Andy Truman PhD
@TrumanLab
Followers
6,342
Following
4,687
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307
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7,044
Professor in Biological Sciences @unccharlotte Group leader, Charlotte Group for Proteostasis Research Interested in the role of Hsp70 PTMs (Chaperone Code)
Charlotte, NC
Joined December 2018
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Pinned Tweet
1/Excited to share our latest study "Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications" in
@PLOSBiology
: This work started with a simple idea-
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Reviewers: if you are assigned a manuscript that is well written and data are clear, can we agree to say no changes needed? It seems many suggest unnecessary changes just to feel they are a good reviewer. This is damaging to students, postdocs and PIs 😡
@AcademicChatter
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When students select papers to present for my class they also are required to email the authors and ask the following: what was the most unexpected/exciting result? What was the hardest experiment to do? How was the publishing process? The answers they get are always excellent 😀
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Experiments while in quarantine: 2yr old and 6yr old entertained with old (decontaminated) pipettes, a couple of plates and food coloring 😀
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As a former first-gen student who struggled with a lot of courses as an undergrad, I really hate it when I see faculty mention with pride that their classes are designed to “weed out bad students” 😡
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@NicoleNuckolls
All universities should have free on campus 9-5 daycare for grad students and postdocs
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Based on the recent news, I really hope we will see a greater crackdown on PIs that:
-are guilty of discrimination/harassment
-pressure to fabricate data
-make lab members compete against each other on the same project
-force lab members work insane hours
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As a lab who uses a lot of plasmids, three companies have been a game changer for us:
1)
@VectorBuilder
We get all our expression plasmids made here
2)
@GenScript
for all our point mutations
3)
@plasmidsaurus
Whole plasmid sequencing for $15 😀
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Remembering the first and only time I made science themed cookies 😂
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What if we all made a promise when reviewing manuscripts not to demand any extra experiments but just ask authors to 1) fix formatting, missing refs, errors in text, 2) moderate overzealous claims, 3) honestly admit pitfalls in their study that could be addressed in future work?
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I am leading a discussion soon with postdocs in my dept on the importance of setting up their own websites. Would any grad students or postdocs be willing to share the links for their own sites below that I can use as examples?
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I still don’t understand why major funding agencies like NIH don’t have their own jounals that are mandatory and free to publish in if you are funded by them. It would solve many of the issues we have now and save those agencies a ton of money wasted on publication fees
Want to change the system? Post preprints and only post preprints - don't submit to journals, don't subscribe to journals, don't read journals - only hire and fund people based on their preprints.
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Does anyone know of any online courses students (and faculty) can take on constructing scientific figures using illustrator or other similar software? I am often blown away by the figures I see in papers from complex -omic data to beautiful color schemes in simple bar graphs 🤔
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This may be a first gen thing, but I never understand some PIs obsession with academic lineage or which institutes someone trained at. Show me interesting and innovative science and then I will be impressed 😀
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A trend I’ve noticed over the past few years on faculty search committees: an increasing number of established assistant profs applying for new assistant prof positions. Has anyone else noticed this and do you have thoughts why this may be?
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To those researchers who respond to plasmid/strain requests in a friendly and timely manner, I thank you from the bottom of my heart. To those who make me fill out unnecessary MTAs, wait months or never respond, may your Western Blot transfers always have air bubbles 😡
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$11,390 is absolutely disgusting. Think of how this money could be better used ie to to pay students and postdocs. There is no way that any of us, and especially funding agencies should be okay with this 😡😡😡
In this scenario, the cost of publication is covered by an Article Processing Charge (APC) paid at the time of publication. The APC for Nature Neuroscience in 2022 is €9,500/US $11,390/£8,290.
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Grad programs should have courses at an early stage that bring in speakers from range of careers paths who will discuss required skills, salaries, benefits, and honest job pros and cons. By the time a student graduates they should be prepared for their ideal next step 😀
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It’s clear from the discussion on salaries that many postdocs and students do not know where the money for their stipend/salaries (or even their PI salaries) come from. PIs should be more open about this to allow trainees to make informed career decisions
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I know I am going to offend a bunch of people but honestly I don’t see any good in taking about lineages. Every time I have heard it used has been to suggest a group of scientists are better than another and it comes across as a form of gatekeeping 😡
What are the most impressive academic lineages in the biological sciences?
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The undergrads I teach were not born when the first Harry Potter movie came out 😬
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Excited to announce that I received notification that my promotion to Associate Professor with Tenure
@unccharlotte
has been approved as of July 1st! So grateful to all my mentors, collaborators and students for helping me on this journey!
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Sometimes I just wish that all NIH funded research was required to be published freely in one journal maintained by NIH. No fussing about novelty and publishing fees.
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My incredible student
@Nitika154
has published 12 papers and has another on the way. She knows most yeast, mammalian and bacterial molecular technologies including crispr and xl-ms. She graduates at the end of April if anyone needs a superstar postdoc 😀
@AcademicChatter
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Despite the negative posts we often see on social media about academia, 60% faculty would choose to keep their job after winning $100M. How many other professions would say the same?
I ask this question now and again: PIs in Biological Sciences, if you won $100M tomorrow, would you quit your faculty job?
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@philosofarr
I was horrified to learn that my undergrads were not born when the first Harry Potter movie came out 😬
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Pro tip for universities/departments: Don’t schedule important meetings before 9am! Many faculty have to drop children off at school/daycare.
@AcademicChatter
#parents
#academia
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Just got the official word from
@unccharlotte
that my promotion to Full Professor has been approved as of July 1st! So grateful to all the people that have made this possible from wonderful mentors to fantastic students!
#firstgen
@UNCCBiology
@ChancellorGaber
🍾🎉🍾🎉🍾🎉
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PIs in biological sciences, what software do you create your paper figures with?
PowerPoint
1745
Illustrator
2309
Biorender
1090
Other
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Great suggestions improving the peer review system yesterday as follows: 1) ask reviewers how long they may need to review a paper 2) use more postdocs as reviewers 3) have more systems in place like
@ReviewCommons
and 4) pay reviewers. Any other thoughts?
@AcademicChatter
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A really important skill for trainees to learn is to be a “closer” of a project-that is to take it over the finish line for publication. This means doing the experiments, getting the figures/text ready for submission and being prepared to do review corrections 😀
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1) preprint everything
2) publish in well respected society journals with good editors
2) use the $10k publication fee to pay students more
knowing that a friend's paper was rejected after 3 years under review at
@Nature
is just devastating. Asking for animal data that takes years and just claim "the hypothesis is not novel anymore" is low. It's irresponsible to research money spent. Reviewers also need to do better.
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The number of PIs over not able to send plasmids I have requested is astounding. Either they can’t find them, they used their stock up(?) or are giving me insane MTAs. This is not good for science! Please consider storing reagents with companies like
@Addgene
!
#AcademicChatter
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Please RT: We have Senior Scientist, Postdoctoral Researcher and PhD student positions available in our lab focusing on the role of Hsp70 PTMs in a variety of processes including cancer, aging and host-pathogen interactions. Please see:
#hsp70
#chaperones
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I love JBC, it has a great reputation, good editors and fantastic science published in there. I have always been confused why it’s impact factor (I know it’s an imperfect measurement 😀) has remained relatively low over the years
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Re: discussion of switching co-first authors on CVs for faculty positions. Another thing that I see commonly are postdocs listing themselves as having grants when they are not the PI of the grant. Don’t do this-it’s easy to look up and check…
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Please retweet: We are seeking postdoc applicants for a new project understanding the role of the Hsp70 phosphorylation in ALS. This will involve lots of cool technologies including CRISPR and XL-MS. See for more info 😀
#proteostasis
#chaperones
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I would rather see “Extreme Lab Makeover” where they come into a poorly funded lab and replace all the old equipment with new stuff.....
#extremelabmakeover
#AcademicTwitter
#AcademicChatter
#movethatbus
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So many jobs that PIs do on a regular basis and received no formal training for. This includes mentoring, managing large amounts of money, running a business and in some cases even teaching a class 🤔
@AcademicChatter
Mandatory training for PhD advisors
Mandatory training for PhD advisors
Mandatory training for PhD advisors
Mandatory training for PhD advisors
Mandatory training for PhD advisors
Mandatory training for PhD advisors
Mandatory training for PhD advisors
Mandat...
@AcademicChatter
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A lot of great webinars have happened since the start of the pandemic. A huge issue is the same high profile speakers being reused again and again. Organizers, please go for more diverse speakers and PIs let your postdocs/students present instead of yourself!
@AcademicChatter
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As PIs, we need to read over (if requested) students/postdocs materials when they are preparing to leave the leave the lab and are looking for positions. The number of postdoc applicants with horribly formatted cover letters and CVs etc I am seeing is disheartening 😬
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Topics that are in continuous rotation on Ac Twitter 😂
1) hours per week spent in lab for success
2) CNS papers required for faculty jobs
3) should reviewers of manuscripts get paid?
4) impact factors
5) joint first author on papers
6) justifying 1 or 2 sides of text
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Excited to announce that our NIH R01 “interplay between Hsp70 and the DNA damage response” has been funded!!!! 😀 Very grateful to mentors
@ShanYanLab
@MedMol
and
@rwsobol
. Thank you to my awesome students
@Nitika154
and Laura Knighton for all their hard work!
#hsp70
#dnadamage
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We hear a lot of negative stuff about academia. For me, being a Professor is my dream job-I love every day of it. I get to work with talented colleagues and discover new stuff about the world every day with students in the lab!
@AcademicChatter
@unccharlotte
@thoughtsofaphd
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Are there any amino acids in proteins that do not get PTMs?
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1st day as an Associate Professor with Tenure
@unccharlotte
! So grateful for the support of my students, our wonderful faculty and of course
@ChancellorGaber
! Excited to continue our work on the Chaperone Code in cancer 😀
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Evolutionary biologists: if I have a gene that is present in humans but not in yeast, what’s the easiest way to find out when it appears/what other organisms have it/don’t have it ? 😀
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Controversial thought of the day: Given major issues with many journals (holding manuscripts for weeks then desk rejecting, poor peer review, crazy revisions), is it fair that PIs cannot submit their work to multiple journals at the same time?
@AcademicChatter
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What is your favorite piece of biological science equipment under $5000?
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Please RT: We are seeking postdoc applicants to join us in studying the role of the Hsp70 chaperone code in cancer! See below for more info 😀
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Please retweet/let suitable candidates know: We have a 4 year postdoc position available on interplay between molecular chaperones and the DNA damage response in mammalian cells! Please see: !
@EMGSUS
#dnadamage
#ddr
#chaperones
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@chingonacademic
This is awful, I am sorry you experienced this. I never make students buy textbooks, it is never necessary. I provide pdfs of the textbook, arrange copies to be in the library and lend students my personal versions
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Me: submits NIH proposal on a new chaperone PTM. Reviewer: This PI has not published on this exact PTM before, score: 8 significance 😬😡😢
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One of the weirdest things I noticed when first doing science in the US was being asked my pedigree- where I got my degrees from and whose lab I had worked in, all to judge how good I was as a scientist. For those of you out there who need to hear it: DONT DO THIS 😬
This issue is huge and profoundly problematic. There’s nothing about academic pedigrees that says anything about the ultimate quality or importance of scholarly contributions, and the elitism perpetuates inequities.
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My daughter loves coming to the beautiful
@unccharlotte
campus with me and always asks when she can work in the lab full time. Should be ready in about 15 years 😂
#uncc
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Hsp70-Hsp90 complex seen in the wild today at UNC Charlotte 🔥🔥🔥
@unccharlotte
@UNCCBiology
with
@HawleLab
#chaperones
#proteostasis
#hsp70
#hsp90
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@AstroKatie
This may be a really dumb question but if the universe is about 14 billion yrs and speed of light is limiting, how can the universe be 90 billion light years across? Which part am I getting wrong?
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Enjoyed doing my tenure talk today
@UNCCBiology
! Scary but super exciting to lay out my vision for the future of our chaperone code research
#Hsp70
#chaperones
#phosphorylation
#ptms
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@kalchhauser
@hugofgante
@AcademicChatter
Sorry I disagree. As many commenters have said we are judging the paper as is, not how we want it personally to be. We are evaluating if the authors claims are warranted by their data. If the paper is good enough, it’s good enough.
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Just wanted to say how great our experience with
@plasmidsaurus
has been! $25 to sequence a WHOLE PLASMID! Took only a couple of days and the data are beautiful! Highly recommend!
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We outsource all our cloning and mutagenesis to companies-a major time saver especially when working with undergrads:
-Twist (
@TwistBioscience
) for smaller DNA constructs
-Genscript (
@GenScript
) for mutagenesis
-Vectorbuilder (
@VectorBuilder
) for yeast expression constructs.
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I’m being dragged into the 21st century by finally setting up slack for my lab 😂 Aside from channels for updating projects and posting interesting papers, what else should be on the lab slack?
@AcademicChatter
#slack
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Please RT: We are recruiting PhD students in the Truman Laboratory at UNC Charlotte for Fall 2022! If you might be interested in studying the connection between chaperones, cancer, cell cycle progression and DNA damage response, check out
#hsp70
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@drjessmaddox
My father was a policeman and my mother was a stay at home mom. Neither went to college. I was the first in my family to go to college let alone get a PhD and become a professor. Over 30% of our students are first gen and I try to help them as best I can
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Good start to the day-we have been awarded an NIH R15 grant from
@NIGMS
to study the interplay between the ER protein folding machinery and genome integrity! Thanks to
@laurk187
and
@Nitika154
who worked hard to collect the preliminary data.
#hsp70
,
#ddr
#genomeintegrity
#BIP
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Very excited to share our latest preprint “A novel multifunctional role for Hsp70 in binding post-translational modifications in clients”: . This is the cumulation of 5 years of work by
@Nitika154
😀
#hsp70
#chaperonecode
please RT!
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Lots of posts at the moment celebrating increases in mandatory increases in student and postdoc stipends. However, without increased support from funding agencies or universities there is no way to pay for this=large no. of grad students/post positions being cut 😬
I hope the University of California is throwing its substantial lobbying power at the NIH to raise the R01 modular budget cap, which has been set at $250,000 per year since 2000. Twenty-two years. The entire lifetime of many grad students.
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More than just fixers of denatured proteins, we now understand that chaperones integrate a myriad of cellular signals in the form of PTMs allowing crosstalk between different pathways. For more about this, see our review in
@jbiolchem
:
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@Kamraniat
100% have responded so far. I think many first authors are flattered and excited to get the emails 😀
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New lab stickers arrived 😀 Thanks to
@CterminiPhD
for the excellent recommendation for
@StickerApp
#chaperone
#hsp70
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We are looking for a postdoc to join our highly collaborative group! Lots of cool experiments to be done on the interplay of chaperones and neurodegenerative disease. Charlotte also has a great cost of living 😀
Postdoctoral position available on Hsp70 and ALS
@trumanlab
Postdoctoral position available on using structural proteomics to investigate the role of Hsp70 in Amyotrophic Lateral Sclerosis (ALS).
#UnitedStatesUS
#Postdocto
...
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In an ideal world, how many NIH R01s should a lab need to operate?
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Can’t believe this was a year ago! I think the kids are ready for the lab now 😂
Experiments while in quarantine: 2yr old and 6yr old entertained with old (decontaminated) pipettes, a couple of plates and food coloring 😀
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Excited to welcome our new postdoc Dr. Chathura Paththamperuma! He will be studying the structures of chaperone-client complexes and the BIP/Kar2 chaperone code in yeast and mammalian cells!
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Postdocs, if you are happy to review for journals, please reach out to them. As an editor I am happy to send manuscripts to postdocs 😀
I read on here all the time that nobody can find reviewers and PIs don't have time.
As a postdoc, I do have time and would review things. I haven't gotten a request in a year.
Asking 3 other postdocs and same story.
Why aren't postdocs asked to review more?
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Thread (1/x): Super excited to see our review on Hsp70 Chaperone Code out on
@jbiolchem
! . This was a great collaboration between my lab (thanks
@Nitika154
!) and Matthias Truttman.
#hsp70
#chaperone
#phosphorylation
. Brief summary:
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We were clearing out an old lab the other day when my students uncovered a filing cabinet full of paper reprints. I had to explain to them what that was for in the old days 😂😂😂
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@samanthaplas_
This is when the whole lab should file an official complaint and go on strike until it is resolved
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The Truman Lab is now looking for 2 postdocs: 1) to study the link between chaperones and the DNA response in mammalian cells and 2) chaperone code regulation in yeast. See here for more details:
@EMGSUS
@Hsp90Machine
@AcademicChatter
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I am absolutely over the moon that my graduate student
@megan_mitchem
has been awarded a GRF by
@NSF
! This award will support Megan for 5 years studying the interplay between the Hsp70 chaperone code and metabolism! 🎉🎊🎉
@unccharlotte
@UNCCBiology
@ChancellorGaber
#hsp70
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@dmimno
@aetiology
One of my lab students wasn’t born when the original Jurassic Park came out....
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We are currently accepting applications for postdoctoral researchers to join our team! We are looking for candidates with a strong background in yeast genetics/cell biology! See 😀
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I miss the simpler times of academic Twitter, debating what is the best font (it’s Avenir) and whether double justified is better than single justified for a grant proposal (it is)
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Excited to share our new paper on Hsp70 PTMs! Yeast Hsp70 is deacetylated during heat shock altering regulation of the heat shock response.
@Nitika1504
#hsp70
#ptm
#chaperones
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Undergrads bring a wonderful energy to labs. They are excited to do research and are not limited by knowledge of what and what isn’t possible. I have 5 undergrads right now and am grateful for all that hey contribute 😀
Why do PIs take on undergraduates in their lab?
Why would someone who has ongoing big projects decide, 'I’m going to take someone who is inexperienced in research and has a high chance of messing up, to help me with it'?
Genuinely interested
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The present discussions reveal that PIs should talk to their labs more about:
1) how much money standard grants provide
2) what is budgeted in grants
3) where PI salaries come from, how much they are and how this varies across the US and in different kinds of institution 😀
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Summary statement for my last R01- Reviewer 1: Aim 1 is too big. Reviewer 2: the PI only proposes looking at one Hsp70 phosphorylation site, why aren’t they looking at ALL of them 🙄
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Solution is simple: 1) pay reviewers 2) recruit more postdocs and students to review (after completing some basic review training). If a business is relying on free labor to survive (often making huge profits) then it is broken 😬
Being an associate editor is really frustrating. It takes forever to find even 2 reviewers. I'm well over 10 invites for some manuscripts. Maybe corresponding authors should be required to review at least two manuscripts for each manuscript they submit to that journal?
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Hot take alert: How about we make it that if reviewers take longer than 3 weeks to submit a review for a manuscript that their recommendation automatically becomes Accept with no revisions 😂
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Are you soon to be PhD
#yeast
researcher with expertise in DNA damage, Autophagy, MAP kinase or related signaling? We have a postdoctoral position open to understand the connection between these processes and molecular chaperones! Please see for info
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Please RT! Two exciting faculty positions are available to join us in Biological Sciences at UNC Charlotte: a Belk-endowed Associate Professor (tenured) position ()
and an Assistant Professor (Physiology) ()
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Our new paper ”The C-terminal domain of Hsp70 is responsible for paralog-specific regulation of ribonucleotide reductase” is now out in
@PLOSGenetics
! Grateful to Laura Knighton,
@Nitika154
and
@psiddhi273
for their hard work
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I finally need to buy a new -80 freezer. What’s the most reliable these days?
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PIs who employ a lab manager: At what stage in your career/lab size did you hire them and what jobs do they typically do?
#AcademicChatter
#AcademicTwitter
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