Nitin Jain
@NitinJainMD
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Professor, Dept of Leukemia, MD Anderson Cancer Center | Director, CAR-T Leukemia Program | #CLL #ALL #TcellRx | via @aiims_newdelhi | Tweets: my own opinions
Houston, Texas
Joined August 2014
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👉👉Super delighted to share that I have been promoted to Professor of Medicine, Department of Leukemia at MDACC
My journey
AIIMS->MCW->MDACC->MSKCC->UofC->MDACC
MDACC has been my home since 2012
#hope
#endcancer
Heartfelt THANKS to all who have guided me through the yrs
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👉👉Super excited to share that I received this year’s Leukemia & Lymphoma Society (LLS) Career Development Award
A huge THANKS to Drs Kantarjian, Konopleva, Wierda, Gandhi, Mesa, Stock and many others 🙏🏽🙏🏽
@MDAndersonNews
@LLSusa
#leusm
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👉👉👉 Excited to share results of nivolumab + ibrutinib in patients with Richter Transformation | Published today in
@BloodAdvances
-24 pts DLBCL RT
-Median prior Rx for CLL/RT = 3
-10/24 (42%) had a response (64% BTKi-naive; 23% BTKi-exposed)
-Median DOR 15 mos
#CLL
#lymsm
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Super cheers to our super 🌟 Leukemia fellow Dr Senapati
@jayastuMD
who is completing Leukemia fellowship and will join us as Faculty in the Department of Leukemia 👏👏🎊🎉
@MDAndersonNews
Wishing you all the BEST!!
WELCOME!! Super proud
@DrHKantarjian
@garciamanero
@TapKadia
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👉👉I found this table derived from
@NCCN
#CML
guidelines to be extremely helpful in TKI selection based on ABL1 kinase domain mutations (I used it recently to select TKI for a patient with relapsed CML in myeloid blast crisis)
#leusm
@DrHKantarjian
@GCC_Cortes
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Something to be said about garam chai in the morning before going to work!
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👉👉It looks like we will have 2 different classifications for Hem Malignancies!! Very interesting read about history of WHO Classification.
A new International Consensus Classification of Myeloid and Lymphoid Neoplasms (ICC-MLN) vs WHO Classification
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👉👉👉Celebrating 1000th cell therapy infusion at
@MDAndersonNews
A great team effort led by Drs EJ Shpall and Sattva Neelapu
Quoting Dr Neelapu ‘We are curing patients and we are making Cancer History’ 👏👏🙏🏽🙏🏽
@EJShpallMD
@ppisters
#CARTOX
#CAR
-T
#TcellRx
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Looking forward to visiting family and friends in India! 🇮🇳
(Pic of immigration hall in Delhi- a familiar place to many of us coming to India)
#HomeSweetHome
#LoveIndia
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👉👉 Thrilled to receive second LLS award this year. This is Translational Research Program (TRP) award to target LCK in T-cell ALL. Clinical trial (IST) with ponatinib activated today.
@MDAndersonNews
Collaboration with Dr Konopleva and
@Junjyang
of
@StJude
🙏🏽🙏🏽
@LLSusa
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When you misplace you car keys for 2 days…look everywhere in the office/hospital….and finally find it👇👇😀😀
As no one took the car from the parking lot, I guess it’s time to buy a new car
#whowants2006Accord
NO ONE!!!
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When a resident is presenting detailed social history in a
#leukemia
patient and you just want know the white blood cell count
#BernieSandersMittens
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Excited to visit India to see family and friends after more than 2 years
(Long tiring journey 32 hours door to door from Houston to India ✈️ !!! )
Finally
#homesweethome
I remember a similar pic of Delhi airport by
@PallawiTorkaMD
few months ago
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Inflight to San Diego
#ASH23
Looking forward to meeting friends and colleagues! 👍👍
@doctorpemm
@mkonople
@sanamloghavi
@Anand_88_Patel
@KMirza
@HemeReports
@DrKTakahashi
@mpdrc
@bshah
@GBorthakur
@TapKadia
@Daver_Leukemia
@LoriMuffly
@TalhaBadarMD
@Dr_AmerZeidan
@jaltmanmd
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👉👉 Delighted to share our review article in
@BloodAdvances
on the role of CAR T in adult B-ALL
Strong work by our SCT/cellular therapy fellow Dr Oren Pasvolsky 👏👏 along with Drs Kebriaei, Jabbour and Shah
@bshah
@MDAndersonNews
#leusm
#cart
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Here is a summary of ABL1 and ABL2 fusions seen in Ph-Like ALL. Important to know these translocations as conventional cytogenetics may give a clue | Preclinical and anecdotal clinical data to support TKI use
#leusm
@MDAndersonNews
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July 1 always brings back old memories.
Start of residency (
@MedicalCollege
), start of fellowship (
@UChicagoMed
), and start of faculty position (
@MDAndersonNews
)
Today, I mark 10 wonderful years at MDACC !! 🙏🏽🙏🏽
#Endcancer
#leusm
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Welcome Dr Jayastu Senapati
@jayastuMD
as Leukemia faculty
@MDAndersonNews
after two wonderful years as Leukemia fellow
Looking forward to continue to work with you to
#EndCancer
👏👏👍👍
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Excited to share results of iFCG (ibrutinib, FC, Obinutuzumab) trial published in Journal Leukemia today!! Almost 7 years from the protocol writing to the publication of these results
@wwierda
@MDAndersonNews
1/4
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👉👉Exactly 10 yrs to the day, ibrutinib was approved for patients with relapsed CLL. This was the start of a paradigm shift in CLL Rx👏👏
👉👉BTKi remain one of the most effective drugs in CLL and now we are increasingly using 2nd gen and non covalent BTKi
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For Desi Twitter
Simple pleasures of life
Chai with bread pakora and Maggi tomato ketchup at 5pm after work!
yummy 🤤
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👉👉👉 Delighted to share updated results of our study with Ibrutinib Plus Venetoclax in firstline
#CLL
@wwierda
@JAMAOnc
@JAMANetwork
#leusm
@MDAndersonNews
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👉👉Last clinic day for Hima
@HimaglobinA
with us. Will miss her. Wonderful clinician, researcher and colleague. All the very best in your new adventure at
@NorthwesternMed
🙏🏽🙏🏽👏👏
cc
@doctorpemm
@TapKadia
@jaltmanmd
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Brightly lit skybridge on a chilly 🥶 sunny 🌞
#Saturday
morning in Houston
#WeekendRounds
at
@MDAndersonNews
#endcancer
#hope
#leusm
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Who uses venetoclax 400mg with posa? I mean who? I told them before not a good idea. But they don’t listen. No one listens. And 28 day continuous venetoclax. Why? Why?
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Excited to share publication of UCART19, an allogeneic CD19 CAR-T in B-ALL.
@TheLancetHaem
25 pts. Median 4 prior Rx. 72% had prior allo-SCT. Median age 37.
CR/CRi 12/25 (48%).
Median DOR 7.4 mos.
9/12 responders had subsequent allo-SCT.
Median OS 13.4 mos.
#leusm
#TcellRx
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For trainees
🌟Isolated extramedullary B-ALL is rare (unlike T-cell ALL where EMD common)
🌟Make sure to check for FISH for t(9;22) on the extra-medullary mass (as marrow would be normal). 👉👉This is very important for Rx (sometimes gets missed)
#leusm
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My 9 yr old son: Papa, does Bill Gates own all of Microsoft?
Me: I don’t know. Not all but some part, I think
Him: ok which part he owns? PowerPoint or Word or Excel??!!!
😂😂😂
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I am so glad I was able to grab
@McDonalds
Veggie Burger 🍔 before I board my flight back to USA from Mumbai! I miss these in the US
Yummy yummy 🤤
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What an inspirational evening at MPN hero event
My dear friend
@doctorpemm
receiving MPN hero award
#Congratulations
👏👏
@MDAndersonNews
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Wonderful to celebrate India’s CD19 CAR T approval on the sidelines of
#ASH23
with the
@ActImmuno
team
@purwarrahul2
@hkJain_kmc
@DrGauravNarula
Dr Nirali Shah
@ACTREC_TMC
💥A great advance for patients in India and beyond
👏👏👏🙏🏽🙏🏽
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Today (yes today Halloween 🎃 day!) marks 20 years to the today when I first came to USA
Landed in NYC (JFK) from Delhi, India
🇮🇳-> 🇺🇸
10-31-2003
NYC->Milwaukee->Houston->NYC->Chicago->Houston
Grateful for all the opportunities & looking forward to the journey ahead 🙏🏽🙏🏽
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Dr Litzow presented E1910 trial at
#ASH22
LBA
@ASH_hematology
- Blina 4 cycles added to chemo vs chemo improved OS.
Practice changing study 👏👏
Notably, pts in both arms received 4 cycles of consolidation chemo (less maintenance cycles in blina)
One important question 👇 /2
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Reviewer 2 strikes again! In part helped by Reviewer 1 and 3 😕 But there is always the next journal. Took almost 7 yrs from protocol writing to this manuscript! Wish me luck
#Reviewer2
#AcademicTwitter
#MedTwitter
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👉👉👉 Wanted to share a summary slide that I made for recently published and
#ASH21
data on dual CD19/22
#CART
in B-ALL
#Immunotherapy
#Tcellrx
#leusm
(let me know if I missed any trials or any edits)
@ASH_hematology
@ASTCT
@MDAndersonNews
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In the midst of
#COVID19
era, taking a quick break in order to help give back in these uncertain times
@MDAndersonNews
@LeukemiaMDA
@LLSTXG
@doctorpemm
#endcancer
#leusm
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Hopefully this gives a perspective of what to expect if you are planning an IST. Obviously, the timeline mentioned is just an example.
If any fellow/junior faculty want to learn more about nuts & bolts of running ISTs, please feel free to DM me. 19/19
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Remembering Dr Emil Freireich. I took this picture on his 90th Birthday in 2017
@DrHKantarjian
@LeukemiaMDA
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On way back home from a very well organized
#ASH21
with my dear friend and colleague!!
@doctorpemm
@ASH_hematology
😀
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Great to be back at
@aiims_newdelhi
(with
@doctorpemm
)
An amazing place for training, research, and patient care.
Fond memories from medical school days (central lawn in pic below looks the same as 20 yrs ago!)
@myelomaMD
@RanjitKSMD
@Prasshmehta
@Aiims1742
@vinaykjain17
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7
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Time for chai break before the start of the poster session. My
#desi
colleagues will recognize this omnipresent Indian biscuit brand
@BldCancerDoc
#ASH20
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👉👉Excited to share preclinical data with CRLF2 bispecific antibody for CRLF2-rearranged B-ALL, a high-risk disease subgroup.
Development led by ORBIT Platform at MDACC
@MDAndersonNews
@mkonople
@jmolldrem
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After a busy day of work today, this made me smile as I was exiting the parking garage at
@MDAndersonNews
| Everyone has plans for
#MemorialDay
🙂🙂🙂
@doctorpemm
@TapKadia
@sanamloghavi
@VivekSubbiah
@Aiims1742
@DrKTakahashi
@BldCancerDoc
@Transplant_Doc
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Finished my final meeting at
#ASH23
and made it to the Indian restaurant in San Diego! Looking forward to yummy food!
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One of the best part about
#ASH21
is reconnecting with friends and colleagues.
Here is a picture with 2 of the most wonderful people I know!!
Dr Stock and my former UofC Co-fellow
@LoriMuffly
👏👏
@ASH_hematology
@UCHemOncFellows
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A BIG THANK YOU to the wonderful team at MD Anderson Leukemia
@LeukemiaMDA
@MDAndersonNews
for making this possible. Amazing Colleagues. Wonderful Research team.
The BTK inhibitor ibrutinib and the BCL2 inhibitor venetoclax are active in CLL, and each has distinct adverse effects. This study examined the safety and efficacy of combined ibrutinib and venetoclax treatment in previously untreated patients with CLL.
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👉👉 Our new investigator-initiated trial of time-limited Pirtobrutinib (ncBTKi) + Venetoclax + Obin for patients requiring first-line CLL Rx is now open.
There is also a cohort for pts with Richter transformation (frontline or R/R)
@wwierda
@DrHKantarjian
1/2
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👉👉 Excited to share that our trial of ponatinib (as LCK inhibitor) + VEN + mini-CVD for R/R T-ALL is now open
👉Joint collaboration MDACC and St Jude
@Junjyang
@jiyang_yu
showed 40% T-ALL overexpress LCK and sensitive to ponatinib/dasatinib (Notably, none had ABL fusion) 1/2
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Congratulations 🎊🎉 to my friend and colleague
#LeukemiaMDA
Drs Marina Konopleva & Elias Jabbour for receiving awards for Clinical Research and Patient Care at
@MDAndersonNews
Faculty Convocation today. Very well deserved. Congrats Marina and Elie!!
@DrHKantarjian
@garciamanero
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👉👉 A summary slide of various asparaginase preparations for patients with B- and T-cell Acute Lymphoblastic Leukemia (ALL)
Thank you to our superstar Leukemia PharmD Caitlin Rausch and Shilpa Paul (
@SPaul_PharmD
) for review of the slide
#leusm
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👉👉 Super excited to join Indian Leukemia Academy workshop with
@Prasshmehta
@doctorpemm
at Amrita Hospital, Faridabad
@amritafbd
👏👏🙏🏽🙏🏽
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8
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So wonderful to see myeloma guru Dr Shaji Kumar
@myelomaMD
who and I share medical school
@aiims_nd
at the
@btfoundation
summit in Nashville!
Such an amazing person who has worked tirelessly to advance the field of myeloma
@MayoClinic
👏👏🙏🏽🙏🏽
@Aiims1742
(Pic by
@doctorpemm
)
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👉👉👉 Excited to present data on allogeneic off the shelf CD19 CAR in R/R adult B-ALL in an oral abstract session today at
#ASH21
@ASH_hematology
@DrHKantarjian
@MDAndersonNews
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Very much enjoyed hosting Dr Hasmukh Jain (
@hkJain_kmc
) and Dr Rahul Purvar (
@purwarrahul2
) at MDACC today.
#PreASH2022
Along with Dr Neelapu and Dr Senapati (
@jayastuMD
)
#TcellRx
#Leusm
#Immunotherapy
#CAR
-T
#collaboration
#cure
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👉Super delighted to see dear friend colleague mentor Dr Sattva Neelapu being awarded Faculty Achievement Award in Clinical Research at
@MDAndersonNews
Convocation with keynote by
@carlhjune
Truly well deserved award for an amazing physician scientist
Congratulations Sattva👏👏
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Whole genome sequencing as replacement for cyto, FISH, targeted mutation panel in
#AML
#MDS
| median time to WGS results 5.1 days!!
@DrKTakahashi
@doctorpemm
@sanamloghavi
@KMirza
@kanagalshamanna
@NEJM
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Thank you for the birthday wishes today! 🎉🎉 Such an honor to be working with such a wonderful group of people. A big thanks to the Leukemia team 🙏🏽 👏
(Drawings are by my kids from few years ago)
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With caveat of cross trial comparison, here are 3 trials with Ibr + Ven in frontline CLL from ASH
I think duration of I+V is a major factor in durability of responses. CAPTIVATE with 12 cycle combo numerically lower than MDACC (24 cycles) and FLAIR (2-6yr combo I+V)
Thoughts?
8
20
72
Just attended retirement farewell party for Dr Jorge Cortes | A great mentor and teacher for all of us | A big loss to
@LeukemiaMDA
@MDAndersonNews
| A BIG personal thank you 🙏🏽 for setting me on track for an academic career in Leukemia
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👉👉As we are increasingly using NGS MRD (10-6 sensitivity) vs. flow (10-4 sensitivity) such as in B-ALL, here is a brief summary slide with some general concepts about assay depth, and blood vs marrow as sample source
Welcome additional thoughts and comments.
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Amazing talk on Venetoclax resistance and overcoming resistance in
#AML
by Dr Marina Konopleva
#SOHO22
@SocietyofHemOnc
#leusm
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Super excited to see no lines at the registration desk to pick up my badge for
#ASH22
but then realized it does not open until 3pm today !
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Last day of 2 week inpatient leukemia rotation with our superstar leukemia fellow Dr Jayastu Senapati
@jayastuMD
#patientcare
#Learning
Super Thanks to our Leukemia PharmD team, Advanced Practice Providers, consulting teams, nurses and other team members 🙏🏽🙏🏽
@DrHKantarjian
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Looking forward to presenting investigator initiated phase 2 trial of time-limited pirtobrutinib + venetoclax + obinutuzumab as frontline Rx for pts with CLL at
@EHA_Hematology
EHA 2024
@wwierda
@MDAndersonNews
9
8
70
Lunch at neighborhood haldidam restaurant at AIIMS. Yummy food 🤤
Lots of fun discussion such as
👇👇
A new research project can either ‘distinguish you or extinguish you’
😂 😂 so choose wisely!
@RanjitKSMD
@SanjeevGuptaDM
@batraatulmd
@DeepamPushpam
@doctorpemm
Dr Akash
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👉👉 Thank you
@RanjitKSMD
for taking me for Ward rounds at the BMT unit at AIIMS
@aiims_nd
and for hosting me for talk and discussion on Ph like ALL 🙏🏽🙏🏽
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#India
#MedTwitter
#HemMalignancies
Saw some disturbing Twitter exchange yesterday about hematology, transplant etc. (some of the tweets now deleted)
I hope we can all rise above our differences and work together towards the common goal. Peace ✌️
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3
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Had a great time last night with our dear friend mentor colleague collaborator Dr Sattva Neelapu 👍👍🙏🏽🙏🏽
@doctorpemm
#Mentorship
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3
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Delighted to spend some time with Dr Gaurav Prakash
@DrGPrakash
@PGI_HematOnc
A wonderful doctor and human being
🙏🏽🙏🏽👏👏
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2
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Delighted to meet
@MathewsVikram
from
@cmcvelloreoff
at
#ASH22
A true visionary and pioneer in the field of hematology in India and beyond 🙏🏽🙏🏽👏👏
cc
@jayastuMD
@ManjuSengar7
@HCC_HemeCancer
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1
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Looking forward to discussing
#ASH21
updates and program priorities for
#CART
in Acute Lymphoblastic Leukemia at our
@MDAndersonNews
Leukemia Research Meeting tomorrow!
#Tcellrx
@DrHKantarjian
Auto vs Allo CAR-T
Single vs Dual vs Triple CAR-T
CAR-T for T-ALL: unmet medical need
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👉👉As we start
@ASCO
@EHA_Hematology
summer meetings, here is a summary slide I made for MRD responses in firstline CLL with combination targeted Rx. Doublets vs triplets. Marrow and PB MRD at different sensitivity at about 1 yr combo Rx. caveat- cross trial comparison
#CLL
6
18
65
👉👉 CLL Moonshot holiday lunch with Dr Keating - Father of CLL therapy . An amazing clinician. A great human being.
#Respect
#mentorship
#leadership
#ThankYou
@MDAndersonNews
🙏🏽🙏🏽👏👏🎊🎊
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63
Here is a case-based discussion for therapy of frontline
#CLL
| Clinical Advances in Hematology & Oncology | A table comparing MRD rates across novel targeted therapy combinations included.
#HappyFriday
Enjoy Reading!!
#leusm
#lymsm
#CLLsm
@MDAndersonNews
3
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My 7 yr old son: has time travel been invented yet?
Me: Why do you ask?
Him: I want to go to future to become an adult and come back to 2020 to vote!!
#Vote2020
#VoteEarly
#EveryVoteCounts
1
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63
Reading about Juvenile Myelomonocytic Leukemia (JMML) today. Some important points
- median age Dx 2 yrs (majority <6 yrs)
- elevated abs monocyte count
- splenomegaly
- skin rash
- elevated HbF
- mutations in Ras-pathway >90% (NF1, PTPN11, NRAS, KRAS)
- Allo-SCT
1/2
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