Pulmonary Cell News
@pulmonary_news
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⌛ We know how busy it can get!
Science News by
@STEMCELLTech
is here to help! Our website and weekly 💌 newsletters keep scientists current with the latest peer-reviewed research, as well as industry and policy news.
Get started today 👉
0
0
3
🔎 New in
@iScience_CP
!
Scientists at
@DukeCellBiology
propose that the multi-apical domains of
#alveolar
type-2 epithelial cells enables them to be poised to support the
#regeneration
of a large array of alveolar sacs.
Learn more: 🔗
0
13
53
🫁 Drs. Calum Bain (
@bainlab
) and Andrew MacDonald (
@ProfAndrewMac
) reviewed how the lung environment affects
#macrophage
development, activation, and function.
📚 Read the
@MucosalImmunol
paper:
0
16
51
🔬 Dr. Mark Jones from
@unisouthampton
led researchers to uncover some answers to questions around lung fibrosis, including the discovery that the loss of
#alveolar
epithelial NFKBIZ/IκBζ expression dysregulates the IL-6 axis.
@CellReports
📎
0
8
46
#Organoid
model of 👶 fetal
#alveolar
development reveals mechanisms of cell fate patterning and
#neonatal
respiratory disease.
👏 Congratulations to Dr. Emma Rawlins' (
@LabRawlins
) team with
@KyungtaeL
at
@CRUKCamCentre
@GurdonInstitute
!
@CellStemCell
|
1
2
34
💬 Cell-
#ExtracellularMatrix
interactions for alveolar repair!
Dr. Erin Plosa's team at
@vumcpeds
shows that functional
#alveolar
repair after injury 🩹 with terminal
#epithelial
differentiation requires β1-containing
#integrins
.
@JCI_insight
| 🔗
2
11
35
Led by Drs.
@AliDoryab
and Otmar Schmid, scientists at
@HelmholtzMunich
developed a mini-lung
#FibrosisModel
that allows for the combined longitudinal testing of pharmacodynamics and pharmacokinetics of drugs. 🧫
#OpenAccess
: 🖱️
0
8
33
A recent paper by scientists at
@TheCrick
and other institutions including Dr. Charles Swanton uncovers the multifaceted roles of A3B in NSCLC and identifies A3B as a potential target for more durable responses to targeted 🎯 cancer therapy.
24
11
32
Dr. Paola Marignani (
@PMarignani
) and colleagues at
@DalhousieU
identified markers of early-stage
#lung
cancer that were validated in primary lung tumors and circulating blood. 💉
0
3
30
🥼 Dr. Emma Rawlins (
@LabRawlins
) and the team at
@GurdonInstitute
used
#organoids
to study the cellular mechanisms regulating human lung development.
👇 Learn all about RTK signaling in maintaining columnar shape of
#lung
tip progenitors.
@Dev_journal
|
0
6
29
Led by Dr.Olivia Merkel (
@LabMerkel
), researchers 👨🔬👩🔬 at the University of Munich, (
@LMU_Muenchen
) developed a formulation for pulmonary administration of siRNA to suppress SARS-CoV-2 replication in
#LungEpithelialCells
.
@JCRnEDITORS
| 📑
0
5
29
In a recent
@NatureGenet
article, researchers led by Dr. Patrick Hsu (
@pdhsu
) used genome-wide
#CRISPR
screens to identify
#mucins
as host factors modulating
#SARSCoV2
infection.
👨🔬👩🔬
@SKonermann
@ScottBiering
@HarrisProgram
@EleanorWang
1
4
27
.
@harvardstemcell
Institute researchers 👨🔬👩🔬 revealed methods to interrogate
#LungProgenitorCell
potential and model transitional cell states relevant to pathogenic features of lung disease in vivo.
#OpenAccess
in
@CellReports
👉
0
4
27
Recent studies have identified impaired type II
#alveolar
epithelial cell renewal in idiopathic
#pulmonary
fibrosis human
#organoids
! 🫁
0
4
27
A group of scientists including Nicholas E. Banovich (
@NeBanovich
) observed a similar cellular distribution and relative expression of SARS-CoV-2 entry factors in control and samples from chronic
#lung
disease patients.
Read more 👇
📌
0
10
27
Led by Dr.
@Kam_Dua
,
@UTSEngage
researchers formulated berberine-loaded liquid crystalline nanoparticles and investigated their in vitro antiproliferative activity in human
#LungEpithelial
cancer cell line.
#OpenAccess
here 👇
1
7
25
The discovAIR project: a roadmap towards the Human Lung Cell Atlas 🗺️
As part of the
#HumanCellAtlas
consortium, this atlas is anticipated to be the founding stone for a more detailed understanding of the pathogenesis of
#LungDiseases
.
@ERSpublications
|
0
2
25
🥼 Drs. Minze Guo and Yan Xu at
@CincyKidsNeo
led researchers in the development of a computational pipeline utilizing the 🧫 LungMAP CellCards as a dictionary to consolidate single-cell transcriptomic datasets of human & mouse
#lungs
!
@naturecomms
|
0
7
24
A new study published in
@ModernPathology
shows distinct mutational features between preinvasive lesions and invasive tumors with mutations enriched in
#adenocarcinoma
in situ (MEA), suggesting the involvement of MEA in the early stages of tumorigenesis.
0
9
23
Dr.
@RhiannonWerder
collaborated with other researchers, including Dr. Michael Cho (
@mikecho95
), to study chronic obstructive pulmonary disease and genes 🧬 of interest using
#CRISPR
interference in iPSC-derived type 2
#alveolar
epithelial cells.
1
6
23
A recent study published in
@NatureCellBio
indicates that hAEC2 loss and expansion of
#alveolar
metaplastic basal cells in severe human
#lung
injuries are causally connected through an hAEC2-basal cell lineage trajectory driven by aberrant mesenchyme. 🔬
0
9
23
A team of researchers from
@ASTRAZENECAUK
demonstrate that small extracellular vesicles transfer senescence to neighboring 🏘️ healthy cells, promoting the disease state in
#IPF
.
More on their discovery: 👉
0
6
22
What is the
#discovAIR
project? 🤔
It aims to establish the first draft of an integrated
#HumanLung
#CellAtlas
, through single-cell transcriptional and epigenetic profiling and spatially resolving techniques.
📚
@ERSpublications
| 🔗
0
6
21
Researchers from
@unibern
present a second-generation lung-on-a-chip with an array of stretchable 🧘 alveoli made with a biological membrane.
#OpenAccess
in
@CommsBio
0
4
21
🥼
@BiotechBarron
,
@biochemist_hero
& colleagues used a human-derived in vitro air liquid interface culture to model bronchial epithelial-fibroblast cross-talk in idiopathic
#PulmonaryFibrosis
. 🧫
Learn more about their system's utility:
➡️
1
6
20
Basal cells in
#IPF
- what do they do? 🤷
Dr.
@dianhuajiang
's team at
@CedarsSinai
use 3D
#organoid
culture assays to interrogate basal cell effects on AEC2 renewal capacity, as well as
#fibroblast
activation.
Check it out!
@AJRCMB
|👉
1
8
19
How do the lungs repair themselves after injury? 🤕
Drs.
@JoePlaner
and Edward Morrisey at
@PennMDForum
review the major mechanisms of damage, regeneration ♻️, and repair within the
#alveolar
niche where gas exchange occurs.
@AnnualReviews
|🔗
0
3
19
Drs.
@Tyson_Sharp
, Sarah Martin, and colleagues at
@QMBCI
identified a novel drug tool with significant preclinical characterization that serves as an excellent candidate to explore and define LIMD1-deficient cancers.
Learn more ⬇️
0
10
20
🙌 Congratulations to Drs. Venkataramana Sidhaye (
@sidhayelab
), Baishakhi Ghosh (
@bgosh226
) & team at
@HopkinsPCCM
on their discovery of E-cadherin's causal role in the pathogenesis of
#emphysema
and airway dysfunction in
#COPD
.
More in
@CommsBio
!
👉
0
3
18
New in
@AJPLung
! 📍 Scientists at
@UniLeiden
demonstrated an
#organoid
-based expansion of patient-derived primary alveolar type-2 cells for the establishment of alveolus epithelial lung-chip cultures.
#LungOnAChip
Read the full article: 🔓
0
2
19
Led by Dr. Reinoud Gosens (
@gosensr
), University of Groningen (
@univgroningen
) scientists concluded that specific targeting of EP and IP receptors offers therapeutic potential for injury to repair in
#COPD
.
Read it in
@ScienceAdvances
| 📑
0
0
17
Findings detailed in
@Dev_Cell
indicate that during aging, the epigenetic regulation that coordinates lung progenitor cells’ regenerative responses becomes dysregulated, aiding our understanding of age-related susceptibility to lung disease.
📘
0
7
17
Scientists including Dr. Jichao Chen, reported that Nkx2-1 mutant alveolar type 1 (AT1) and AT2 cells gain distinct chromatin accessible sites, suggesting an epigenetic plasticity unexpected from transcriptional changes.
@MDAndersonNews
📝
@NatureComms
0
4
17
🆕 From the lab of
@PGTimmune
:
Scientists provide evidence that excess activity of damage-responsive lung
#fibroblasts
drives lethal immunopathology during severe
#influenza
virus infection.
1
5
18
Led by Dr. Jason Spence (
@TheSpenceLab
) at
@UMichMedSchool
, researchers 🔎 reveal opposing roles for TGFβ- and BMP-signaling in AT2 differentiation and provide a new strategy to generate a 💉 therapeutically relevant cell type.
🏫
@UMichMedSchool
|
0
4
16
Researchers review recent advances in understanding
#PulmonaryFibrosis
pathology, mechanism, and targets, as well as the development of various drug delivery systems for its treatment.
📎
0
5
15
A new
#review
from Dr. Rajkumar Savai (
@r_savai
) at
@mpi_hlr
explores new insights into the
#epigenomic
📍🧬 landscape of small cell
#LungCancer
.
📗:
@ATSBlueEditor
🔗:
1
7
16
Check out this
@NatureCommes
paper from the
@SotilloLab
!
They used
#LineageTracing
to investigate the cell of origin of lung
#adenocarcinoma
& show that ♣️
#ClubCells
&
#alveolar
type 2 cells give rise to tumors.
@chocarro_sara
@rn_toth
@rociosotillo
📓
0
4
15
Dr.
@NeBanovich
and team identified disease interaction expression quantitative trait loci and showed that this class of associations is more likely to be cell-type-specific and linked 🔗 to cellular dysregulation in pulmonary
#fibrosis
.
@TGenResearch
3
3
15
☔ The hydrophobic nature of Wnt proteins limits their use.
Scientists devised a strategy to deliver Wnt3a by anchoring ⚓ it to the surface of
#extracellular
vesicles, promoting
#alveolar
epithelial
#regeneration
after injury!
@AdvSciNews
|
0
1
15
📖 Drs. Stuart Mazzone (
@MazzoneLab
) and Pedro Trevizan-Baú (
@TrevizanBau
) at
@UniMelb
#review
the
#neuroimmune
pathways regulating airway 🌡️
#inflammation
!
Check out the recent discoveries that can improve the management of
#airway
disease.
👉
0
3
15
🥼 Dr. Wojciech Chrzanowski's team from
@SydneyNano
established two classes of lung-mimicking models, healthy and
#COPD
lungs, in hopes to accelerate 💨 the development of new therapeutics for
#lung
diseases.
🔗
0
2
15
Led by Mahyar Aghapour (
@mbiores
), researchers at Guericke University discuss the immunological mechanisms involved in physical barrier disruption induced by airborne pollutants and outline their implications in asthma and
#COPD
.
@ERSpublications
| 📑
0
8
14
Using airway
#organoid
media developed by
@TheCleversLab
, Kawasaki Medical School scientists succeeded in generating three
#lung
tumoroid lines for long-term culture from 41
#LungCancer
cases.
Open access:
0
5
16
Dr. Kirsty Short (
@K_RenfreeShort
) used primary nasal epithelial cells from children and adults, differentiated at an air–liquid interface, to show that
#SARSCoV2
replicates to significantly lower titers in children. 🔬
@yanshan_zhu
@AshaBowen
0
3
13
Diseases that affect gas exchange ♻️ in the lungs are often caused by the corruption of
#alveolar
cells.
Drs. Mark Krasnow, Tushar Desai & team at
@StanfordMed
find that FGF signaling controls alveolar cell fate selection and maintenance!
@NatureComms
|
0
4
13
New
@NatureComms
paper led by Dr. Ali Önder Yildirim (
@AlionderCPC
)!
🫁 The lab showed that in chronic obstructive pulmonary disease (COPD) patients, PRMT7 expression is elevated in the lung tissue and localized to the
#macrophages
:
1
3
14
A study led by Dr. Alexander Kabanov (
@alkabanov
) at
@msu_ru
has shown that poly(2-oxazoline)-formulated Resiquimod has a superior tumor inhibitory effect in a metastatic model of lung adenocarcinoma, relative to other therapies.
6
4
12
Check out this new
#review
discussing the role of
#ferroptosis
☠️ in the pathogenesis of pulmonary diseases 🫁 including asthma, lung injury, lung cancer, fibrotic lung diseases, and pulmonary infection.
Published in
@cddpress
:
0
2
12
🔬🧫 Researchers discover that
#pulmonary
#neuroendocrine
cells cause contraction of
#myoepithelial
cells within submucosal glands due to succinate.
Learn more from Dr.
@Wenjie_Yu_
and the team led by Dr. Michael Welsh from
@IntMedatIowa
.
📖
@Dev_Cell
|🔓
0
3
12
From the lab of
@jeremyhirota
at
@McMasterU
:
Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells. 🫁
📌
@scireports
🔗
3
3
12
A key controller: Lung Colonization by Aspergillus fumigatus Is Controlled by ZNF77
@NatureComms
@UofMMFIG
@MFIG_SaraGago
@NickReadMFIG
@dwdenning
0
7
13
A team of collaborators, led by Drs. Elsa Flores (
@LabElsaFlores
), Cristian Coarfa (
@CCoarfa
), and Min Gyu Lee, provide a unifying oncogenic role for ∆Np63 in both
#LungAdenocarcinoma
and squamous cell carcinoma. 🔬
@MoffittResearch
|
@MDAndersonNews
📖
0
3
13
Mutations of TP53 and STK11/LKB1 are rarely observed in human LUAD, even though engineered co-mutation is highly aggressive in mice.
🤷 What causes this difference? More from Dr. Lewis Cantley's team (
@CantleyLab
) at
@DanaFarber
.
@CD_AACR
|
0
3
12
Scientists from
@jlugiessen
established a three‐dimensional murine bronchioalveolar lung
#organoid
model. 🔬
Published in
@embojournal
0
3
13
Dr. Vivek Mittal (
@mittallab
), Juan Cubillos-Ruiz (
@JCubRuiz
), and team at
@WCM_CTSurgery
developed a gene signature 🖋️ that predicts immune cell infiltration and survival in
#NSCLC
!
@NatureComms
|
0
1
11
🔍 Researchers discover that airway basal cells in
#IPF
have the capacity to augment
#fibrosis
, remodeling, and bronchialization in the mouse lung.
Learn more from Drs. Benedikt Jaeger,
@jonas_schupp
, & Antje Prasse from
@Fraunhofer
.
@NatureComms
|🔓
0
2
11
Dr. Giovanni Ligresti at
@BUMedicine
has published in
@NatureComms
! 👇
He shows that lung endothelial
#ChromatinRemodeling
deteriorates with
#aging
, leading to abnormal transcription, vascular disrepair, and persistent fibrosis following injury.
🔗:
0
1
11
Pulmonary Alveolar Type I Cell Population Consists of Two Distinct Subtypes that Differ in Cell Fate
#Organoids
@PNASNews
0
5
12
A team of
@YalePCCSM
collaborators, led by Drs.
@MaorSauler
and John McDonough (
@jmcdonou
), used scRNA sequencing to highlight cell-specific mechanisms involved in the pathobiology of advanced
#COPD
and characterize its
#AlveolarNiche
. 🔬
➡️:
0
6
12
Dr. Sanjay Chotirmall and Louisa Chan's team at
@NTU_LKCMedicine
present an
#organoid
model that recapitulates the physiological lung 🫁 microenvironment to study of host-pathogen interaction and emerging
#InfectiousDiseases
. 😷
@NatureComms
|
0
2
11
Dr. Mark McVey's team at
@SickKidsNews
assesses emerging concepts of
#extracellular
vesicles (EVs) as effectors of transfusion-related acute
#LungInjury
(TRALI).
💡 EVs represent targets for therapeutic intervention to prevent or treat TRALI!
@AJPLung
|
0
2
11
🥼 Dr. Elsa Flores and colleagues at
@MoffittNews
grade lung adenocarcinomas (LUAD) with simultaneous segmentation by
#ArtificialIntelligence
.
Check out the benefits of GLASS-AI in
#LUAD
models in studying the molecular pathways of cancer progression.
🔗
1
2
10
Scientists from
@ImperialNHLI
showed an association between inhaled corticosteroid use and increased bacterial proliferation in lungs.
#COPD
0
5
10
The 💎 crystal ribcage and its broad applications presented in this
@naturemethods
study will facilitate further studies of nearly any
#pulmonary
disease and lead to the identification of new treatment strategies.
👏 Congratulations to the team on this fantastic achievement!
We are so excited to share our paper in Nature Methods
We developed
#CrystalRibcage
, a transformative platform that allows real-time probing of a functional lung during active breathing-circulation from whole lobe to single cell, in health and disease 1/10
16
25
110
0
3
10
#Retinoids
have more than just skincare benefits.
🥼
@ColumbiaPS
researchers establish the importance of local cellular retinoid stores within the
#lung
alveolus for maintaining its health in the face of an acute inflammatory challenge.
@NatureComms
|
0
1
10
New work led by Dr. Mark Kaplan (
@statfourwork
) at
@IUMedSchool
demonstrates that mouse 🐭 pulmonary interstitial
#macrophages
mediate the pro-tumorigenic effects of IL-9.
📚
@NatureComms
| 🔗
0
2
10
Dr.
@SerenaZacchigna
's team at
@ICGEB
find that lung endothelial cells 🧫 secrete angiocrine factors that regulate alveolar cell differentiation.
They discuss novel mechanisms by which miR-200c-3p protects from and reverts
#PulmonaryFibrosis
!
@cddpress
|
0
3
10
Beautiful! 😍
#FluorescenceFriday
Curious about the origin of our winning image? Dive into our captivating 3D video animation! Explore how lung macrophages maintain homeostasis during expsoure to envirmental insults.
@helmholtz_image
@HelmholtzMunich
@LungHealthMUC
@dzlacademy
@Health_talents
@pulmonary_news
3
14
88
0
1
10
Scientists found that, in an
#AlveolarOrganoid
acute lung injury model, keratinocyte growth factor in MSC-conditioned medium could improve the proliferation and decrease the differentiation of alveolar type II epithelial cells.
📎
0
3
9
📣 Next up on 4th place in our
#TopTweet
countdown!
🎉 Congratulations to Drs.
@AliDoryab
and Otmar Schmid and the team from
@HelmholtzMunich
on developing a mini-lung fibrosis model for drug testing!
Led by Drs.
@AliDoryab
and Otmar Schmid, scientists at
@HelmholtzMunich
developed a mini-lung
#FibrosisModel
that allows for the combined longitudinal testing of pharmacodynamics and pharmacokinetics of drugs. 🧫
#OpenAccess
: 🖱️
0
8
33
0
1
9
Scientists from the
@CarlaKimLab
present a review on alveolar progenitor cells and the origin of
#LungCancer
.
@BostonChildrens
0
1
10
Researchers suggest in
@AgingJrnl
that miR-135a might function as a suppressor of
#NSCLC
cells, and thus could be used as a potential therapeutic target.
#LungCancer
0
2
10
#LungCancer
accounts for nearly 20% of all cancer deaths worldwide. 🔬🩺
Check out this review for an in-depth analysis of the signaling pathways implicated in lung cancer, the mutations involved, and the current treatment strategies being used.
📚
0
2
9
🌡️ Reducing inflammatory damage and improving
#alveolar
epithelium
#regeneration
are two key approaches to promoting lung repair in acute lung injury/
#ARDS
.
👇 Check out the novel therapeutic role of α7nAChR in acute
#lung
injury.
@JCI_insight
|
0
4
8
Check out this new
@cddpress
#review
! 👇
It discusses the role of
#necroptosis
☠️ in airflow limitation in chronic obstructive pulmonary disease.
#COPD
Read it here:
0
4
9
💡 Researchers at
@mpi_mr_hd
developed a pulmonary
#alveolar
capillary barrier model that mimics physiological functions!
🧫 They combined a synthetic biofunctionalized
#nanofibrous
membrane system with a novel
#3D
-printed bioreactor.
@ACSBiomaterials
|
1
3
8
Publication in
@NatureCancer
| Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell
#LungCancer
.
@MDAndersonNews
0
6
10
University of Washington (
@UWPedsRes
) researchers, led by Dr. Jason Debley, differentiated
#BronchialAirwayEpithelialCells
from children and older adults to generate organotypic cultures.
Read more of their findings in
@SciReports
| 📑
0
4
9
A fascinating look at how
#SARSCoV2
establishes itself into the airways of its host. Thanks for sharing!
Our SARS-CoV-2 paper is now out in Nature Communications!
We examine three different variants and show new insight into SARS-CoV-2 entry and budding in human airway epithelium.
4
8
42
0
2
9
A new
@JCRnEDITORS
study demonstrates that Fc-receptor-targeted peptide-functionalized polyethylene glycol
#nanoparticles
could overcome multiple obstacles in the airway to prolong the
#pulmonary
retention of drugs.
Learn more:
➡️
0
1
9
👩🔬👨🔬 A group of scientists presented single-cell RNA profiling of
#lung
adenocarcinoma which provides additional prognostic information based on the microenvironment.
Read more 👇
0
4
9
🥼 Dr. Cristina Alvira's team (
@AlviraLab
) at
@StanfordPeds
explored the transcriptional regulators directing pulmonary
#angiogenesis
!
They created a 🐭 mouse model allowing inducible deletion of the NFκB activator, IKKβ, in endothelial cells.
@AJPLung
|
0
1
9
Pim-1 Kinase and the senescent
#LungFibroblast
inflammatory 🌡️ secretome!
@AJPLung
features research led by Drs. Ashley Gao & Andrew Haak (
@aj_haak
) at
@MayoClinic
on a positive feedback loop 🔂 that produces inflammatory cytokines in
#IPF
.
Read more👉
0
0
9
.
@MieUniversity
and
@IGBIllinois
researchers 👩🔬👨🔬, including the
@ShuklaGroup
, demonstrate that an anticorisin monoclonal antibody ameliorates
#LungFibrosis
by significantly inhibiting acute exacerbation.
#OpenAccess
in
@NatureComms
👇
0
4
9
Trace the origin of alveolar stem cells 🧫 in lung repair 🩹 and regeneration with researchers from the University of Chinese Academy of Sciences.
Now in
@CellCellPress
!
0
1
9
Dr.
@RachelZemans
' lab at
@UMich
showed that human keratin 8 🧬
#genetic
variants are associated with idiopathic pulmonary fibrosis.
#IPF
👇 Keratin 8 regulated the expression of
#macrophage
chemokines and macrophage recruitment.
@jclinicalinvest
|
0
1
9
🔬A recent study out of
@YalePCCSM
elucidates a major role of miR-33 in
#macrophages
in the regulation of
#PulmonaryFibrosis
and uncovers a novel therapeutic 💊 approach to treating this disease.
🍾Congratulations to the team!
1/n Our first
#CurePF
paper for 2023 is OUT! A novel role in Pulmonary Fibrosis for miR-33, a key regulator of macrophage immuno-metabolic response & mitochondrial function, providing evidence that inhibition may be antifibrotic
#miR33PFPaper
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Researchers revealed that Fgfr2 maintains
#alveolar
epithelial type 2 cell fate, balancing proliferation and differentiation during
#lung
alveolar regeneration.
📕
@CellReports
0
3
9
In this study, scientists detailed a method for
#cryobanking
🧊 of epithelial cells from either mouse or human
#lung
tissue for preservation of their phenotypic and functional characteristics.
📌
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2
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In a new
@PNASNews
study, the
@WeiTaoLab
team & collaborators detail proof-of-principle evidence for the design and use of dual-targeted mRNA
#nanoparticles
in homing to specific cell types to up-regulate target proteins in lung tissues. 🎯
In
@PNASNews
|
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1
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Contributing to anti-fibrotic actions: Differential Effects of Nintedanib & Pirfenidone on Lung AEC Function in Ex Vivo Murine and Human Lung Tissue Cultures of
#PulmonaryFibrosis
@LMU_Muenchen
@m_konigshoff
0
3
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Led by Dr. Rolf Brekken (
@brekkenlab
),
@utswcancer
researchers conclude that AXL is a critical targetable 🎯 driver of immune suppression in STK11/LKB1 mutant
#NSCLC
.
#OpenAccess
in
@CellRepMed
👉
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Congratulations to the team at
@MedicineUoN
on this review, providing a detailed account of 👶 postnatal lung development, risks of
#BPD
, and the current and future medicines 💊 to target TGT-b signaling.
@AJPLung
|
Tight temporal + spatial regulation of TGFb is crucial for normal lung development. Here we discuss how major
#bronchopulmonarydysplasia
risk factors are associated with aberrant TGFb signalling
@DrRCalthorpe
@AlanRSmyth
@IPFdoc
@DrDonSharkey
@AJPLung
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Researchers examined genome-wide changes in
#DNAmethylation
🧬 in acquired resistance to the anticancer drug
#ceritinib
and identified cytidine deaminase among the hypomethylated and upregulated genes in drug-resistant cells.
🔗
0
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Review | Dr. Anne‐Karina Perl and colleagues at
@CincyChildrens
summarize the role of alveolar fibroblasts and their activation stage in alveolar septation and regeneration and incorporate them into the context of human lung disease. 🫁
📌 Full Review:
0
2
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In this
@Dev_Cell
study, Drs.
@parahsaramore
,
@ctrenado_yuste
,
@celestemnelson
, Danelle Devenport, & team show that Vangl1/2 is required in the lung mesenchyme for sacculation.
💬 More here:
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♻️
#Regenerating
airway epithelial with
#mesenchymal
cells!
Drs.
@ElieElAgha
, Saverio Bellusci & colleagues from
@jlugiessen
highlight GLI1+ cells as a critical source of repair-supportive mesenchymal cells for bronchial epithelium repair.
🔗
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