Bio-art of the finest sort. Klimt has nothing on Mother Nature.

@david_terrano @MarcelaSaebL @HENRYY_MD @tonitatirado @gonzadetoro @et565 @RACARR51 @kis_lorand @DrGeeONE @TristanRutland7 @SGottesmanMD @pepeheffernan @Dermpathl Including some places in which you wouldn’t even think much fat was around

@HENRYY_MD @RACARR51 @david_terrano @tonitatirado @MarcelaSaebL @et565 @DrGeeONE @kis_lorand @gonzadetoro @ChristineJKoMD @SGottesmanMD @VHNguyenMD @TristanRutland7 Agree def not verrucous carcinoma

@HENRYY_MD @melanopath @david_terrano @et565 @MarcelaSaebL @DrGeeONE @kis_lorand @gonzadetoro @VHNguyenMD @TristanRutland7 @SGottesmanMD Hey Hongyu this tumor has been irritated by all the genomic aberrations inside it. You’d be irritated as well if you had whole body genomic instability

@MarcelaSaebL @RACARR51 @HENRYY_MD @TBrennster @SGottesmanMD @gonzadetoro @JCGarcesPath @kis_lorand @david_terrano @DrPascalMeier throw an RB on it

@HENRYY_MD @Dr_Jukic @HoustonArsenal @DanGrahamMD @TristanRutland7 @TBrennster No it does not

@HENRYY_MD @et565 @melanopath @MarcelaSaebL @david_terrano @gonzadetoro @Dermpathl @tonitatirado You just blew my mind HY

@et565 @HENRYY_MD @melanopath @MarcelaSaebL @david_terrano @gonzadetoro @Dermpathl @tonitatirado We are talking about a hypothetical about something that can’t happen, so I think my best answer is to say sure. If you find a perfect MYO5A and it’s p16 absent, send it to me. Or better yet we can write a paper about it.

@et565 @HENRYY_MD @melanopath @MarcelaSaebL @david_terrano @gonzadetoro @Dermpathl @tonitatirado First of all, it couldn’t happen. Because a MYO5A can’t really do that. But, if it was partially MYO5A and then had a p16-neg blob in there somewhere, then the dx would be Spitz melanocytoma arising in a MYO5A.

@HENRYY_MD @et565 @melanopath @MarcelaSaebL @david_terrano @gonzadetoro @Dermpathl @tonitatirado Agree I do deeply love them

@HENRYY_MD @et565 @melanopath @MarcelaSaebL @david_terrano @gonzadetoro @Dermpathl @tonitatirado It is pretty unlikely for MYO5A to go PRAMEapalooza but I guess it could happen. But I’m with you HY, would not have pursued

@HENRYY_MD @melanopath @MarcelaSaebL @et565 @david_terrano @gonzadetoro @Dermpathl @tonitatirado It’s what I expected.

@HENRYY_MD @melanopath @MarcelaSaebL @et565 @david_terrano @gonzadetoro @Dermpathl @tonitatirado More precisely NTRK3/MYO5A rearrangement. Def Spitz lineage. Should be p16 +++. Nothing else is likely to be helpful but will bolster lab revenue.

@gonzadetoro @pepeheffernan @JMGardnerMD @JCGarcesPath @SGottesmanMD @HENRYY_MD @ariella8 @padmapathology1 @FungMaxwell @RACARR51 @FFortarezzaMD @Histopatolomon @DrGeeONE @mvmd0908 @Dermpathl @melanopath @MarcelaSaebL @PIorfino I feel included

@paddyemanuel Ursus americanus is a better diagnostic fit.

@SkinMD13 The diagnosis of dog is absolutely correct. That’s my BFF and hiking pal named Mica. Is there a third diagnosis?

@STEVENKOLKERMD @CakePath @RACARR51 @david_terrano @FungMaxwell @GregHoslerMDPhD @Dermpathl @forthejon I’m with Steve

@STEVENKOLKERMD @RACARR51 @david_terrano @FungMaxwell @GregHoslerMDPhD @Dermpathl @forthejon Not KA. Too atypical