC

@drtimbracey @RaulSGonzalezMD @Pathoutlines @diagnexia @DrCycloPath @Vik_deshpandeMD @drkeithsiau @LizMontgomeryMD @RhondaYantiss @TristanRutland7 @DrMarkOng Fabulous demo of the pathology Tim, thx.

@STEVENKOLKERMD I see this nearly every day!

@david_terrano Thank you. Free to download too!

@DraEosina @drtimbracey @diagnexia @RaulSGonzalezMD @Pathoutlines @Pathmath1 @DrMarkOng @jansen_marnix @GIJamesMD @DrCycloPath @TristanRutland7 @Vik_deshpandeMD Do we know what the risk of malignancy is if we left these in situ after Bx?

@mismatchdef A strong contender...

@drtimbracey @LumirKunovsky @UEGJournal @my_ueg @WileyHealth @Y_ECCO_IBD @imedverse @DCharabaty @JosephHabibi_MD @joostphdrenth @HaoYin20 @Bealoquebea @juliomayol @stevenbollipo @ibdseb @MariettaIacucci @DVinsard @RogerFeakins But they have to get to the epithelium somehow, presume transiting through the lamina propria - relevance depends on the context. If looks like UC / CD on scope, the findings of LP neutrs could be supportive of disease activity - might be bad luck you are missing cryptitis etc.

@ArjunRamaiya1 Your image is beautiful; it is clearly sparing some suprabasal rete, and I wonder what you might call it if 'fully' confluent with similar atypia, no upward ascent or adnexal colonisation, but with PRAME positivity. Kossard believed lentig naevi of elderly = MIS if I'm correct?

@ArjunRamaiya1 I do hope they ask for further clarification 😆

@ArjunRamaiya1 @RishiAgraw21699 I think it can be quite difficult to know when budding + stromal reaction = (incipient) vs dermal invasion. Even more tricky when tumour has a pushing front in a superficial bx!

@drtimbracey @DrMarkOng @RunjanChetty @RahulADeb I recall TATs reducing in GI resections when we introduced them. Yes, great to look at but a really well described macro is fine for small blocks in complex cases. We seemed to manage before!!

@DrMarkOng @drtimbracey @RunjanChetty @RahulADeb I think this means someone doesn't have enough work to do!

@RACARR51 Are they periungual?

@ArjunRamaiya1 Fantastic example Arjun. Totally agree - incisional and punch are nonsense here

@dgbrackett Seen a few times and not sure what to call, so usually go for post-inflammatory polyp or similar.

@ArjunRamaiya1 Panfolliculoma.

@ArjunRamaiya1 I literally had a fab case of acantholytic dyskeratosis yesterday. It must be in the water Arjun!

@drtimbracey @drkeithsiau This position can cause issues during my Body Balance gym class

@RACARR51 Just seen the additional pics, which support SCCis!