Simone
@SimonePands1111
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Alberta Public Health RN, BScN, IBCLC, 🇨🇦who likes reading quality scientific studies and sharing informed Covid-19 global health impacts. Politics too
Calgary, Alberta
Joined October 2016
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@ChrisCuomo
Systemic viral persistence
“We demonstrate systemic SARS-CoV-2 persistence for more than 2 years after Covid-19 infection” ⬆️Amount viral RNA correlates w/⬆️disease severity, ⬇️lymphocytes, ⬇️immunometabolism & ⬆️platelets. + in 65% of LC & 25% of controls
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@waysidewhelp
@ravenscimaven
Exhausted CD8 Tcells too (kill cells infected by viruses/bacteria), showed signs of exhaustion in LC…observed in T cells that recognize SARS-CoV-2 virus, not in broader population of CD8 T cells. Such exhaustion typically seen in viral infections like HIV
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@fitterhappierAJ
“Immunity debt”: a made-up 2021 concept.
C-19 infections are linked to the 2022 RSV surge in young children through large buildup of C-19-infected & the potential long-term adverse effects of C-19 on immune and respiratory systems
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@DonEford
“L-Arginine (improve endothelial function) & Vitamin C (reduce oxidation”
“indicates that the supplementation with L-Arginine + Vitamin C has beneficial effects in Long-COVID, in terms of attenuating its typical symptoms and improving effort perception”
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@farid__jalali
Acknowledgement of SARS-CoV-2 viral persistence, especially within megakaryocytes, that produce infected platelets needed ASAP..
…so antiviral/antiretroviral therapies can start for millions worldwide
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@erincandy
Son went to GP to ask to trial antivirals to treat Brainfog. Bloodwork shows T-cell reactivity to CMV & HHV6. She was a deer in headlights, with no idea about anything Covid. Asked for us to send her info as rational. I'm happily sending her ample evidence. I'm on page 177 so far
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@PatriciaVellet1
@EnemyInAState
Today’s vaccine data in Alberta: Most of our young children got Covid before they were even eligible for the vaccine. Today less than 8% of our kids under the age of five have had a first dose of covid-19 vaccine. Our youngest are sick and filling our children’s hospitals.
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@waysidewhelp
@ravenscimaven
Tired little CD8+😓“findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection with viruses such as hepatitis C or HIV”
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@DJcalligraphy
@aaronhoyland
In 2022 infants were being hospitalized with Covid at higher rates than most adults and seniors.
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@Realist87982417
@nerdyblue
His communication style is quite curt, but Dr. Leonardi has been correct about Covid T-cell dysfunction
from the start. His T-cell expertise offers arguments that are attacked/disregarded/criticized, but T-cell research backs him. Shooting the messenger?🤷♀️
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@lisa_iannattone
Lung damage from SARS-CoV-2 could contribute to the severity of an influenza infection? Many children got infected with Covid in the last 11 months (with no vaccine protection). Their vulnerable lungs need protection from all infections post covid😷
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@ravenscimaven
@waysidewhelp
Have you seen these 3 small studies? 8 case studies on Acyclovir & a study on combination Valacyclovir/Celecoxib resolving long covid symptoms? >4 months to clear virus w/single and 14 weeks with combo
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@sasswashere
3/ Nasal sprays: Emerging research worldwide for nasal sprays with different products in them look promising. They kill the virus in the nasalpharyngeal area, so it can’t colonize and get swallowed and inhaled into our body. We use Enuvid from Israel:
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@Giantbob1962
@alexmeshkin
Data collected from Veterans Health was from the first year of the pandemic, pre-vaccines.
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@r_prior
2 new studies:
LC and ME/CFS individuals, both w/PEM.
-immunological dysregulation in both
-Amyloid deposits one study and improper platelet activation other
These connected? Microclots? Thrombolytics?
@resiapretorius
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ME/CFS w/PEM pre/post exercise:
“immunological defects present at baseline in patients and an additional layer of dysregulation in platelets”
-Monocyte dysregulation is prominent. Dysregulation correlates with disease severity
-improper platelet activation post exercise
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@sasswashere
I’m hopeful these tools, backed w/ emerging science, we’ve been using will hopefully prevent covid-19, and other infections: normal saline nasal/mouth wash, mouthwash w/CPC, & nasal sprays like Enuvid from Israel (I ordered Viraleze from Australia too)⬇️1/
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@Charyyc
@callmechris316
@BogochIsaac
@SystemsVirology
@MLS_Dave
@BCDFoundation
@ApheresisLC
@DGBassani
@BrodinPetter
@VirusesImmunity
@AMannanBaig
@tilliesjourney
@SolNataMD
@Survivor_Corps
@chungk1031
@doctorfabrowski
@microbeminded2
@DrAnnaNZ
@WesElyMD
@LongCovidGroup
@LongCovidScot
@NoLongCovid
@mugecevik
I guess I feel the same way about exposing oneself to coronavirus. I am not comfortable exposing myself, without some vaccine protection, over and over to a virus with known injury, unknown long term outcomes, with known longcovid risk and possible death🤷♀️
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@lilsistweets
@AlisaValdesRod1
@ChristelJGW
@lizditz
Yes
Study from 2020, prior to any vaccines
“T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted. Non-ICU patients with total T cells counts ⬇️800/μL may still require urgent intervention”
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@TCSalvi
@kadamssl
@Imani_Barbarin
Looks like vaccination reduces risk: “reduced risk of post-C19 heart attack and stroke by 41% in people who are fully vaccinated. Even partial vaccination reduced risk by 24%. Fully vaccinated was defined as having received at least 2 mRNA vaccine doses”
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@frogess33
Clear the virus from the nasopharyngeal & oral mucosa several times a day with normal saline nasal/mouth rinses. That’s where the virus attaches, replicates and spreads to the rest of the body initially. Add nasal sprays/mouthwash below if you can access them in your region.
Nasal sprays like:
Nitric Oxide:
Astodrimer sodium:
Iota-Carrageenan:
Normal saline nasal/mouth rinses:
Also, mouthwashes:
w/CPC:
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@bk_belton
@MullenMulling
Tucker Carlson Takes Break From M&M’s Meltdown to Suggest US Invade Canada
Jan 2023
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@jaclynmacrae
@frozen
My heart goes out to teachers too. Classrooms are super spreaders exposing all to high viral loads. It’s going to get harder to hire/retain teachers if we disable them. Long Covid risk is 38% by 3rd infection. Research shows viral persistence & microclots
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@COVID19_disease
@DavidJoffe64
@LauraMiers
@ejustin46
@RajlabN
Covid leaves lungs vulnerable to other respiratory assaults? “Irrespectively of COVID-19 severity, participants who had had COVID-19 demonstrated a modest increase in ventilation inhomogeneity, broadly equivalent to that associated with 15 yr of aging”
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@zbabies_68
@amandatoryfigs
@drseanmullen
I’d also saline nasal rinse 2-4X a day, flushing active SARS-CoV-2 from sites it initially attaches/replicates/spreads: the naso/epipharyngeal area. Virus replicates in salivary glands too so mouthwash with CPC may kill virus too. Viraleze & streptococcus Salivarius lozenges also
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@NikkiTNYC
@KatePri14608408
“Gut microbiota are vital to immunomodulation…microbiota-based therapies such as fecal microbiota transplantation, probiotics, and prebiotics have been used in the clinical treatment” “Recent studies have manipulated gut microbiota to treat COVID-19”
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@MrkStdngr
My son did IV Ozone, IV NAD+ and IV Glutiothone with some success at Nardella Clinic in Calgary. Dr Haggarty understands/treats viral damage. His brain fog started April 2021, brought on by possible Covid infection prior to vaccines. He tested high for molds, CMV, HHV6 & Lyme.
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@sameo416
The precautionary principle should apply with novel viruses. Especially C-19, where we have ample short term research (3 years worth) and real world experiences showing significant harm in our populations.
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@Realist87982417
@waysidewhelp
The investigators words were directly quoted. You don’t agree with these actual scientists who discovered and studied T-cells and CD8+ responses showing decreased functionality, who wrote the paper and offered their own conclusions? You’ve come up with your own “theory” I bet
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@jeffgilchrist
This circulated in 2020 during early discovery of the case fatality rate and damage SARS-CoV-2 does to the body. A hypothetical 1% death rate with morbidity fallout is visualized. We hadn’t even considered reinfection risks, nor the consequences of viral persistence.
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@jeffgilchrist
@DGBassani
I’m a 25yr postpartum public health nurse who homevisits new moms/babies. In the last 8 weeks I’ve seen a significant amount of pregnant women hospitalized, very sick due to Covid infections. They did not receive updated C-19 vaccines due to misinformation
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@Alyssa_Milano
@JonathanToews
TY for sharing your story. You helped open my eyes to this vile virus. The video brushing your hair was impactful. Still trying to prevent infection for myself/family with masks, vaccines, nasal rinses, Enuvid and CPC mouthwash. Seeing research and hoping for LC treatments soon.
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@ballerina9999
I am hoping you recover fast and well. Have you seen the research on normal saline rinses during infection? We use it as a preventative method, but would plan to continue its use when and if we get a Covid infection
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@k1llstreakz
@Dakota_150
1. Normal saline nasal rinses 2. Mouthwash w/CPC 3. Nasal sprays like: Enuvid (nitric oxide) , Viraleze (astodrimer) and Betadine Cold Defense (iota-carrageenan)
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@yesallcrops
We’ll travel to Italy for my daughters vball soon. We’ve added prevention tools, backed by emerging research: Normal saline nasal & mouth rinses, mouthwash w/ CPC & nasal sprays that kill the virus like Enuvid, Viraleze, Xlear & Betadine Cold Defense⬇️ 1.
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@ErinAPN1
Send her every high-quality study, backing up why recommending exercise to LC suffering from Post Exertional Malaise (if she is) might in fact be malpractice at this point. It can do more damage. Solid research is available. They need to get up to speed
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@beahaven
@TimothyVollmer
@1goodtern
Measures telomere length. Telomeres are the protective caps on the ends of DNA. “Telomere length is a marker of aging” “A significant telomere shortening parallels this finding in the post-COVID-19 cohort”
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@AlisaValdesRod1
Research shows viral persistence. PASC/LC showed strong evidence of viral reservoirs/persistence. Amazingly high frequency of cd8 T-Cells(100x higher), higher than in HIV. “inverse correlation w/ pulmonary function & frequency of COVID-19-specific T cells”
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@1goodtern
I am so worried about all our children too. We have known since 2020 this virus harms the cardiovascular system.
“a “high proportion” of children infected with SARS-CoV-2 show elevated levels of a biomarker tied to blood vessel damage”
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@SoftPriestess
@ChrisAlvino
Definitely could be a temporary stimulant effect but physiologically Nicotine might kick SARS-CoV-2 virus off the nAChR receptors they share. Nicotine has a 30-fold higher affinity to those nAChR receptors. My son’s brainfog improves while on the patches
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@MaskedTeacherNL
@Emma40025133
@humblesauce1
Yes to viral persistence.
“showed the same absolute elevated markers of exhaustion at 24 months compared with 12 months, suggesting everyone infected with SARS‑CoV‑2 in this study experienced increased T cell activation as a result of infection”
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@K8Stott
Kate have you added any tools below to try prevent infections? Emerging research shows some tools that treat active Covid infections. We’ve been using these as preventative tools. Wondering if nasal/mouth rinses, nasal sprays & mouthwashes w/CPC will help prevent some infections.
@sasswashere
I’m hopeful these tools, backed w/ emerging science, we’ve been using will hopefully prevent covid-19, and other infections: normal saline nasal/mouth wash, mouthwash w/CPC, & nasal sprays like Enuvid from Israel (I ordered Viraleze from Australia too)⬇️1/
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@Michael59503746
Have you added tools to drive viral load down in the nasopharyngeal & mouth where virus colonizes, replicates and spreads. Emerging studies shows tools treat active Covid infections. Normal Saline nasal/mouth rinses, nasal sprays & mouthwashes w/CPC 1:
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@blondbanshee
@Yash25571056
I’m interested in the results of this study due next year on long covid treated with Baricitinib
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@cleanair_4life
It got harder to protect myself, as my 3 kids & husband started socializing and not masking. I have been using the tools below to help prevent any infections. So far no Covid, that I know of. They use the tools now too, and we have had no sickness in our family for 7 months.
@k1llstreakz
@Dakota_150
1. Normal saline nasal rinses 2. Mouthwash w/CPC 3. Nasal sprays like: Enuvid (nitric oxide) , Viraleze (astodrimer) and Betadine Cold Defense (iota-carrageenan)
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@SimonHume17
@ToshiAkima
Dosage maybe? For 18+ year olds the first dose of Moderna is 100ug of mRNA, subsequent doses are 50ug. All Pfizer dosages are 30ug of mRNA for ages 12+. Canada recommends Pfizer for males under age 30 to decrease risk of myocarditis.
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@sadie_luck
@JamesEKHildreth
Omicron is breaking through because its many mutations have caused a reduced susceptibility to our neutralizing antibody response, but thankfully the majority of our T cell response recognizes Omicron and can neutralize it.
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@PatriciaPouncey
@1goodtern
@SandraDunn1955
Yes, but worse?
1 Viral persistence b
2 Blood vessels
3 Atrial fibrillation
4 ⬇️ cardiorespiratory in healthy young
5 Hypertension
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@KLucasMcKay
@dsethlewis
@gtamoeb
@Dakota_150
My son tested high for several molds (urine sent for Mycotoxin panel to US Biotek). He has started IV Ozone Therapy, IV NAD+ and IV Glutiothone alternating weekly. He has had brain fog for 2 years from what we think was a bacterial or viral infection exacerbated by sleep apnea.
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@MLS_Dave
Patients w/cancer more likely to have adverse outcomes from Covid infection compared to patients without cancer. Mortality rate: 1.6% for patients without cancer, 5.0% for patients w/no recent cancer treatment & 7.8% for patients w/recent cancer treatment
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@CoastalK8
@HarrySpoelstra
@CRY_UK
Research has always shown cardiovascular damage in kids, +resp, LC, diabetes…
Why data is minimized/ignored is a mystery to me🤷♀️
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@Csphy66
@Nova_Thistle
@NipseyHoussle
@julie_bush
4 yrs of high-quality research on vaccines & SARS-CoV-2 show vaccines protective of cardiovascular, neuro, long Covid damage. Covid is HIV/AIDS-like destroying our immune systems: T&B cells, dendritic&monocytes, leaving us vulnerable to all infections
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Nasal sprays like:
Nitric Oxide:
Astodrimer sodium:
Iota-Carrageenan:
Normal saline nasal/mouth rinses:
Also, mouthwashes:
w/CPC:
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@LongCovidHell
Ask how they are protecting children from SARS-CoV-2? Research shows covid spreads in schools. COVID is destructive to the immune, cardiovascular, respiratory/neuro systems…
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@ThreeQueensDown
@DrGrahamLJ
Yes, I was thinking to find some mouthwash with CPC and start using to help prevent infection.
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@1goodtern
Me too. Except once in awhile, I wake up to research discovering answers for folks suffering from long Covid. Like this one for LC w/post exertional malaise (PEM): muscle abnormalities, myopathy, deposits. “Recommend to avoid strenuous exercise for now”
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@BoomslangCreate
@ChrisAlvino
Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration?
SARS-CoV-2 related spike glycoprotein attaches to ACE-2 receptors & nicotinic acetylcholine receptors
Jan 2023
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@1goodtern
@MelanieWeckert
5-10 yrs earlier?
“results show a consistent biological age increase in the post-C-19 population, determining a DeltaAge acceleration of 10.45 ± 7.29 years compared w/3.68 ± 8.17 years for the COVID-19-free population. A significant telomere shortening”
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@I_need_a_razor
LC? Read the new Belgium study? Confirmed markers of active viral replication in 65% of LC & 25% “recovered”. Reactivations of EBV/HV/CMV too. Antivirals are needed & available:
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@GenX_BlueHippie
Been holding strong for 3 yrs too. It is difficult. We’ve added defensive tools against infection backed with some research. Hubby&kids have been socializing and no-one has been sick. Nasal sprays like Enuvid, Viraleze, Xlear..et. Mouthwash w/ CPC & normal saline nasal rinses 1/
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@leahajk
Leah, have you added other tools to prevent infection? We have been using a nasal spray Enuvid, ordered from Israel. We’ve ordered Viraleze from Australia. Using normal saline nasal rinses & mouthwash w/CPC. All supported with emerging studies. See below:
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@user748596363
@MeetJess
Yes:
“Female reproductive health impacts of Long COVID and associated illnesses: ME/CFS, POTS, and connective tissue disorders”
“key peptides in angiogenesis & vascular permeability and thus, oocyte development — were lower in the follicular fluid”
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@gracekellman
@Valtex7B
@julianambanana
@adriel_rose
BLIS K12 in oral lozenges/gum is a probiotic streptococcus Salivarius. Several good studies show protection and treatment against SARS-CoV-2 infections. Suck on one at bedtime. 1-4 billion CFU.
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@WestcoastBCLife
@hav_free
@arghavan_salles
@zalaly
Here are the same cohort of US Department of Veterans Affairs, continuing the excellent 1 year study you posted, followed for 2 years now.
Published: 21 August 2023
Postacute Sequelae of COVID-19 at 2 years
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@dlingenfelter
@SolidEvidence
That’s what I was wondering too. SARS-CoV-2 uses macrophage nAChR too right? Is that lineage so mutated it doesn’t need ACE2 and could use nAChR instead?
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@CovidCaution
@Jrlanger
@maolesen
@infinityfotorob
Our Canadian/Alberta Covid wastewater & hospitalization rates are very high currently. I’m a nurse and can confirm our system is very strained, many of my coworkers, patients & friends are having bad reinfections last 6weeks. JN.1? It’s quite the beast
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@DTNTherapy
@1goodtern
Good questions
“Looking at place of death, from 3June2022-30June2023 there were 22% more deaths in private homes than expected compared w/10% more in hospitals, but there was no excess in deaths in care homes & 12% fewer deaths than expected in hospices”
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@_EarnieBanks
@sunstarsys
@hotjugsbev3
@IanCopeland5
My family switched to Novavax XBB. Had 2nd one lastnight. Few side effects compared to mRNAs. We use Viraleze & Enuvid nasal sprays & s. Salivarius lozenges to prevent infections. I also normal saline nasal rinses 2/day and N95s at work, stores & travel. Trying to stay a novid🤞
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@celestial_bean_
@_CatintheHat
Research shows vaccination DURING pregnancy is highly protective for neonates from SARS-CoV-2 & other respiratory infections, to at least 6 months old. Update family members too
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@Misslefist
@SFdirewolf
10-14% chance of long Covid 1st infection
27% by 2nd
38% by 3rd
Research shows similarity to an airborne version of HIV/AIDS for majority w/LC. Viral persistence & microclots. Fucked immune system. Understand?!
You’d be an idiot not to have a healthy fear of this vicious virus
@ChrisCuomo
Systemic viral persistence
“We demonstrate systemic SARS-CoV-2 persistence for more than 2 years after Covid-19 infection” ⬆️Amount viral RNA correlates w/⬆️disease severity, ⬇️lymphocytes, ⬇️immunometabolism & ⬆️platelets. + in 65% of LC & 25% of controls
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@nyssabulous
@ValerieJay16
Yes. We have added Lumify to our tool box to prevent infections. Also using normal saline nasal/mouth rinses, nasal sprays (Viralese, Enuvid, Betadine Cold Defense) and mouthwash w/CPC.
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