Check out the agenda for the upcoming virtual
#LymHubSS
! We’re excited to bring you four fantastic presentations and a round table discussion on ‘How I treat R/R disease - DLBCL and CLL! For more information visit:
#ESHLYMPHOMA2020
#lymsm
During
#ASH23
, updates from three key trials evaluating ctDNA as a tool to predict treatment response in patients with DLBCL were presented.
Read more here 👉
#lymsm
#lymphoma
#MedEducation
⭐VISUAL ABSTRACT⭐
📚 The Lymphoma Hub is happy to present a Visual Abstract representing key data from the primary analysis of the phase III ZUMA-7 study!
👉 👈
#lymsm
#lymphoma
#DLBCL
#ASCO19
🌎 is fast approaching. The
@LymphomaHub
team will be reporting live from the meeting and bringing you the latest updates and expert opinions🗣️ in
#lymphoma
. We will keep you up to date with the advances coming from the
@ASCO
Annual Meeting in
#Chicago
!
#lymsm
🎥🔬⚗️
CONGRESS |
#SOHO2024
@gilles_salles
@MSKCancerCenter
discusses how to sequence therapies in R/R DLBCL, with the aim to optimize the chance of cure; concluding with a look to the future landscape and the possibility of achieving a cure amongst a substantial fraction of patients.
💉 Does a third SARS-CoV-2 booster vaccine improve humoral and T-cell-mediated immune responses in patients with lymphoid malignancies who failed to respond to their previous two doses?
📚Read the Lymphoma Hub overview of two phase II trials, IMCL-15 and WINDOW-1, evaluating the safety and efficacy of ibrutinib–rituximab combinations for frontline use in patients with mantle cell
#lymphoma
:
👉 👈
#MCL
#lymsm
CONGRESS
#EHA2024
| Peter Borchmann
#cioabcd
presents the final analysis of phase III
#HD21
trial of PET2-individualized BrECADD regimen vs intensified BEACOPP in patients with advanced-stage
#HodgkinLymphoma
. BrECADD had superior efficacy (PFS 94.3% vs 90.9% at 4 yr) with
If a potential new radiotherapy regimen achieved the following results for Waldenstrom's macroglobulinemia patients at a median of four lines of therapy, which data point would be the most persuasive in influencing your treatment decisions?
🚨 N E W S 🚨
Zandelisib receives orphan drug designation by the
@US_FDA
for the treatment of follicular
#lymphoma
. Read the update on this oral PI3Kδ inhibitor on the
#LymphomaHub
👉 👈
#lymsm
#FL
The countdown is on for the Lymphoma Hub Satellite Symposium NEXT WEEK!
#LymHubSS
Visit for all the details including how you can register to attend!
#ESHLYMPHOMA20
#lymsm
CONGRESS |
#ASCO20
| GALLIUM phase III trial | Updated results of obinutuzumab + chemo in patients with follicular
#lymphoma
, presented by William Townsend
@uclh
#lymsm
CONGRESS |
#ASCO21
| Jia Ruan,
@WeillCornell
, highlights the potential of romidepsin + lenalidomide for the treatment of PTCL. In a phase II study, the chemo-free combination demonstrated an ORR of 75% (30% CR), which increased to 85% (39% CR) in patients with AITL.
#lymsm
@ASCO
⭐Lymphoma Hub spotlight: results from the ALPINE trial⭐
In a patient-reported outcome-based recurrent symptomatic deterioration analysis from the ALPINE trial, zanubrutinib was associated with a decrease in risk of progression events vs ibrutinib.
#lymphoma
#lymsm
#EHA2024
CONGRESS
#EHA2024
| Arnon P. Kater
@amsterdamumc
shared early results of the EPCORE CLL-1 trial of epcortitamab in Richter's transformation (RT). N=35, mFU=8.1 mo, ORR was 53% (60% & 44% in 1L RT & 2L RT, resp), CR rate was 42% (50% & 33% in 1L RT & 2L RT, resp), OS was 11.7 mo,
CONGRESS
#ASCO22
| Stephen Ansell
@MayoClinic
reports on 6 year follow-up of the ECHELON-1 trial of pts with stage III/ IV cHL of A+AVD vs ABVD. OS favored A+AVD vs ABVD (p = 0.009). Estimated 6-year OS rates were 93.9% vs 89.4% with A+AVD vs ABVD, respectively.
#lymphoma
#lymsm
CONGRESS
#EHA2024
| Late-breaking |
@michaelwangmd
@MDAndersonNews
reports phase 3 ECHO trial of acalabrutinib (A) plus bendamustine (B) and rituximab (R) vs placebo (P) BR in untreated MCL. N=598, mFU=17 mo, mPFS=66.4 mo & 49.6 mo with ABR & PBR, resp; P=0.0160. OS was positive
CONGRESS |
#ASCO20
| MURANO phase III trial |
@anthonymatomd
, of
@MSKCC_OncoNotes
, reports a new analysis about the impact on survival outcomes of venetoclax early discontinuation, interruption, or dose modification when combined with rituximab to treat patients with R/R
#CLL
CONGRESS |
#IACH2021
| Waldenström’s macroglobulinemia field is advancing quickly!
@thanosdimop
gives a practical talk on its current management and some upcoming novel targeted therapies
#lymsm
@TheIACH
🗝️KEY POINTS
▪️Addition of etoposide to CHOP improved OS for ALK+ ALCL, but not for ALK- ALCL, AITL and PTCL NOS.
▪️Consolidation with ASCT in first-line significantly increased OS for ALK- ALCL, AITL and PTCL NOS
👉 👈
#lymsm
#lymphoma
CONGRESS |
#ASCO21
|Caron Jacobson,
@DanaFarber
, presents the data from a subanalysis of the ZUMA-5 trial evaluating patients with iNHL who had progression of disease within 24 months of starting CIT (POD24). Axi-cel demonstrated durable responses in this high-risk population.
CONGRESS | Getting to the end of
#IACH2021
with
@AnnaSureda5
and her summary of CAR T cell therapies for DLBCL and FL. Of note, initial RWD is in line with CT in terms of efficacy and toxicity, but how to better determine patient eligibility to CAR-Ts?
@TheIACH
#lymsm
#lymphoma
CONGRESS |
#EHA2024
In the plenary abstracts session, Jeremy Abramson
@harvardmed
presents the phase III STARGLO trial of the CD20xCD3 bispecific antibody glofitamab plus gemcitabine and oxaliplatin (Glofit-GemOx) vs rituximab plus GemOx (R-GemOx) in R/R DLBCL.
▪️ Primary
CONGRESS
#EHA2023
|
@LeppaSM
@helsinkiuni
presents initial safety data from ph III POLAR BEAR trial. R-pola-mini-CHP & R-mini-CHOP had comparable safety profile & were tolerable in elderly or frail pts with DLBCL. GI events were more common in pola group.
#lymhoma
#lym
#lymsm
CONGRESS |
#ASH23
| Franck Morschhauser, University of Lille, presents a post-hoc analysis of the POLARIX study on the prevalence & clinical outcomes of molecularly defined subtypes of DLBCL. N=594, high-risk DHL/THL patients with DZsigPos DLBCL may benefit from Pola-R-CHP vs
#EHA2022
|
@AnnaSureda5
presented a subgroup analysis of ZUMA-7. Second line axi-cel vs SOC was associated with superior EFS (HR, 0.276, P<0.0001), and higher CR rates (75% vs 33%). Grade ≥3 TEAEs occurred in 94% and 82% of axi-cel and SOC pts, respectively
#lymphoma
#lymsm
CONGRESS
#EHA2024
|
@NitinJainMD
@MDAndersonNews
reports results of the phase 2 trial of pirtobrutinib, venetoclax & obinutuzumab in first-line treatment of pts with CLL. N=40, mFU=11.7 mo, 6 mo uMRD was 64% (PB=79%), 12-mo uMRD was 85% (PB=90%). Safety profile was similar to the
CONGRESS
#EHA2023
| Marco Ladetto
@UniAvogadro
talks about how to approach a patient with R/R follicular
#lymphoma
. Novel agents like T-cell engagers & rational combinations of existing treatments might further broaden therapeutic armamentarium.
#lym
#lymsm
@EHA_Hematology
CONGRESS |
#SOHO2024
Stephen M Ansell,
@MayoClinic
, discusses whether ABVD and BEACOPP are still relevant for the treatment of advanced stage Hodgkin
#lymphoma
. He believes that A(B)VD chemotherapy still has a role for low-risk patients, while younger patients or those with
CONGRESS
#EHA2024
| Tycel Phillips, MD (
@LymphClinician
) from
@cityofhope
presented an updated analysis of the phase I/II study of glofitamab for R/R
#mantlecelllymphoma
, demonstrating high response rates and durable responses in both BTKi-treated and -naïve pts. Majority of
CONGRESS|
#17ICML
Martin Hutchings(
@DocHutchings
),
@Rigshospitalet
presents the updated data on glofitamab plus polatuzumab vedotin in R/R DLBCL which led to high & durable responses & a manageable safety profile.
-Best responses: ORR of 78% & CR: 56%
-Mostly low-grade CRS
#lymsm
CONGRESS|
#17ICML
@Othman_Al_Sawaf
,
@UniCologne
presents the 6-yr results of the CLL14 study. Compared to Clb-Obi, fixed duration Ven-Obi showed a long-term PFS benefit across all subgroups of pts with previously untreated CLL, with no new safety signals reported
#lymsm
#lymphoma
CONGRESS |
@TheIACH
#IACH2024
| PRESENTATION
Andrew Davies
@AndyD1036
@UHSFT
shares insights on bispecific antibodies in patients with DLBCL.
They highlight key clinical trial data and discuss potential advantages over CAR T-cell therapies.
Follow our live feed for more updates:
#IACH23
| Laurence de Leval shares new insights into the molecular pathogenesis of PTCL. The presentation focuses on genetic susceptibility, signaling pathways, immune evasion, microenvironment, epigenetics, immune surveillance, and antigen stimulation in PTCL pathogenesis.
CONGRESS |
#ASCO20
| Auto-HSCT should still be a
#SoC
for relapsed
#DLBCL
, despite the availability of anti-CD19 CAR T-cell therapy. Using
@CIBMTR
database, Nirav Niranjan Shah reports a 5-year PFS of 41% in patients achieving only a PR prior to transplant.
#lymsm
#bmt
CONGRESS |
@TheIACH
#IACH2024
| PRESENTATION
Farrukh Awan
@awandoc
@UTSWMedCenter
discusses first-line therapy in patients with CLL.
They highlight the role of BTK inhibitors, anti-CD20 antibodies, BCL2 inhibitors, and potential combination therapies in patients with CLL, and
CONGRESS | POSTER |
#SOHO2024
| Daniel Kerr presents first results from the phase Ib/II EPCORE NHL-5 study investigating subcutaneous epcoritamab + pola-R-CHP as 1L treatment for
#DLBCL
(N=37). The ORR was 100% with CR 89%, demonstrating that epcoritamab can be combined with 1L
📝 Results of the placebo-controlled, phase III ECHO study presented at
#EHA2024
showed that addition of acalabrutinib to bendamustine & rituximab significantly improved PFS in older pts with newly diagnosed
#MCL
More news:
#lymphoma
#lymsm
@MichaelWangMD
CONGRESS |
#EHA2021
| Ulrich Jäger
@MedUni_Wien
describes pt selection & treatment of
#lymphoma
in the
#CARTcell
era. Pt, disease & treatment related factors are important in outcome. Use of CAR T-cell therapy in earlier lines of therapy should continue to improve outcomes
#lymsm
Pleased to be recognized as a top influencer during
#ASCO20
! If you weren’t able to join the ASCO 2020 virtual meeting, visit over the coming days to view our summary articles and virtual expert interviews!
#lymsm
#ASH23
@gloria_iacoboni
discusses a comparison of response rates, survival outcomes and toxicity after CAR T (axi-cel, tisa-cel and liso-cel) accorrding to previous bispecific antibody exposure. N=47; PFS and OS was similar between control and CAR-T treated groups.
CONGRESS |
@TheIACH
#IACH2024
| PRESENTATION
Mariana Bastos-Oreiro
@DrBastosOreiroM
Gregorio Marañón Hospital, Madrid, provides an overview of CAR T-cell therapies for patients with DLBCL.
They discuss efficacy and safety results from clinical trials and real-world studies, and
CONGRESS |
#ASCO20
| GENUINE phase III trial |
@jeff_sharman
from
@WVCancer
, presented the final results of ublituximab (anti-CD20) + ibrutinib vs. ibrutinib alone in patients with high-risk R/R
#CLL
. The combination showed better results in terms of ORR, MRD-neg, and PFS
#lymsm
CONGRESS
#EHA2022
| Catherine Thieblemont
@HopSaintLouis
presented EPCORE-NHL-1 phase II study results of epcoritamab in pts with R/R LBCL. N=157, median follow-up=10.7 months, ORR=63%, CR=39%, low grade AEs including CRS
#lymsm
#lymphoma
CONGRESS
#CART22
@MediHumdani
,
@ASTCT
talked about second line treatment,
#CARTcells
or autologous transplant, in aggressive B-NHL
➡️auto HCT is a tested, relatively inexpensive option for
#DLBCL
with disease responding to salvage
➡️CART is SOC for refractory relapse
Congress |
#SOHO22
Alison Moskowitz from
@MSKCancerCenter
delivers an interesting talk on the novel agents brentuximab vedotin, nivolumab, and pembrolizumab, and how their introduction has changed the management of Hodgkin
#Lymphoma
#lymsm
#medicalcongress
CONGRESS
#ASCO24
| Jennifer Kimberly Lue
@MSKCancerCenter
reports subgroup analysis of genomic pattern from the POLARIX trial of Pola-R-CHP vs R-CHOP in pts with previously untreated DLBCL and extranodal (EN) disease. Distinct pattern of genetic mutations were present between
Are you up to date with the latest treatment options for second-line relapsed/refractory diffuse large B-cell
#lymphoma
?
Read our latest article to learn more!
CONGRESS |
#TCTM21
|
@JulioChavezMD
,
@MoffittNews
reported outcomes from the phase II ZUMA-5 study looking at the clinical efficacy of retreatment with axi-cel, an anti-CD19 CAR T cell therapy, for iNHL 👉 axi-cel retreatment demonstrated a 100% ORR in pts with iNHL.
#lymsm
CONGRESS |
#EHA25Virtual
| Andrea Kuhnl,
@KingsCollegeNHS
, presented the updated real-world experience of the outcomes of patients with high-grade lymphoma that receive CD19 CAR T therapy in the UK. She compared treatment responses from patients receiving axi-cel vs tisagen
#lymsm
CONGRESS |
#ASCO20
| LYSA trial primary analysis, presented by
@Charles_Herbaux
(
@CHU_Lille
) demonstrate that the atezolizumab + obinutuzumab + venetoclax combination is well tolerated with efficacy comparable with currently available treatment options in R/R
#DLBCL
#lymsm
CONGRESS
#EHA2023
|
@gilles_salles
@MSKCancerCenter
discusses a phase I/II trial of epocoritamab vs axi-cel in R/R DLBCL CAR-T naïve & eligible pts. There was no sig. difference in ORR or CR rates for CAR T-naive vs axi-cel. Results were similar for Ep vs Axi-cel
#lymsm
#lymphoma
CONGRESS
#17ICML
| Late-breaking abstract
Franck Morschhauser at Centre Hospitalier Universitaire de Lille presented phase 2 TRANSCEND FL study of liso-cel in pts with R/R FL. ORR=97%, CR=94% with low rates of Gr ≥3 TEAEs of CRS/NEs, prolonged cytopenia, & infection
#lymsm
#leusm
CONGRESS |
#EBMT20Virtual
|
@michaelwangmd
,
@MDAndersonnews
, presents the data from the latest follow-up of the ZUMA-2 study. KTE-X19 demonstrated a manageable safety profile and promising clinical efficacy in patients with R/R MCL.
#lymsm
CONGRESS |
@TheIACH
#IACH2024
| PRESENTATION
Graham Collins
@graham74GC
@OUHospitals
@OxfordCancer
examines first-line treatment in older/unfit patients with Hodgkin lymphoma.
They highlight some of the key challenges and considerations, and discuss a potential treatment
#ASH18
Philippe Armand from
@DanaFarber
establishes the robust anti-tumor activity of pembrolizumab in the treatment of
#PMBCL
, with durable responses and survival in responding patients, providing the basis for accelerated FDA approval
#lymsm
#lymphoma
CONGRESS |
#17ICML
Alex F Herrera
@cityofhope
presented results from the SWOG S1826 trial of nivolumab(N)-AVD vs brentuximab vedotin (BV)-AVD in pts with advanced-stage HL. 1-year PFS was 94% vs 86% in N‐AVD & BV-AVD, respectively with a manageable safety profile
#lymphoma
#leusm
132 talks, 37 interviews and 1
@lymphomahub
satellite symposium...
#15ICML
has been a great success! Thank you for all the fascinating talks and those who took part in an interview. Watch out over the coming week for articles and more expert interviews from the conference!
#lymsm
CONGRESS |
#PPLC21
| Christopher R. Flowers, University of Texas MD Anderson Cancer Center, provides a comprehensive comparison of BiTEs under development for the treatment of
#lymphoma
.
@MDAndersonNews
#lymsm
CONGRESS
#EHA2023
|
@DocHutchings
@Rigshospitalet
describes a phase II trial of glofitamab in pts with R/R LBCL. N=154. After a median FU =18.3 months, 39/59 pts who achieved CR were ongoing. Median duration of CR =24.1 months. 18-month OS rate =80%
#lymsm
#lymphoma
Great location, with even better presentations. The plenary abstracts award session
@EHA_Hematology
conference never fails to disappoint. A massive congratulations to all winners!
#EHA2023
#medicalcongress
CONGRESS
#ASCO24
| Peter Borchmann, MD
#cioabcd
presented the first report of the final analysis of phase III
#HD21
trial of PET2-individualized BrECADD regimen vs intensified BEACOPP in patients with advanced-stage
#HodgkinLymphoma
. BrECADD had superior efficacy (PFS 94.3% vs
CONGRESS|
#16ICML
| Brian Sworder,
@Stanford
, highlights the complexity of resistance to CD19-directed CAR T-cell therapy in patients with
#lymphoma
and outlines prognostic markers in relation to tumor intrinsic factors, CAR19 T-cell levels, and endogenous T-cell properties.
#lymsm
#EHA2023
| Arnon Kater
@amsterdamumc
shares the final 7-year follow up data from the MURANO trial of VenR in R/RCLL. OS 69.6% and 51% in VenR and BR treated pts, respectively. PFS 23% VenR and 0% BR. Median PFS 23.3mo in VenR-retreated pts.
#CLL
#lymsm
The
@lymphomahub
team have now arrived in Orlando and we can’t wait for
#ASH19
to begin! Don’t miss our coverage of the meeting and the lymphoma and
#CLL
updates and advances!
#lymsm
Tomorrow is World
#Lymphoma
Awareness Day! Around the world, there are more than 735,000 people diagnosed with lymphoma, including CLL, every year. We will be joining
@knowyournodes
and the global community to thank those who help people with lymphomas!
#lymsm
#WLAD2020
CONGRESS
#EHA2022
|
@mike_dickinson1
presents the latest data of glofitamab, CD20xCD3 bispecific, in patients with r/r DLBCL and a median of 3 PL, including
#CARTcell
. The primary endpoint was met: fixed-duration treatment led to a 39.4% CR rate
#lymphoma
#lymsm
#ASCO23
OS analysis from the ZUMA-7 trial presented by
@Lymphoma_Doc
Axi-cel improves OS in 2L for refractory or early relapsed LBCL vs previous chemo-based regimen.
#lymsm
#CARTcells
#ASH21
|Rahul Lakhotia
@theNCI
on prognostic factors driving the risk of progression in adults with Burkitt lymphoma treated with DA-EPOCH-R: age is not prognostic, but CNS, BM, and PB involvement are prognostic across BL-IPI groups
#ASH23
@drsarahruth
summarizes results from pts with
#HL
≥60 years in the SWOG S1826. PFS in N-AVD vs Bv-AVD= 93% vs 64%; 1-yr OS in N-AVD vs Bv-AVD=95% vs 83%. Results support N-AVD as astandard of care treatment for older advanced HL patients fit for anthracycline-based