Gregory A Hosler
@GregHoslerMDPhD
Followers
3K
Following
2K
Statuses
1K
Dermatopathologist, ProPath Fellowship Director, The Dermpath Forum (FB), #PathTwitter #DermTwitter #Dermpath #Pathology #Dermatology
Dallas, TX
Joined October 2015
Haha. Nobody fact checked me! It was great! Haha #dermpathjc
Is Twitter gonna be around still for future #dermpathjc? Lol
0
0
4
I’m checking out the rest of ur fridge. What else? #dermpathjc
@JMGardnerMD Luxardođź‘Ť@JMGardnerMD . . . belated cheers from Sacramento, California. No COI & No GLI1 (TMK) #dermpathJC This is staying corked tonight: on call.
0
0
9
I’m working on one right now that I don’t recognize, and have done extensive IHC but it “looks” like something that likely will have a translocation or other consistent molecular abnormality. Should have gone straight to NGS #dermpathjc
I do start to wonder that tumors which are not readily recognizable will soon be triaged into “expression panels” (IHC) or molecular panels (NGS), but possibly not both?!? Thoughts? #dermpathjc
1
0
9
I do start to wonder that tumors which are not readily recognizable will soon be triaged into “expression panels” (IHC) or molecular panels (NGS), but possibly not both?!? Thoughts? #dermpathjc
2
5
21
0
0
5
Good question actually, and not 100% sure what best panel is. CD56 strong. The MDM2, CDK4, STAT6 are good ones but only if those regions are also amplified (may be neg for tumors w rearrangements, but not sure) #dermpathjc
@LinskeyKaty @GregHoslerMDPhD Immunophenotype seems quite variable. Among our in-house IHC, strong D2-40 or cyclinD1 might be a clue in the proper H&E/IHC context? . . . #dermpathJC
1
2
8
She found that some included MDM2, CDK4, +/- STAT6, and it seemed to correlate w the IHC results #dermpathjc
The other really cool think Bridge did was map the areas of amplification for the 3 tumors using different probes to the chromosome #dermpathjc
0
2
7
The other really cool think Bridge did was map the areas of amplification for the 3 tumors using different probes to the chromosome #dermpathjc
1
0
7
Idk!! I wonder that too. I suspect pretty rare but not sure. #dermpathjc
How rare do you think it is or have i missed this entity? @GregHoslerMDPhD #dermpathjc
1
0
4
Yes! That is what caught my eye. It looked almost sinusoidal as the cells filled stroma around the vessels, but not true “vascular” tumor. I would lump it w the “perivascular” family of tumors
@GregHoslerMDPhD I was just going to ask if there's one feature we should keep an eye out for -- would it be the pericyte pattern? #dermpathjc
0
0
2
Yes. Variable biology tho, it seems. It some soft tissue tumors, there is variability in biology based on whether there is rearrangement vs amplification, but not enough is know about these
So despite the low mitotic count of some of GLI1 amp tumors there’s risk of metastasis particularly lung? #dermpathJC
0
1
2
To make long story short, all 3 had amplified GLI-1. These tumors can have rearrangements too…..#dermpathjc
0
0
5
While these 2 cases were being studied and written up, I got a routine one from a derm in TX that looked very similar…I mean, what are the odds?!?!? #dermpathjc
1
1
6
It has peculiar histology, right? Particularly that “pericyte” pattern where it hugs vessels…..#dermpathjc
1
1
7
Julia shares all her weird derm consults w me, which I am thank for. Something was id’d on NGS, and then FISH performed/requested to see if there was GLI-1 amp ….#dermpathjc
0
0
8
The details of back story may not be 100% accurate, but I believe Konstantinos Linos accumulated 2 cases in collab with other authors…. #dermpathjc
0
1
6
GLI-1 rearrangements have been known for a little while, but in soft tissue and head/neck literature. Not so much derm…..#dermpathjc
0
2
9