Synthesis Workshop
@MatthewHorwitz1
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Synthesis Workshop is a video podcast exploring the frontiers of synthetic organic chemistry created by Matt Horwitz, Ph.D.
Joined April 2020
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Missed this webinar? No worries, you can find it here!!
Are you interested in learning how cutting-edge chemistry can drive your drug discovery project forward? Check out this upcoming webinar, "Accelerating Drug Discovery with Synthetic Chemistry Advances", on October 9th!
Register now:
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What a creative and beautiful paper on
@ChemRxiv
on "Molecular Sonification" (turning molecules into music)!
DOI: 10.26434/chemrxiv-2022-g7xkl
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806
IT'S FINALLY HERE! Starting October 28th, the Synthesis Workshop Advanced Organic Chemistry course will begin releases through our regular YouTube channel for FREE, thanks to the massive efforts of presenters from many researchers from academia and industry!
Support by sharing!
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Starting a Masters or PhD in organic chemistry this fall? Synthesis Workshop () can help you stay up to date on advances in organic synthesis! Detailed open access videos and guest talks on a wide range of topics can help you get started!
RTs appreciated!
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Today on Synthesis Workshop, Jeff
@Kerkovius
takes us through his work on a pyridine dearomatization approach to the synthesis of lupin alkaloids with
@Sarah_Reisman
@Caltech
!
Full episode:
Key paper:
@J_A_C_S
2022, 144, 15938.
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As we reach 3,000 followers today, a huge thank you to everyone who has helped turn this pandemic project into a vibrant, grassroots-style research outreach initiative! We've come so far and there is still so much exciting chemistry left to explore!
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Join the 2021 Synthesis Workshop
#NamedReactionChallenge
! To participate, make a poster about a named reaction and post it on Twitter using
#NamedReactionChallenge
. Let's collect and share knowledge together!
RTs appreciated, example below.
#RealTimeChem
#ChemTwitter
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In our first episode of 2023, Julia Reisenbauer
@morandilab
@ETH_en
joins us to discuss her work on diversification of indole skeletons through nitrogen atom insertion!
@ScienceMagazine
2022, 377, 1104–1109.
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Episode
#2
of the Synthesis Workshop Advanced Organic Chemistry course is live now - come watch
@DennisKutatela1
teach kinetics!!
Link:
IT'S FINALLY HERE! Starting October 28th, the Synthesis Workshop Advanced Organic Chemistry course will begin releases through our regular YouTube channel for FREE, thanks to the massive efforts of presenters from many researchers from academia and industry!
Support by sharing!
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Coming soon...a new web app to convert raw NMR data to publishable entries, ready to go into your Supporting Information! A new direction for
@splotch_io
!
#chemtwitter
#RealTimeChem
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Did you know photoexcited nitroarenes can be used to achieve C-H hydroxylation? Come hear all about it as
@JoshPaolillo
@ParasramLab
@nyuchemistry
joins us in a new Research Spotlight episode!
Episode:
Key paper:
@J_A_C_S
2023, 145, 2794.
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We continue our Advanced Organic Chemistry course this week as Patrick Deneny
@RoySocChem
gives us an overview of carbonyl reactivity!!
Link:
Also huge thanks to
@94peter
for an amazing problem set! Check it out here:
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How do you oxidatively cleave an alkene without ozone or osmium? Tune in this week on Synthesis Workshop to find out as
@Emma_Gogarnoiu
(
@ParasramLab
@nyuchemistry
) joins us to share her work!
@J_A_C_S
2022, 144,15437.
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BIG NEWS!!! We are launching a new episode format: "How Can We Make This???" Two researchers propose routes to challenging targets and discuss them with an expert! Thanks to
@aplooby28
(host and participant),
@NaOHBartfield
, and Prof. Jeremy May!
Link:
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Today Dr. Jayabrata Das joins us to share his work with
@maiti_iitb
on the synthesis of bicyclic lactones published a few months ago in Nature Chem!!
Link:
Key paper:
@NatureChem
2023, 15, 1626–1635.
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Join us today as Katherine Xie
@RovisGroup
shares her work on orange light-driven cross couplings using spin-forbidden metallaphotoredox catalysis!
Link:
@J_A_C_S
2023, 145, 36, 19925-19931.
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The
@ChemDraw
and PowerPoint templates used in Synthesis Workshop are now available to download! Includes examples of showing complex molecules, retrosynthesis, concepts, mechanisms, and reaction schemes!
See the downloads section for more!
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This week we continue our Advanced Organic Chemistry course as
@SWM_Crossley
teaches Retrosynthesis!!
Link:
IT'S FINALLY HERE! Starting October 28th, the Synthesis Workshop Advanced Organic Chemistry course will begin releases through our regular YouTube channel for FREE, thanks to the massive efforts of presenters from many researchers from academia and industry!
Support by sharing!
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How can you easily convert an amide into an enamide? Tune in tomorrow to find out in a brand new Research Spotlight episode!!
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In a new total synthesis mini-lecture, we explore a line of research developed by
@BaranLabReads
which is a story over a decade in the making!
Synthesis Workshop: The Two-Phase Approach to Taxanes
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Join us on Synthesis Workshop as Dr. Katherine Forbes
@KCFchemistry
(
@JacobsenLab
@HarvardCCB
) joins us to share her work on the synthesis of stereogenic-at-phosphorus building blocks!
Key paper:
@ScienceMagazine
2022, 376 (6598), 1230–1236.
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Join us this week as we continue our Advanced Organic Chemistry course with a beast of a talk on Hammett analysis and KIEs by
@HaydenChem
!!
Full talk:
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Overview of the first 30 episodes of Synthesis Workshop! I'm thrilled to report that what began as a small pandemic project has become a community effort as many chemists have begun joining to explain their recently published work!
@RealTimeChem
#ChemTwitter
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Really enjoyed this Short Review from Jake Aquilina and Prof. Myles Smith in Synthesis!
Here was one impressive highlight from
@thestoltzgroup
synthesis of myrifabrals A and B using asymmetric allylation:
@thiemechemistry
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Today on Synthesis Workshop, we welcome Dr.
@DavidBKonrad
, who shares his work on the total synthesis of tetrodotoxin with
@DirkTrauner
!
Episode:
Key reference:
@ScienceMagazine
2022, 377, 411-415.
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Nice initiative to highlight recent advances in homogenous catalysis!
Are there other companies out there doing similar show-and-tell initiatives for advances in organic chemistry?
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Very excited to announce our year-end event on Synthesis Workshop - a virtual research poster symposium! Come share your published work with
#chemtwitter
and beyond!
Winning posters will be displayed on ! RTs appreciated!!!
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Today on Synthesis Workshop, Maximilian Palkowitz
@mx_million
@BaranLabReads
@scrippsresearch
takes us through the incredible story behind his recent work using electrochemistry for terpene synthesis!
Full episode:
@ScienceMagazine
2022, 375, 745-752.
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Talk
#1
of this course is now LIVE! Check it out here:
This talk is also accompanied by a problem set which can be found at !
IT'S FINALLY HERE! Starting October 28th, the Synthesis Workshop Advanced Organic Chemistry course will begin releases through our regular YouTube channel for FREE, thanks to the massive efforts of presenters from many researchers from academia and industry!
Support by sharing!
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Summary of what happened in the last year on Synthesis Workshop! Extremely grateful to all those who presented and helped to create new open access material to stay up to date in organic synthesis!
#ChemTwitter
#RealTimeChem
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Today on Synthesis Workshop we celebrate 50 episodes, made possible by the contributions of a lot of top chemists from around the world! Thank you so much to the online chemistry community for supporting this initiative!
#ChemTwitter
#RealTimeChem
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Very excited to announce a new direction for
@splotch_io
: Splotch Labs! At you can process NMR data for free, generate publishable text entries and PDFs for your Supporting Information, and even learn NMR hands-on from the ground up!
#NMR
#NMRchat
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Join us in a new Research Spotlight today as Benjamin Gross (
@thestoltzgroup
@CaltechCCE
) takes us through his total synthesis of (+)-ineleganolide!
Episode:
Key reference:
@J_A_C_S
2023, 145, 7763–7767.
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How would you make beta-proline? Join us this week as Shambhu Deo Chandra shares his approach from the Perrin group at University of British Columbia in a virtual research poster!
Check out the paper in Synthesis (DOI: 10.1055/a-2145-5470)!
@thiemechemistry
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Join us this week as Isaiah Eckart-Frank shares his work on the synthesis of spirocyclic cyclobutanes!
Link:
@J_A_C_S
2023, 145, 18591–18597.
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IT CONTINUES! Check out Talk
#5
in our Advanced Organic Course on the topic of Reversible Reactions, given by
@j_reisenbauer
(PhD from
@MorandiLab
@ETH_en
, SNSF Postdoctoral Fellow with
@francesarnold
@Caltech
)!!
Link:
IT'S FINALLY HERE! Starting October 28th, the Synthesis Workshop Advanced Organic Chemistry course will begin releases through our regular YouTube channel for FREE, thanks to the massive efforts of presenters from many researchers from academia and industry!
Support by sharing!
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Today on Synthesis Workshop,
@EleanorMLandwe1
@scrippsresearch
@Shenvi_Lab
joins us to share her work on the total synthesis of GB22, GB13, and himgaline!
Episode:
@ScienceMagazine
2022, 6586, 1270-1274.
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What kind of reactions can this kind of organocatalyst enable? Tune in tomorrow to find out!
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Dear
#ChemTwitter
, we are now in the process of forming a Synthesis Workshop Editorial Board to make this initiative more sustainable in the long run and continue to become more community-based. Check below for more details! RTs highly appreciated!!
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Join us on Synthesis Workshop as
@DennisKutatela1
shares his work on enantioselective catalysis of Prins cyclizations!
Full episode:
@J_A_C_S
2021, 143, 20077–20083.
@JacobsenLab
@HarvardCCB
@BuchwildGroup
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Want to make
@ChemDraw
graphics that look like Synthesis Workshop? Here is how to make the custom template in under a minute!
More tips and tricks in this week's episode:
#RealTimeChem
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How can you make this reaction happen? Tune in tomorrow to find out in a brand new Research Spotlight episode!
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Today on Synthesis Workshop,
@billthechemist
@TempleWLab
joins us to share his work on electrochemical benzylic collidination!
Full episode:
Org. Lett. 2022, 24, 6060.
@JOC_OL
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Aside from being a really nice advance in Bronsted base organocatalysis, this paper has a really exceptionally well-organized SI, particularly with regard to substrate preparation! Check it out!
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Today on Synthesis Workshop,
@MattTheChemist
shares his work on the electrochemical synthesis of isocyanides with
@KLchemistry
!
Full episode:
Key paper:
Org. Lett. (
@JOC_OL
) 2021, 23, 9371-9375.
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Tune in this week as Jonas Rein and Soren Rozema share the story of their work on enantioselective aminoxyl radical catalysis, published in
@ScienceMagazine
!
Ref: Science 2023, 380, 6646, 706–712.
Thanks to Andy Tran for hosting!!
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This week we continue our Advanced Organic Chemistry course as
@GeorgiaRitzema
gives us an introduction to radicals - check it out!!
Link to the talk:
Thanks to
@aplooby28
for hosting and Thomas Verheyen for a great problem set!
IT'S FINALLY HERE! Starting October 28th, the Synthesis Workshop Advanced Organic Chemistry course will begin releases through our regular YouTube channel for FREE, thanks to the massive efforts of presenters from many researchers from academia and industry!
Support by sharing!
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806
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Today on Synthesis Workshop we're joined by Lalita Tanwar (
@ritter_lab
) who shares with us her work on late-stage C-H oxygenation and iodination!
@J_A_C_S
2018, 140, 16026.
@J_A_C_S
2019, 141, 17983.
Org. Lett. (
@JOC_OL
) 2021, 23, 5024.
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Cross coupling reactions are a priceless cornerstone of organic synthesis. Today, Dr. Thomas Verheyen joins us to give an overview of this topic in the latest installment of our Advanced Organic Chemistry course!
Link:
Problem set:
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Today we start the new year at Synthesis Workshop as
@chem_em
(
@SchindlerLab
@MichiganChem
) joins us to share her work on photochemical azetine synthesis!
Key paper:
@J_A_C_S
2021, 143, 16235-16242.
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This week on Synthesis Workshop,
@VDaskova
@FeringaLab
joins us to talk about turning enantiomeric relationships into diastereomeric ones!
Full episode:
@J_A_C_S
2022, 144, 23603-23613.
2
12
68
Today on Synthesis Workshop,
@GeorgiaRitzema
joins us to share her work on a photocatalytic asymmetric synthesis of α-trialkyl-α-tertiary amines with
@Gaunt_Group
@ChemCambridge
!
Full episode:
@JOC_OL
Org. Lett. 2023, 25, 861–866.
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This week,
@thiemechemistry
#JournalAwardee
Dr. David Nelson
@TheNelsonLab
@StrathChem
takes us through some of the key differences between palladium and nickel in catalysis!
Full episode:
Key paper:
Synthesis 2020, 52, 565-573.
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A quick overview of what's happened so far in the first 20 episodes of this video podcast! Thank you so much to everyone who helped make this happen, especially
@nsaper3
, Dr. Blane Zavesky,
@joshmc42
,
@reid_indeed
,
@mzliang
, and Prof. David Yu-Kai Chen! More coming!
#realtimechem
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Tune in this week on Synthesis Workshop as Dr. Hayden Sharma (
@HaydenChem
@JacobsenLab
@HarvardCCB
) shares his work on enantioselective 1,2-boronate rearrangements!
Full episode:
Key paper:
@ScienceMagazine
2021, 374, 752–757.
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Today on Synthesis Workshop we dive into manganese-promoted 1,2-radical migrations as Hayden Carder joins us to share his work from the
@LabWendlandt
@ChemistryMIT
!
Full episode:
Key paper:
@J_A_C_S
2021, 143, 13798–13805.
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Total synthesis returns this week on Synthesis Workshop as we dive into the Chen/Yang approach to Haperforin G!
Episode:
@J_A_C_S
2020, 142, 19487-19492.
Project homepage:
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Today on Synthesis Workshop, Riley Roberts (Stuart Lab, Portland State University) joins us to share his work on formal arena dehydrogenation!
Full episode:
@J_A_C_S
2023, 145, 3306-3311.
3
10
67
This week we continue our Advanced Organic Chemistry course as
@Riya_Hal1
gives us an introduction to protecting groups!! Thanks to Thomas Verheyen for an excellent accompanying problem set, which is available at !
Link to the talk:
0
12
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This week on Synthesis Workshop we dive into Schlenk technique with Dr.
@AndryjBorys
of the
@EvaHeviaGroup
, creator of The Schlenk Line Survival Guide!
2
12
63
Tune in this week as Marlene Fadel
@CarreiraGroup
@ETH_en
shares her work on the total synthesis of (+)-pedrolide in a Research Spotlight hosted by
@medicinAlicia
!
Full episode:
@J_A_C_S
2023, 145, 8332–8337.
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Thanks to all the people who have put in the time and effort to give open access virtual talks about their work in many exciting areas from all over the world, there are now 4,000 people learning about organic synthesis with Synthesis Workshop!
#ChemTwitter
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This week Julianna Mouat
@weixgroup
joins us to share her work on the use of semiconductor quantum dots for cross-electrophile coupling reactions!! Thanks to
@medicinAlicia
for hosting!
Link:
Ref:
@ACSCatalysis
2023, 13, 9018.
0
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How can internal olefins be converted into less stable terminal olefins? Today, Kuo Zhao (Knowles group
@PrincetonChem
) joins us on Synthesis Workshop to share the story of this exciting advance!
@J_A_C_S
2022, 144, 137−144.
0
12
63
In our 101st episode, Dr. Tanner Jankins
@W0TangClan
@morandilab
@ETH_en
joins us to share his work on low-valent tungsten redox catalysis from the
@EngleLab
@scrippsresearch
!
Full episode:
@NatureChemistry
2022, 14, 632-639.
1
8
60
Today Dr. Tyler Pabst
@NotTylerPabst
joins us to share his work on meta-selective C-H borylation with cobalt catalysis from
@ChirikGroup
@PrincetonChem
!
Full episode:
Recent work:
@J_A_C_S
2022, 144, 6465-6474.
3
6
60
This week on Synthesis Workshop,
@philipp_spie
(
@MaulideLab
) joins us to share his work on the synthesis of enamides via amide activation in a brand new Research Spotlight episode!
Full episode:
@J_A_C_S
2021, 143, 10524-10529.
0
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Very excited to launch "The SW Pod" today with
@aplooby28
, an interview-based sub-podcast of Synthesis Workshop operating on Spotify and YouTube!! This week we chat with Prof. Daniele Leonori
@LeonoriLab
!
Spotify:
YouTube:
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This week's episode features the total synthesis of talatisamine by the Inoue group - published in
@angew_chem
in 2019. A huge synthetic effort to make an impossible-looking target. Enjoy!
@Realtimechem
0
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This week on Synthesis Workshop, Isaac Yu shares his work on catalytic borylation of tertiary C–H bonds in BCPs and BCHs
@HartwigGroup
with
@EnamineLtd
and
@JanssenEMEA
!
Episode:
@NatureChemistry
2023, 15, 685-693.
1
12
57
How can photoredox catalysis be used in cyclopropanation reactions? Today,
@AGHerraiz
(alumnus of
@thiemechemistry
#JournalAwardee
@MarcosGSuero
@ICIQchem
) joins us on Synthesis Workshop to explain this approach!
Key paper:
Synthesis 2019, 51, 2821–2828.
0
7
59
Today Craig Day (
@TheCraigDay
@MartinLab_ICIQ
@ICIQchem
) joins us once again on Synthesis Workshop to present his work from the
@HartwigGroup
@UCB_Chemistry
on iron-catalyzed azidation!
@J_A_C_S
2021, 143 (39), 16184–16196.
0
9
58
Joining us from the
@WickensGroup
, Dylan Holst (
@De_holst
) comes on Synthesis Workshop today to talk about his work on electrochemical synthesis of aziridines!
@Nature
2021, 596, 74-79.
@UWMadisonChem
@RealTimeChem
0
11
57
This week on Synthesis Workshop, Dr. Christopher Kelly (
@ckellzchem
) takes us into the world of radical polar annulation reactions (RPARs)!
Full episode:
Key papers:
@OrgSynth
2017, 94, 16.
@J_A_C_S
2018, 140, 8037.
Org. Lett.
@JOC_OL
2018, 20, 6840.
1
7
58
Came across a very nice example of 1,3-diol desymmetriyation being used to define a stereocenter in the synthesis of a drug by
@faul_margaret
and team!
@thiemechemistry
1
7
59
Today on Synthesis Workshop, Dr.
@Mark_P_Walsh
(
@ClaydenGroup
@SynthAtBris
) joins us to share his work on the enantioselective synthesis of ammonium cations with
@MattOKitch
@DurhamChemistry
!
@Nature
2021, 597, 70–76.
0
8
58
This week we continue our Advanced Organic Chemistry course with a talk from Emma Gogarnoiu on Halogen-Atom Transfer (XAT)!! Check it out here:
Thanks to Aidan Looby for hosting and Morgan Jouanneau for a great problem set!
0
11
59
This week's Advanced Organic Chemistry talk on Retrosynthesis by
@SWM_Crossley
also has a problem set now available on , thanks to our Associate Editor of Problem Sets
@franjoTro
! Check it out!
This week we continue our Advanced Organic Chemistry course as
@SWM_Crossley
teaches Retrosynthesis!!
Link:
1
20
104
1
8
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1
8
54
This week on Synthesis Workshop we continue our Advanced Organic Chemistry course as Terry McCallum gives us an introduction to radical clocks! Thanks to Xingfeng Bai for hosting and editing this talk!!
Link:
1
14
58
Tune in this week as Sebastian Brunen from
@ListLaboratory
shares his work on asymmetric Friedel-Crafts reactions of unactivated arenes!
@J_A_C_S
2023, 145, 29, 15708.
Also a new problem set available on thanks to Peter Bellotti!
0
14
56
Today on Synthesis Workshop, we are joined by
@BaranLabReads
members Kelly Eberle, Fabian Schneider, and You-Chen Lin, who share with us their work on the synthesis of darobactin A!
Full episode:
@J_A_C_S
2022, 144, 14458–14462.
1
7
55
Today on Synthesis Workshop,
@AndryjBorys
(
@EvaHeviaGroup
) shares his work on the Phospha-Bora-Wittig Reaction from the
@cowley_group
@EdinburghChem
!
@J_A_C_S
2021, 143, 14065.
0
2
53
Today on Synthesis Workshop we're joined by Saswata Gupta, who shares with us his work on ruthenabenzenes from the group of Prof. Daesung Lee at UIC!
@J_A_C_S
2021, 143, 7490-7500.
@ChemistryatUIC
@IITKgp
#RealTimeChem
#ChemTwitter
0
13
52
Today on Synthesis Workshop, Alex Fanourakis (Phipps group,
@ChemCambridge
) joins us to share his work on enantioselective intermolecular amination!
Full episode:
Key paper:
@J_A_C_S
2021, 143, 10070-10076.
0
14
54
This week we're joined by Kevin Fengler
@OGManchenoLab
who explains how to fine-tune halogen-bonding interactions in asymmetric catalysis!! Thanks to Xingfeng Bai for hosting!
Link:
Key paper:
@angew_chem
0
9
55
In today's Research Spotlight episode, hosted by our Editorial Board member
@MBalletti2
, Sarah French
@Teamfrench_
(George group,
@AdelaideChem
) joins us to share her work on the total synthesis of atrachinenins A and B!!
@J_A_C_S
2022, 144, 22844.
0
14
52
Today on Synthesis Workshop,
@AntonioJLaPorte
(Burke group
@ChemistryUIUC
) joins us to share his work on Csp3 Suzuki-Miyaura cross couplings that evade beta-oxygen elimination!
Episode:
@ACSCatalysis
2022, 12, 10905-10912.
1
9
52
On today's episode of Synthesis Workshop, we're joined by
@thiemechemistry
#JournalAwardee
@GellrichUrs
, who shares his group's work on catalysis with pyridone borane complexes!
Recent work: Synthesis 2021, 53, 666–672.
0
9
51
This week on Synthesis Workshop, Dr. Sebastian Peil joins us to share his work on hydrogenative C-H insertion reactions from the Fürstner lab
@maxplanckpress
!
Full episode:
@J_A_C_S
2022, 144, 4158 – 4167.
0
8
50
Today on Synthesis Workshop, Dr. Anirban Mondal
@FeringaLab
takes us through his work on the synthesis of chiral phosphorus compounds by asymmetric C-P coupling reactions!
Full episode:
Key paper:
@NatureCatalysis
2022, 5, 10–19.
0
6
51
Very excited to have
@TheCraigDay
back with us on Synthesis Workshop this week, talking about electron transfer events in nickel complexes with
@rmartinICIQ
@MartinLab_ICIQ
@ICIQchem
!!
Full episode:
Key paper:
@NatureCatalysis
2023, 6 (3), 244-253.
1
8
50
Remembering this time last year, when we were joined by
@Lalitatanwar4
, who shared her work on late-stage C-H functionalization! ~1,400 views to date!
@J_A_C_S
2018, 140, 16026.
@J_A_C_S
2019, 141, 17983.
Org. Lett. (
@JOC_OL
) 2021, 23, 5024.
1
5
50
Today on Synthesis Workshop, Joe Anderson (GSK, University of Strathclyde) joins us to share his work on the synthesis of bridge-substituted BCPs!
Link:
Key paper:
@ChemEurJ
2024, 30, e202304070.
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Also check out a beautifully presented new problem and solution set by
@94peter
on oxidative addition and reductive elimination on our project homepage!!
Oxidative addition and reductive elimination are fundamental organometallic steps in cross coupling reactions, but how do they work? Tune in this week as
@TheCraigDay
dives into this topic in a new installment of our Advanced Organic Chemistry course!
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Today on Synthesis Workshop we're joined by Craig Day (of
@MartinLab_ICIQ
/
@rmartinICIQ
), who takes us through his mechanistic work on Ni-catalyzed Negishi coupling reactions!
@NatureCatalysis
2021, 4, 124-133.
#RealTimeChemistry
#ChemTwitter
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Surprisingly, hydrogen bond donors (HBDs) can be used to control the regiochemical outcome in fluorination reactions!
Now in
@J_A_C_S
:
"May the Fluorce be with you"
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"Should You Start a Chemistry Podcast?"
Thanks to
@danithechemist
and
@DrLCsquare
for working on this piece to share our experiences from podcasting in chemistry with
@PharmToTablePod
and Synthesis Workshop!
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