A little learning is a dangerous thing; Drink deep, or taste not the Pierian spring: There shallow draughts intoxicate the brain, And drinking largely sobers us again. A. Pope If a little knowledge is dangerous, where is the man who has so much as to be out of danger? T. Huxley

RT @William28538949: Which of the following mutations is characteristically found in MEITL but rarely in EATL?

Bone marrow trephine from elderly patient with anaemia. Based on the megakaryocyte morphology, what's the diagnosis? #hemepath #pathology

RT @MirunaPopescu13: 40s F, gastric erythema. 🔬What's your diagnostic impression? What are some common etiologies of this injury pattern a…

Thank you @kriyer68 @SingJamieD @ThatGlassTho @prachipath123 @Margazhi_ta @PrasadCsbr @WakagothoK @DrHctorDeLosSa1 @vincenzopolizz7 @NeelamBeee @LeukocyteLuke

@Markie27070028 No, I haven't, but we don't routinely do MYC immunohistochemistry. All our aggressive B cell lymphoma get FISH, so IHC doesn't influence ultimate diagnosis. It's theoretically possible for IHC to be negative if MYC antibody targets epitope near translocation site.

RT @ziad_zaatari: 🔬 Glomangioma ~ Glomus cells (blue, round, uniform) with associated blood vessels ~ #BSTpath #Dermapath #Dermatology #Pat…

RT @javidiparsijani: Classic but exuberant scenario: HIV pos/AIDS patient with lymphadenopathy and pancytopenia: LN biopsy concerning for l…

RT @A_pathology_: Bone marrow sinusoids distended by hepatosplenic T cell lymphoma #PathTwitter #pathology #pathX #pathresidents #hemepath…

@krithik27724048 I don't know. They're not common cases and we generally don't use CK7/20 as it's usually assumed to be a primary gastric tumour.

@mhassanaimc @DrGeeONE @ADamronMD @fouad_boulos @kis_lorand @AGrabenstetter @RazaHoda @VickeryJasmine @Janiranavarro DCIS-like carcinoma? I don't report breast any more, but had a case like you described. Call it invasive.

@MeredithKHerman @MirunaPopescu13 @UMichPath Wouldn't CD68 highlight the sinusoids? Great case! Like a lot of diagnoses, it's obvious once you know the answer.

RT @MeredithKHerman: Soft tissue, abdominal wall, debridement: Hx: Non healing wound. This is what you see. How would you sign it out? Wh…

RT @doctor_oxford: And another one… this is beginning to look awfully coordinated… Nothing to see here, just the National Medical Directo…

@RibianszkyA @DanGrahamMD +1 for me

@drtimbracey @IHC_guy @Teclis82 Surgeon needs to turn down the diathermy!

@krithik27724048 A case with this appearance could be either EBV+ or mismatch repair deficient, so loss of MLH1/PMS2 in your case fits too.

Accounts for about 9% of gastric tumours in this paper by the Cancer Genome Atlas Research Network: