Marco Ruella
@MarcoRuella
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Amazing results in pediatric neuroblastoma of CART-GD2: CR 44%!!!! Presented by Dr.CONCETTA QUINTARELLI and Prof. Franco Locatelli at
#CART23
@TheEBMT
@EHA_Hematology
10
48
203
Our letter to the
@NEJM
reporting the five-year outcomes of CART19 (CTL019, now called tisagenlecleucel) in lymphoma patients is out! Thanks to Drs. Schuster, Chong and
@PennMedicine
@PennCancer
@Penn_IFI
@carlhjune
@BLLPHD
5
33
139
Thanks to all collaborators who have worked at this project!
@MelodySmithMD
@vandenBrinkLab
@Dr
.facciabene
@PennMedicine
@MSKCancerCenter
6
26
128
#CART
are moving fast into autoimmunity, after the Lupus reports more reports in other autoimmune diseases...
@carlhjune
@PennMedicine
@PEGSboston
2
24
98
Congrats to
@JaneWinterMD
and
@ASH_hematology
for a great
#ASH22
. Great science, but also appreciated space between sessions, no 7 AM sessions, power nap pods, more food stations, coffee distributed during the plenaries, child care and much more!
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3
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In this study, we discovered that impaired death receptor signaling in leukemia causes antigen-independent resistance to CAR T cells by causing T cell dysfunction.
@NathanSinghLab1
@GillSaar
@RuellaLab
@carlhjune
@PennMedicine
@CD_AACR
@NovartisNews
10
30
73
Our latest review on single-cell RNAseq in immunotherapy is out in
@JExpMed
! Thanks for this Herculean endeavour to
@puneeth_guru
and
@RuellaLab
@PennMedicine
@Penn_IFI
This review by
@puneeth_guru
,
@MarcoRuella
et al.
@RuellaLab
@PennMedicine
examines how single-cell RNA sequencing has transformed the understanding of basic
#cancer
and immune biology in the context of cancer
#immunotherapy
.
#JEMCancerFocus
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Our latest crazy idea just published: "A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor positive cells"
@BloodJournal
@PennMedNews
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15
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Tazemetostat enhances
#CART
immunotherapy for
#NHL
.
@PatriziaPorazzi
from our
@RuellaLab
presenting her newest results at
#ASH23
@PennMedicine
@ASHClinicalNews
@kenderian_ss
2
10
55
Thank you
@EHA
and
@TheEBMT
for inviting me to present at this amazing
#CART
meeting...but competing with
@carlhjune
at the meet-the-expert?!?! I did appreciate the "prof" though..
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Yunlin Zhang is ready to present her poster on a first-in-human CART19 targeting a non-FMC63 CD19 epitope with low avidity.
@RuellaLab
#ASH23
published today!
@_ruchipatel
AT101, a new
#CART
with a distinct binding mechanism is showing promising early responses, according to data published today in
@SN_Oncology
. Poster session at
#ASH23
at 5:30pm PT.
@MarcoRuella
@PennCancer
@ASH_hematology
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Thank you
@CD_AACR
and
@ElizSMcKenna
for the guidance during the review and publication process!
Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T cell
#Immunotherapy
against Cancer, by Lee,
@MarcoRuella
et al.
@PennMedicine
@PennCancer
@RuellaLab
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Every year I end up celebrating my birthday at
#ASH
, like today! While it is tough to be far from my family, I did appreciate the thoughtful present found in my room. Thanks
#ASH23
!
@PennMedicine
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0
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Thank you
@PhilaUnion
for a wonderful night at Subaru park. My family and research team had a blast!
@RuellaLab
@PennMedicine
GO UNION!!!
Healthcare Hero 🏥
Dr. Marco Ruella treats patients with lymphoma, myeloma & leukemia. His research is focused on CAR T-cell immunotherapy which engineers patients’ immune systems to recognize & fight cancer cells.
Thank you, Dr. Ruella, for all you do!
#DOOP
|
@PennMedicine
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@carlhjune
opening the
#CART24
meeting in Valencia! So many trials ongoing... 50-50 allo and auto!
@EHA_Hematology
@TheEBMT
@PennMedicine
@AnnaSureda5
@michaelhudechek
1
8
40
@carlhjune
telling the "Improbable story" of CART clinical development at
@Phacilitate
#AdvancedTherapiesWeek
#ATW23
. Patients with over 10 years of remission still have CART cells in their blood!
@BLLPHD
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8
39
Congratulations to Dr.
@BernardAFox
for receiving the SITC extraordinary service award! WELL DESERVED!!!
@sitcancerECS
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Very excited to receive the 2019
@GileadSciences
Research Scholar Award at
#ASH19
together with my friend and 2018 Gilead Scholar
@kenderian_ss
!
@PennMedicine
@MayoClinic
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Hi all, I will be giving this webinar on 11/7 at 1 PM ET:
"Understanding the Mechanisms of Resistance in CART Immunotherapy for Lymphoma and Strategies to Over"
@Labroots
@PennMedicine
@RuellaLab
@BeckmanCoulter
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Thank you to
@ASH_hematology
and the Japanese Society of Hematology for inviting me to
#JSH2022
. Enjoyed the science and Japanese hospitality!
@JaneWinterMD
Jim Kochenderfer.
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Come and join our group at Penn!
We are looking for a bioinformatician to help us with our scRNAseq and digital spatial profiling studies to understand resistance to CART immunotherapy!
@PennMedicine
@RuellaLab
1
9
32
I am honored to become the 2021-22 Chair of the
@sitcancerECS
make sure to apply for becoming a member, it is a great opportunity to serve
@sitcancer
and make a difference for early career scientists!
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#ASH22
Ruchi Patel presenting the clinical development of Senza5 CART-5 against T Cell lymphomas!
@PennMedicine
@vittoriabio
@RuellaLab
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Outstanding talk by
@CapitiniMD
from
@WiscPediatrics
on targeting GD2 in pediatric solid tumors.
#PMFG2022
@sidra
@QF
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1
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Thanks to
#cti360
for the opportunity to return to Lyon and discuss
#CART
and more with my French friends! Loved the Pastis
@PennMedicine
@RuellaLab
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Congratulations to these extraordinary leaders for their service
@sitcancer
. The
@sitcancerECS
wants to thak you for your mentorship!
@BernardAFox
@ButterfieldLisa
@DrK4CINJ
@FrancoMarincola
,
@DrNDisis
, Alessandra Cesano, David Kaufman
@Wiggie0
Michael Lotze
0
9
25
The
@RuellaLab
was very active at
#ASH22
! Great to work with this group of people!
@PennMedicine
@Penn_IFI
more to come...:)
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2
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Super interesting talks at the
@sitcancer
Workshop on Engineering Immune Cells for Cancer Therapy on Monday 11/9!
@sitcancerECS
@PennMedNews
@RuellaLab
#sitc2020
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#ASH19
PLENARY SESSION: Dr. Schuster from
@PennMedicine
shows that mosunetuzumab (CD3/20 biAbs) can reinvigorate anti-CD19 CAR T cells and lead to complete responses.
@BLLPHD
@genentech
2
8
23
My commentary on a cool paper from
@chiarlelab
combining ALK inhibitors and ALK-CART... I also took the opportunity to review the most recent successes of
#CART
in solid cancers!
@PennMedicine
@CR_AACR
0
5
22
Please consider donating to Penn Medicine to support our fight against COVID-19!
@PennMedicine
@PennMedEVDCSO
@kevinbmahoney
@lynn_schuchter
0
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Outstanding panel at
#ASH22
discussing the lymphoma tumor microenvironment and its impact on immunotherapy.
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One of the perks of being in person at
#ASH22
is that you can bump into these guys and end up watching the most upsetting final moments of WorldCup match so far!
@ESmithMDPhD
@MarcoLDavila
@Ghoshomy
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#NHL
#HCL
cell targeting with
#CART
but no B-cell aplasia? It might be possible with VH4-34 CART as presented at
#ASH23
by Ivan Cohen of the
@RuellaLab
from
@PennMedicine
@kenderian_ss
0
6
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Congratulations to
@sitcancer
for the new
@jitcancer
impact factor! I am excited to be part of the Editorial Board!
@sitcancerECS
SITC is proud to announce the Journal for ImmunoTherapy of Cancer (
#JITC
), the society’s
#OpenAccess
, peer-reviewed journal, increased its impact factor to 9.913! Read highly-cited articles and check out more journal metrics at .
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We have an open post-doc position to work on a collaboration with a biotech startup
@viTToriabio
to study next-generation gene-edited CART:
Contact me at mruella
@upenn
.edu
1
11
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Great discussion at the annual meeting of the
#ASH19
Scientific Committee on Transplantation Biology and Cellular Therapies! This year our session
#ASH2019
attracted more than 500 colleagues! Great job
@AlanHanash
, Cathy Wu,
@MarcoLDavila
@MarcelaMaus
and many more!
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I feel fortunate to be able to continue working during these rough times with this great team
@RuellaLab
@PennMedicine
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Dr.Kenderian
@PEGSboston
shows that GM-CSF inhibition reduces
#CARTcell
toxicity and AXL-RTK inhibition improves their activity! Great talk!
@kenderian_ss
@MayoCancerCare
0
2
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@carlhjune
officially opens the 2023 Cellicon Valley meeting
@PennMDForum
@Penn
! Excited to meet colleagues and hear about the newest developments in
#CART
immunotherapies.
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2
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My laboratory at UPenn is hiring post-docs and research specialists to study the mechanisms of relapse after CART therapy and develop novel treatments. Email me if interested: mruella
@upenn
.edu
1
6
16
Great opportunity for early-career scientists, still a couple of weeks to apply!
@PennMedEVDCSO
@Penn_IFI
@sitcancerECS
@sitcancer
@JennGuerriero
@PennBPP
Apply for the opportunity to attend SITC’s Sparkathon 2.0 Accelerator, an exclusive program for the top emerging leaders in the cancer
#immunotherapy
field. For more information on
#SITCSparkathon
visit
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First Italian Workshop on CART therapy in Milan. Great talks from
@carlhjune
and many
@PennMedicine
colleagues!
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Excited to be here in Qatar!
Our keynote speakers for Day 2 are:
Dr.
@gorka_orive
from
@upvehu
Dr. Matthew Porteus from
@Stanford
Dr.
@MarcoRuella
from
@PennMedicine
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@_ruchipatel
from the
@RuellaLab
at
@PennMedicine
shows that CD5 deletion enhances CART function in multiple liquid and solid cancer models by enhancing T cell effector functions. Soon first-in-human trial for T-cell lymphoma with
@viTToriabio
#ASH23
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5
15
Love the enthusiasm!
@sitcancer
@MarcoRuella
@PatrickHwuMD
Can we create an
#SITC5K
walk/run organizing committee in San Diego? This will be fun, healthy, positive, and engagement for more people. 🏃🏻♂️
#letsdoit
#running
#yesyoucan
for
#CancerResearch
#immunotherapy
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At the
@TempleUniv
@FoxChaseCancer
annual retreat,
@JennGuerriero
shows great progress on targeting macrophages for cancer immunotherapy!
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2
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@sitcancer
has played a mayor role in my career development and I am very thankful to the SITC leadership, staff, and colleagues!
@sitcancerECS
@PennMedicine
Hear from the very first
#SITCFellowship
recipient
@marcoruella
of
@pennmedicine
! Learn how the award impacted his career and research. If you’re in need of funding, apply to a 2024 fellowship opportunity today.
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Post-doctoral Fellow Position Available!
The Ruella laboratory at the University of Pennsylvania is seeking post-doctoral fellows to study Next-generation CART immunotherapies.Apply by email:
@PennMedicine
@PennMedNews
@RuellaLab
@PennBPP
@nationalpostdoc
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The Ruella Laboratory at UPenn is seeking post-doctoral fellows to study the mechanisms of relapse after CART therapy and develop novel approaches. Both clinical and laboratory research projects available! Submit your application to: mruella
@upenn
.edu
1
5
14
@kenderian_ss
from
@MayoClinic
moderating a round table at
#PEGS22
ok n CART safety and toxity. Key steps forward with GM-CSF modulation!
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1
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Thanks to
@CureCancerNow
for supporting our research
@RuellaLab
@PennMedicine
@Penn_IFI
@PennMedNews
!
We are excited to announce support for 5 outstanding new scientists -
@KanarekNaama
,
@MarcoRuella
, Dr. Pengda Liu
@UNCLineberger
, Dr. Agnieszka Czechowicz
@StanfordChild
and Dr. Sahand Hormoz
@DanaFarber
. Welcome to the Gabrielle’s Angels family!
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Very exciting data on donor-derived CAR19-CIK cells for B-cell leukemia from Dr. Chiara Magnani, Monza, Italy
@ChiaraF0977243
!
1
1
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Congratulations to my graduate students to be awarded the
@NSF
GRFO fellowship! Good job!
@PennMedNews
@RuellaLab
Excited to be a new
@NSFGRFP
Fellow! This would not have been possible without the unwaivering support of
@MarcoRuella
and my family
@RuellaLab
.
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2
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Panel discussion on gene editing
@sitcancer
. Will CRISPR-Cas9allow us to enhance the power of CAR T cells? Interesting discussion with
@carlhjune
HelenHeslop, MatthewPorteus, Zhaohui Ye, Chrystal Louis.
@sitcancerECS
#SITC2020
@PennMedicine
0
2
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We look forward to having you in our group!
@RuellaLab
Very proud to receive Prix Bertrand Coiffier and to join soon
@MarcoRuella
lab in few weeks !
@LysaLymphoma
@EliLymphoma
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2
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2
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WOW! I can't wait to start seeing patients in this new Pavillion!
@RuellaLab
@PennMedicine
You’ve never seen a hospital like this. And you’ve never seen a hospital... LIKE THIS. Take a soaring journey through our revolutionary hospital, the Pavilion. Now open.
Thanks
@johnlegend
for the
#dronetour
!
@skycandystudios
@nurkfpv
@FosterPartners
@kevinbmahoney
#pennpavilion
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542
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Dr. Kenderian from
@MayoClinic
presenting on Novel strategies to avoid CART toxicities. Phenomenal results and outstanding talk!
@PennMedicine
@BLLPHD
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1
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Always nice to catch up with my Scottish friend with an Italian last name...
#cti360
@paulmaciocia
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Congrats to my friend Dr. Filippo Milano
@fmilano976
to be featured in
@ASHClinicalNews
... not just science but also football/soccer passion!
@fredhutch
0
2
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@sitcancerECS
#SITC21
Carl June moderating a "boxing match" between engineered vs. endogenous T cells against cancer!
@PennMedicine
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Thank you
@TheMarkFdn
for supporting our efforts to bring novel effective immunotherapies to cancer patients!
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Looking forward to moderating Session 703. Adoptive Immunotherapy tomorrow Saturday at 2 PM W415A. GREAT ABSTRACTS!
#ASH19
#ASH2019
@PennMedicine
@MelodySmithMD
@ASHClinicalNews
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2
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Looking forward to this
@CellPressNews
webinar on Adoptive Cell Therapies with
@lab_rezvani
and Robbie Majzner on 6/16.
@PennMedNews
0
2
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@PuneethGuru_
from the
@RuellaLab
showing our newest data on the role of modulation of BTLA in CART immunotherapy
#ASH23
@PennMedicine
0
4
8
We will discuss
#microbiota
and
#hematology
at the Scientific Symposium organized by the Transplant Biology/Cell Therapy and Immunology/host defense ASH committees.
#ASH23
@ASHClinicalNews
@ToddFehr143093
@MarcelaMaus
0
2
8
It is always great to catch up with the Italian hematology community at
#ASH22
, in particular my mentors and colleagues from Torino
@unito
!
@corradotarella
@benedettobruno
@marioboccadoro
and
@Paologhia
@PennMedicine
@Penn_IFI
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Thank you Dr. Maleki
@SMImmunology
and
@WesternU_CTCR
for organizing an amazing symposium!
@PennMedicine
@Penn_IFI
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America we have a big problem here: is it reasonable that (paying together with my employer $1,783.38/month to
@Aetna
) I am charged $1,307 for a 7-min ambulance ride for my son (luckily nothing serious) ?
@Aetna
@NarberthAmb
shame on you!
#MedicareForAll
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It would be nice also to have the option not to receive the paper copy of Blood
Hello
@ASH_hematology
!! It is 2019, isn’t it prime time to switch to planet friendly packaging! Please fix!
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Great job
@YongGuLee1
and team! Indeed, tumor apoptosis is the final goal of any cancer immunotherapy but .. but T CELL apoptosis is an issue
@PennMedicine
@PennMedEVDCSO
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Excited to present our work at this Symposium organized by
@PennMedicine
@TempleUniv
@Columbia
! Great list of speakers and a phenomenal Keynote Lecture by
@DrMvandenBrink
!
@RuellaLab
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@Mat_Angelos
from our
@RuellaLab
presenting for the for the first time a novem CD2 deleted CART2 for T-ALL: High preclinical efficacy against primary leukemias
#ASH23
@PennMedicine
0
3
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Great on CART for lymphoma by Dr. Schuster
@ESHaematology
@PennMedicine
in Mandelieu! Exciting results but still a lot of work to do...
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Welcome
@CVanpouilleBox
as new co-chair of the
@sitcancerECS
! Looking forward to working with you!
One of the greatest honors of my career has been serving as the Chair of the
@sitcancer
early career scientists committee for the past 2 yrs to support early career scientists. The
@sitcancerECS
committee is lucky to have
@MarcoRuella
&
@CVanpouilleBox
lead them into the future
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Join us at the JOINT SESSION on THE LYMPHOMA MICROENVIRONMENT AND ITS IMPACT ON THERAPY
Organized by the
Scientific Committees on Lymphoid Neoplasia a d Transp Biology & Cellular ther.
#ASH22
@GreenLymphoLab
and Kelli MacDonald. Room R03
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Dr. Drew Weissman
@WeissmanLab
at
#ASH22
stresses that COVID-19 mRNA vaccines were not developed in 10 months but rather over 30 years!
@PennMedicine
@Penn_IFI
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@DelgoffeLab
Exhausted T cells have severely altered metabolism with increased lactate uptake ... Stay tooned for upcoming publication!
@FoxChaseCancer
retreat
@TempleUniv
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@JennGuerriero
has led the
@sitcancerECS
for the last 2 years and has done an amazing job bringing innovation, building a strong peer comunity and set the bases for future developments. Thanks Jenn! We are very grateful for your service!
I’m grateful for the
@sitcancer
leadership for listening to our voice and for their unwavering support. I can’t wait to see all that
@sitcancer
will accomplish to support
@sitcancerECS
.
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Scientists: Support for the innovation engine of American science: immigrants - Sign the Petition! via
@Change
0
1
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This documentary is really inspiring. It should be watched by all of us and especially our political leaders. We need to save our planet now!
@JoeBiden
@GretaThunberg
@GiuseppeConteIT
@AttenboroughSir
@UN
#saveourplanet
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1
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Congratulations
@andrei_thomas_t
and team for this great work published in a new great journal
@BCD_AACR
A lovely cover image for our new paper depicting aberrant
#mRNA
#splice
variants in leukemia!
@YosephBarash
@RNA_Ken
@kat_hayer
@aanaqvi
@KristenWLynch1
@MarcoRuella
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Our latest review is out! Congrats to Guido, Peter, and the whole team! CAR‐T TREK through the lymphoma universe, to boldly go where no other therapy has gone before
@PennMedicine
@RuellaLab
@BritSocHaem
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1
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Looking forward to speaking tomorrow on engineering immune cells (including
#NK
cells of course) for treatment of solid tumors.
@myESMO
@OnkTherapeutics
#cart
#cancer
#geneediting
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Great point! Patrick and I together with many leaders in the field discussed this issue at the recent SITC Cellular Therapy regulatory summit.. No evidence so far that potency assays are predictive..
@sitcancer
@sitcancerECS
@FDA
>15,000 patients have been treated with CAR T cells. Do we see a correlation between potency assays and patient outcome?
#cart
#potencyassay
#celltherapy
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0
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5
.
@RepMGS
@SenToomey
@SenBobCasey
Please continue to make medical research a priority by providing robust, sustained, and predictable funding levels for NIH in FY 2022!
@RuellaLab
@PennMedicine
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Congratulations Elena, Andrei and team!
Yes! That's me &
@andrei_thomas_t
talking 6 years later about how we found that splicing and mutations were involved in resistance to CD19 CAR-T cells. Thank you
@CD_AACR
for the recognition, to the community who cited our work and all our collaborators!
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#AACR21
#AACR2021
Very interesting TownHall of the
@aacr
CIMM working group! Dr. Sandra Demaria Dr. SusanKaech
@KunleOdunsiMD
@NinaBhardwaj
@RuellaLab
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