Nature Reviews Molecular Cell Biology
@NatRevMCB
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A Reviews journal from @SpringerNature. Timely Review articles, Comments and Highlights of the latest research in molecular cell biology.
London, UK
Joined November 2011
Now Online Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
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We've just published a tour-de-force Review on the metabolic regulation of skeletal muscle in response to exercise 💪🏼🏃🏾. Fantastic effort by the authors: @JonoSmith01.@KevinMurachPhD @DyarKen @JuleenRZierath . This Review is free to access for 30 days!.
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Now Online Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology
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Now Online Challenges and directions in studying cell–cell communication by extracellular vesicles
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Now Online The molecular basis of translation initiation and its regulation in eukaryotes
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Now Online Cell cycle control in cancer
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Now Online Global view of human protein glycosylation pathways and functions
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Now Online The assembly, regulation and function of the mitochondrial respiratory chain
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Now Online CRISPR technologies for genome, epigenome and transcriptome editing
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Now Online Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions
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Now Online Energy-driven genome regulation by ATP-dependent chromatin remodellers
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Now Online Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression
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Now Online A guide to membraneless organelles and their various roles in gene regulation
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Now Online The principles of directed cell migration
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Now Online: The role and regulation of integrins in cell migration and invasion
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Now Online Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
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Now Online Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens
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Now Online: Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases
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Now Online A guide to cell death pathways
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Now Online Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
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Now Online The molecular basis for cellular function of intrinsically disordered protein regions
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Now Online MicroRNA-mediated regulation of glucose and lipid metabolism
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Now Online Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
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Now Online Mechanisms of SARS-CoV-2 entry into cells
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Now Online Cell–extracellular matrix mechanotransduction in 3D
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Now Online Intracellular mRNA transport and localized translation
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Now Online The expanding world of tRNA modifications and their disease relevance
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Now Online The cell biology of ferroptosis
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Now Online A guide to machine learning for biologists
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Now Online Mechanical regulation of early vertebrate embryogenesis
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Now Online Co-transcriptional gene regulation in eukaryotes and prokaryotes
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Now Online Quality control of the mitochondrial proteome
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Now Online SenNet recommendations for detecting senescent cells in different tissues
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Phase separation is hotter than ever! Don't miss out on the Review by Hyman & Rosen -- read the full article:
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Now Online Mechanics and functional consequences of nuclear deformations
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Now Online Control of satellite cell function in muscle regeneration and its disruption in ageing
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Now Online Cellular senescence in ageing: from mechanisms to therapeutic opportunities
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Now Online Nuclear compartmentalization as a mechanism of quantitative control of gene expression
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Now Online Molecular mechanisms of dietary restriction promoting health and longevity
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Now Online The roles of histone variants in fine-tuning chromatin organization and function
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Now Online Fibroblast and myofibroblast activation in normal tissue repair and fibrosis
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Now Online The aetiology and molecular landscape of insulin resistance
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Now Online Targeted protein degradation: from mechanisms to clinic
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Now Online Ubiquitin ligases: guardians of mammalian development
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Now Online ncRNA regulation of mitochondrial transcription
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Now Online Re-evaluate evaluation letters — set scientists free!
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Now Online The physiology of alternative splicing
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Now Online The senescence-associated secretory phenotype and its physiological and pathological implications
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A great read: Review by Statello, Guo, Chen & Huarte on Gene regulation by long non-coding RNAs . #lncRNAs #generegulation. @MaiteHuarteLab @CIMA_unav .
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Our newest #NRMCBReview is now online!.🧬Revolutionizing DNA repair research and cancer therapy with CRISPR–Cas screens✂️. by @SamahAwwad3, @almuseben, John C Thomas, @vg29029 and @SPJacksonGroup . 🔗
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A classic! Review on CRISPR -- know more abut this powerful tool. Full text here:
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Now Online Guidelines and definitions for research on epithelial–mesenchymal transition
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Now Online The plasticity of DNA replication forks in response to clinically relevant genotoxic stress
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✨New #NRMCBReview 🥳.Control of stem cell renewal and fate by YAP and TAZ.by @driskilljordan1 & Duojia Pan. Read here how the 🦛pathway effectors YAP/TAZ regulate stem cell function:.
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Now Online Cellular and molecular mechanisms of skin wound healing
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Now Online Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation
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Now Online Cellular origins of dsRNA, their recognition and consequences
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To further explore the universe of #biomolecularcondensates see this Collection of #Reviews, journal clubs and selected research articles @NaturePortfolio highlighting recent progress in mechanisms and roles of #LiquidLiquidPhaseSeparation in biology .
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Now Online Regulation of microtubule dynamics, mechanics and function through the growing tip
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Fresh from press #Review by Henry De Belly, Ewa Paluch & Kevin Chalut discussing the cooperation between #mechanosensing, #cellsignalling and #cellmechanics in regulating #cellfate. @KevinChalut @PaluchLab @Henry_de_belly @Cambridge_Uni @UCSF .
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Now Online Cytoskeletal control of early mammalian development
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Fresh from press #Review by Claudio Collinet and Thomas Lecuit discussing how tissues are shaped during development - program versus self-organization. @LecuitLab @centuri_ls @cdf1530. #morphogenesis #development.
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Now Online Applications of CRISPR–Cas in agriculture and plant biotechnology
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Now Online Human topoisomerases and their roles in genome stability and organization
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New frontiers in #mechanobiology !. Fresh from press #Review by Dupont, Frezza and co. on the crosstalk between #mechanotransduction and #metabolism . @SirioDupont.@UniPadova.@FrezzaLab.@MRC_CU. #cellmechanics #cellmetabolism.
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New #Review from @VolkerHaucke lab @LeibnizFMP. on the role of #phosphoinositides in shaping and directing membrane dynamics #lipidsignaling. Access FREE pdf here: #sharedit
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Now Online Context-dependent TGFβ family signalling in cell fate regulation
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Now Online The molecular principles of gene regulation by Polycomb repressive complexes
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Now Online Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
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Now Online Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design
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Now Online Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins
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Now Online Phosphoinositides as membrane organizers
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Now Online Mechanisms of substrate processing during ER-associated protein degradation
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Now Online Cellular and molecular mechanisms of Hedgehog signalling
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Featured on June cover #Review by Tsutomu Suzuki on #tRNA modifications and their roles in disease. #RNAmodifications.@UTokyo_News_en.
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The lipotype hypothesis - our newest comment from.@Gio_Dangel0 and @GioeleLaManno (@EPFL) on how membrane lipid composition impacts on signalling:. 🔗
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♨️Hot article notification♨️. Challenges and directions in studying cell–cell communication by #ExtracellularVesicles. @DaveCarter1234, @guillaume_niel @VaderPieter Clayton Lambert & Raposo. #EVsAreCool. FREE pdf: Full text:
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Now Online Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
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Now Online Long non-coding RNAs: definitions, functions, challenges and recommendations
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Now Online Autophagy and autophagy-related pathways in cancer
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Our first #NRMCBReview of 2023 is out now and it's a special one! John Mattick and colleagues have put together a Consensus Statement addressing the definition, nomenclature and classification of long non-coding RNAs. Have a read here: 🔗 #lncRNA
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Now Online Molecular mechanisms underlying nucleotide repeat expansion disorders
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Now Online Immortalizing switch to OXPHOS
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A must read for all #CRISPR enthusiasts. This time highlighting the yang: mechanisms and #biotechnology applications of anti-CRISPR proteins!. by Ning Jia & Dinshaw Patel. @sloan_kettering. . FREE pdf available #sharedit
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Are you looking for a comprehensive Review on selective #autophagy? Tamotsu Yoshimori, @LabYoule and colleagues discuss the different autophagy pathways in their recent.#NRMCBReview:. 🚨
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Now Online Mechanisms of assembly and remodelling of the extracellular matrix
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Now Online Mechanisms of bone development and repair
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Now Online Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics
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Now Online White adipocyte dysfunction and obesity-associated pathologies in humans
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Check out our new #Review by Pere Roca-Cusachs @IBECBarcelona and Johanna Ivaska @johannaivaska @IvaskaLab on Integrins as biomechanical sensors of the microenvironment #integrin #mechanobiology #extracellularmatrix #mechanosensing #development #cancer
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In their recent #Review Chen And Rechavi discuss the role of small RNAs in cellular and organismal communication. #signaling #smallRNA.@UCRCNAS @odedrechavi .
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Celebrate #DNAday2020 with this #Review by Maxim V. C. Greenberg @maxvcg & Deborah Bourc’his @DeborahBourchis @institut_curie discussing the diverse roles of #DNAmethylation in mammalian #development and #diseases . Access here:
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Now Online Mechanisms controlling pancreatic islet cell function in insulin secretion
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Now Online Pore-forming proteins as drivers of membrane permeabilization in cell death pathways
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✨ICYMI: New #NRMCBReview on the role of actin in mitochondrial biology, e.g., during mitochondrial fission, dysfunction and #mitophagy, or motility. ➡️"The multiple links between actin and mitochondria" by @TakShunFung, @raj_mito and @hhiggslab.
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New #Review by Ivana Jerkovic´ & Giacomo Cavalli.critically discussing methods for #GenomeOrganization analysis. #3Dgenome #ChromatinOrganization. @giacomo_cavalli.@IGH_MTP . Full article link: FREE pdf is here: #sharedit
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Now Online Regulation and functions of non-m6A mRNA modifications
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Now Online The multiple links between actin and mitochondria
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Our newest & very comprehensive #NRMCBReview discusses both established and cutting-edge multi-omics technologies, and the optimization of throughput and resolution, modality integration, and accuracy. @AlevBaysoy, @Zhiliang_Bai, @RongFan8 & @satijalab .👉🏼
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Now online 📢 New #NRMCBReview 🚨.@BakerLabUtah and @RutterLab review the literature on how metabolites can act as signalling molecules in different cellular processes. Read their comprehensive discussion here:. 🔗
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