John W. Krakauer
@blamlab
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Brain, Learning, Animation, & Movement Lab: studying motor control, motor recovery, aesthetics of action, the cognitive-motor interface, & philosophy of science
Johns Hopkins; Santa Fe Inst.
Joined February 2013
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Daniel Dennett has died - genuinely devastated. Will forever miss his presence in the intellectual universe and our discussions.
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The Brain Isn’t Supposed to Change This Much - The Atlantic by
@edyong209
. Where I comment that I find the results a bit 🤷🏻♂️
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the film is a stunning reminder that a kind of neoliberal logic has worked for decades to make the culture, language, organization, and aims of academic research institutions virtually indistinguishable from those of capitalist firms
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In
@eLife
: Against cortical reorganisation Tamar Makin
@plasticity_lab
& I argue that one area of the brain cannot take over for another as claimed by remapping studies. Instead brain largely fixed in its capacities but some latent & can be up-regulated.
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Slowed canonical progress in large fields of science | PNAS - “we find a deluge of papers does not lead to turnover of central ideas in a field, but rather to ossification of canon.”
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Low frequency sound is processed via vibrotactile and vestibular (in addition to auditory) pathways, and stimulation of these non-auditory modalities in the context of music can increase ratings of groove (the pleasurable urge to move to music).
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1/Proper corrected abstract of my review of
@PessoaBrain
book “The Entangled Brain” finally out:
1/ It has become a truism that brain a complex structure. One idea associated with complex systems is that of emergence, which is often characterized
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Our provocation is out. Neuroscience Needs Behavior: Correcting a Reductionist Bias
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Ha ! here we go again..
Excited to host a debate between Gyorgi Buzsaki and John Krakauer (
@blamlab
)
@JHUArtsSciences
Psychology and Brain Sciences about ways to understand the mind and brain. The event is in-person tomorrow at 4pm (Wednesday, 5/25), please join us!
@HopkinsNeuro
@HopkinsKavli
@JHUBME
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Our article out about Learning Salon
@criticalneuro
@neuro_data
@bradpwyble
@KanakaRajanPhD
@csuncodes
@eva_y7
| Home
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If you want old ideas read new books but if want new ideas read old books.
I just finished reading an all-time classic of experiment psychology “Principles of Behavior” by Clark Hull (1943). In the book, the author tries to delineate the first principles of a scientific theory of behaviour, based on a capillary survey of (mainly) animal experiments 1/n
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An essential corrective from
@Nancy_Kanwisher
regarding a disturbing trend as of late to throw the baby out with the bath water when it comes to thinking about functional specialization in the brain.
Time to clear up some of the misconceptions and incorrect claims in this thread and accompanying paper:
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John Krakauer: Neuron - interview I gave for the SFN edition of Neuron. Be infuriated :)
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"It was not very hard to write papers that get published in good journals, but it's immensely difficult to develop treatments that will help people and change medical practice."
Eugene Braunwald
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The relationship between habits and motor skills in humans
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@spiantado
So could you please now express this philosophical opinion/thought mathematically. Thanks.
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Excited to post this latest BLAM-lab study that took a while to see the light of day. Led by
@david_huberdeau
, joined by
@adrianhaith
and
@blamlab
Continuous motor skills as flexible control policies: a video game study
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Yes - the neglect of behavioral research is a source of great shame. This belief in genes and magic bullets is a cult.
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Critical Period After Stroke Study (CPASS): A very important phase II clinical trial by Alex Dromerick (huge loss) & colleagues showing that extra intervention better early than late - humans DO show a window.
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In memoriam: Daniel C. Dennett | Santa Fe Institute
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Mental Phenomena Don’t Map Into the Brain as Expected | Quanta Magazine.
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Representation in Cognitive Science by Nicholas Shea: But Is It Thinking? The Philosophy of Representation Meets Systems Neuroscience| John W. Krakauer
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I do not think any of us who wrote the article ever thought it would have the impact, especially on young scientists, that it seems to have had. Speaking out is important in all things. Thanks for great thread
@GraziosiSergio
& to
@behaviOrganisms
@davidpoeppel
@malcolmmaciver
I also remember the precise moment when things started to click together, and I suddenly began to make sense of my previous (failed and short!) life as a researcher.
It was when I read this paper by
@blamlab
:
14/n
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"Standardized measurement of quality of upper limb movement after stroke: Consensus-based core recommendations from the Second Stroke Recovery and Rehabilitation Roundtable" (via
#referencesontap
)
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The Strength of the Corticospinal Tract Not the Reticulospinal Tract Determines Upper-Limb Impairment Level and Capacity for Skill-Acquisition in the Sub-Acute Post-Stroke Period
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My brother David being introduced at a sold out venue in Amsterdam - science can be exciting
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Science is also a transparent marketplace of attention, and it is following the same trajectory as film and music. Scientists know what journals are publishing and what the NIH is funding.
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Come hear an evening of discussion with the inimitable Yuri Buzsaki
Friends of the
#learningSalon
, please mark your calendars & pen your book margins as we host:
György Buzsáki,
"The brain from the inside out"
Friday Jan 28, 4 PM ET.
Event link:
The book:
Buzsaki lab:
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The book is out! Broken Movement: The Neurobiology of Motor Recovery after Stroke (MIT ...
#Amazon
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In Charleston
@ASNRehab
@randynudo
Steve Cramer and Tom Carmichael. Nice to be together again.
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Many Neuroscience Conferences Still Have No Black Speakers - Scientific American - excellent and sobering piece by
@lwheaton
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I am so so sorry. I loved Krishna
@shenoystanford
. Gentle, kind, funny, brave and brilliant. He gave friendship and advice so often. I hope the times he called me about what was happening health wise over the years was of some help. Heartbroken.
A brief note to remember a brilliant scientist, mentor, and cherished friend. Krishna made deep connections with everyone he interacted with. It's hard to overstate this loss.
@shenoystanford
we will miss you profoundly.
More in time. To all - please reach out if I can help.
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Learning salon was very zoological today. Thanks
@neuro_kim
- you were on fire.
@criticalneuro
@neuro_data
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The big idea: should we drop the distinction between mental and physical health?
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Lovely piece by
@YuLikeNeuro
@aaronbatista
and
@chethan
Krishna was a very good friend and we had scientific disagreements of the most fun and constructive kind.
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❤️the Putrino effect - glad to be a friend and a colleague of someone who is both an intellectual and ethical force in this space. Need both these attributes and
@PutrinoLab
has them in abundance.
and more so that we can really understand why systemic change in medicine takes so damn long. Our first episode is with
@blamlab
. I've always said that if you have a new idea about the brain, John had it first and better, so what better place to start?
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Epidural stimulation of the cervical spinal cord improves voluntary motor control in post-stroke upper limb paresis | medRxiv
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A cautionary tale and very interesting. But results of this kind have existed for a very long time if you look. For example, many observations of activation of the ipsilateral motor areas but with no consequence when deactivated/ablated.
**NEW PREPRINT ALERT** co-authored w/
@seb_trem
(yes, 2nd in a week!!)
We show that inferring a brain area’s function from neural recordings alone can be misleading, with severe consequences to the field of neuroscience.
🧵👇 (1/10)
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“All complex systems are modular and hierarchical - - by necessity” Wonder some people find this hard to accept?
All complex systems are modular and hierarchical -- by necessity. So when two complex systems are both modular and hierarchical (say, the brain and a neural network), that doesn't mean they're similar to each other. It just means they're both complex systems.
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Just published from BLAM-lab. Practice induces a qualitative change in the memory representation for visuomotor learning | Journal of Neurophysiology
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‘For 30 years I’ve been obsessed by why children get leukaemia. Now we have an answer’ | Science | The Guardian
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The SMARTS2 randomized neuroanimation trial now on medRxiv
@cereneoclinic
@TKitago
@MeretBr
@promit_roy
@JCCortex
@MChanCortes
@Steve_Zeiler
@Celnik_Lab
@JustinCMcArthu1
@HopkinsMedicine
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Excited and proud to have been invited to be part of this groundbreaking ongoing project.
#Stroke
is a devastating disease that leaves millions of people with permanent motor deficits. We explored the use of spinal
#neurotechnology
to restore voluntary arm and hand movements. Here’s a preview of the results from our first two participants
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Capitalism Is Ruining Science
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In praise of n=1 and in praise of John Rothwell
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@DrYohanJohn
🙄- all complex systems are modular. The ribosome cannot do what a mitochondrion does & vice-versa. These nevertheless interact in the life of a cell. Is it profound to say either life is distributed across the cell or that there are no organelles just nodes in a network? No.
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Too exciting
We (=
@criticalneuro
+
@blamlab
+me) are thrilled to host *Jay McClelland* (who wrote PDP, the 'bible' of cogsci according to many) on
#LearningSalon
this Friday @ 4PM ET at on "Why people are still smarter than machines?" Everyone is welcome to join!
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@neuro_data
@KordingLab
@criticalneuro
@russpoldrack
@pollyp1
@tyrell_turing
@neurograce
@alfairhall
@SaraASolla
@bttyeo
@behrenstimb
@TonyZador
@anne_churchland
I would like to believe that we will converge on a more synthesized view of the interaction between cortex, basal ganglia, and cerebellum for control of movement. It seems computationally and experimentally doable but 10 years may be too optimistic.
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Should be sent to NIH and HHMI ASAP.
Absolute 🔥 from
@yael_niv
:
"Behavioral, rather than neuroscientific research, is essential for understanding the brain, contrary to the opinion of prominent funding bodies and scientific journals, who erroneously place neural data on a pedestal"
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Something on the verge of being lost….
Fantastic piece by Marten Scheffer on the forgotten half of thinking:
".. taking walks, reading things unrelated to your research, and hanging out with strangers in a campus pub should be considered part of the serious process of thinking .."
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Get ready for some fiery debate 😆
This Friday Feb 11th, 4 PM ET please join
@blamlab
@csuncodes
& myself as we are excited to host
@fierycushman
.
Salon:
Fiery's lab studies moral decision making, social learning, & uses RL & neuroscience to do so.
Lab:
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Original work - as usual 😊
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Please join us at the Salon for what promises to be a very deep discussion with Steven Piantadosi on the computational origins of mental representation.
The Learning Salon hosted by myself &
@blamlab
is super excited to host
@spiantado
tomorrow, Friday 4 PM ET, to talk about:
"Church Encoding as the link between Cognition and Neuroscience"
Related reading:
Join us
#learningsalon
!
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Javier has been studiously commenting on and translating my stroke recovery work into Spanish. It was lovely to finally meet him in Madrid in December.
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Come hear us discuss cognitive control with David Badre.
The
#LearningSalon
with
@blamlab
@csuncodes
& me is delighted to host
@BadreLab
this Friday
July 29th, 4 PM ET
David will tell us about his book, On task. Escape the heatwave & join us!
On Task: How Our Brains Get Things Done
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Latest from BLAM-Lab: A theory for curing the diseases of modernity
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Interesting
We’ve identified the somato-cognitive action network (SCAN), a newly recognized network within human primary motor cortex that disrupts the famous—but incorrect—motor homunculus, and has strong connections to high-level control networks. Now out in
@Nature
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New paper from
@Celnik_lab
@blamlab
@MeretBr
@jingxulvscience
@JCCortex
@cereneoclinic
: Differential Poststroke Motor Recovery in an Arm Versus Hand Muscle in the Absence of Motor Evoked Potentials
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Very proud of this exciting work by an amazing team that I am lucky to be part of. The core idea is that chronic stroke is going to need principled physiological intervention. Going forward will need amplification by new impairment-focused behavioral interventions.
🚨New paper out in
@NatureMedicine
! Epidural Spinal Cord Stimulation (SCS) has shown amazing results for improving
#MotorControl
, but does it work in
#Stroke
? Here we explore the effect of SCS on upper limb motor control in chronic stroke hemiparesis (1/9)
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Alzheimer’s disease large-scale gene expression portrait identifies exercise as the top theoretical treatment | Scientific Reports
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Very proud of my soul sister and partner in crime 🥳
Excited to say I was promoted to Principal Researcher
@MSFTResearch
NYC. Cousin wondered if now I chase researchers in the yard & call ppl to my office but
@hannawallach
says it’s about intellectual innovations with creativity & freedom, & being the goto in my field.
Grateful😊
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Roger Lemon a big influence - very pleased to see him recognized in this way.
Delighted to see Roger Lemon elected as a Fellow of
@royalsociety
for pioneering neuroscience research. Congratulations Roger!
You can read more about Roger’s research in our special 50 years’ collection of articles here:
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Interesting and very important
‘Why FND is not Feigning or Malingering’ - our new
@NatRevNeurol
review and synthesis - with
@M_Yogarajah
and Mark Edwards . a thread… 1/
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Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial - The Lancet
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via
@NYTimes
“I want to make clear my own attitude,” Dr. Lewontin said in 2009. “I think most of the interesting questions about human individual and social behavior will never be answered. The human species will be extinct before they are.”
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Tamar Makin’s
@plasticity_lab
great thread on our paper just out.
1/14 Just out in eLife : Against Cortical Reorganization, a critical review by Tamar Makin and John Krakauer
@blamlab
, challenging historical perspectives on remapping. A great resource for educators developing seminars/modules on brain plasticity! A thread
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What a refreshing perspective !
Rather than asking AI researchers how soon machines will become "smarter than people", perhaps we should be asking cognitive scientists, who actually know something about human intelligence?
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Devastating facts - the US is a strangely malignant country
NEW: I’m not sure people fully appreciate how dire the US life expectancy / mortality situation has got.
My column:
And some utterly damning charts.
1) at *every* point on the income distribution, Americans live shorter lives than the English.
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“Again, an administrator called him into his office. “If you were gay and not flamboyant, we would keep you,” Dr. Fryer recalled him saying. “If you were flamboyant & not gay, we would keep you. But since you are both gay & flamboyant, we cannot keep you.”
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“Yoshua Bengio,, agreed that current A.I lacks something related to symbols or abstract reasoning. Dr. Dehaene’s work, he said, presents “evidence that human brains are using abilities that we don’t yet find in state-of-the-art machine learning.”
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No effect of transcranial direct current stimulation of frontal, motor or visual cortex on performance of a self-paced visuomotor skill - ScienceDirect
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Holding the arm still through subcortical mathematical integration of cortical commands - new work from
@reziliusReza
with some help from us :)
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MindMaze and Mount Sinai Launch at Home Tele-Neurorehabilitation Program for Stroke Patients
@PutrinoLab
@MindMazeTech
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Allan McDonald, Who Refused To Approve Shuttle Challenger Launch, Dead At 83 : “Always, always do the right thing for the right reason at the right time with the right people. [And] you will have no regrets for the rest of your life."
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