Prash
@prash_singh
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Structural biologist/engineer working to better understand biological systems and engineer solutions that improve human life.
Nashville
Joined September 2009
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My grandfather built motors that powered big machines. In a lab not so different from his workshop, my colleagues and I uncovered the assembly of the bacterial motor. Today, this discovery has been published in
@NatureMicrobiol
#MolecularNodes
#Discovery
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Here’s the much-requested 3D printed bacterial motor from our study. My 3-year-old thinks it’s a tiara, while some think it’s a lamp shade! I have made the 3D print file available here:
@NIH3D
#Science
#STEAM
#OpenAccess
#3Dprint
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@ZoldenGames
@NatureMicrobiol
Hi Zolden! yes, the bacteria uses the flagellar motor to swim.
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Engineering Protein Assemblies: Envisioning the future workbench for integrating structural biology and engineering
#Science
#Engineering
#Technology
#STEM
#STEAM
Learn more about the proteins here:
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Royal Society of Chemistry just featured our latest research on the bacterial flagellar motor in Chemistry World. Read the article here: And the paper here:
#Science
#STEM
@VUBasicSciences
@VandyPharm
@ChemistryWorld
#AlphaFold
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@MarkRober
@MKBHD
Something similar was launched in 2017 called the Light L16 camera. After Softbank’s acquisition, the technology was implemented in Nokia smartphones and self-driving cars. Here is a picture I took with the L16 on one of my cycling trips a few years ago.
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@MCATstudySesh
@NatureMicrobiol
Thank you, and you are absolutely right. We can now integrate decades of data on chemotaxis, and this comprehensive understanding opens up numerous exciting avenues. I have discussed some of these in a 'Behind the Paper' blog post here:
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We will be hosting a Reddit AMA session tomorrow, April 25th, at 12:00 PM USA ET to discuss our latest research published in
@NatureMicrobiol
. Please join us to ask your questions here:
#Science
#Discovery
#MolecularNodes
#STEAM
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@AtlasBeefy
@ZoldenGames
@NatureMicrobiol
In vivo, it's quite stable, but in vitro, it tends to be very fragile and begins to degrade within the first hour. I briefly talk about it here: Hope this answers your question.
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@ksc_sean
@NatureMicrobiol
Hi Sean, you are correct! It is like a gear where the MotAB (brown protein) moves inwards so it can keep its rotation the same (due to the uni-directional proton flow) while changing the rotation (counterclockwise to clockwise) of the flagellar motor.
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Take a closer look at the engineering behind bacterial flagella in our latest publication. Our high-resolution structure provides numerical insights into the flagellar switch complex.
#Science
#STEM
#cryoEM
#Engineering
#Discovery
#LabLife
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Hi
@elonmusk
, I was told by a teenager that if a post gets a million views, you may leave a reaction. Just testing that hypothesis.
My grandfather built motors that powered big machines. In a lab not so different from his workshop, my colleagues and I uncovered the assembly of the bacterial motor. Today, this discovery has been published in
@NatureMicrobiol
#MolecularNodes
#Discovery
286
2K
12K
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3
45
@graveolens
@NatureMicrobiol
Hi Owen, the animation was made and rendered in
@Blender
, an open source 3D software using
#MolecularNodes
which is developed and maintained by
@bradyajohnston
.
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This is one of the best tutorial where a complex animation is summed up in around 15 mins.
#science
#Blender
For anyone interested
I made a tutorial covering how to make the nanopore sequencing animation I posted last week😊
#b3d
#MolecularNodes
#sciart
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Preparing a coloring page for my kid! 🖍️ This was my first protein structure. If you or your kids are interested, the download option for the coloring page is in second thread.
#SciArt
#STEM
#Science
#MolecularNodes
Thread 1/2
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This is a critical component of the bacterial flagellum, which is essentially the motor that allows bacteria to swim. This ring acts as the base for the flagellum's structure and is embedded in the inner membrane of the bacterial cell.
#science
#STEM
#biology
#BioTrivia
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@Mick_Goulish
@NatureMicrobiol
Hi
@Mick_Goulish
, the diameter is approx. 450Å and the different colors show different proteins.
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@AdrianThonig
@BrunoLevy01
@NatureMicrobiol
Hi
@AdrianThonig
, by assembly I mean the organization of the proteins (FliG, FliM and FliN) that form the base (C-ring) of the flagellar motor. This video might be helpful:
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@NatureMicrobiol
@VanderbiltU
This movie shows the C-ring at the base with FliG in red, FliM in yellow, and FliN in shades of purple; the MS-ring in blue; the MotAB in brown; the LP-ring in pink; and the rod in gray. You also can read the Behind the Paper blog here:
#MolecularNodes
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@RiyanMendonsa
@NIH3D
I used a SLA printer to printout and then used ceramic colors to paint different proteins. What you see here is proteins FliF in blue, and FliG in red. Proteins FliM (yellow) and FliN (purple) are not colored yet in these images.
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The Himalayas, Manali to Leh. Day 9, Whiskey Nullah to Tso Kar lake. The Himalayan Marmots and wolves were spotted too.
@bikestreetboys
#bsbexperience
#roadtrip
#biketour
#manali
#leh
#himalayas
#bicycletour
#cycling
#strava
#explore
#bikestreetboys
#cycling
#gopro
#light
#l16
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The Himalayas, Manali to Leh. Day 13, Leh to Khardung La. This is the toughest climb I have ever done. At 18,380 ft and unpaved roads makes the Khardung La the most challenging climb.
#bsbexperience
#roadtrip
#biketour
#manali
#leh
#manalidiaries
#lehdiaries
#himalayas
#light
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This protein, QFR, helps generate energy in cellular respiration by converting fumarate to succinate in the presence of quinones. Download the coloring page PDF here:
thread 2/2
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The Himalayas, Manali to Leh. Day 5 Tandi to Patseo.
@bikestreet
#bsbexperience
#igtravel
#roadtrip
#timelapse
#traveller
#terrain
#biketour
#manali
#leh
#manalidiaries
#lehdiaries
#himalayas
#whiskeynullah
#travelers
#wanderlust
#bicycletour
#cycling
#strava
#explore
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Our latest review article reveals intriguing new insights. Complex II isn’t limited to the electron transport chain and the Krebs cycle alone. We take a semi-chronological approach, highlighting paradigm shifts and delving into the multifaceted functions of Complex Il.
#Cell
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This can revolutionize and significantly expedite drug discovery and deepen our understanding of cellular processes. Exciting times ahead!
#AI
#Breakthrough
#AlphaFold3
#Science
#AI
@google
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@algxtradingx
@NatureMicrobiol
More like "MotAB-power". I am not sure if equivalent HP has been/can be calculated but a bacterial flagellar motor can rotate up to 100,000 RPM. In comparison, a typical car wheel at 100 mph rotates at ~1,400 RPM.
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Much needed. Looking forward to this series.
Starting a tutorial series about scientific
#journalcovers
✨
In ep1, I break down the ideation, design + Blender setup for one of my own:
Have a cover art suggestion? Comment below! (Can't promise much but I'll do my best😅)
#sciart
#scicomm
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The Himalayas, Manali to Leh. Day 8, Sarchu to Whiskey Nullah. The day started with some easy cycling but we soon tackle the zigzag "21 loops of Gata" at 15,030 ft up the canyon wall.
@bikestreetboys
#bsbexperience
#himalayas
#cycling
#bikestreetboys
#cycling
#gopro
#light
#L16
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The Himalayas, Manali to Leh. Day 4 Marhi to Tandi via Rhotang pass.
@BikeStreet_Boys
#bsbexperience
#igtravel
#roadtrip
#terrain
#biketour
#manali
#leh
#manalidiaries
#lehdiaries
#himalayas
#whiskeynullah
#travelers
#wanderlust
#bicycletour
#cycling
#strava
#explore
#travel
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$VERU COVID-19 & Cancer Drug: I wrote about using tubulin inhibitors to treat COVID-19 in March 2020. Drug VERU-111 (Sabizabulin) is a tubulin inhibitor. And with no side effects in Phase 3, it could be ideal for treating cancer too. Imagine possibilities.
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@bradyajohnston
@bradyajohnston
inspired by your animation and help from your
#MolecularNodes
toolkit, here is an updated flagellar assembly with my newly discovered C-ring structure and symmetry mismatched MS-ring.
#MolecularNodes
made it feasible to render this complex animation on a laptop.
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@Christo25568024
@digger_c64
@NatureMicrobiol
Not yet. I plan to place it on a platform with some solar cells.
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Cycling in Bhutan. Day 8, Hike to Tiger’s Nest. This is the world’s 8th wonder in my books.
#bsbexperience
#cycling
#hiking
#travel
#bhutan
#tigersnest
#monestary
@BikeStreet_Boys
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High-altitude cycling takes air out of your lungs and water bottles. From Thimphu riding uphill to Dochu-la (10,600 ft) and then going downhill to Punakha on Day 3 of Princely Bhutan.
#bsbexperience
#bhutan
#cycling
@BikeStreet_Boys
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The Himalayas, Manali to Leh. Day 5 and 6 (rest day for hiking) Patseo to Sarchu
@BikeStreet_Boys
#bsbexperience
#roadtrip
#terrain
#biketour
#manali
#leh
#manalidiaries
#lehdiaries
#himalayas
#travelers
#wanderlust
#bicycletour
#cycling
#strava
#explore
#bikestreetboys
#gopro
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The Himalayas, Manali to Leh. Day 3 at Marhi. Morning coffee at the campsite.
@BikeStreet_Boys
#bsbexperience
#igtravel
#roadtrip
#terrain
#biketour
#manali
#leh
#manalidiaries
#lehdiaries
#himalayas
#whiskeynullah
#travelers
#wanderlust
#bicycletour
#cycling
#strava
#explore
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@triXcellence
@NatureMicrobiol
You are correct. There have been multiple attempts to create drug delivery systems using nanomotors.
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The Himalayas, Manali to Leh. Day 4 Marhi to Tandi via Rhotang pass. Bike Street Boys
#bsbexperience
#igtravel
#roadtrip
#terrain
#biketour
#manali
#leh
#manalidiaries
#lehdiaries
#himalayas
#whiskeynullah
#travelers
#wanderlust
#bicycletour
#cycling
#strava
#explore
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@FronkRansom
@NIH3D
I had the same thought! Even visited few bakeries to see if they could make one for my kid. 3D print was the secondary option.
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@CulperResearch
And also read this:
@CulperResearch
Read the competing interest statement here. It is normal for PI to be working with multiple groups. You hand picked the companies and did not mention other companies they are involved with like Novartis, FujiFilm, etc.
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This is an excellent tutorial by
@luminous_lab
on presenting 3D molecular structures in PowerPoint.
#SciComm
📣 The tutorial is online:
Go teach some molecule how to fly in PowerPoint 😁
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Night sky at Tso Kar lake.
@BikeStreet_Boys
#bsbexperience
#igtravel
#roadtrip
#terrain
#biketour
#manali
#leh
#manalidiaries
#lehdiaries
#himalayas
#whiskeynullah
#travelers
#wanderlust
#bicycletour
#cycling
#strava
#explore
#bikestreetboys
#gopro
#light
#l16
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The Himalayas, Manali to Leh. Day 12, Rest day in Leh also known as ‘getting Leh’d’.
@BikeStreet_Boys
#bsbexperience
#igtravel
#roadtrip
#terrain
#biketour
#manali
#leh
#manalidiaries
#lehdiaries
#himalayas
#whiskeynullah
#travelers
#wanderlust
#bicycletour
#cycling
#strava
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@CulperResearch
Read my response here:
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Here is an updated link to the Reddit AMA:
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The Himalayas, Manali to Leh. Day 5 and 6 (rest day for hiking) Patseo to Sarchu Bike Street Boys
#bsbexperience
#igtravel
#roadtrip
#terrain
#biketour
#manali
#leh
#manalidiaries
#lehdiaries
#himalayas
...
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@lubufra
@NatureMicrobiol
The membrane (not shown here) around the MS-ring (blue) could act like one.
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@Ella_Maru
@NatureMicrobiol
Thank you, Ella! I like how you think about this. The protons flows via MotAB (brown). Specific amino acid residues on MotAB interact with FliG (red), causing the flagellar motor to rotate with it. Figure 6 of the paper illustrates this better.
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@nehaludyavar
This particular animation was made using
@Blender
, an open source 3d software, Adobe Illustrator and
#molecularNodes
which is built and maintained by
@bradyajohnston
.
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@barrygoldman1
@philipcball
Yes, that is MotAB. A membrane protein that uses uni-directional proton gradient for bi-directional rotation of the bacterial flagella.
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The Himalayas, Manali to Leh. Day 10, Tso Kar to Rumptse. This was a challenge indeed, but truly satisfying when we reach the top, before we set off down the exhilarating 1,200m descent of switchbacks to the village of Rumptse.
@BikeStreet_Boys
#bsbexperience
#igtravel
#roadtrip
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From the cycling trip in Bhutan🇧🇹, the land of the thunder dragon🐉
#everest
#tigersnest
#monastery
#BikeStreetBoys
#bsbexperience
#travel
#explore
#adventure
#adventuretravel
#cycling
#bhutan
#video
#natgeo
@Discovery
@NatGeoTravel
@TravelLeisure
@natgeo
@ATOAIExplore
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@AlanZucconi
Sorry about that. Rookie mistake. 😬 Now they are open. Thank you for letting me know.
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After a long on/off road cycling the view from the hotel balcony can’t be any more relaxing. Trongsa Dzong after sunset.
@BikeStreet_Boys
#BSBexperience
#cycling
#travel
#Bhutan
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@Ryo_M_Graphics
Wow, Ryo! This looks amazing 🤩
I am also working on a salmonella version but not as cool as this!
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@trader_steve1
Dude, you the GOAT! 🙇♂️followed your previous tweet and it played out as you called, and that too within hours. 👏👏👏
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@HunterNJoeBidet
This is incorrect. The MoA of both drugs are completely different. Also, Ivermectin is a medicine used to treat parasites such as intestinal parasites in animals and has not been shown to treat COVID-19. Please stop spreading misinformation.
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Top 10 travel tips when traveling to countries off the beaten path: Part 1
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@alliseeis_W
Thanks for your hard work and keeping us updated. I enjoy listening to your stock picks.
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