18 years ago, I came to the US to pursue my dream of becoming a scientist. Last week marked a major milestone in this journey, as I accepted an Assistant Professor position at
@UChicago
, where I am thrilled to start my own research group in January 2025! (1/5)
Favorite
@sloan_kettering
holiday tradition. Walking through the incredible 'Holiday Hallway' created by our phenomenal Facilities team. Thank you & happy holidays to everyone!
My 1st-ever
@NIH
@theNCI
NOA! Deeply grateful to all my mentors & colleagues, and for this nation’s continued support of my education & research. Excited to continue my efforts to better understand & target
#PancreaticCancer
#Metastasis
! (1/2)
Excited to share our latest preprint! Here, we asked: Does a tumor’s dependence on driver mutations change after it spreads to other organs? This led us to uncover a critical interplay b/w tumor
#Genetics
,
#Epigenetics
and
#AnatomicLocation
... 🧵 1/n
Truly honored by this recognition, which is really a reflection of the phenomenal mentorship, environment & colleagues, incl. key collaborators
@LoweLabMSKCC
@MSKCancerCenter
. Thank you! 🙏
The final version of our manuscript that develops the
#EPOGEMM
platform of mouse models to study
#MetastaticGastricCancer
. 6 diff genotypes + 4 diff genetic backgrounds = new insights into the interplay b/w metastatic site, tumor genotype & immune surveillance. 🧬⚡🐭 (1/4)
New preprint, super fun collaboration with the amazing Pancho 'MACHETE'
@BarrigaFM
! We present a flexible method to study large genomic deletions & use it to uncover how the pervasive 9p21 dels promote tumor immune evasion & metastasis. 🧬🔪🧬
#MACHETE
#Cancer
#Deletions
#Teamwork
New Preprint! Led by
#DynamicDuo
@BarrigaFM
&
@KTsanov
, this study set out to understand how somatic copy number alterations (CNAs) promote cancer. CNAs are prevalent across cancer types & correlate w/ clinical outcomes but remain difficult to study. 1/n
Had a blast celebrating my inspiring friend
@DirenaAC
's Blavatnik Award. Big congratulations to her & the other 2021-22
@BlavatnikAwards
honorees! 👏🥳🚀
Another fantastic CSHL Cancer Meeting for the books! Had a blast presenting our work, hearing about all the exciting advances in the field, and hanging out with old & new friends -- CSHL style! See you next time.
@cshlmeetings
#cshlcancer
Watch out
@officialDannyT
, there’s a new MACHETE in town — a powerful technique developed at MSK's Sloan Kettering Institute to study frequent, large-scale genetic deletions in
#cancer
called copy number alterations.
The
#TsanovLab
will combine next-gen mouse models, functional genetics & multiomic approaches to understand and target the
#drivers
and
#vulnerabilities
of metastatic tumors, with the ultimate goal of novel
#therapies
that are specifically tailored to
#metastatic
cancers. (2/5)
Happening this afternoon, postdoc
@KTsanov
presents brand-new work uncovering surprising roles for the SMAD4 tumor suppressor gene in metastatic pancreatic cancer. Check it out!
#AACR23
Equally as important, I will be dedicated to
#mentoring
future generations of scientists and fostering a collegial, collaborative & inclusive culture of excellence, where everyone can reach their full potential while enjoying the journey of scientific discovery. (3/5)
It was amazing to reunite with old friends, put faces to the names whose papers I've read (and stories I've heard) & to see that the culture of excellence, collaboration & fun has remained a constant throughout 25+ years of the Lowe lab. Here's to the next decade!
#LoweLab25
What an incredible Reunion! It was wonderful to see all former lab members who traveled to NYC from all over the world & to experience the joy that we all shared in getting together. THANK YOU & stay in touch!
#LoweLab25
Anyone looking for a highly creative, supportive & fun mentor should not miss this opportunity! Having worked closely with Pancho for the past 4 years, I can say that he is an outstanding scientist AND person. Sad to see him leave but so excited about the
#BarrigaLab
! 🚀🎉🍻
I’m delighted to announce two major developments for my career:
First, I will be joining the amazing
@VHIO
as a Group Leader!
Second, I have been awarded an
#ERCStG
(MACHETE!) to start my lab
@ERC_Research
.
I look forward to join the vibrant Barcelona research community!
Absolute pleasure talking to
@AspenHighSchool
students about science/research, along w/ super inspiring leaders Dr. Knudsen
@AmerCancerCEO
& Dr. Harris
@theNCI
. Brought me back to my high school days, when an amazing teacher sparked my interest in Biology. The future is bright!
Congratulations to the 2024 Leading Edge Fellows!
34 exceptional postdocs doing biomedical research 🤩
Search committees, seminar committees, keep your eyes on these superstars.
We're excited for their presentations
@janeliaconf
@HHMIJanelia
!
Have you been thinking about how to make megabase-sized deletions? Does MACHETE ring a bell, but maybe the details seem daunting? Fret no more, since our protocol has just been published
@NatureProtocols
!
@VHIO
@MSKCancerCenter
Today is the AACR Early-Career National Day of Action, and we're calling on early-career scientists, trainees, students, and all who support them to contact members of Congress and ask them to prioritize
@NIH
funding. Take action:
#AACRontheHill
#FundNIH
New paper day! Since the development of
#baseediting
tools, we have been excited about the ability of this technology to engineer and understand the hundreds of cancer-associated genetic variants of unknown significance. BUT… it wasn’t as easy as hoped. 🧵
I ask for your help to support this Turkey Earthquake Fund that will directly help affected families in the region. Thanks everyone who reached out during these difficult times, truly appreciate and will never forget your support ❤️ Please share this 🙏
T-4 hours! Excited to present my research in a 3-minute 'elevator pitch' format, along with 9 of my
@MSKCancerCenter
colleagues. Join us -- and get to vote for the 'People's Choice' winner! 🙂
#MSKPostdocSlam
#NPAW2023
Happy National Postdoc Appreciation Week to our phenomenal
#MSKPostdocs
(
@MSKPDA
)!
@MSKCancerCenter
community, join us today @ 4pm for the Postdoc Slam competition. We will also announce the winners of the 📸 contest and show the annual postdoc appreciation video.
#NPAW2023
Immense pleasure and proud satisfaction hosting former postdoc
@barrigafm
. We’ll learn from the fantastic work he’s developed
@LoweLabMSKCC
next week at the
#IRBBarcelona
Stem Cells &
#Cancer
BioMed conference
What an amazing & inspiring moment. To receive a revolutionary vaccine based on your own foundational research, which was ignored by most. Thank you, Dr. Kariko!
While receiving the vaccine I reflected on my long journey by remembering my colleagues
@barnathanes
and
@drdavidlanger
who were so enthusiastic about the mRNA therapeutic use in my early days at Penn. Thank you!
Very cool work shedding new light on the 'dark matter' of the cancer genome. 🔥🔎🧬
Super fun to be involved in this study & other ongoing collaborations with the Greenbaum lab!
(Also, love the
#TransposonThursday
hashtag 🤓)
Its
#TransposonThursday
! Sharing our newest preprint on context dependent mechanisms by which cancer cells co-evolve with retrotransposons (LINE1 and SINEs) to mitigate viral mimicry. A
#TeamScience
effort led by our postdoc
@sunsiyu1
@CompOncMSK
👇👇👇
#WorkoftheWeek
: In Vasily Kandinsky's “Dominant Curve” (1936), the figures within the green rectangle recall microscopic marine animals, while embryo-like shapes appear elsewhere. These biomorphic forms gesture to rebirth and regeneration. Learn more:
Super cool! A transposon jump created an alt splice site leading to tail loss in humans. 🤯 I have sometimes lamented the fact we don't have tails (think about tail-based accessories, sports, etc...😄). Now we know why 👇
Losing our tail had big consequences for our ancestors, but how did it happen? In our paper, led by
@BoXia7
, and with
@JefBoeke
, we propose that tail-loss involved the insertion of a single transposable element, with implications for our health today.
Francisco Sanchez-Rivera (
@fjsanchezrivera
)
@LoweLabMSKCC
share his research on genetic variants in cancer.
"One of my main interests centers on developing & applying high-throughput methods to assess the function of cancer-associated genetic variants of unknown significance."
Beautiful work & example of the magic that happens when amazing computational and experimental biology meet. Powerful insights into
#PancreaticCancer
that open many new avenues of investigation. Big congrats
@CassBurdziak
@DirenaAC
et al!!
My lab’s first pre-print! We present the “Killifish” for a mammalian model:-) We describe a mouse model that was generated by 45 years (!!) of breeding. These are the biggest mice in the world - say hello to Titan mice... More work to follow...
Are you interested in:
🧩Understanding how cell and tissue plasticity go awry in
#cancer
?
🔬Single-cell technologies, organoid/mouse models and functional genomics approaches?
🌻Creating a lab
#environment
that promotes the best of us?
JOIN US! We are
#HIRING
at all levels!
Enjoy our ‘Proteome Landscape of the Kingdoms of Life’
@Nature
. We analyzed 100 species by
#proteomics
#automation
#µpac
#AI
and doubled the number of experimentally verified proteins.
Happy Transposon Day 2022! Today is the 120th birthday of Barbara McClintock, founder of the
#transposon
field and Nobel laureate. Please celebrate with us by using the hashtag
#TransposonDay2022
. How has Barbara McClintock or her work influenced you?
Happy to share our latest work
@CD_AACR
developing fast & flexible method to model
#ProstateCancer
that led us to uncover an actionable role for
#WNT
signaling in driving
#metastasis
in this cancer. (1/2)
Pancho
@BarrigaFM
is an innovative molecular biologist & mouse modeler who is currently looking for faculty positions. He will be a great colleague & collaborator at any institute lucky enough to get him! –SWL 9/9
Cool story. A secreted
#RNA
binding protein in the honeybee royal jelly stabilizes RNA for horizontal transfer between bees. Could RBP/RNA granule secretion be a widespread phenomenon?
How much do you know about Marie Curie?
Curie dedicated her life to science. She was the first woman to be awarded a Nobel Prize, the first person to be awarded twice and is still the only person to receive the prize in two different scientific fields.
Curie died
#OTD
in 1934.
BREAKING NEWS:
The 2020
#NobelPrize
in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”
Out in
@Nature
today, our latest work provides a proof of concept for the utility of
#CART
cells as
#senolytics
. This study was an exciting collaboration with the
#SadelainLab
... (1/3)
We’re proud to announce the launch of Break Through Cancer, a new foundation dedicated to supporting multi-institutional teams focused on the most difficult to treat cancers. Read the full press release here:
#BreakThroughCancer
1/6
@CellStemCell
publishes today our recent work on
#CancerStemCells
. Tremendous amount of work 🙌🏻 from
@clara_morral
PhD project 🎓 and Jelena Stanisavljevic 👍🏻 with help of the rest of the team 🌊🔝
Thread 👇🏼
Of all the innocent victims of the war in Ukraine, kids with cancer are among the most vulnerable. Just donated. Pls consider it too if you can: .
#StandWithUkraine
🇺🇦
Shermlab goes east! A new chapter begins
@MSKCancerCenter
@CpcrMsk
in Jan 2023. Forever grateful to my amazing OHSU mentors and colleagues, and excited for the scientific interactions, NYC adventures, and
#feiginworthy
bagels ahead! 1/2
Congrats, Simon! Pleasure to contribute to this study that establishes a key role for
#Hypoxia
in driving the pro-tumorigenic
#iCAF
phenotype in
#PancreaticCancer
(and likely beyond).
Another beautiful & insightful study by
@whitefishlab
. Super cool story that was a pleasure to see unfold at dept seminars/retreats. Congrats
@Joshua_M_Weiss
& team!
A longstanding question in cancer: why do tumors only form in certain locations in the body? In our new
@nature
paper (), we define anatomic position of the cell as a mechanism for this.
1. ENTER
#mRNAvaccines
for
#pancreaticcancer
! Long-term
#PDAC
survivor story PART3.
"Do
#PDACs
REALLY have vaccine neoantigens (NAs)"? (aren’t they lowly mutated?)
If each patient = own NAs, how do you vaccinate?
Maybe mRNA? But how?
@Nature
👇🏽 [1/32]
@aemonten
Indeed. People often quote Seneca: "Luck is what happens when preparation meets opportunity." True. But behind "preparation" & "opportunity" lie many random factors (what country/family were you born in, what education was accessible to you, etc). Humility is important.
Great read on origins & milestones of cellular
#reprogramming
by
@morris_lab
! My favorite part (besides the Methods describing accidental loss of a frog) is the elegant use of mutant frog nucleoli or naturally rearranged mouse nuclei as donor cell markers.
In the 1800s, it was thought that cells lose genetic material as they differentiate, making differentiation irreversible. In 1958, John Gurdon challenged this notion to reset differentiated cells to early embryonic stages
#Nature150
@NatureNV
We continue the celebration of
#MSKPostdocs
for
#NPAW
. Check out this video, where our postdocs got grilled by kids with very hard Q’s such as ‘What do you want to do when you grow up?’ and ‘have you broken anything in lab?’
@sloan_kettering
@MSKPDA
🤣😂
The application cycle for the next round of Jane Coffin Childs Memorial Fund for Medical Research Postdoctoral Fellowships opens on October 10th. Please spread the word to postdocs (and soon to be postdocs) in biomedical sciences.
1/8
our paper out today in
@ScienceMagazine
showing how plasticity in early cancer progression influences cells’ ability to communicate w/ their environment! huge thank you & congrats
@DirenaAC
@LoweLabMSKCC
@dana_peer
!
After many long years filled w/ delight and disappointment, often in the same day, our paper on a new function of histones is out
@ScienceMagazine
! Thx to incredible team
@NarsisAttar
@OA_Campos
Maria Vogelauer
@jencheng65
and many collaborators.
Excited to share a paper in our longstanding collaboration with
@bradleybio
identifying tumorigenic loss of BRD9 in SF3B1-mutant malignancies out today in
@nature
. Co-led by
@DaichiInoue5
and Guo-Liang "Chewie" Chew with amazing help from
@kadochlab
.
PhDone!!!🍾🎓 Earlier this week I crossed the finish line of my PhD
@GSKGradSchool
. Thanks to my mentor Scott and everybody in the
@LoweLabMSKCC
for all the support along the way. It was a marathon rather than a sprint - but a marathon full of learnings and fun. (1/n)
@aisha_dickerson
Not weird & makes a difference. My 1st ever Thanksgiving in the US was like that. I was a foreign student who didn't know anyone - it taught me the spirit of Thanksgiving & became a tradition. The kind person who invited me has been my 'American mom' ever since!
Ever wonder if damaged tissues try to regenerate better via somatic evolution? Our team effort explores this question: . Congrats Min Zhu, Tianshi Lu, Joyce Jia, Xin luo
@TaoWang27112003
, Adam Yopp,
@docamitgs
,
@CRI_UTSW
,
@UTSWNews
. Tweetorial 1/6.