Journal of Clinical Investigation
@jclinicalinvest
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The JCI is a premiere venue for discoveries in basic & clinical biomedical science. Est. 1924- https://t.co/xG7OGiBetO Bluesky: https://t.co/jMpYqQZxOk
Ann Arbor, MI
Joined December 2010
Pharmacological treatment of hyperglycemia in type 2 diabetes: #Review by Simeon I. Taylor et al. @UMmedschool in the #ReviewSeries: 100th Anniversary of Insulin's Discovery (
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Normal and defective pathways in biogenesis and maintenance of the insulin storage pool: #Review by Ming Liu et al. @peterarvan @umichmedicine in the #ReviewSeries: 100th Anniversary of Insulin's Discovery (
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The convalescent sera option for containing COVID-19 . @ACasadevall1 and Liise-Anne Pirofski discuss a strategy for preventing and treating COVID-19 disease using sera from recovered patients.
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Gastrointestinal motility disorders in neurologic disease: #Review by Michael Camilleri @MayoClinicGIHep in the #ReviewSeries: 100th Anniversary of Insulin's Discovery (
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Insulin signaling in health and disease: #Review by @LabSaltiel @UCSDMedSchool in the #ReviewSeries: 100th Anniversary of Insulin's Discovery (
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.@tonipollin @UMmedschool: Monogenic diabetes: a gateway to precision medicine in #diabetes: #Review by Haichen Zhang et al. in the #ReviewSeries: 100th Anniversary of Insulin's Discovery (
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In honor of the 100th anniversary of the discovery insulin, the JCI has collected a series of review articles, interviews with prominent scientists, and classic JCI papers reporting seminal findings in diabetes, insulin signaling, and insulin resistance:
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Monoclonal antibody targets pathogenic IFN source in cutaneous lupus lesions @biogen @ZuckerSoM #autoimmune #clinicalmedicine
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Conversations with Giants in Medicine: Peter Hotez: . JCI’s editor-at-large @UshmaNeill spoke with @PeterHotez about his motivation to become a physician-scientist and his interest in tropical diseases.
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JUST PUBLISHED: Clinical and immunologic features in severe and moderate Coronavirus Disease 2019 . Also: Savannah Pederson and Ya-Chi Ho comment on Chen et al.'s characterization of the cytokine storm in severe COVID-19 disease:
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Macrophage–endothelial cell crosstalk orchestrates neutrophil recruitment in inflamed mucosa: .@SumaginLab @NUFeinbergMed .#CellBiology #Inflammation
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The discovery of insulin revisited: lessons for the modern era: #Review by Gary F. Lewis and Patricia L. Brubaker @uoftmedicine in the #ReviewSeries: 100th Anniversary of Insulin's Discovery (
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IL-6 helps weave the inflammatory web during acute coronary syndromes: .In this #Commentary, Tetsushi Nakao, and Peter Libby fit the results into an inclusive schematic for IL-6 effects following MI. Related:
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#ReviewSeries edited by JCI’s Editor-in-chief @rex_ahima.: 100th Anniversary of Insulin's Discovery: Reviews in this series address a modern understanding of insulin's role in metabolism and the pathophysiology and treatment of disease.
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#Review: Targeting memory T cell metabolism to improve immunity: by @MauroCorradoBio and Erika L. Pearce in JCI's latest #ReviewSeries: Immunometabolism: @CECAD_ @HopkinsMedicine
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Immune cells to the rescue! Innate and adaptive contributions to tissue repair Featuring reviews on epigenetics, immunometabolism, and the innate, immune, and epithelial cell contributions to repair
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Obesity-linked reductions in adipose tissue oxygenation parallel reduced insulin sensitivity: @WUSTLmed .#ClinicalMedicine #Metabolism
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#ClinicalMedicine: Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities: @unimib #clinicaltrials #hematology
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Molecules in Blood Spike Hours before Seizures - @sciam profiles @marionhogg2 @Futureneuro_ie's research, published this summer in the JCI. (JCI article: .
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This week, JCI and @JCI_Insight announce the Reviewer Rewards program, which recognizes the outstanding contribution of peer reviewers to our evaluation process. More details can be found here:
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#ClinicalMedicine: Residual beta cell function benefits type 1 diabetes hypoglycemic events: @GWtweets #Autoimmunity #Endocrinology.
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Understanding immune toxicity triggered by immune checkpoint inhibitors . Michael Dougan and Massimo Pietropaolo review the immune-related adverse events (irAEs) associated with ICIs and clinical clues to irAE pathogenesis.
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JUST PUBLISHED: Clinical and immunologic features in severe and moderate Coronavirus Disease 2019 . Also: Savannah Pederson and Ya-Chi Ho comment on Chen et al.'s characterization of the cytokine storm in severe COVID-19 disease:
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.@pauljmeakin @LeedsMedHealth: Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction: #Endocrinology #VascularBiology
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People with vitiligo develop skin depigmentation that can now be reversed with treatment. In this review, @HarrisVitiligo et al. @UMassChan suggest that recent advances in treating vitiligo open new avenues for studying other mechanisms in autoimmune diseases.
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Sex Differences in Medicine: . Biological sex influences disease risk, progression, & treatment. This review collection, edited by @be_stranger, highlights the potential to leverage sex-dependent mechanisms to optimize therapies across medicine
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Conflicting interests: when whistleblowers profit from allegations of scientific misconduct: . Read the #Editorial by @emmcnally, JCI's Editor in Chief.
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Just Published: Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier: @LaelYonker @MassGeneralNews @harvardmed .#ClinicalMedicine #COVID_19 #Inflammation
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#clinicalmedicine Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease @WUSTLmed #hepatology #metabolism.
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The new tool in fighting cancer: Antibiotics.The antibiotic vancomycin’s effect on the gut microbiome can boost the body’s immune response (via @Penn_Today)
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SARS-CoV-2 variants resistant to monoclonal antibodies in immunocompromised patients is a public health concern: .In this #Commentary, @ACasadevall1 & @dfocosi discuss the emergence of immunity-evading SARS-CoV-2 variants. Related:
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Just published a review in @JCI_insight: The complement system in #COVID_19: friend and foe? @anuja_java @alhkim @WUNephrology @WUSTLmed
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We are excited to announce that bioRxiv preprints can now be directly transferred to the JCI for consideration! For more information, please visit
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Hemorrhage-activated NRF2 in tumor-associated macrophages drives cancer growth, invasion, and immunotherapy resistance: . @Unispital_USZ .#Inflammation #Oncology
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Author's Take: MICAL1 constrains and protects against disease by oxidizing CaMKII: Mark Anderson @HopkinsMedicine explains latest research from their group: Article: Full video: #Cardiology #CellBiology.
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#Cover: Dual therapy increases survival in a pediatric high-grade glioma model: .@castro2355_mg @umichmedicine .Image credit: @Ella_Maru .#Oncology #Therapeutics
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Why do some patients with a CBL genotype develop autoinflammatory disease? @Jonathan_Bohlen @casanova_lab and team report on chronic monocyte activation through the ERK pathway as a major contributor in patients with CBL LOF variants.
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#ClinicalMedicine: Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis: @DukeMedSchool #InfectiousDisease
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#Review: Unpacking macrophages’ many interactions with the vasculature in atherosclerosis: @KateyRayner @LeahSusser @UOttawaMed
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Just Published: Antituberculosis BCG vaccination: more reasons for varying innate and adaptive immune responses: A Commentary by Sarah Prentice and Hazel M. Dockrell @LSHTM @enherts .#Immunology #vaccines.
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#ClinicalMedicine: Inflammatory states predict progression to renal failure in lupus nephritis: .@UCCancerCenter .#Autoimmunity
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Just Published #Review: The intersection of #COVID_19 and autoimmunity: @jasonsknight @DrPujaMehta1 @YogenKanthi @casanova_lab @aaronmring @SharonEFoxMD @alexis_combes @umichmedicine @TempleUniv @RockefellerUniv
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NEW REVIEW SERIES: Linking mitochondrial dysfunction to disease A collection of 7 reviews curated by the @NIH's Michael Sack #mitochondria
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#Review: Hypoxia-inducible factors and diabetes: A review by Jenny E. Gunton @Sydney_Uni in the #ReviewSeries:
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On the Cover: Neonatal diabetes- and microcephaly-associated YIPF5 mutations cause increased ER stress: @Elisa_EDF @OtonkoskiT @athattersley @ExeterMed @ULBruxelles @helsinkiuni #CellBiology #Genetics
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This new review by Mark Herman et al. at @DukeHealth doesn't sugarcoat the role of fructose metabolism in metabolic disease: #obesity #diabetes #sugar
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Mitochondrial function in macrophages controls cardiac repair after myocardial infarction: ..David Weissman & @ChristophMaack highlight the metabolic mechanism by which macrophages regulate cardiac repair following myocardial infarction; #Commentary
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Author's Take: Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes: FULL VIDEO: ARTICLE: @KobeU_Global #Endocrinology #Metabolism.
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#ClinicalMedicine Influence of adiposity, insulin resistance, and intrahepatic triglyceride content on insulin kinetics @WUSTLmed. #endocrinology #metabolism
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#ClinicalMedicine: Biomarkers of inflammation and repair in kidney disease progression: @KidneydrChirag @HopkinsMedicine .#Inflammation #Nephrology.
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#Review: Recent advances in lung organoid development and applications in disease modeling: .Ana I. Vazquez-Armendariz and Purushothama Rao Tata .@Tatalab_Duke @DukeMedSchool @LIMES_Bonn
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A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60: @RoswellPark .#CellBiology #Oncology
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Changing the editorial process at JCI and JCI Insight in response to the COVID-19 pandemic and its effects on the worldwide scientific community:
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Assessing #COVID_19’s impact on New York City resident physicians: @ColumbiaMed .Accompanying commentary: @yaron_tomer @EinsteinMed.#InfectiousDiseases.
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ICYMI: #ReviewSeries: Circadian rhythm’s wide-ranging impact on human health and disease: This collection of reviews, curated by Amita Sehgal @PennMedicine considers the critical role of the circadian system in human health.
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Just published in @JCI_insight: Cytokine profile in plasma of severe #COVID19 does not differ from ARDS and sepsis: .@StanfordMed #ClinicalMedicine #InfectiousDisease
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Clinical insights into variable immune responses to BCG vaccination: Two clinical trials led by Mihai G. Netea @Radboud_Uni interrogated heterogeneous immunological outcomes of BCG vaccination.
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Many congratulations to JCI's deputy editor Gregg Semenza on this well-deserved recognition!.
BREAKING NEWS:.The 2019 #NobelPrize in Physiology or Medicine has been awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability.”
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ICYMI: #ClinicalMedicine: Early safety indicators of #COVID_19 convalescent plasma in 5,000 patients: @DrMJoyner @ACasadevall1.
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SIRT6 protects against vascular calcification in chronic kidney disease: #CellBiology #VascularBiology
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.@UshmaNeill interviews @DanielJDrucker @sinaihealth @uoftmedicine in the latest episode of JCI's Conversations with Giants in Medicine: Full Video:
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Inherited STAT2 deficiency accounts for adverse reactions to viruses: .@IsabelleMeyts @giorgia_bucciol @casanova_lab @BoissonDupuis @MasatoOgishi @ManaMomenilandi @BeziatV .#Immunology
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#ClinicalMedicine: Tobacco smoking induces metabolic reprogramming of renal cell carcinoma: @UCHealthNews #Metabolism #Oncology
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β3-adrenergic receptor agonist improves glucose homeostasis in two human trials (thread)
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Indoxyl sulfate in uremia: an old idea with updated concepts: Anders H. Berg, Sanjeev Kumar, S. Ananth Karumanchi discuss the link between IS and PAD and suggest possibilities for improving clinical outcomes. #Commentary.@CedarsSinai @BIDMChealth
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#Review: The lung mesenchyme in development, regeneration, and fibrosis: .by @ElieElAgha & Victor J. Thannickal in the JCI's latest review series on "Lung inflammatory injury and tissue repair":
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Antigen-presenting aged neutrophils induce CD4+ T cells to exacerbate inflammation in sepsis: .@NorthwellHealth .#CellBiology #Immunology
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Dietary potassium stimulates Ppp1Ca-Ppp1r1a dephosphorylation of kidney NaCl cotransporter and reduces blood pressure: .@PAWellingMD @HopkinsMedicine .#Nephrology
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In @JCI_insight: Severe immunosuppression and not a cytokine storm characterizes #COVID_19 infections: @WUSTLmed #InfectiousDisease
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Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome: @NIH .#Development #Neuroscience.
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KRAS mutations as essential promoters of lymphangiogenesis via extracellular vesicles in pancreatic cancer: In this #Commentary, @RaduPirlogMD & @GeorgeACalin1 @MDAndersonNews provide a model for KRASG12D-induced lymphangiogenesis in PDAC.
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#Cover: Visualizing the cardiac conduction system: .Image: an intact wild-type heart (gray) from a mouse injected with mCntn2-800 (gold), illuminating the entire cardiac conduction system in vivo. @Will_Goodyer @SeanM_Wu @StanfordMed .#Cardiology
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The 2019 Nobel Prize honors fundamental discoveries in hypoxia response @CardioOncology and @KimrynRathmell discuss the discoveries of Professors Sir Peter Ratcliffe @UniofOxford, Gregg Semenza @HopkinsMedicine, and William Kaelin Jr. ( @DanaFarber).
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B cells join T cell clusters in the host response to recurrent herpes simplex virus 2 infection: In this #Commentary, @JeffGehlhausen & @VirusesImmunity @YaleMed highlight role for antibody producing cells & B cells following HSV-2 reactivation
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#Review: Metabolic changes in aging humans: current evidence and therapeutic strategies: .in JCI's latest #ReviewSeries on Aging: .@allysonkpalmer @MayoClinic
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#ClinicalMedicine: Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure: @Rongtian2 @UWMedicine #Cardiology #Inflammation
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Review Series on Metabolism and Inflammation: 10 reviews on the link between inflammation and metabolic dysfunction
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The key role of NLRP3 and STING in APOL1-associated podocytopathy: @KSusztak @PennMedicine .#CellBiology #Nephrology
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REVIEW SERIES: Emerging roles for lipid mediators in health and disease Curated by series editor Charles Serhan.
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#Cover: PD-1 signaling in aged kidneys and diseased podocytes: .@StuartShankland @podocytes @ChangUCanSpare @VaughanLabUW @biofizzycist @UW .#Aging
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PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma: . @MattDun17 @childrenshealth @Uni_Newcastle .#Oncology #Therapeutics
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Preferential Gq signaling in diabetes: an electrical switch in incretin action and in diabetes progression? In this #Commentary, Colin Nichols, Nathaniel York, & Maria Remedi provide insights into T2D progression. Related article:
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#ClinicalMedicine: Pharmacogenomics of intracellular methotrexate polyglutamates in patients’ leukemia cells in vivo: @StJudeResearch #Hematology
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A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice: .@UWMadison .#Hematology
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#ReviewSeries: Understanding & exploiting the immune microenvironment in glioblastoma: ..JCI editors @HeimbergerAmy @DanielJBrat @maciejlesniakmd curated the reviews to confront the many aspects of immune involvement in clinically challenging tumors.
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Clinical and immunological features of severe and moderate coronavirus disease 2019 . Plus: @HoLabHIV 's commentary: SARS-CoV-2: a storm is raging
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#Cover: Monocyte-derived macrophages in necrotic liver lesion repair: .Image: multiplex immunofluorescence staining of liver tissue 96 hours after concanavalin A–induced liver injury. @NIAAAnews .#Gastroenterology #Hepatology
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#Viewpoint by Rana K. Gupta @dukemedicine: Human brown fat and metabolic disease: a heated debate:
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Fibroblasts suppress T cells in diffuse large B cell lymphoma: .@RamsayLab @KingsCollegeLon .#Immunology #Oncology
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Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells: @MDAndersonNews .#Immunology
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Just Published: Baricitinib restrains the immune dysregulation in severe #COVID_19 patients: @UniVerona #ClinicalMedicine #InfectiousDiseases
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A partial form of AIRE deficiency underlies a mild form of autoimmune polyendocrine syndrome type 1: .@UiB .#Autoimmunity #Endocrinology
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YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress: @Elisa_EDF @OtonkoskiT @athattersley @ExeterMed @ULBruxelles @helsinkiuni.#CellBiology #Genetics
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#ClinicalMedicine: Haploinsufficiency of immune checkpoint receptor CTLA4 induces a distinct neuroinflammatory disorder: @NINDSnews @NIAIDNews #Inflammation #Neuroscience.
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Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling: . #Immunology
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Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity: @ColumbiaMed #Hematology #Metabolism
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On the Cover: Inhibiting isocitrate dehydrogenase 1 mutant glioma: Image: small molecule inhibition of 2HG production promoted T cell response to glioma, which led to enhanced immunological memory & survival. Credit:@Ella_Maru.@castro2355_mg @umichmedicine
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YIPF5 mutations cause neonatal diabetes and microcephaly: progress for precision medicine and mechanistic understanding: A #Commentary by @tonipollin and Simeon I. Taylor discussing recent study by De Franco and Lytrivi et al.:
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12(S)-HETE mediates diabetes-induced endothelial dysfunction by activating intracellular endothelial cell TRPV1: @UK_Muenster #VascularBiology
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