Neurdle - Neurology Word Game
@Neurdle
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A daily word-guessing game. Final answers are all related to neurology or neuroscience. Be careful... proper nouns, plurals, and abbreviations are fair game!
Joined April 2023
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Neurdle, April 22, 2023:
Paul Broca (1824-1880) described an area in the frontal lobe of the dominant hemisphere, usually the left, important for production of speech. Lesions of the area result in an expressive aphasia.
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Neurdle, May 11, 2023:
Spanish anatomist Ramón y Cajal won the Nobel Prize in 1908 for his work describing ‘mossy fibres’ in the hippocampus and the cerebellum. Read about those here () or just enjoy Cajal's beautiful artwork here ()
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Hey Neurds! 🎉 Happy birthday to me! I'm on Twitter (and Insta, same handle) and will be posting the previous day's results from .
@zach_london
@OligoclonalBand
#NeuroTwitter
#AANAM
@AANmember
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Neurdle, August 7, 2023:
Guest Neurd Maria Xiang from
@OHSUDoernbecher
:
Myelin oligodendrocyte glycoprotein antibody disease can cause a constellation of symptoms. Complicating the picture, the serum MOG antibody is not always specific for the disease:
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Neurdle, May 2, 2023:
Leigh syndrome: a rare progressive genetic neurodegenerative disorder of children with a deficiency in thiamine triphosphate, also called subacute necrotizing encephalomyelopathy. Named after Archibald Leigh, who described it in 1951.
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Is Neurdle not providing a deep enough menu of neurology-themed NYT puzzle parodies?
Let’s fix that.
@OligoclonalBand
@zach_london
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Happy birthday to us, Neurds! 🎈🎈🎈 It's the 100th day of Neurdle... and we have so many more 5-letter words for you.
Respond here with your favorite Neurdle word so far - and why - and you'll be entered in a drawing to win a Neurdle print.
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Neurdle, May 12, 2023:
CN X: what doesn't it do? Vagal nerve stimulation has been used to decrease seizure frequency and more recently in migraine, depression, IBD, and rehab. Read about VNS for seizures here () and migraine ()
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This Neurdle was made in consultation with Eseosa Ighodaro,
@Dr_Ighodaro
, who wrote this incredible opinion piece on the need for representation of people of color in medical textbooks - a need we feel extends to online educational word games
Neurdle, May 12, 2023:
CN X: what doesn't it do? Vagal nerve stimulation has been used to decrease seizure frequency and more recently in migraine, depression, IBD, and rehab. Read about VNS for seizures here () and migraine ()
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Neurdle, May 14, 2023:
If only there was an awesome parody song that taught you about the use of a penlight in neurology OH WAIT
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Neurdle, May 13, 2023:
The Weber test: Put a tuning fork in the center of the skull. With a CONDUCTIVE hearing loss, the sound is LOUDER in the affected ear. A patient can use a vibrating cell phone for the test during a telemedicine consult:
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Neurdle, May 16, 2023:
What should we bolus? Tenecteplase, a new tPA (tissue-type plasminogen activator) for thrombolysis in acute ischemic stroke. When should we bolus it? NOW, don't just stand there, time is brain!
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Neurdle, July 7, 2023:
The uncus (meaning hook) is the anterior part of the hippocampal gyrus.
You never think about it until ICP rises and the uncus herniates over the tentorial notch, presses against the brainstem, and affects the 3rd cranial nerve.
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Neurdle, May 3, 2023
The word epilepsy is derived from the Greek word epilambanein, meaning "to seize." A person having a seizure was thought to be seized from themselves. For an excellent history of epilepsy from ancient times, read more here:
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We're obviously big fans of
#Halloween
over here at Neurdle so show us all your
#NeuroTwitter
costumes - neurologically themed and otherwise!
#NeuroHalloween
#NeurologyIsNotScary
👻
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We’re back! Thanks for your patience. You should be able to play today and not lose your streak!
But if it was 6 letters, what would your starting word be?
@zach_london
@OligoclonalBand
@PedsNeuroMD
@DrYasminKhakoo
@jepatinom
@ansharp
@gyriandsulci
@yagnikdee
@RGottliebSmith
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Neurdle, May 17, 2023:
The sympathetic nervous system causes the pupil to dilate, allowing more light in. The parasympathetic nervous system causes the pupil to constrict, allowing less light in. More on David Bowie here (I got you, fam): )
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Neurdle is 100 days young today! 🎂🧠 Grateful to all our Neurds for making this journey a blast! 🙏
Meanwhile, I think we need a slogan for .
"Friends who Neurdle together... Limb-Girdle together?" Nope. Clearly we need your help. What have you got?
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Neurdle, May 15, 2023:
The hippocampus has 3 subfields: CA1, CA2 and CA3 - using the old name for the organ, "cornu ammonis" - and contributes to memory, navigation and cognition. Here are some smart people chatting about it in Nature Neurosci in 2017:
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We are so close to 1000 followers! Today, let's look back at some of our most challenging Neurdles - and all our amazing guest Neurds (we❤️you!):
(Remember our birthday word, April 22?)
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Neurdle, May 9, 2023:
Prednisone seems to improve outcomes in adults with acute 7th cranial nerve palsy; acyclovir doesn't help. Do you still prescribe both? (There's really no evidence for either in children!)
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Neurdle, July 13, 2023:
In 1952, Alan Hodgkins and Andrew Huxley described the action potential of the neuron, with experiments performed in the giant axon (0.5 mm in diameter) of the giant squid. They won the Nobel Prize for this work in 1963.
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Remember when someone complained because the Neurdle was SEIZE?
...those were good times, oh such innocence back then 🥹
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Neurdle, May 25, 2023:
Limen is a beautiful word meaning a threshold or a boundary - the limen of consciousness, the limen of perception (like subliminal perception). Anatomically, the threshold of the insula of the brain is called the limen insulae:
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Whoops, that was supposed to be me
Neurdle, July 21, 2023:
Functional neurological disorders and "spells" present unique challenges for neurologists and patients. Listen to a podcast with Dara Albert, medical director of a multidisciplinary Psychogenic Nonepileptic Events Clinic:
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Neurdle, April 28, 2023:
In this 1879 article, J. Creighton Browne says arachnoid cysts "are calculated, by their situation, by their glistening surface, their variegated tints, their essentially morbid appearance, to impress and dwell in the memory."
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Neurdle, July 29, 2023:
Guest Neurd
@StaceyLClardy
!
The ExTINGUISH Trial for NMDAR Encephalitis is an clinical trial enrolling newly diagnosed NMDAR Encephalitis. Call the 24-hour ExTINGUISH hotline at 844–4BRAIN5 with new NMDAR encephalitis patients for more information.
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...ok yes it's another difficult Neurdle day.
It will get easier later this week! 😁
Hints later today. Don't panic.
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Neurdle, May 27, 2023:
Ali Christy
@OligoclonalBand
, editor-in-chief of Child Neurology Open, makes a podcast with
@JChildNeurol
on all kinds of topics related to pediatric neurology:
Tell us why you like child neuro!
@ChildNeuroSoc
@Child_Neurology
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Neurdle May 18, 2023:
Velum: anatomically, any membranous structure, usually used for the soft palate - but can also be (incorrectly) in the term cavum velum interpositum
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Neurdle, July 9, 2023:
Neuromyelitis optica spectrum disorder is a demyelinating disease of the optic nerves, spinal cord, and area postrema. For many years NMO was considered a subset of MS, but in 2005, Vanda Lennon found antibodies to aquaporin 4:
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Hold on to your occipital horns, because it's time for another Neurology Connections puzzle!
Find the four groups of four, and bask in your neurdy glory.
@zach_london
@OligoclonalBand
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Can't believe they would talk about me behind my back like this 😔 I thought we were friends
Oh hey there,
@zach_london
and
@OligoclonalBand
! Thanks for joining us on the podcast to talk all things
#Neurology
including
@Neurdle
and
#Match2024
. The new episode will be released THIS Monday, March 18!
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Neurdle, May 10, 2023:
Central hypoventilation syndrome, known as “Ondine’s curse”, is a congenital condition from a variation in the PHOX2B gene. Who was Ondine, and who was cursed? Read more here:
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Neurdle, May 7, 2023:
You want guidelines? We've got 2020 guidelines for treatment of acute cerebral edema in the NSICU:
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Hey Neurds, tomorrow's Neurdle is going to be a challenge... so hints will start dropping here tomorrow morning if you get stuck. Look away if you're one of those "no-hint Neurdlers."
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Neurdle, Oct 1, 2023:
Neuro: I love it, you love it, it's why we're here. But some medical students are scared of it, even after completing a neurology rotation: . How do we improve this (& why is the answer introducing all students to Neurdle)?
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I can't believe we did a whole retrospective and forgot to mention my personal favorite painfully challenging Neurdle - criteria for ALS, named after a Japanese island. You don't get more esoterically neuro than that (oh, just wait, we will)
We are so close to 1000 followers! Today, let's look back at some of our most challenging Neurdles - and all our amazing guest Neurds (we❤️you!):
(Remember our birthday word, April 22?)
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Neurdle, May 4, 2023:
Jean-Martin Charcot and Pierre Marie described ""Progressive Muscular Atrophy"" in 1886, but localized it to the lower motor neurons. British neurologist Howard Henry Tooth localized CMT to peripheral nerves 3 months later.
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Neurdle, August 24, 2023:
EEG: often useful, but measuring electrical dipoles through scalp and skull is prone to error. Here's a history of invasive EEG techniques, with depth electrodes and subdural grids:
Guest Neurd
@gyriandsulci
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Neurdle, August 29, 2023:
The quantitative sudomotor axon reflex test (QSART) can detect small fiber neuropathy when other nerve conduction tests are normal. Abnormalities in the autonomic control of sweat glands can be the 1st sign of a problem.
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An anonymous Neurd points out that we rarely use this verb in neurology - "seizure," "seizing," but not "to seize." What do you think? Is SEIZE a fair Neurdle?
(Pro tip: Do not expect your Neurdle to be fair, and don't forget that we allow plurals, proper nouns and acronyms.)
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Neurdle, May 21, 2023:
Dandy-Walker malformation is a specific type of cerebellar hypoplasia with hypoplasia of the cerebellar vermis and expansion of the 4th ventricle. Read more:
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Time for another Neurdle Connections!
Can you find the right groups of four?
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Neurdle, June 17, 2023:
The brain is the complex organ in the center of the nervous system. Walter Russell Brain (1895-1966) was a neurologist, he wrote Brain's Diseases of the Nervous System, and for a few years he was even editor of the journal Brain.
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Neurdle, April 23, 2023:
Axons: stretching out from the cell bodies of neurons to make connections - like us. 💚
Read
@EvaFeldmanMDPhD
on Schwann cell–axon transport in the demyelination and degeneration of sensory neurons of diabetic neuropathy:
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Neurdle, Sept 27, 2023:
Every neurologist needs a reflex hammer (not your stethoscope - but you know that). We may be able to use other tools - like telemedicine - to reduce healthcare disparities:
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So... how do you put "Guest Neurd" on your CV? Thought we'd crowd-source this one.
@JRGoldstein
@dr_jmartindale
@aoglasser
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Neurdle, May 1, 2023:
Are you using cenobamate for focal seizures?
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Neurdle, May 30, 2023:
In 1892, Jules Dejerine challenged Pierre Marie to an actual duel over the neurology of sensory ataxia. Their friends calmed them & no shots were fired. Please do not consider dueling us over future Neurdle words. For more:
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Neurdle, Sept 25, 2023:
Cranial nerve
#12
, the hypoglossal nerve, is a motor nerve that innervates the muscles of the tongue. CPAP is an uncomfortable way of treating sleep apnea - but maybe we can stimulate the hypoglossal nerve electrically instead:
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Neurdle, April 25, 2023:
Neurotoxicity occurs when a substance – naturally occurring in the brain, like amyloid beta, or found in the environment, like tetrodotoxin – damages nervous tissue. Tetrodotoxin is a powerful sodium channel inhibitor:
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It’s Neurdle Connections Time!
(Abbreviated NCT, but not to be confused with Nashville Children’s Theatre or Nobody Cares, Tracy.)
Be like Goldilocks and tell us if these are too easy, too hard or just right.
@zach_london
@OligoclonalBand
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Hey Neurds! April 22nd is our birthday 🎉! One whole year of Neurdle!
Don't worry if you didn't get us anything - we got you something, and yes, it's another REALLY HARD NEURDLE.
This one will definitely leave you questioning our mental status....
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Neurdle, May 20, 2023:
The musculocutaneous nerve - a terminal branch of the lateral cord of the brachial plexus - supplies the biceps brachii. The biceps tendon can spontaneously rupture in amyloid transthyretin (ATTR) amyloidosis:
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Neurdle, April 24, 2023:
Poliomyelitis, a vaccine-preventable viral infection contracted through the fecal-oral route, affecting the motor neurons of the ventral horn of the spinal cord. --> flaccid paralysis, primarily of the lower extremities.
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What up Neurds! Today, June 5th, is another Neurdle Day of Difficulty so remember:
-no duels
-acronyms are fair game
-we might throw some hints out, depending on how it's going
-NO DUELS
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Neurdle, May 28, 2023:
If you're looking at head imaging, axial means there's an imaginary line cutting the head in half, top to bottom, through both ears. But actually there are six axial planes used in 3D imaging:
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Neurdle, May 5, 2023:
Large fiber neuropathies come from damage to the a Aβ fibers, which regulate the proprioceptive signals of vibration and touch. Here's an extremely thorough review of all kinds of neuropathic pain:
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Ever play Strands? If you found a neuroloanatomy one, would your life (or at least your day) be complete? Try this!
Find the words to fill the board. They do not overlap.
@zach_london
@OligoclonalBand
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Neurdle, June 23, 2023:
Now that it's raining more than ever / I've got high intracranial pressure / you can tell from my empty sella (ella, ella, eh, eh, eh)
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Neurdle, May 22, 2023:
Glial cells - making up about half the cells of the brain parenchyma - orchestrate CNS formation and function, and are much more than the "glue" of the brain. Read more:
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Neurdle, May 19, 2023:
Stroke Alert is not just one of the worst things to see on your pager at 2 a.m. - it's also the name of the American Heart Association's Stroke journal's podcast. Listen here:
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Neurdle, Nov 18, 2023:
Yes, MTHFR sounds like an abbreviated curse word, but folic acid and the enzyme that converts it to 5-methyltetrahydrofolate, methylenetetrahydrofolate reductase (MTHFR), are not only important for formation of the neural tube ()...
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Neurdle, May 29, 2023:
Herpes simplex encephalitis is a viral encephalitis that primarily affects the temporal lobes. This is a
@zach_london
video about prior authorizations that went viral online:
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Neurdle, Sept 14, 2023:
I thought that I would never see
A poem about neuropathy
But now for Neurdle (so fantastic!)
I write of POEMS, neoplastic.
Read about POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes):
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*gasp* it's a Neurdle-NeuroEtymology crossover!
#Neuroetymology
Word 🔆8
Substantia Nigra
🌟Substantia Nigra finds its origin in Latin, which literally translates to "Black Substance", owing to its appearance being darker than the surrounding areas due to high neuromelanin content. Hint for its location within the brain:
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Neurdle August 4, 2023:
William James West described infantile spasms (1793-1848) in his own son in 1841. The triad of infantile spasms, hypsarhythmia on EEG, and developmental regression is called West syndrome. . Art from Guest Neurd David Curfman.
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Neurdle, August 19, 2023
The crista galli, or "rooster's crest," of the ethmoid bone separates the olfactory bulbs and attaches to the falx cerebri of the dura mater. This area can becomes air-filled as the sinuses develop:
Guest Neurd
@MikaelaStiver
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Neurdle Hint
#1
, Nov 10
There is no one who hates brand names more than Neurdle creator
@zach_london
.
Except when it comes to Neurdle.
Then all bets are off.
Hear ye! Residents and students on service with me, if you make it one week and only use generic drug names, I will literally shower you with candy.
You are strong, you are proud, you are not under the thumb of Big Pharma, and you shall be rewarded!
#medtwitter
#NeuroTwitter
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Neurdle, May 6, 2023:
Dorothy Horstmann (1911-2001) was the first to isolate the polio virus from the bloodstream, facilitating Albert Sabin's (1906-1993) creation of the oral polio vaccine.
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Bernard Sachs (1858-1944) is often called the father of Child Neurology - - and the GM2 gangliosidosis hexosamindinase-A deficiency is named after him, and the British ophthalmologist Waren Tay (Tay-Sachs disease)
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Neurdle, February 19, 2024
Tuberous sclerosis complex (TSC) is a neurocutaneous multisystemic disorder, usually inherited in an autosomal dominant manner. Skin findings include ash leaf spots, Shagreen patches, adenoma sebaceum and ungual fibromas....
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Neurdle, August 13, 2023:
Single fiber EMG is the most sensitive test for impaired transmission at the neuromuscular junction, as in myasthenia gravis, Lambert-Eaton syndrome, or botulism:
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Pronate and supinate into the weekend with a new neurology-themed Connections!
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Neurdle, July 31, 2023:
There are 3 types of cone photoreceptors for color vision. Neural processing is complex: .
Today's Guest Neurd is artist Laura Bundesen, with "That's How The Light Gets In." She celebrates brains and color at
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Neurdle, June 24, 2023:
Alpha rhythms (8-13 Hz) are present in most people over the age of 8. The frequency may be increased transiently after eye closure (alpha squeak). Here's a PNES study of cortical and thalamic generation of alpha rhythms:
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Neurdle, Sept. 1, 2023:
Moebius syndrome is a rare congenital disorder of heterogenous origin affecting the cranial nerves - most commonly, the 7th (facial) and the 6th (abducens), leading to facial palsy and abnormal eye movements. Guest Neurd Anne Chen
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Neurdle, Sept 3, 2023:
Before azoles were available to treat meningitis caused by the fungus Coccidiodes in the 1990s, the best option was intrathecal amphotericin. Read more about CNS coccidiodomycosis infection: Guest Neurd:
@MichaelCosimini
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Neurdle, July 26, 2023:
#100
!!!
from Guest Neurd: Idha Sood
@JoyfulAstrocyte
: Substantia Nigra finds its origin in Latin, which literally translates to "Black Substance", owing to its appearance being darker than the surrounding areas due to high neuromelanin content.
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Neurdle, March 2, 2024:
Myoclonic epilepsy myopathy sensory ataxia (MEMSA), previously referred to as spinocerebellar ataxia with epilepsy, is a mitochondrial syndrome caused by a variant in the POLG gene, which codes for polymerase gamma....
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Neurdle, April 28, 2024
Optic is a great starting word for Neurdle - some vowels, a C at the end, it's a solid choice. This paper's abstract starts "The optic nerve is the most important cranial nerve," which is a bold statement (vagus, anyone?) ....
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Neurdle, Nov 11, 2023:
Guest Neurd Maria Xiang: "FIRES stands for febrile infection-related epilepsy syndrome and usually affects school-aged children ranging from 2 years to early adulthood. FIRES affects a previously healthy child after a brief, nonspecific febrile illness...
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We're more surprised than anyone that Paris Hilton dressed up like this Neurdle for Halloween - but then, neurology is pretty cool. ☺️
Be a Guest Neurd and who knows, maybe Paris'll dress like YOUR NEURDLE next year!
Neurdle, April 25, 2023:
Neurotoxicity occurs when a substance – naturally occurring in the brain, like amyloid beta, or found in the environment, like tetrodotoxin – damages nervous tissue. Tetrodotoxin is a powerful sodium channel inhibitor:
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(Is "Is seize a fair neurdle" the weirdest sentence you've read today? You're welcome 🧠)
An anonymous Neurd points out that we rarely use this verb in neurology - "seizure," "seizing," but not "to seize." What do you think? Is SEIZE a fair Neurdle?
(Pro tip: Do not expect your Neurdle to be fair, and don't forget that we allow plurals, proper nouns and acronyms.)
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Neurdle, July 23, 2023:
Positive sharp waves (P waves) arise when an EMG needle damages a muscle fiber and spontaneous action potentials propagate up to the needle tip. They are fundamental to the diagnosis of ALS:
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Neurdle, June 2, 2023:
Pupils Equal, Round, and Reactive to Light - usually an unnecessary abbreviation, and can be confusing, copied forward without thought, and meaningless.
What do you think?
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According to
@zach_london
, it takes 1 minute to play
@Neurdle
. 👀
Happy Monday
#NeuroTwitter
! 🧠 Thrilled to be sharing our new episode with you all, featuring two of the most incredible educators
@zach_london
@OligoclonalBand
✨ Listen in to hear about all things
#Neurology
,
#Games
, and
#MedEd
🎲📚
@mdgoels
@BlakeBuletko
@nsaini413
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Neurdle, May 26, 2023:
Zach London wrote a song about the subservient nature of this organ. "The heart is bound/ The heart is bound/ To serve the mind/ And not the other way around./ You're just a pump,/ When brain says jump/ You say, 'How high?'"
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Neurdle, June 4, 2024:
As you get older, you start getting multi-vessel lumens in a single vascular channel in the frontal cortex! Maybe this is a good thing, and a sign of increased wisdom (haha, jk, nothing about brain aging is ever good)
@Dr_Ighodaro
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Prepare for another hard Neurdle tomorrow, Neurds! Here's a hint now:
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Neurdle, July 20, 2023:
Fragile X associated Tremor/Ataxia Syndrome (FXTAS- pronounced “fax-tas”) is an X-linked age-related neurodegenerative disorder that affects both males and females.
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Neurdle, August 28, 2023:
Spanish anatomist Ramón y Cajal won the Nobel Prize in 1908 for his beautiful neuropathological drawings, including describing ‘mossy fibres’ in the hippocampus and the cerebellum. Read about those here ()....
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What up, Neurds! Tomorrow's Neurdle is a difficult one so I'll start dropping hints around 6:30 PST 🧠
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Decided not to glitch on y'all today. You're welcome.
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Neurdle, May 24, 2023:
Joseph J. Volpe is THE neonatal neurologist: author of Volpe's Neurology of the Newborn, and professor emeritus at Harvard Medical School.
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I didn't even think it was a hard Neurdle day! It's April 20, guys, loosen up a little....
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Neurdle, June 4, 2023:
What the hecksin is a neurexin? Neurexins are presynaptic cell adhesion proteins that bind with neuroligin to connect neurons at the synaptic cleft. Precise alignment facilitates neurotransmission.
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